Research on Mechanisms of Appetite-regulating Peptides
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摘要: 食欲调节肽是一类能够调节食欲的多肽，主要分布在胃肠道、脂肪组织等外周组织以及下丘脑中，按其作用机理的不同，可分为正向调节食欲肽和负向调节食欲肽。下丘脑在食欲调节的过程中扮演了重要角色，其与胃肠道、脂肪组织等外周组织的信息交流是食欲调节的重要方式。通过对神经肽Y（Neuropeptide Y，NPY）、胃饥饿素（Ghrelin）、肽YY（Peptide YY，PYY）和瘦素（Leptin）四种食欲调节肽以及食物与食欲调节肽关系的综述，利用数学和统计学方法探究食欲调节的热点问题及其关系，有助于了解食欲调节肽的作用机制和研究现状，以期通过食疗来调节食欲，预防疾病的发生，可为进一步研究食欲调节肽提供思路参考。Abstract: Appetite-regulating peptides are a class of polypeptides which can regulate appetite. They are mainly distributed in peripheral tissues such as the stomach and intestines,as well as in the hypothalamus. They can be divided into appetite-stimulating peptides and appetite-suppressing peptides according to their different mechanisms. The hypothalamus plays an important role in the process of appetite regulation,and its communication with peripheral tissues such as stomach and intestinal tract is an important way of appetite regulation. Our review discusses four appetite signaling pathways such as neuropeptide Y(NPY),ghrelin,peptide YY(PYY),leptin and the relationship between food and appetite-regulation peptides. Using mathematical and statistical methods can explore hot issues and their relationships in appetite regulation. This helps to understand the mechanism and research status in appetite-regulating peptides,in order to regulate appetite through diet,prevent the happening of the disease,and can provide references for further research on appetite regulation.
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Keywords:
- appetite-regulating peptides /
- neuropeptide Y(NPY) /
- peptide YY(PYY) /
- ghrelin /
- leptin
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