Abstract: Objective: To investigate the hypoglycemic effect of oat peptides in rats. Methods: In this research, hypoglycemic functions of oat peptides were studied in vivo. Using the ICR diabetes mice, hypoglycemic related indicators after peptides intervention were tested.90 female ICR rices were divided into six groups randomly: nomal control group, model group ( DMBG0.6 g/kg) , low-dose oat peptides group ( oat peptides 0.25 g/kg) , medium-dose oat peptides group ( oat peptides 0.5 g/kg) , high-dose oat peptides group ( oat peptides 1 g/kg) , continuous filling stomach for 28 days. The level of weight, diet, drinking water, blood glucose, insulin and liver glycogen were measured.Results: The weight of mice in the oat peptides groups were all increased slowly.Compared with the model group, the food-intake in the high-dose oat peptides group were significantly induced from the second week ( p < 0.05) , and the water consumption in the high-dose oat peptides group were significantly induced from the thind week ( p < 0.05) , blood sugar was significantly decreased from the second week to fourth week ( p <0.01) and from the third week to fourth week in the medium-dose group ( p < 0.01) .At the end of the fourth week mice in the high-dose and medium-dose group, its hepatic glycogen content were significantly increased ( p < 0.05) , and insulin level were significantly improved in the high-dose group ( p < 0.05) . Conclusion: Oat peptides could increase mice body weight, and improve its diabetes symptoms of food intake.