Study on extraction technology of flavonoids and polyphenols from Coreopsis tinctoria Nutt.by using Random Centroid Optimization
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摘要: 采用随机质心优化设计研究了新疆雪菊中黄酮和多酚类化合物的亚临界水提取工艺。实验结果表明,亚临界水可有效地提取雪菊中的黄酮和多酚类物质,通过对提取温度、料液比和提取时间三个因素的优化和验证,获得了亚临界水的最佳提取工艺条件为:提取温度160~170℃、料液比0.04、提取时间47min。在该条件下,雪菊黄酮和多酚总含量达到了25.85%以上,其中,总黄酮的含量大于15.81%,总多酚的含量大于10.04%。随机质心优化法可以不进行单因素实验直接优化实验参数,具有优化过程简单,实验次数少、广泛的适应性等特点,而亚临界水同时提取多酚和黄酮的工艺完全避免有机溶剂和酸的使用,是高效、无毒、环保的绿色提取技术。Abstract: Random- Centroid Optimization ( RCO) methodology was used to optimize the extraction technology of flavonoids and polyphenols from the Coreopsis tinctoria Nutt.grow in xinjiang.The results showed that Subcritical Water Extraction was a effective methods for flavonoids and polyphenols.By comparing the extraction temperature, solid- liquid ratio and extraction time, the optimum extraction process of flavonoids and polyphenols from the Coreopsis tinctoria Nutt.has been established as follows: extraction temperature 160~170℃, solid- liquid ratioratio0.04, extraction time 47 min.In this condition, the total yields of flavonoids and polyphenols was more than 25.85%, and among them the flavonoids was more than 15.81%, the polyphenols was more than 10.04%. Parameter optimization could be carried out directly without single test by using Random- Centroid Optimization methodology, which had the advantages of simplicity, fewer experiments and flexibility.Meanwhile flavonoids and polyphenols could be extracted simultaneously with subcritical water, which was organic solvent- free and acid-free.That is a green extract technology with high-efficiency, non toxic and environmental-friendly.
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