CHEN Chunming, MI Rui, YU Shuang, et al. Research Progress on Preparation and Skin Care Related Effects of Sea Cucumber Peptides[J]. Science and Technology of Food Industry, 2025, 46(11): 1−12. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024060393.
Citation: CHEN Chunming, MI Rui, YU Shuang, et al. Research Progress on Preparation and Skin Care Related Effects of Sea Cucumber Peptides[J]. Science and Technology of Food Industry, 2025, 46(11): 1−12. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024060393.

Research Progress on Preparation and Skin Care Related Effects of Sea Cucumber Peptides

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  • Received Date: June 26, 2024
  • Available Online: March 30, 2025
  • Sea cucumber is rich in protein, polysaccharides, unsaturated fatty acids, saponins, minerals, vitamins and various nutrients and bioactive ingredients, showing a variety of nutrition value and health effects. Therefore, there has been a traditional habit of using sea cucumber as food and medicine in China and some Asian countries. Sea cucumber peptides possess a variety of bioactivities such as immunity enhancing ability, anti-fatigue, anti-aging, anti-inflammatory, and their application has been expanded. With the changing concept of nutritious diet and skin health maintenance, sea cucumbers have attracted much attention for their high edible value and rich collagen. In this paper, the preparation, deodorization, separation and purification methods of sea cucumber peptides from sea cucumber were summarized, and the research progress of sea cucumber peptides stability and skin care related effects such as moisturizing, antibacterial, anti-inflammatory, anti-aging, whitening and sunscreen, promoting tissue repair were reviewed. Finally, the scientific problems to be solved in the study of sea cucumber peptide were discussed, and the development potential of sea cucumber peptide in new application directions was prospected, providing a reference for the research of sea cucumber deep processing and sea cucumber peptide products.
  • [1]
    孙小飞, 罗国瑞, 刘念, 等. 海参多肽生物活性研究进展[J]. 中国食品学报,2023,23(9):409−419. [SUN X F, LUO G R, LIU N, et al. Research progress on bioactivities of sea cucumber polypeptides[J]. Journal of Chinese Institute of Food Science and Technology,2023,23(9):409−419.]

    SUN X F, LUO G R, LIU N, et al. Research progress on bioactivities of sea cucumber polypeptides[J]. Journal of Chinese Institute of Food Science and Technology, 2023, 23(9): 409−419.
    [2]
    SHOU Y W, FENG C, LU Q P, et al. Research progress on the chemical components and biological activities of sea cucumber polypeptides[J]. Frontiers in Pharmacology,2023,14:1290175.
    [3]
    赵丽, 吴光斌, 陈发河. 海参多肽提取纯化及其生物活性研究进展[J]. 食品工业,2019,40(2):252−256. [ZHAO L, WU G B, CHEN F H. Research progress on extraction, purification and biological activity of sea cucumber peptide[J]. The Food Industry,2019,40(2):252−256.]

    ZHAO L, WU G B, CHEN F H. Research progress on extraction, purification and biological activity of sea cucumber peptide[J]. The Food Industry, 2019, 40(2): 252−256.
    [4]
    OMRAN N E. Nutritional value of some Egyptian sea cucumbers[J]. African Journal of Biotechnology,2013,12(35):5466−5472.
    [5]
    EGLOSO N, DELANTAR F. Acceptability of sea cucumber (Holothuria nobilis) food chips and its nutritional value:inputs to income generating project[C]//9th International Conference on Environmental, Chemical, Biological and Medical Sciences, 2018:8−12.
    [6]
    苏永昌, 刘淑集, 刘秋凤, 等. 海地瓜营养成分的分析及评价[J]. 渔业研究,2016,38(4):288−294. [SU Y C, LIU S J, LIU Q F, et al. Analysis and evaluation of nutritional components in Acaudina molpadioides[J]. Journal of Fisheries Research,2016,38(4):288−294.]

    SU Y C, LIU S J, LIU Q F, et al. Analysis and evaluation of nutritional components in Acaudina molpadioides[J]. Journal of Fisheries Research, 2016, 38(4): 288−294.
    [7]
    JAYATHILAKE N J, WIMALAGUNARATHNA N D, WIJESEKARA I, et al. Holothuria atra:An underutilized marine resource for nutritional and collagen benefits[J]. Asian Journal of Biotechnology and Bioresource Technology,2023,9(3):41−51.
    [8]
    KETHARANI U, SIVASHANTHINI K. Nutritional composition of selected species of sea cucumbers from waters around Jaffna Peninsula, Sri Lanka[J]. Ketharani and Sivashanthini,2016,13:67−72.
    [9]
    WEN J, HU C Q, FAN S G. Chemical composition and nutritional quality of sea cucumbers[J]. Journal of the Science of Food and Agriculture,2010,90(14):2469−2474.
    [10]
    周光东. 东海光参的特性及利用研究[D]. 舟山:浙江海洋大学, 2018:16. [ZHOU G D. Study on characteristics and utilization of Cucumaria japonica from the East China Sea [D]. Zhoushan:Zhejiang Ocean University, 2018.]

    ZHOU G D. Study on characteristics and utilization of Cucumaria japonica from the East China Sea [D]. Zhoushan: Zhejiang Ocean University, 2018.
    [11]
    GAO Y, LI Z B, QI Y X, et al. Proximate composition and nutritional quality of deep sea growth sea cucumbers (Stichopus japonicus) from different origins[J]. Journal of the Science of Food and Agriculture,2016,96(7):2378−2383.
    [12]
    李伟, 佟长青. 海参肽果汁:中国, CN 103330160A[P]. 2013-10-02 [2024-08-15]. [LI W, TONG C Q. Sea cucumber peptide juice:China, CN 103330160A [P]. 2013-10-02 [2024-08-15.]

    LI W, TONG C Q. Sea cucumber peptide juice: China, CN 103330160A [P]. 2013-10-02 [2024-08-15.
    [13]
    杨艳艳. 一种海参肽的制备方法:中国, CN 117016794A[P]. 2023-11-10 [2024-08-15]. [YANG Y Y. A preparation method for sea cucumber peptide:China, CN 117016794A [P]. 2023-11-10 [2024-08-15].]

    YANG Y Y. A preparation method for sea cucumber peptide: China, CN 117016794A [P]. 2023-11-10 [2024-08-15].
    [14]
    赵兴坤, 赵楠. 一种海参肽功能食品及其制备方法:中国, CN 101341978[P]. 2009-01-14[2024-08-15]. [ZHAO X K, ZHAO N. A functional food of sea cucumber peptide and its preparation method:China, CN 101341978 [P]. 2009-01-14[2024-08-15].]

    ZHAO X K, ZHAO N. A functional food of sea cucumber peptide and its preparation method: China, CN 101341978 [P]. 2009-01-14[2024-08-15].
    [15]
    孙娜, 崔蓬勃, 吴海涛, 等. 一种海参卵肽钙螯合物的制备方法:中国, CN 105671114A[P]. 2016-06-15[2024-08-15]. [SUN N, CUI P B, WU H T, al. A preparation method of calcium chelate of sea cucumber roe peptide:China, CN 105671114A [P]. 2016-06-15[2024-08-15].]

    SUN N, CUI P B, WU H T, al. A preparation method of calcium chelate of sea cucumber roe peptide: China, CN 105671114A [P]. 2016-06-15[2024-08-15].
    [16]
    CHENG M Y, YANG M L, MU X, et al. The isolation, purification and active mechanism of sea cucumber bone-strengthening functional peptides [J]. Preprints, 2024, 2024040096.
    [17]
    MAN J C, ABD EL-ATY A, WANG Z Z, et al. Recent advances in sea cucumber peptide:Production, bioactive properties, and prospects[J]. Food Frontiers,2023,4(1):131−163.
    [18]
    WANG Y C, SONG Y, CHANG Y G, et al. Dynamic changes of peptidome and release of polysaccharide in sea cucumber (Apostichopus japonicus) hydrolysates depending on enzymatic hydrolysis approaches[J]. Food Science and Human Wellness,2022,11(5):1331−1341.
    [19]
    刘金丽, 樊芳, 何晓霞, 等. 红极参肽的酶法制备工艺优化及其抗氧化评价[J]. 食品工业科技,2022,43(20):235−243. [LIU J L, FAN F, HE X X, et al. Enzymatic preparation of the peptide of Cucumaria frondosa and its antioxidant evaluation[J]. Science and Technology of Food Industry,2022,43(20):235−243.]

    LIU J L, FAN F, HE X X, et al. Enzymatic preparation of the peptide of Cucumaria frondosa and its antioxidant evaluation[J]. Science and Technology of Food Industry, 2022, 43(20): 235−243.
    [20]
    王扬铎, 苏永昌, 王晓燕, 等. 仿刺参不同部位ACE抑制活性分析及活性肽制备工艺优化[J]. 食品工业科技,2024,45(10):187−197. [WANG Y D, SU Y C, WANG X Y, et al. Analysis of ACE inhibitory activity in different parts of sea cucumber (Apostichopus japonicus) and optimization of preparation process of active peptides[J]. Science and Technology of Food Industry,2024,45(10):187−197.]

    WANG Y D, SU Y C, WANG X Y, et al. Analysis of ACE inhibitory activity in different parts of sea cucumber (Apostichopus japonicus) and optimization of preparation process of active peptides[J]. Science and Technology of Food Industry, 2024, 45(10): 187−197.
    [21]
    刘畅, 张慧艳, 常雨晴, 等. 内外源酶制备海参肽的组成及抗氧化性质研究[J]. 食品工业科技,2022,43(11):136−143. [LIU C, ZHANG H Y, CHANG Y Q, et al. Study on composition and antioxidant properties of sea cucumber peptides prepared by internal and external enzymes[J]. Science and Technology of Food Industry,2022,43(11):136−143.]

    LIU C, ZHANG H Y, CHANG Y Q, et al. Study on composition and antioxidant properties of sea cucumber peptides prepared by internal and external enzymes[J]. Science and Technology of Food Industry, 2022, 43(11): 136−143.
    [22]
    FAN X R, WU K, TIAN X H, et al. Endogenous proteases in sea cucumber (Apostichopus japonicas):Deterioration and prevention during handling, processing, and preservation[J]. Foods,2024,13(13):2153.
    [23]
    LIU Z Q, LIU Y X, ZHOU D Y, et al. The role of matrix metallo protease (MMP) to the autolysis of sea cucumber (Stichopus japonicus)[J]. Journal of the Science of Food and Agriculture,2019,99(13):5752−5759.
    [24]
    LIU Y X, ZHOU D Y, MA D D, et al. Changes in collagenous tissue microstructures and distributions of cathepsin L in body wall of autolytic sea cucumber (Stichopus japonicus)[J]. Food Chemistry,2016,212:341−348.
    [25]
    YAN L J, ZHAN C L, CAI Q F, et al. Purification, characterization, cDNA cloning and in vitro expression of a serine proteinase from the intestinal tract of sea cucumber (Stichopus japonicus) with collagen degradation activity[J]. Journal of Agricultural and Food Chemistry,2014,62(20):4769−4777.
    [26]
    张美. 刺参性腺酶解物及其美拉德反应产物风味和抗氧化活性研究[D]. 上海:上海海洋大学, 2023:4. [ZHANG M. Study of flavor and antioxidant activity in Stichopus japonisus gonads enzymatics and maillard reaction products [D]. Shanghai:Shanghai Ocean University, 2023.]

    ZHANG M. Study of flavor and antioxidant activity in Stichopus japonisus gonads enzymatics and maillard reaction products [D]. Shanghai: Shanghai Ocean University, 2023.
    [27]
    QUAISIE J, MA H, GUO Y T , et al. Impact of sonication on slurry shear-thinning of protein from sea cucumber (Apostichopus japonicus):Proteolytic reaction kinetics, thermodynamics, and conformational modification [J]. Innovative Food Science & Emerging Technologies, 2021, 70:102678.
    [28]
    JIN H X, XU H P, LI Y, et al. Preparation and evaluation of peptides with potential antioxidant activity by microwave assisted enzymatic hydrolysis of collagen from sea cucumber Acaudina molpadioides obtained from Zhejiang province in China[J]. Marine Drugs,2019,17(3):169. doi: 10.3390/md17030169
    [29]
    TAN Z F, DING Y, TIAN J Y, et al. Inhibition of ultraviolet-induced sea cucumber (Stichopus japonicus) autolysis by maintaining coelomocyte intracellular calcium homeostasis[J]. Food Chemistry,2022,368:130768.
    [30]
    YASUDA M, MORIKAWA S, SAKAGUCHI M, et al. A novel fermented food product prepared from soybean protein-calcium-gel with Monascus fungus:Changes in protein and nitrogen compounds during fermentation[J]. Food Science and Technology Research,2009,15(3):325−330.
    [31]
    韩爽, 刘奎, 张健, 等. 一株分解海参体壁蛋白的耐盐菌株的筛选及发酵条件优化[J]. 食品与发酵工业,2021,47(21):39−45. [HAN S, LIU K, ZHANG J, et al. Screening of a salt-tolerant strain decomposing of sea cucumber and fermentation optimization[J]. Food and Fermentation Industries,2021,47(21):39−45.]

    HAN S, LIU K, ZHANG J, et al. Screening of a salt-tolerant strain decomposing of sea cucumber and fermentation optimization[J]. Food and Fermentation Industries, 2021, 47(21): 39−45.
    [32]
    SARI S S, MUSTOPA A Z, IRAWAN H, et al. Extracellular protease characterization of the Lactococcus lactis subsp. lactis and its application on protein hydrolysis toward indonesian sea cucumber (Holothuria sp. ) and Lorjuk shelfish (Solen sp. ) as an antioxidant alternative[J]. Philippine Journal of Science,2023,152(6B):2305−2314.
    [33]
    孟令辉. 基于菌酶交互技术的刺参肠低聚肽与越橘果渣可溶性膳食纤维的制备方法及微囊化研究[D]. 烟台:烟台大学, 2022:25. [MENG L H. Preparation method and microencapsulating study of Stichopus japonicas intestine oligopeptide and bilberry pomace soluble dietary fiber based on bacterial enzyme interaction technology [D]. Yantai:Yantai University, 2022.]

    MENG L H. Preparation method and microencapsulating study of Stichopus japonicas intestine oligopeptide and bilberry pomace soluble dietary fiber based on bacterial enzyme interaction technology [D]. Yantai: Yantai University, 2022.
    [34]
    梁杰, 陈熙. 海参内脏蛋白提取工艺研究[J]. 食品科技,2015,40(11):117−121. [LIANG J, CHEN X. Extracting of sea cucumber viscera protein[J]. Food science and technology,2015,40(11):117−121.]

    LIANG J, CHEN X. Extracting of sea cucumber viscera protein[J]. Food science and technology, 2015, 40(11): 117−121.
    [35]
    孟春英. 仿刺参体壁中抗菌肽的分离纯化及抗菌活性研究[D]. 上海:上海海洋大学, 2016. [MENG C Y. Isolation and antibacterial activity of peptide from body wall of Apostichopus japonicas [D]. Shanghai:Shanghai Ocean University, 2016.]

    MENG C Y. Isolation and antibacterial activity of peptide from body wall of Apostichopus japonicas [D]. Shanghai: Shanghai Ocean University, 2016.
    [36]
    TSUGITA A, UCHIDA T, MEWES H W, et al. A rapid vapor-phase acid (hydrochloric acid and trifluoroacetic acid) hydrolysis of peptide and protein[J]. The Journal of Biochemistry,1987,102(6):1593−1597.
    [37]
    MOORE S, STEIN H. Methods in enzymohgy [M]. New York:Academic Press, 1963:819-831.
    [38]
    CRUZ-CASAS D E, AGUILAR C N, ASCACIO-VALDÉS J A, et al. Enzymatic hydrolysis and microbial fermentation:The most favorable biotechnological methods for the release of bioactive peptides[J]. Food Chemistry:Molecular Sciences,2021,3:100047.
    [39]
    ABUINE R, RATHNAYAKE A U, BYUN H G. Biological activity of peptides purified from fish skin hydrolysates[J]. Fisheries and aquatic sciences,2019,22(1):1−14.
    [40]
    贾楠, 沙炫利, 吴琳蓉, 等. 海参胶的脱腥精制及体外消化特性研究[J]. 食品安全质量检测学报,2023,14(8):138−147. [JIA N, SHA X L, WU L R, et al. Investigation of the deodorization refinement and in vitro digestion properties of sea cucumber gelatin[J]. Journal of Food Safety and Quality,2023,14(8):138−147.]

    JIA N, SHA X L, WU L R, et al. Investigation of the deodorization refinement and in vitro digestion properties of sea cucumber gelatin[J]. Journal of Food Safety and Quality, 2023, 14(8): 138−147.
    [41]
    SHI L F, LI Z R, YANG Z Q, et al. Adsorption characteristics of V-type starch for off-odors of sea cucumber intestinal peptides in solid-phase environment[J]. Food Chemistry,2024,433:137171. doi: 10.1016/j.foodchem.2023.137171
    [42]
    郑金娃, 汪秋宽, 何云海, 等. 海参多肽脱色脱腥工艺的优化研究[J]. 大连海洋大学学报,2013,28(3):303−306. [ZHENG J W, WANG Q K, HE Y H, et al. Technique optimization of decolorization and deodorization for sea cucumber hydrolysates[J]. Journal of Dalian Ocean University,2013,28(3):303−306.] doi: 10.3969/j.issn.2095-1388.2013.03.017

    ZHENG J W, WANG Q K, HE Y H, et al. Technique optimization of decolorization and deodorization for sea cucumber hydrolysates[J]. Journal of Dalian Ocean University, 2013, 28(3): 303−306. doi: 10.3969/j.issn.2095-1388.2013.03.017
    [43]
    孔令娟, 迟玉森, 郑琳. 一种富含海参活性多糖的刺参口服液及其制造方法:中国, CN201710905450.9[P]. 2020-11-20 [2024-05-13]. [KONG L J, CHI Y S, ZHEN L. A japonicus oral liquid rich in active sea cucumber polysaccharides and its manufacturing method:China, CN201710905450.9 [P]. 2020-11-20 [2024-05-13].]

    KONG L J, CHI Y S, ZHEN L. A japonicus oral liquid rich in active sea cucumber polysaccharides and its manufacturing method: China, CN201710905450.9 [P]. 2020-11-20 [2024-05-13].
    [44]
    陶卫建. 一种海参除腥方法:中国, CN201710895063.1[P]. 2018-02-09 [2024-05-13]. [TAO W J. A method of removing fishy water from sea cucumber:China, CN201710895063.1 [P]. 2018-02-09 [2024-05-13].]

    TAO W J. A method of removing fishy water from sea cucumber: China, CN201710895063.1 [P]. 2018-02-09 [2024-05-13].
    [45]
    包卫洋, 马普, 杨大苹, 等. 一种海参肽去除腥味工艺:中国, CN108065412A[P]. 2018-05-25[2024-08-17]. [BAO W Y, MA P, YANG D P, et al. A process for removing the fishy smell of sea cucumber peptides:China, CN108065412A [P]. 2018-05-25[2024-08-17].]

    BAO W Y, MA P, YANG D P, et al. A process for removing the fishy smell of sea cucumber peptides: China, CN108065412A [P]. 2018-05-25[2024-08-17].
    [46]
    LIU B Y, SU Y W, LÜ D F, et al. Efficient and green deodorization of sea cucumber peptides by using a low concentration of hydrogen peroxide [J]. Research Square, 2023-06-29.
    [47]
    LIU Y, HUANG Y Z, WANG Z M, et al. Recent advances in fishy odour in aquatic fish products, from formation to control[J]. International Journal of Food Science & Technology,2021,56(10):4959−4969.
    [48]
    张胜男, 崔琦, 喻佩, 等. 海参肠酶解液美拉德反应增香工艺研究[J]. 食品安全质量检测学报,2019,10(15):4944−4952. [ZHANG S N, CUI Q, YU P, et al. Study on flavoring technology of enzymatic hydrolysate of sea cucumber sausage by maillard reaction[J]. Journal of Food Safety & Quality,2019,10(15):4944−4952.] doi: 10.3969/j.issn.2095-0381.2019.15.017

    ZHANG S N, CUI Q, YU P, et al. Study on flavoring technology of enzymatic hydrolysate of sea cucumber sausage by maillard reaction[J]. Journal of Food Safety & Quality, 2019, 10(15): 4944−4952. doi: 10.3969/j.issn.2095-0381.2019.15.017
    [49]
    杨坤. 叶瓜参提取物的酶法制备及其抗衰老活性研究[D]. 广州:华南理工大学, 2018. [YANG K. Study on the enzymatic preparation and anti-aging activities of Cucumaria frondosa extracts [D]. Guangzhou:South China University of Technology, 2018.]

    YANG K. Study on the enzymatic preparation and anti-aging activities of Cucumaria frondosa extracts [D]. Guangzhou: South China University of Technology, 2018.
    [50]
    NICOLI M C, ANESE M, PARPINEL M T, et al. Loss and/or formation of antioxidants during food processing and storage[J]. Cancer letters,1997,114(1-2):71−74.
    [51]
    汪韬, 温运启, 于娇, 等. 富含乳酸菌的脱腥海参肽粉的制备[J]. 食品与发酵工业,2020,46(18):187−191. [WANG T, WEN Y Q, YU J, et al. Preparation of deodorized sea cucumber peptide powder rich in lactic acid bacteria[J]. Food and Fermentation Industries,2020,46(18):187−191.]

    WANG T, WEN Y Q, YU J, et al. Preparation of deodorized sea cucumber peptide powder rich in lactic acid bacteria[J]. Food and Fermentation Industries, 2020, 46(18): 187−191.
    [52]
    刘咏霖. 红曲海参和乳酸菌发酵红曲海参的制备及其挥发性成分分析[D]. 烟台:烟台大学, 2023:62. [LIU Y L. Preparation and analysis of volatile components of monascus sea cucumber and Lactobacillus fermented monascus sea cucumber [D]. Yantai:Yantai University, 2023.]

    LIU Y L. Preparation and analysis of volatile components of monascus sea cucumber and Lactobacillus fermented monascus sea cucumber [D]. Yantai: Yantai University, 2023.
    [53]
    CHEN Z X, LIU Y L, PAN Y Y, et al. Effect of different deodorization methods on enzymatic hydrolysate of sea cucumber (Stichopus japonicas) intestines and gonads[J]. Food and Fermentation Industries,2022,48(5):187−192.
    [54]
    王家伟, 秦德文. 一种去腥味的海参口服液的制备方法:中国, CN201710249070.4[P]. 2017-04-17 [2024-05-13]. [WANG J W, QING D W. A preparation method for sea cucumber oral liquid with deodorization of fishy smell:China, CN201710249070.4 [P]. 2017-04-17 [2024-05-13].]

    WANG J W, QING D W. A preparation method for sea cucumber oral liquid with deodorization of fishy smell: China, CN201710249070.4 [P]. 2017-04-17 [2024-05-13].
    [55]
    石友盛, 谢文强, 陈贤功, 等. 3种海参脱腥方法的效果比较研究[J]. 食品研究与开发,2021,42(20):79−85. [SHI Y S, XIE W Q, CHEN X G, et al. Comparative study on the effects of three deodorization methods on sea cucumber[J]. Food Research and Development,2021,42(20):79−85.] doi: 10.12161/j.issn.1005-6521.2021.20.012

    SHI Y S, XIE W Q, CHEN X G, et al. Comparative study on the effects of three deodorization methods on sea cucumber[J]. Food Research and Development, 2021, 42(20): 79−85. doi: 10.12161/j.issn.1005-6521.2021.20.012
    [56]
    张聿钦, 杨希. 一种去除海参腥味的处理方法:中国, CN 201310017237[P]. 2013-10-01 [2024-05-13]. [ZHANG Y Q, YANG X. A method of removing fishy water from sea cucumber:China, CN 201310017237 [P]. 2013-10-01 [2024-05-13].]

    ZHANG Y Q, YANG X. A method of removing fishy water from sea cucumber: China, CN 201310017237 [P]. 2013-10-01 [2024-05-13].
    [57]
    YD S, EM A, YUSOFF A, et al. Extraction, purification and physical characterization of collagen from body wall of sea cucumber (Bohadschia bivitatta)[J]. Journal of Environmental Health,2013,4(2):53−65.
    [58]
    ZHONG M, CHEN T, HU C Q, et al. Isolation and characterization of collagen from the body wall of sea cucumber Stichopus monotuberculatus[J]. Journal of Food Science,2015,80(4):C671−679.
    [59]
    于淑池, 张鸣芯. 光参多肽的酶解制备工艺及其功能特性研究[J]. 中国食品添加剂,2021,32(5):60−67. [YU S C, ZHANG M X. Research on the enzymatic preparation and functional properties of polypeptide from Cucumaria japonica[J]. China Food Additives,2021,32(5):60−67.]

    YU S C, ZHANG M X. Research on the enzymatic preparation and functional properties of polypeptide from Cucumaria japonica[J]. China Food Additives, 2021, 32(5): 60−67.
    [60]
    高芮. 海参加工液中蛋白及多糖的提取工艺[D]. 大连:大连理工大学, 2019:56. [GAO R. Extraction process of polysaccharide and protein from waste liquor of processing sea cucumber [D]. Dalian:Dalian University of Technology, 2019.]

    GAO R. Extraction process of polysaccharide and protein from waste liquor of processing sea cucumber [D]. Dalian: Dalian University of Technology, 2019.
    [61]
    周田田, 张红, 袁文鹏. 海洋多肽的提取纯化及生物活性研究进展[J]. 食品工业科技,2022,43(19):419−426. [ZHOU T T, ZHANG H, YUAN W P. Research progress on extraction, purification and biological activity of marine peptides[J]. Science and Technology of Food Industry,2022,43(19):419−426.]

    ZHOU T T, ZHANG H, YUAN W P. Research progress on extraction, purification and biological activity of marine peptides[J]. Science and Technology of Food Industry, 2022, 43(19): 419−426.
    [62]
    包玉刚. 鳀鱼蒸煮液电渗析脱盐及反渗透浓缩技术研究[D]. 杭州:浙江工业大学, 2016:13-14. [BAO Y G. Study on electrodialysis desalination and reverse osmosis concentration technology of Engraulis japonicus cooking liquid [D]. Hangzhou:Zhejiang University of Technology, 2016.]

    BAO Y G. Study on electrodialysis desalination and reverse osmosis concentration technology of Engraulis japonicus cooking liquid [D]. Hangzhou: Zhejiang University of Technology, 2016.
    [63]
    邓波. 海参内脏酶解产物活性研究[D]. 厦门:集美大学, 2015:44. [DENG B. Study on the activity of the enzymatic hydrolysis product of sea cucumber viscera [D]. Xiameng:Jimei University, 2015.]

    DENG B. Study on the activity of the enzymatic hydrolysis product of sea cucumber viscera [D]. Xiameng: Jimei University, 2015.
    [64]
    董丽莎, 李妍妍, 张红燕, 等. 两种海参多肽对糖尿病大鼠肾脏的防护作用研究[J]. 食品工业科技,2017,38(9):343−348. [DONG L S, LI Y Y, ZHANG H Y, et al. Protective effect of two kinds of sea cucumber polypeptide on kidney of diabetic rats[J]. Science and Technology of Food Industry,2017,38(9):343−348.]

    DONG L S, LI Y Y, ZHANG H Y, et al. Protective effect of two kinds of sea cucumber polypeptide on kidney of diabetic rats[J]. Science and Technology of Food Industry, 2017, 38(9): 343−348.
    [65]
    ZHAO Y H, LI B F, LIU Z L, et al. Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate[J]. Process Biochemistry,2007,42(12):1586−1591.
    [66]
    陈娟娟. 黑乳海参胶原蛋白活性肽的研究[D]. 郑州:河南大学, 2013:27-29. [CHEN J J. Study on the collagen activity peptide of Holothuria nobilis selenka [D]. Zhengzhou:Henan University, 2013.]

    CHEN J J. Study on the collagen activity peptide of Holothuria nobilis selenka [D]. Zhengzhou: Henan University, 2013.
    [67]
    GUO K X, SU L N, WANG Y C, et al. Antioxidant and anti-aging effects of a sea cucumber protein hydrolyzate and bioinformatic characterization of its composing peptides[J]. Food & Function,2020,11(6):5004−5016.
    [68]
    DONG X F, YANG X H, LI H Y, et al. Effects of oxidation on the structure of collagen fibers of sea cucumber (Apostichopus japonicus) body wall during thermal processing[J]. LWT-Food Science and Technology,2021,138:110528.
    [69]
    JIANG B X, HU L P, ZHANG X M, et al. Uncovering proteome variations of differently heat-treated sea cucumber (Apostichopus japonicus) by label-free mass spectrometry[J]. Food Chemistry,2021,344:128575.
    [70]
    WANG J, LIN L, SUN X, et al. Mechanism of sea cucumbers (Apostichopus japonicus) body wall changes under different thermal treatment at micro-scale[J]. LWT-Food Science and Technology,2020,130:109461.
    [71]
    ZHANG M, LIU Y X, WU Z X, et al. Analysis of texture properties and water-soluble fraction proteome of sea cucumber body wall with different boiling heating treatment[J]. Food Chemistry,2023,409:135333. doi: 10.1016/j.foodchem.2022.135333
    [72]
    LI X R, YANG R W, JU H P, et al. Identification of dominant spoilage bacteria in sea cucumber protein peptide powders (SCPPs) and methods for controlling the growth of dominant spoilage bacteria by inhibiting hygroscopicity[J]. LWT,2021,136:110355.
    [73]
    WANG K, SUN N, LI D M, et al. Enzyme-controlled hygroscopicity and proton dynamics in sea cucumber (Stichopus japonicus) ovum peptide powders[J]. Food Research International,2018,112:241−249.
    [74]
    陶腾州. 刺参肠道源抗菌肽的分离、纯化及抗菌活性研究[D]. 烟台:烟台大学, 2019:43-45. [TAO T Z. Optimum extraction, isolation and antimicrobial activity analysis of intestinal antimicrobial peptides from Apostichopus japonicus [D]. Yantai:Yantai University, 2019.]

    TAO T Z. Optimum extraction, isolation and antimicrobial activity analysis of intestinal antimicrobial peptides from Apostichopus japonicus [D]. Yantai: Yantai University, 2019.
    [75]
    LI C Y, FU Y, DAI H J, et al. Recent progress in preventive effect of collagen peptides on photoaging skin and action mechanism[J]. Food Science and Human Wellness,2022,11(2):218−229.
    [76]
    LI P H, LU W C, CHAN Y J, et al. Extraction and characterization of collagen from sea cucumber (Holothuria cinerascens) and its potential application in moisturizing cosmetics[J]. Aquaculture,2020,515:734590.
    [77]
    米锐, 周遵春, 孟楠. 海参内脏酶解物和体壁溶出物的护肤功效评价[J]. 现代食品科技,2023,39(1):222−229. [MI R, ZHOU Z C, MENG N. Evaluation on the skin-care efficacy of the viscera enzymatic hydrolysates and body wall extracts of sea cucumber Apostichopus japonicas[J]. Modern Food Science and Technology,2023,39(1):222−229.]

    MI R, ZHOU Z C, MENG N. Evaluation on the skin-care efficacy of the viscera enzymatic hydrolysates and body wall extracts of sea cucumber Apostichopus japonicas[J]. Modern Food Science and Technology, 2023, 39(1): 222−229.
    [78]
    王奕. 日本刺参胶原蛋白多肽和鱿鱼皮胶原蛋白多肽护肤活性的研究[D]. 青岛:中国海洋大学, 2007:39-41, 53-55. [WANG Y. Study on skin protective property of AJCP and SSCP [D]. Qingdao:Ocean University of China, 2007.]

    WANG Y. Study on skin protective property of AJCP and SSCP [D]. Qingdao: Ocean University of China, 2007.
    [79]
    OH C T, KWON T R, JANG Y J, et al. Inhibitory effects of Stichopus japonicus extract on melanogenesis of mouse cells via ERK phosphorylation[J]. Molecular Medicine Reports,2017,16(2):1079−1086. doi: 10.3892/mmr.2017.6686
    [80]
    YIN H W, YUE H, WANG M, et al. Peptides from sea cucumber intestine:Preparation and promoting cartilage callus formation in mice with tibial fractures by promoting the polarization of M1 to M2 macrophages[J]. Journal of Functional Foods,2023,108:105718. doi: 10.1016/j.jff.2023.105718
    [81]
    ZHENG Z H, LI M Q, JIANG P F, et al. Peptides derived from sea cucumber accelerate cells proliferation and migration for wound healing by promoting energy metabolism and upregulating the ERK/AKT pathway[J]. European Journal of Pharmacology,2022,921:174885. doi: 10.1016/j.ejphar.2022.174885
    [82]
    POPOV A, ARTYUKOV A, KRIVOSHAPKO O, et al. Biological activities of collagen peptides obtained by enzymic hydrolysis from Far-Eastern holothurians[J]. American Journal of Biomedical and Life Sciences,2013,1(1):17−26. doi: 10.11648/j.ajbls.20130101.14
    [83]
    王铭遥, 郑明静, 任中阳, 等. 凡纳滨对虾抗菌肽的筛选及与DNA的结合机制[J]. 中国食品学报,2023,23(7):140−151. [WANG M Y, ZHENG M J, RENG Z Y, et al. Antimicrobial peptides screened from Penaeus vannamei shrimp and investigation of their DNA binding mechanism[J]. Journal of Chinese Institute of Food Science and Technology,2023,23(7):140−151.]

    WANG M Y, ZHENG M J, RENG Z Y, et al. Antimicrobial peptides screened from Penaeus vannamei shrimp and investigation of their DNA binding mechanism[J]. Journal of Chinese Institute of Food Science and Technology, 2023, 23(7): 140−151.
    [84]
    TAN J, LIU Z H, PERFETTO M, et al. Isolation and purification of the peptides from Apostichopus japonicus and evaluation of its antibacterial and antitumor activities[J]. African Journal of Microbiology Research,2012,6(44):7139−7146.
    [85]
    孟春英, 王茂剑, 张健, 等. 仿刺参体壁中抗菌肽的分离及抑菌活性[J]. 食品科学,2016,37(7):33−38. [MENG C Y, WANG M J, ZHANG J, et al. Isolation and activity of antimicrobial peptide from body wall of Apostichopus japonicas[J]. Food Science,2016,37(7):33−38.] doi: 10.7506/spkx1002-6630-201607007

    MENG C Y, WANG M J, ZHANG J, et al. Isolation and activity of antimicrobial peptide from body wall of Apostichopus japonicas[J]. Food Science, 2016, 37(7): 33−38. doi: 10.7506/spkx1002-6630-201607007
    [86]
    CUSIMANO M G, SPINELLO A, BARONE G, et al. A synthetic derivative of antimicrobial peptide holothuroidin 2 from mediterranean sea cucumber (Holothuria tubulosa) in the control of Listeria monocytogenes[J]. Marine Drugs,2019,17(3):159. doi: 10.3390/md17030159
    [87]
    LIN Y G, LIN C X, CAO Y, et al. Caenorhabditis elegans as an in vivo model for the identification of natural antioxidants with anti-aging actions[J]. Biomedicine & Pharmacotherapy,2023,167:115594.
    [88]
    赵玲, 殷邦忠, 刘淇, 等. 4种海参多肽抗氧化活性的比较研究[J]. 中国海洋药物,2012,31(2):19−24. [ZHAO L, YIN B Z, LIU Q, et al. Comparative study on antioxidation activity of polypeptides from four kinds of sea cucumbers[J]. Chinese Journal of Marine Drugs,2012,31(2):19−24.]

    ZHAO L, YIN B Z, LIU Q, et al. Comparative study on antioxidation activity of polypeptides from four kinds of sea cucumbers[J]. Chinese Journal of Marine Drugs, 2012, 31(2): 19−24.
    [89]
    ZHANG Y, HE S D, BONNEIL É, et al. Generation of antioxidative peptides from Atlantic sea cucumber using alcalase versus trypsin:In vitro activity, de novo sequencing, and in silico docking for in vivo function prediction[J]. Food Chemistry,2020,306:125581. doi: 10.1016/j.foodchem.2019.125581
    [90]
    WANG T T, ZHENG L, LIU X L, et al. Sea cucumber (Holothuria nobilis) hydrolysates improve diabetic nephropathy via suppression of oxidative stress in high-fat diet/streptozotocin-induced diabetic rats[J]. Journal of Functional Foods,2023,106:105589. doi: 10.1016/j.jff.2023.105589
    [91]
    WANG Q Q, SHI J Y, ZHONG H, et al. High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice[J]. Journal of Functional Foods,2021,86:104677. doi: 10.1016/j.jff.2021.104677
    [92]
    ZHANG X M, LI H N, WANG L Z, et al. Anti-inflammatory peptides and metabolomics‐driven biomarkers discovery from sea cucumber protein hydrolysates[J]. Journal of Food Science,2021,86(8):3540−3549. doi: 10.1111/1750-3841.15834
    [93]
    SONG J J, LI T G, CHENG X, et al. Sea cucumber peptides exert anti-inflammatory activity through suppressing NF-κB and MAPK and inducing HO-1 in RAW264. 7 macrophages [J]. Food & Function, 2016, 7(6):2773−2779.
    [94]
    CAI N, LUO W Q, YAO L J, et al. Activation of murine RAW264. 7 macrophages by oligopeptides from sea cucumber (Apostichopus japonicus) and its molecular mechanisms [J]. Journal of Functional Foods, 2020, 75:104229.
    [95]
    杨军楠, 栾俊家, 崔方超, 等. 不同蛋白酶海参酶解液的制备及其体外免疫调节活性[J]. 食品研究与开发,2023,44(11):43−52. [YANG J N, LUAN J J, CUI F C, et al. Preparation of hydrolysates of sea cucumber with different proteases and the in vitro immunomodulatory activities[J]. Food Research and Development,2023,44(11):43−52.] doi: 10.12161/j.issn.1005-6521.2023.11.007

    YANG J N, LUAN J J, CUI F C, et al. Preparation of hydrolysates of sea cucumber with different proteases and the in vitro immunomodulatory activities[J]. Food Research and Development, 2023, 44(11): 43−52. doi: 10.12161/j.issn.1005-6521.2023.11.007
    [96]
    SHI H, HU X Q, ZHENG H, et al. Two novel antioxidant peptides derived from Arca subcrenata against oxidative stress and extend lifespan in Caenorhabditis elegans[J]. Journal of Functional Foods,2021,81:104462. doi: 10.1016/j.jff.2021.104462
    [97]
    GARCEZ M L, CASSOMA R C S, MINA F, et al. Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose[J]. Metabolic Brain Disease,2021,36:213−224. doi: 10.1007/s11011-020-00647-7
    [98]
    LIN L Z, ZHU Q Y, ZHENG L, et al. Preparation of sea cucumber (Stichopus variegates) peptide fraction with desired organoleptic property and its anti-aging activity in fruit flies and D-galactose-induced aging mice[J]. Journal of Functional Foods,2020,69:103954. doi: 10.1016/j.jff.2020.103954
    [99]
    CHEN K X, SHI L F, REN Z Y, et al. Antioxidant characteristics of hydrolysate from low-value sea cucumber:In vitro and in vivo activities of Caenorhabditis elegans[J]. Food Chemistry:X,2023,19:100836.
    [100]
    HUANG S S, WANG K Y, HUA Z, et al. Size-controllable food-grade nanoparticles based on sea cucumber polypeptide with good anti-oxidative capacity to prolong lifespan in tumor-bearing mice[J]. International Journal of Biological Macromolecules,2023,253:127039. doi: 10.1016/j.ijbiomac.2023.127039
    [101]
    BUKHARI S N A, ROSWANDI N L, WAQAS M, et al. Hyaluronic acid, a promising skin rejuvenating biomedicine:A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects[J]. International Journal of Biological Macromolecules,2018,120:1682−1695. doi: 10.1016/j.ijbiomac.2018.09.188
    [102]
    DING Y L, JIRATCHAYAMAETHASAKUL C, KIM E A, et al. Hyaluronidase inhibitory and antioxidant activities of enzymatic hydrolysate from Jeju Island red sea cucumber (Stichopus japonicus) for novel anti-aging cosmeceuticals[J]. Environmental Science, Agricultural and Food Sciences,2018,10(2):62−72.
    [103]
    REILLY D M, LOZANO J. Skin collagen through the lifestages:Importance for skin health and beauty[J]. Plastic and Aesthetic Research,2021,8(1):21−44.
    [104]
    王欢. 刺参多肽影响NIH/3T3细胞增殖及Ⅰ型胶原蛋白表达的研究[D]. 济南:山东大学, 2015:50-51. [WANG H. The preliminary studies of the polypeptide from Stichopus japonicus on the proliferation and type I collagen expression of NIH/3T3 cells [D]. Jinan:Shandong University, 2015.]

    WANG H. The preliminary studies of the polypeptide from Stichopus japonicus on the proliferation and type I collagen expression of NIH/3T3 cells [D]. Jinan: Shandong University, 2015.
    [105]
    宋淑亮, 王欢, 梁浩, 等. 海参肽的分离纯化及其对NIH/3T3细胞胶原蛋白分泌的影响[J]. 现代食品科技,2017,33(3):22−28. [SONG S L, WANG H, LIANG H, et al. Isolation and purification of sea cucumber peptide and its impact on the secretion of collagen by NIH/3T3 cells[J]. Modern Food Science and Technology,2017,33(3):22−28.]

    SONG S L, WANG H, LIANG H, et al. Isolation and purification of sea cucumber peptide and its impact on the secretion of collagen by NIH/3T3 cells[J]. Modern Food Science and Technology, 2017, 33(3): 22−28.
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