A Preliminary Study on the Effects of Tartary Buckwheat-derived Nanoparticles on the Physiology of C57BL/6 Mice

ZHANG Jiyue; REN Chaoqin; CAO Yanan; REN Yuanhang; PENG Lianxin

doi:10.13386/j.issn1002-0306.2024060055

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ZHANG Jiyue, REN Chaoqin, CAO Yanan, et al. A Preliminary Study on the Effects of Tartary Buckwheat-derived Nanoparticles on the Physiology of C57BL/6 Mice[J]. Science and Technology of Food Industry, 2025, 46(11): 1−9. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024060055.

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A Preliminary Study on the Effects of Tartary Buckwheat-derived Nanoparticles on the Physiology of C57BL/6 Mice

ZHANG Jiyue^{1, 2,},
REN Chaoqin³,
CAO Yanan^{1, 2},
REN Yuanhang^{1, 2},
PENG Lianxin^{1, 2, ,}

1.
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu 610106, China
2.
Sichuan Province Engineering Technology Research Center of Coarse Cereal Industralization, Chengdu 610106, China
3.
School of Resources and Environment, Aba Normal University, Aba Prefecture 623002, China

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Received Date: June 05, 2024
Available Online: March 25, 2025

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Abstract

Abstract

Objective: To investigate the effects of dietary supplementation with tartary buckwheat-derived nanoparticles (TBDNs) on key physiological parameters in mice. Methods: Twenty-four C57BL/6 mice were randomly assigned to two groups: a normal control group and a TBDNs group. Changes in body weight, blood biochemical markers, cell histology and immunohistochemistry of the colon and liver, as well as intestinal flora composition, were analyzed. Results: Compared to the normal diet group, the 10 mg TBDNs group exhibited significant reductions in body weight, triglyceride levels, uric acid levels, and alanine aminotransferase activity (P<0.01). Physiological indicators such as aspartate aminotransferase, cholesterol, high-density lipoprotein, low-density lipoprotein, and creatinine, as well as liver and colon tissues, showed no significant changes (P>0.05). The abundance of intestinal Lactobacillus, Turicibacter, and Lachnoclostridium species were all significant increased (P<0.05). Conclusion: Intake of TBDNs has discernible physiological effects on mice, however, further investigations are required to elucidate its underlying mechanisms and potential health benefits. These findings provide novel insights and data for nutritional evaluation of tartary buckwheat.
- tartary buckwheat,
- tartary buckwheat-derived nanoparticles,
- gut microbiota,
- nutrition and health

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