Research Progress and Control Status of Chloropropanol Ester, Perchlorate and Chlorate in Infant Formula Milk Powder

ZHAI Zhifang; LONG Jihong

doi:10.13386/j.issn1002-0306.2024030476

Volume 46 Issue 5

Feb. 2025

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Science and Technology of Food Industry > 2025 > 46(5): 405-414. > DOI: 10.13386/j.issn1002-0306.2024030476

ZHAI Zhifang, LONG Jihong. Research Progress and Control Status of Chloropropanol Ester, Perchlorate and Chlorate in Infant Formula Milk Powder[J]. Science and Technology of Food Industry, 2025, 46(5): 405−414. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024030476.

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Research Progress and Control Status of Chloropropanol Ester, Perchlorate and Chlorate in Infant Formula Milk Powder

ZHAI Zhifang,
LONG Jihong^,

Center for Food Evaluation, State Administration for Market Regulation, Beijing 100045, China

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Received Date: March 31, 2024
Available Online: December 26, 2024

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Abstract

Abstract

Infant formula milk powder, a crucial nourishment for newborns, holds immense significance in relation to their healthy development and overall safety. The presence of chloropropanol ester, perchlorate, and chlorate (collectively known as "trichloride") in these products has garnered significant attention due to their potential harm to infants' growth. In the past three years, through stringent formula registration review requirements and urging enterprises to adopt risk prevention and control measures, remarkable progress has been made in mitigating the risk of "trichloride" in infant formula milk powder. Drawing from recent registration and evaluation work and investigative findings, this paper comprehensively outlines the primary hazards, contamination sources, limit standards, and detection methods for "trichloride" in infant formula milk powder. It further delves into the status of "trichloride" prevention and control measures implemented by both raw material suppliers and manufacturers. By incorporating current registration and evaluation criteria, this paper puts forward opinions and suggestions on how to further minimize the contamination risk of "trichloride", providing technical guidance for infant formula milk powder risk prevention and control efforts. Additionally, it serves as a reference for production enterprises to enhance their quality management standards.
- infant formula milk powder,
- chloropropanol ester,
- perchlorate,
- chlorate

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References (53)

References

[1]	龙继红. 婴幼儿配方乳粉标签规范管理分析[J]. 乳业科学与技术,2017,40(2):34−37. [LONG J H. Analysis of infant formula labeling standardization and management[J]. Journal of Dairy Science and Technology,2017,40(2):34−37.] LONG J H. Analysis of infant formula labeling standardization and management[J]. Journal of Dairy Science and Technology, 2017, 40（2）: 34−37.
[2]	LESSEN R, KAVANAGH K. Position of the academy of nutrition and dietetics:Promoting and supporting breastfeeding[J]. Journal of the Academy of Nutrition&Dietetics,2015,115(3):444−449.
[3]	何湘漪, 周密, 耿健强, 等. 我国婴幼儿配方乳粉标准与CAC标准比较[J]. 乳品与人类,2022,127(6):38−45. [HE X Y, ZHOU M, GENG J Q, et al. Comparison between Chinese infant formula milk powder standard and CAC standard[J]. Dairy and Humankind,2022,127(6):38−45.] doi: 10.3969/j.issn.1671-5071.2022.06.009 HE X Y, ZHOU M, GENG J Q, et al. Comparison between Chinese infant formula milk powder standard and CAC standard[J]. Dairy and Humankind, 2022, 127（6）: 38−45. doi: 10.3969/j.issn.1671-5071.2022.06.009
[4]	中国新闻网. 新国标实施一周年中国婴配乳粉注册工作取得成效[EB/OL]. [2024-02-23]. https://www.samr.gov.cn/xw/mtjj/art/2024/art_c4fe0c069f3c4459b9b4ed3c6b79808f.html.
[5]	BECALSKI A, ZHAO T, FENG S, et al. A pilot survey of 2-and 3-monochloropropanediol and glycidol fatty acid esters in baby formula on the Canadian market 2012-2013[J]. J Food Compost Anal,2015,44:111−114. doi: 10.1016/j.jfca.2015.08.004
[6]	里南, 方勤美, 严小波, 等. 我国市售食用植物油中脂肪酸氯丙醇酯的污染调查[J]. 中国粮油学报,2013,28(8):28−32. [LI N, FANG Q M, YAN X B, et al. Survey of pollution of fatty acid esters of chloropropanols in edible vegetable oils in the retailer in China[J]. Journal of the Chinese Cereals and Oils,2013,28(8):28−32.] doi: 10.3969/j.issn.1003-0174.2013.08.006 LI N, FANG Q M, YAN X B, et al. Survey of pollution of fatty acid esters of chloropropanols in edible vegetable oils in the retailer in China[J]. Journal of the Chinese Cereals and Oils, 2013, 28（8）: 28−32. doi: 10.3969/j.issn.1003-0174.2013.08.006
[7]	熊丽, 周鸿, 梁健. 江西省市售四类食品中3-氯丙醇酯污染水平调查与分析[J]. 现代预防医学,2017,44(21):3883−3886. [XIONG L, ZHOU H, LIANG J. Pollution levels of 3-chloro-1,2-propanediol esters in 4 kinds of commercially available food, Jiangxi[J]. Modern Preventive Medicine,2017,44(21):3883−3886.] XIONG L, ZHOU H, LIANG J. Pollution levels of 3-chloro-1,2-propanediol esters in 4 kinds of commercially available food, Jiangxi[J]. Modern Preventive Medicine, 2017, 44（21）: 3883−3886.
[8]	林丽珊, 傅武胜, 张一可. 气相色谱-串联质谱法测定婴幼儿配方奶粉中氯丙醇酯和缩水甘油酯[J]. 食品科学,2020,41(22):295−300. [LIN L S, FU W S, ZHANG Y K. Gas chromatography-mass spectrometry method for determination of chloropropanol esters and glycidyl esters in infant formula[J]. Food Science,2020,41(22):295−300.] doi: 10.7506/spkx1002-6630-20200218-185 LIN L S, FU W S, ZHANG Y K. Gas chromatography-mass spectrometry method for determination of chloropropanol esters and glycidyl esters in infant formula[J]. Food Science, 2020, 41（22）: 295−300. doi: 10.7506/spkx1002-6630-20200218-185
[9]	刘文菁, 戴明, 王征, 等. 婴幼儿配方乳粉中氯丙醇酯和缩水甘油酯的含量测定[J]. 福建分析测试,2022,31(3):6−13. [LIU W J, DAI M, WANG Z, et al. Determination of chloropropyl ester and glycidyl ester in infant formula milk powder[J]. Fujian Analysis & Testing,2022,31(3):6−13.] doi: 10.3969/j.issn.1009-8143.2022.03.02 LIU W J, DAI M, WANG Z, et al. Determination of chloropropyl ester and glycidyl ester in infant formula milk powder[J]. Fujian Analysis & Testing, 2022, 31（3）: 6−13. doi: 10.3969/j.issn.1009-8143.2022.03.02
[10]	杨凯, 张天博, 李朝旭. 婴幼儿食品中氯丙醇酯和缩水甘油酯的研究现状[J]. 中国乳业,2022(2):81−88. [YANG K, ZHANG T B, LI C X. Research status of 3-chloropropanol esters and glycidyl ester in infant foods[J]. China Dairy,2022(2):81−88.] doi: 10.12377/1671-4393.22.02.14 YANG K, ZHANG T B, LI C X. Research status of 3-chloropropanol esters and glycidyl ester in infant foods[J]. China Dairy, 2022（2）: 81−88. doi: 10.12377/1671-4393.22.02.14
[11]	Scientific committee on food (SCF), opinion of the scientific committee on food on 3-MCPD[J]. 2002.
[12]	European Commission. Science opinion on risks for human health related to the presence of 3- and 2-monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in food[J]. EFSA Journal,2016,14(5):4426.
[13]	EFSA. Update of the risk assessment on 3-monochloropropane diol and its fatty acid esters[J]. EFSA Journal, 2018, 16(1):5083.
[14]	JECFA. Safety evaluation of certain contaminants in food[C]//Prepared by the Eighty-third Meeting of the Joint FAO/WHO Expert Committee on Food Additives, 2016.
[15]	Official Journal of the European Union. Regulation (EU) 2020/1322 of the European parliament and of the council[EB/OL]. [2020-09-24]. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32020R1322&qid=1612793368554.
[16]	Official Journal of the European Union. Regulation (EU) 2024/1003 of the European parliament and of the council[EB/OL]. [2024-04-05]. https://eur-lex.europa.eu/legal-content/EN/ALL/?uri=OJ:L_202401003.
[17]	石贞, 李昌模, 柴佳, 等. 食用油脂中缩水甘油酯检测方法的研究[J]. 中国食物与营养,2011,17(11):5−9. [SHI Z, LI C M, CHAI J, et al. Study on determination methods of glycidyl esters in edible oils and fats[J]. Food and Nutrition in China,2011,17(11):5−9.] doi: 10.3969/j.issn.1006-9577.2011.11.001 SHI Z, LI C M, CHAI J, et al. Study on determination methods of glycidyl esters in edible oils and fats[J]. Food and Nutrition in China, 2011, 17（11）: 5−9. doi: 10.3969/j.issn.1006-9577.2011.11.001
[18]	YAMAZAKI K, OGISO M, ISAGAWA S, et al. A new, direct analytical method using LC-MS/MS for fatty acid esters of 3-chloro-1, 2-propanediol (3-MCPD esters) in edible oils[J]. Food Additives & Contaminants:Part A, 2013, 30(2):412.
[19]	WOHRLIN F, FRY H, LAHREEN-WIEDERKOLT M, et al. Occurrence of fatty acid esters of 3-MCPD, 2-MCPD and glycidol in infant formula[J]. Food Addit Contam PartA Chem Anal Control Expo Risk Assess,2015,32(11):1810−1822. doi: 10.1080/19440049.2015.1071497
[20]	MARIOTTI C, MARTÍNEZ C, HUAMÁN C, et al. Impact of an integrated process of hot pressurized liquid extraction-microporous resin purification over the polyphenols, hydroxymethylfurfural and reducing sugars content of Vitis vinifera ‘Carménère’ pomace extracts[J]. International Journal of Food Science & Technology,2018,53(4):1072−1078.
[21]	周静, 胡守江, 刘天益. 气相色谱-串联质谱法测定婴幼儿配方奶粉中氯丙醇酯和缩水甘油酯[J]. 食品安全质量检测学报,2021,12(16):6465−6471. [ZHOU J, HU S J, LIU T Y. Determination of chloropropanol fatty acid esters and glycidol fatty acid esters in infant formula milk powder by gas chromatography tandem mass spectrometry[J]. Journal of Food Safety & Quality,2021,12(16):6465−6471.] ZHOU J, HU S J, LIU T Y. Determination of chloropropanol fatty acid esters and glycidol fatty acid esters in infant formula milk powder by gas chromatography tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2021, 12（16）: 6465−6471.
[22]	张妮, 周静, 胡守江, 等. 婴幼儿配方奶粉中氯丙醇脂肪酸酯的检测方法优化与污染暴露[J]. 食品科学,2019,40(10):311−317. [ZHANG N, ZHOU J, HU S J, et al. Optimized detection and pollution exposure of chloropropanol fatty acid esters in infant formula[J]. Food Science,2019,40(10):311−317.] ZHANG N, ZHOU J, HU S J, et al. Optimized detection and pollution exposure of chloropropanol fatty acid esters in infant formula[J]. Food Science, 2019, 40（10）: 311−317.
[23]	DUBOIS M, EMPLA M, JAUDZEMS G, et al. Determination of 2-and 3-MCPD as well as 2-and 3-MCPD esters and glycidyl esters (GE) in infant and adult/pediatric nutritional formula by gas chromatography coupled to mass spectrometry method, first action 2018.03[J]. Journal of AOAC International,2019,102(3):903−914. doi: 10.5740/jaoacint.18-0266
[24]	WANG L, YING Y, HU Z, et al. Simultaneous determination of 2-and 3-MCPD esters in infant formula milk powder by solid-phase extraction and GC-MS analysis[J]. Journal of AOAC International,2016,99(3):786−791. doi: 10.5740/jaoacint.15-0310
[25]	SPUNGENJ H, MACMAHON S, LEIGH J, et al. Estimated US infant exposures to 3-MCPD esters and glycidyl esters from consumption of infant formula[J]. Food Additives and Contaminants Part A:Chemistry Analysis Control Exposure and Risk Assessment,2018,35(6):1085−1092.
[26]	ZELINKOVÁ Z, DOLEŽAL M, VELÍŠEK J. Occurrence of 3-chloropropane-1, 2-diol fatty acid esters in infant and baby foods[J]. European Food Research and Technology,2009,228(4):571−578. doi: 10.1007/s00217-008-0965-0
[27]	MIYAZAKI K, KOYAMA K. Application of indirect enzymatic method for determinations of 2-/3-MCPD-Es and Gly-Es in foods containing fats and oils[J]. Journal of the American Oil Chemists’ Society,2016,93(7):885−893.
[28]	郝宇, 马艺荧, 于力涛, 等. 气相色谱-串联质谱法测定婴幼儿配方乳粉中的3-氯丙醇酯和缩水甘油酯及其风险评估[J]. 食品科学,2023,44(8):337−344. [HAO Y, MA Y Y, YU L T, et al. Determination and health risk assessment of 3-chloropropanol and glycidyl esters in infant formula milk powder by gas chromatography-tandem mass spectrometry[J]. Food Science,2023,44(8):337−344.] doi: 10.7506/spkx1002-6630-20220419-240 HAO Y, MA Y Y, YU L T, et al. Determination and health risk assessment of 3-chloropropanol and glycidyl esters in infant formula milk powder by gas chromatography-tandem mass spectrometry[J]. Food Science, 2023, 44（8）: 337−344. doi: 10.7506/spkx1002-6630-20220419-240
[29]	王雪婷, 胡国绅, 朱一鸣, 等. 气相色谱–质谱法同时测定婴幼儿配方乳粉中氯丙醇酯和缩水甘油酯[J]. 化学分析计量,2022,31(9):56−61. [WANG X T, HU G K, ZHU Y M, et al. Simultaneous determination of chloropropanol esters and glycidyl esters in infant formula milk powder by gas chromatography-mass spectrometry[J]. Chemical Analysis and Meterage,2022,31(9):56−61.] doi: 10.3969/j.issn.1008-6145.2022.09.012 WANG X T, HU G K, ZHU Y M, et al. Simultaneous determination of chloropropanol esters and glycidyl esters in infant formula milk powder by gas chromatography-mass spectrometry[J]. Chemical Analysis and Meterage, 2022, 31（9）: 56−61. doi: 10.3969/j.issn.1008-6145.2022.09.012
[30]	张红霞, 卢克刚, 梁秀清, 等. 婴幼儿配方乳粉中氯丙醇酯含量测定方法的研究[J]. 中国酿造,2022,41(2):228−233. [ZHANG H X, LU K G, LIANG X Q, et al. Determination method of chloropropanol esters in infant formula[J]. China Brewing,2022,41(2):228−233.] doi: 10.11882/j.issn.0254-5071.2022.02.038 ZHANG H X, LU K G, LIANG X Q, et al. Determination method of chloropropanol esters in infant formula[J]. China Brewing, 2022, 41（2）: 228−233. doi: 10.11882/j.issn.0254-5071.2022.02.038
[31]	LEIGH J K, MACMAHON S. Extraction and liquid chromatography-tandem mass spectrometry detection of 3-Monochloropropanediol esters and glycidyl esters in infant formula[J]. Journal of Agricultural & Food Chemistry,2016,64(49):9442.
[32]	周洁, 孙骥, 余晓玲, 等. 液相色谱-高分辨质谱快速测定奶粉中氯丙醇酯[J]. 环境化学,2022,41(7):2458−2460. [ZHOU J, SUN J, YU X L, et al. Rapid determination of chloropropanol ester in milk powder by liquid chromatography-high-resolution mass spectrometry[J]. Environmental Chemistry,2022,41(7):2458−2460.] doi: 10.7524/j.issn.0254-6108.2022.7.hjhx202207032 ZHOU J, SUN J, YU X L, et al. Rapid determination of chloropropanol ester in milk powder by liquid chromatography-high-resolution mass spectrometry[J]. Environmental Chemistry, 2022, 41（7）: 2458−2460. doi: 10.7524/j.issn.0254-6108.2022.7.hjhx202207032
[33]	KUMARATHILAKA P, OZE C, INDRARATNE S, et al. Perchlorate as an emerging contaminant in soil, water and food[J]. Chemosphere,2016,150:667−677. doi: 10.1016/j.chemosphere.2016.01.109
[34]	方齐乐, 陈宝梁. 新型环境污染物高氯酸盐的环境化学行为、食品安全及健康风险[J]. 科学通报,2013,58(26):2626−2642. [FANG Q L, CHEN B L. Environmental transport behaviors of perchlorate as an emerging pollutant and their effects on food safety and health risk[J]. Chinese Science Bulletin,2013,58(26):2626−2642.] doi: 10.1360/972013-195 FANG Q L, CHEN B L. Environmental transport behaviors of perchlorate as an emerging pollutant and their effects on food safety and health risk[J]. Chinese Science Bulletin, 2013, 58（26）: 2626−2642. doi: 10.1360/972013-195
[35]	STEINMAUS C M. Perchlorate in water supplies:Sources, exposures, and health effects[J]. Current Environmental Health Reports,2016,3:136−143. doi: 10.1007/s40572-016-0087-y
[36]	孙文闪, 诸骏杰, 董叶箐, 等. 离子色谱-串联质谱法测定生活饮用水中的高氯酸盐、氯酸盐和溴酸盐[J]. 食品安全质量检测学报,2020,11(7):2150−2154. [SUN W S, ZHU J J, DONG Y Q, et al. Determination of perchlorate, chlorate and bromate in drinking water by ion chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality,2020,11(7):2150−2154.] SUN W S, ZHU J J, DONG Y Q, et al. Determination of perchlorate, chlorate and bromate in drinking water by ion chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2020, 11（7）: 2150−2154.
[37]	张昊, 蒋晓宏, 霍宗利. 基于Captiva EMR-Lipid净化的婴儿配方乳粉中氯酸盐和高氯酸盐的离子色谱-串联质谱测定[J]. 食品科学,2021,42(12):315−321. [ZHANG H, JIANG X H, HUO Z L. Determination of chlorate and perchlorate in infant formula powder by ion chromatography coupled with tandem mass spectrometry based on Captiva EMR-Lipid clean-up[J]. Food Science,2021,42(12):315−321.] doi: 10.7506/spkx1002-6630-20191112-149 ZHANG H, JIANG X H, HUO Z L. Determination of chlorate and perchlorate in infant formula powder by ion chromatography coupled with tandem mass spectrometry based on Captiva EMR-Lipid clean-up[J]. Food Science, 2021, 42（12）: 315−321. doi: 10.7506/spkx1002-6630-20191112-149
[38]	陈伟萍, 岑建斌, 叶盛恒, 等. 市售婴幼儿配方乳粉中氯酸盐和高氯酸盐污染情况调查[J]. 食品安全质量检测学报,2021,12(12):5086−5091. [CHEN W P, CEN J B, YE S H, et al. Investigation of chlorate and perchlorate contamination in commercially available infant formula milk powder[J]. Journal of Food Safety & Quality,2021,12(12):5086−5091.] CHEN W P, CEN J B, YE S H, et al. Investigation of chlorate and perchlorate contamination in commercially available infant formula milk powder[J]. Journal of Food Safety & Quality, 2021, 12（12）: 5086−5091.
[39]	李媛, 陈鸿剑, 樊成, 等. 乳制品中高氯酸盐污染分析及来源研究[J]. 中国乳业,2023,8(260):99−104. [LI Y, CHEN H J, FAN C, et al. Analysis and source of perchlorate pollution in dairy products[J]. China Dairy,2023,8(260):99−104.] doi: 10.12377/1671-4393.23.08.18 LI Y, CHEN H J, FAN C, et al. Analysis and source of perchlorate pollution in dairy products[J]. China Dairy, 2023, 8（260）: 99−104. doi: 10.12377/1671-4393.23.08.18
[40]	JECFA. Safety evaluation of certain contaminants in food[C]//Prepared by the seventy-second meeting of the Joint FAO/WHO Expert Committee on Food Additives, 2011.
[41]	EFSA. Scientific opinion on the risks to public health related to the presence of perchlorate in food, in particular fruits and vegetables[J]. EFSA Journal, 2014, 12(10):3869.
[42]	刘卿, 毛伟峰, 蒋定国, 等. 2018年中国婴幼儿配方乳粉高氯酸盐和氯酸盐含量[J]. 卫生研究,2022,51(1):124−127. [LIU Q, MAO W F, JIANG D G, et al. Perchlorate and chlorate content of infant formula powder in China in 2018[J]. Journal of Hygiene Research,2022,51(1):124−127.] LIU Q, MAO W F, JIANG D G, et al. Perchlorate and chlorate content of infant formula powder in China in 2018[J]. Journal of Hygiene Research, 2022, 51（1）: 124−127.
[43]	Official Journal of the European Union. Regulation (EU) 2020/685 of the European parliament and of the council[EB/OL]. [2020-05-25]. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32020R0685&qid=1716879488718.
[44]	张文婷, 华永有, 陆秋艳, 等. 超高效液相色谱-串联质谱法测定婴幼儿配方奶粉中氯酸盐和高氯酸盐[J]. 卫生研究,2021,50(4):625−632. [ZHANG W T, HUA Y Y, LU Q Y, et al. Determination of chlorate and perchlorate in infant formula by ultra-high performance liquid chromatography-tandem mass spectrometry[J]. Journal of Hygiene Research,2021,50(4):625−632.] ZHANG W T, HUA Y Y, LU Q Y, et al. Determination of chlorate and perchlorate in infant formula by ultra-high performance liquid chromatography-tandem mass spectrometry[J]. Journal of Hygiene Research, 2021, 50（4）: 625−632.
[45]	许小茜, 李清清, 顾颖娟. 高效液相色谱联用质谱法测定羊奶粉中的氯酸盐和高氯酸盐[J]. 分析仪器,2020,232(5):46−51. [XU X X, LI Q Q, GU Y J. Determination of chlorate and perchlorate in goat milk powder by HPLC-MS/MS[J]. Analytical Instrumentation,2020,232(5):46−51.] doi: 10.3969/j.issn.1001-232x.2020.05.010 XU X X, LI Q Q, GU Y J. Determination of chlorate and perchlorate in goat milk powder by HPLC-MS/MS[J]. Analytical Instrumentation, 2020, 232（5）: 46−51. doi: 10.3969/j.issn.1001-232x.2020.05.010
[46]	HAKME E, HERRMANN S S, POULSEN M E. Chlorate and perchlorate residues in food products on the Danish market[J]. Food Additives & Contaminants:Part A,2022,39(3):551−559.
[47]	朱建新. LC-MS/MS测定乳粉中高氯酸盐的不确定度影响因素的探讨[J]. 工业微生物,2022,52(3):29−34. [ZHU J X. Discussion on influencing factors of uncertainty in determination of perchlorate in milk powder by LC-MS/MS[J]. Industrial Microbiology,2022,52(3):29−34.] doi: 10.3969/j.issn.1001-6678.2022.03.005 ZHU J X. Discussion on influencing factors of uncertainty in determination of perchlorate in milk powder by LC-MS/MS[J]. Industrial Microbiology, 2022, 52（3）: 29−34. doi: 10.3969/j.issn.1001-6678.2022.03.005
[48]	詹胜群, 张浩, 周钧, 等. 超高效液相色谱-串联质谱法测定婴幼儿配方乳粉中氯酸盐和高氯酸盐[J]. 食品科技,2022,47(1):312−318. [ZHAN S Q, ZHANG H, ZHOU J, et al. Determination of chlorate and perchlorate in infant formula milk powder by UPLC-MS/MS[J]. Food Science and Technology,2022,47(1):312−318.] doi: 10.3969/j.issn.1005-9989.2022.1.spkj202201046 ZHAN S Q, ZHANG H, ZHOU J, et al. Determination of chlorate and perchlorate in infant formula milk powder by UPLC-MS/MS[J]. Food Science and Technology, 2022, 47（1）: 312−318. doi: 10.3969/j.issn.1005-9989.2022.1.spkj202201046
[49]	朱伟, 宁啸骏, 秦宇. 离子色谱串联质谱法测定婴幼儿配方奶粉中氯酸盐和高氯酸盐[J]. 食品安全质量检测学报,2019,10(11):3474−3480. [ZHU W, NING X J, QIN Y. Determination of chlorate and perchlorate in infant formula milk powder by ion chromatography tandem mass spectrometry[J]. Journal of Food Safety & Quality,2019,10(11):3474−3480.] doi: 10.3969/j.issn.2095-0381.2019.11.039 ZHU W, NING X J, QIN Y. Determination of chlorate and perchlorate in infant formula milk powder by ion chromatography tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2019, 10（11）: 3474−3480. doi: 10.3969/j.issn.2095-0381.2019.11.039
[50]	张明辉, 贾舸, 乔为仓, 等. 离子色谱-串联质谱检测牛奶和婴幼儿配方乳粉中的氯酸盐和高氯酸盐[J]. 中国食品学报,2022,22(9):239−247. [ZHANG M H, JIA K, QIAO W C, et al. Determination of perchlorate and chlorate in milk and infant formula powder by ion chromatography-tandem mass spectrometry[J]. Journal of Chinese Institute of Food Science and Technology,2022,22(9):239−247.] ZHANG M H, JIA K, QIAO W C, et al. Determination of perchlorate and chlorate in milk and infant formula powder by ion chromatography-tandem mass spectrometry[J]. Journal of Chinese Institute of Food Science and Technology, 2022, 22（9）: 239−247.
[51]	周晓晴, 吕小丽, 万建春. 高效液相色谱-串联质谱法测定奶粉中氯酸盐和高氯酸盐[J]. 色谱,2019,37(10):1064−1070. [ZHOU X Q, LÜ X L, WAN J C. Determination of chlorate and perchlorate in milk power by high-performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography,2019,37(10):1064−1070.] doi: 10.3724/SP.J.1123.2019.04052 ZHOU X Q, LÜ X L, WAN J C. Determination of chlorate and perchlorate in milk power by high-performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2019, 37（10）: 1064−1070. doi: 10.3724/SP.J.1123.2019.04052
[52]	JECFA. Safety evaluation of certain contaminants in food[C]//Prepared by the Sixty-eighth Meeting of the Joint FAO/WHO Expert Committee on Food Additives, 2008.
[53]	EFSA. Risks for public health related to the presence of chlorate in food[J]. EFSA Journal, 2015, 13(6):4135.