Advance on Transcription Factors Regulating the Synthesis of Secondary Metabolites Mediated by NRPS in Filamentous Fungi

BAI Xiaoxuan; ZHANG Jifeng; LI Jing; LI Ao; LIU Shiping

doi:10.13386/j.issn1002-0306.2023090317

Volume 45 Issue 17

Aug. 2024

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Science and Technology of Food Industry > 2024 > 45(17): 445-453. > DOI: 10.13386/j.issn1002-0306.2023090317

BAI Xiaoxuan, ZHANG Jifeng, LI Jing, et al. Advance on Transcription Factors Regulating the Synthesis of Secondary Metabolites Mediated by NRPS in Filamentous Fungi[J]. Science and Technology of Food Industry, 2024, 45(17): 445−453. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023090317.

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Advance on Transcription Factors Regulating the Synthesis of Secondary Metabolites Mediated by NRPS in Filamentous Fungi

College of Biology & Pharmacy, China Three Gorges University, Yichang 443002, China

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Received Date: September 27, 2023
Available Online: July 07, 2024

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Abstract

Abstract

Secondary metabolites (SM) produced by filamentous fungi have been extensively applied in biomedicine, biological control, food, and other fields. The biosynthesis of most SMs is closely associated with the catalysis of non-ribosome peptide synthetase (NRPS), therefore the expression regulation of NRPS is crucial for SM biosynthesis. In order to further understand the expression regulation patterns of NRPS gene clusters in filamentous fungi, herein, the research progresses on the transcription factors regulating NRPS-mediated SM production are reviewed, of which both pathway-specific transcription factors and global transcription factors are individually descripted. The summarization is hoped to deepen the comprehension of NRPS-mediated SMs production regulated by transcription factors and provide a reference for development of natural products in filamentous fungi in the future.
- transcription factor,
- filamentous fungi,
- non-ribosomal peptide synthetase (NRPS),
- secondary metabolites,
- biosynthesis

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