SHI Changbo, XU Shuo, ZHAO Juyang, et al. Research Progress on the Composition, Preparation and Promotion of Bioactive Substances Bio-utilization of Self-microemulsion Systems in Food[J]. Science and Technology of Food Industry, 2024, 45(17): 426−435. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023090291.
Citation: SHI Changbo, XU Shuo, ZHAO Juyang, et al. Research Progress on the Composition, Preparation and Promotion of Bioactive Substances Bio-utilization of Self-microemulsion Systems in Food[J]. Science and Technology of Food Industry, 2024, 45(17): 426−435. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023090291.

Research Progress on the Composition, Preparation and Promotion of Bioactive Substances Bio-utilization of Self-microemulsion Systems in Food

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  • Received Date: September 26, 2023
  • Available Online: July 01, 2024
  • With the enhancement of people's awareness of healthy diet, the innovation of food function has become a hot topic. Self-microemulsion system is an anhydrous pre-concentration system which contains a mixture of oil phase, surfactants, co-surfactants, and bioactive substances in a certain proportion. Food bioactive substances can be loaded in self-microemulsion system, which can improve the bioavailability of food bioactive substances. Moreover, it also fully exerts the physiological and pharmacological activities of food bioactive substances. In this paper, the basic properties, components and preparation methods of self-microemulsion are systematically reviewed. Further, the application examples of self-microemulsion system to promote bioactive substances bio-utilization in food field in recent years are summarized, which provides a reference for the application of self-microemulsion system in food field.
  • [1]
    常雨, 郑逸梅, 罗碧英, 等. 食品级共价复合物在递送生物活性物质方面的研究进展[J]. 食品工业科技,2022,43(13):389−399. [CHANG Yu, ZHENG Yimei, LUO Biying, et al. Research progress of food-grade covalent complexes for delivery of bioactive substances[J]. Science and Technology of Food Industry,2022,43(13):389−399.]

    CHANG Yu, ZHENG Yimei, LUO Biying, et al. Research progress of food-grade covalent complexes for delivery of bioactive substances[J]. Science and Technology of Food Industry, 2022, 43(13): 389−399.
    [2]
    SANTOS D I, SARAIVA J, VICENTE A A, et al. Methods for determining bioavailability and bioaccessibility of bioactive compounds and nutrients[J]. Innovative Thermal and Non-Thermal Processing, Bioaccessibility and Bioavailability of Nutrients and Bioactive Compounds, 2019:23−54.
    [3]
    陈雨露, 孙婉秋, 高彦祥, 等. 食品运载体系提高酚类物质生物利用度的研究进展[J]. 食品科学,2020,41(5):323−330. [CHEN Yulu, SUN Wanqiu, GAO Yanxiang, et al. Research progress of food delivery system to improve the bioavailability of phenolic substances[J]. Food Science,2020,41(5):323−330.] doi: 10.7506/spkx1002-6630-20190228-225

    CHEN Yulu, SUN Wanqiu, GAO Yanxiang, et al. Research progress of food delivery system to improve the bioavailability of phenolic substances[J]. Food Science, 2020, 41(5): 323−330. doi: 10.7506/spkx1002-6630-20190228-225
    [4]
    TING Y, JIANG Y, HO C T, et al. Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals[J]. Journal of Functional Foods,2014,7:112−128. doi: 10.1016/j.jff.2013.12.010
    [5]
    WIGHTMAN E L, REAY J L, HASKELL C F, et al. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects:A randomised, double-blind, placebo-controlled, cross-over investigation[J]. British Journal of Nutrition,2014,112(2):203−213. doi: 10.1017/S0007114514000737
    [6]
    柳欢. 基于共轭亚油酸的脂质载体构建及应用[D]. 无锡:江南大学, 2022. [LIU Huan. Construction and application of conjugated linoleic acid based lipid carrier[D]. Wuxi:Jiangnan University, 2022.]

    LIU Huan. Construction and application of conjugated linoleic acid based lipid carrier[D]. Wuxi: Jiangnan University, 2022.
    [7]
    DHAVAL M, VAGHELA P, PATEL K, et al. Lipid-based emulsion drug delivery systems-a comprehensive review[J]. Drug Deliv Transl Res,2022,12(7):1616−1639. doi: 10.1007/s13346-021-01071-9
    [8]
    KHAN A W, KOTTA S, ANSARI S H, et al. Potentials and challenges in self-nanoemulsifying drug delivery systems[J]. Expert Opinion on Drug Delivery,2012,9(10):1305−1317. doi: 10.1517/17425247.2012.719870
    [9]
    MAHMOUD E A, BENDAS E R, MOHAMED M I. Preparation and evaluation of self-nanoemulsifying tablets of carvedilol[J]. Aaps Pharmscitech,2009,10(1):183. doi: 10.1208/s12249-009-9192-7
    [10]
    CAO M, ZHAN M, WANG Z, et al. Development of an orally bioavailable isoliquiritigenin self-nanoemulsifying drug delivery system to effectively treat ovalbumin-induced asthma[J]. Int J Nanomedicine,2020,15:8945−8961. doi: 10.2147/IJN.S269982
    [11]
    JIANG F, WU G, LI W, et al. Preparation and protective effects of 1, 8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice[J]. European Journal of Pharmaceutical Sciences,2019,127:14−23. doi: 10.1016/j.ejps.2018.10.012
    [12]
    SANDER C, HOLM P. Porous magnesium aluminometasilicate tablets as carrier of a cyclosporine self-emulsifying formulation[J]. AAPS PharmSciTech,2009,10:1388−1395. doi: 10.1208/s12249-009-9340-0
    [13]
    沈熊, 吴伟. 自乳化和自微乳化释药系统[J]. 复旦学报:医学版,2003,30(2):180−183. [SHEN Xiong, WU Wei. Self-emulsifying and self-microemulsifying drug release systems[J]. Fudan Journal:Medical Edition,2003,30(2):180−183.]

    SHEN Xiong, WU Wei. Self-emulsifying and self-microemulsifying drug release systems[J]. Fudan Journal: Medical Edition, 2003, 30(2): 180−183.
    [14]
    张楠, 周宏兵, 全东琴. 自微乳释药系统提高药物生物利用度的机理与应用[J]. 中国医药生物技术,2009,4(1):47−50. [ZHANG Nan, ZHOU Hongbing, QUAN Dongqin. Mechanism and application of self-emulsion drug delivery system to improve drug bioavailability[J]. Chinese Journal of Pharmaceutical Biotechnology,2009,4(1):47−50.] doi: 10.3969/j.issn.1673-713X.2009.01.012

    ZHANG Nan, ZHOU Hongbing, QUAN Dongqin. Mechanism and application of self-emulsion drug delivery system to improve drug bioavailability[J]. Chinese Journal of Pharmaceutical Biotechnology, 2009, 4(1): 47−50. doi: 10.3969/j.issn.1673-713X.2009.01.012
    [15]
    仲粒, 李小芳, 刘罗娜, 等. 自微乳技术在中药制剂中的应用及其固化研究进展[J]. 中药与临床,2019,10(Z2):53−58,64. [ZHONG Mi, LI Xiaofang, LIU Lona, et al. Application of self-microemulsion technology in traditional Chinese medicine preparations and research progress of curing[J]. Chinese Medicine and Clinic,2019,10(Z2):53−58,64.]

    ZHONG Mi, LI Xiaofang, LIU Lona, et al. Application of self-microemulsion technology in traditional Chinese medicine preparations and research progress of curing[J]. Chinese Medicine and Clinic, 2019, 10(Z2): 53−58,64.
    [16]
    YANG F, FU C, LÜ L, et al. Self-microemulsifying delivery system of WPI-Dai nanocomplex mixed with nonionic surfactant and its superiority in delivering daidzein[J]. Food Hydrocolloids,2020,108:105952. doi: 10.1016/j.foodhyd.2020.105952
    [17]
    马薇. PLH自微乳给药系统及其大鼠体内药动学评价[D]. 广州:广东药科大学, 2016. [MA Wei. PLH self-microemulsion drug delivery system and its pharmacokinetic evaluation in rats[D]. Guangzhou:Guangdong Pharmaceutical University, 2016.]

    MA Wei. PLH self-microemulsion drug delivery system and its pharmacokinetic evaluation in rats[D]. Guangzhou: Guangdong Pharmaceutical University, 2016.
    [18]
    TRUONG D H, TRAN T H, RAMASAMY T, et al. Development of solid self-emulsifying formulation for improving the oral bioavailability of erlotinib[J]. AAPS Pharm Sci Tech,2016,17(2):466−473. doi: 10.1208/s12249-015-0370-5
    [19]
    张娜, 康虞玲, 刘智勤, 等. 自微乳化药物传递系统的应用与进展[J]. 中国医院药学杂志,2010,30(11):960−962. [ZHANG Na, KANG Yuling, LIU Zhiqin, et al. Application and progress of self-microemulsification drug delivery system[J]. Chinese Journal of Hospital Pharmacy,2010,30(11):960−962.]

    ZHANG Na, KANG Yuling, LIU Zhiqin, et al. Application and progress of self-microemulsification drug delivery system[J]. Chinese Journal of Hospital Pharmacy, 2010, 30(11): 960−962.
    [20]
    梅兴国. 维生素K2固体自乳化制剂的处方优化[J]. 湖北科技学院学报:医学版,2020,34(5):381−385,364. [MEI Xingguo. Formulation optimization of vitamin K2 solid self-emulsifying preparation[J]. Journal of Hubei University of Science and Technology:Medical Edition,2020,34(5):381−385,364.]

    MEI Xingguo. Formulation optimization of vitamin K2 solid self-emulsifying preparation[J]. Journal of Hubei University of Science and Technology: Medical Edition, 2020, 34(5): 381−385,364.
    [21]
    李学艳, 王君文, 易金玉, 等. 含虾青素的雨生红球藻粉自微乳的制备及体外评价[J]. 上海海洋大学学报,2021,30(5):940−949. [LI Xueyan, WANG Junwen, YI Jinyu, et al. Preparation and in vitro evaluation of astaxanthin self-microemulsion of Rhodococcus pluvialis powder[J]. Journal of Shanghai Ocean University,2021,30(5):940−949.] doi: 10.12024/jsou.20200703109

    LI Xueyan, WANG Junwen, YI Jinyu, et al. Preparation and in vitro evaluation of astaxanthin self-microemulsion of Rhodococcus pluvialis powder[J]. Journal of Shanghai Ocean University, 2021, 30(5): 940−949. doi: 10.12024/jsou.20200703109
    [22]
    ČERPNJAK K, ZVONAR A, GAŠPERLIN M, et al. Lipid-based systems as promising approach for enhancing the bioavailability of poorly water-soluble drugs[J]. Acta pharmaceutica,2013,63(4):427−445. doi: 10.2478/acph-2013-0040
    [23]
    FENG W, QIN C, CIPOLLA E, et al. Inclusion of medium-chain triglyceride in lipid-based formulation of cannabidiol facilitates micellar solubilization in vitro, but in vivo performance remains superior with pure sesame oil vehicle[J]. Pharmaceutics,2021,13(9):1349. doi: 10.3390/pharmaceutics13091349
    [24]
    GAO H, JIA H, DONG J, et al. Integrated in silico formulation design of self-emulsifying drug delivery systems[J]. Acta Pharmaceutica Sinica B,2021,11(11):3585−3594. doi: 10.1016/j.apsb.2021.04.017
    [25]
    JADHAV H, WAGHMARE J, ANNAPURE U. Study on oxidative stability of deep fat fried food in Canola oil blended with medium chain triglyceride[J]. Indian Journal of Chemical Technology (IJCT),2022,29(1):95−98.
    [26]
    陈倩, 陈晨, 管清香. 葛根总黄酮自微乳化半固体骨架胶囊的制备[C]//全国青年药学工作者最新科研成果交流会,2012,90−96. [CHEN Qian, CHEN Chen, GUAN Qingxiang. Preparation of total Pueraria flavonoids self-microemulsified semi-solid skeleton capsules[C]//National Young Pharmaceutical Workers Latest Scientific Research Achievements Exchange Meeting,2012,90−96.]

    CHEN Qian, CHEN Chen, GUAN Qingxiang. Preparation of total Pueraria flavonoids self-microemulsified semi-solid skeleton capsules[C]//National Young Pharmaceutical Workers Latest Scientific Research Achievements Exchange Meeting, 2012, 90−96.
    [27]
    GURRAM A K, DESHPANDE P B, KAR S S, et al. Role of components in the formation of self-microemulsifying drug delivery systems[J]. Indian Journal of Pharmaceutical Sciences,2015,77(3):249−257. doi: 10.4103/0250-474X.159596
    [28]
    DOKANIA S, JOSHI A K. Self-microemulsifying drug delivery system (SMEDDS)-challenges and road ahead[J]. Drug Delivery,2015,22(6):675−90. doi: 10.3109/10717544.2014.896058
    [29]
    ITA K. Transdermal drug delivery:Concepts and application[M]. Academic Press, 2020.
    [30]
    DHRITLAHRE R K, RUCHIKA, PADWAD Y, et al. Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals:From concepts to clinic[J]. Trends in Food Science & Technology,2021,115:347−365.
    [31]
    WARISNOICHAROEN W, LANSLEY A B, LAWRENCE M J. Toxicological evaluation of mixtures of nonionic surfactants, alone and in combination with oil[J]. Journal of Pharmaceutical Sciences,2003,92(4):859−868. doi: 10.1002/jps.10335
    [32]
    LI P, GHOSH A, WAGNER R F, et al. Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions[J]. International Journal of Pharmaceutics,2005,288(1):27−34. doi: 10.1016/j.ijpharm.2004.08.024
    [33]
    KIM D W, KWON M S, YOUSAF A M, et al. Comparison of a solid SMEDDS and solid dispersion for enhanced stability and bioavailability of clopidogrel napadisilate[J]. Carbohydrate Polymers,2014,114:365−374. doi: 10.1016/j.carbpol.2014.08.034
    [34]
    卢文彪. 连香方自微乳化给药系统的制备与评价[D]. 广州:广州中医药大学, 2008. [LU Wenbiao. Preparation and evaluation of self-microemulsification drug delivery system of Lianxiang prescription[D]. Guangzhou:Guangzhou University of Traditional Chinese Medicine, 2008.]

    LU Wenbiao. Preparation and evaluation of self-microemulsification drug delivery system of Lianxiang prescription[D]. Guangzhou: Guangzhou University of Traditional Chinese Medicine, 2008.
    [35]
    杨丽雄. 自微乳化释药系统在药物制剂中的应用[J]. 海峡药学,2011,23(12):5−7. [YANG Lixiong. Application of self-microemulsification drug release system in pharmaceutical preparations[J]. Straits Pharmacy,2011,23(12):5−7.] doi: 10.3969/j.issn.1006-3765.2011.12.002

    YANG Lixiong. Application of self-microemulsification drug release system in pharmaceutical preparations[J]. Straits Pharmacy, 2011, 23(12): 5−7. doi: 10.3969/j.issn.1006-3765.2011.12.002
    [36]
    凡小燕. 橙皮苷自微乳的制备与评价[D]. 合肥:安徽医科大学, 2011. [FAN Xiaoyan. Preparation and evaluation of hesperidin self-microemulsion[D]. Hefei:Anhui Medical University, 2011.]

    FAN Xiaoyan. Preparation and evaluation of hesperidin self-microemulsion[D]. Hefei: Anhui Medical University, 2011.
    [37]
    CHEN H, YANG F, LÜ L, et al. Interaction among protein, daidzein and surfactants in the WPI-based daidzein self-microemulsifying delivery system[J]. Food Chemistry,2020,332:127461. doi: 10.1016/j.foodchem.2020.127461
    [38]
    杨志欣, 张蕾, 王鑫, 等. 自乳化药物递送系统研究概述[J]. 中文科技资料目录-中草药,2019,42(3):563−569. [YANG Zhixin, ZHANG Lei, WANG Xin, et al. Overview of self-emulsifying drug delivery system[J]. Chinese Science and Technology Bibliography-Chinese Herbal Medicine,2019,42(3):563−569.]

    YANG Zhixin, ZHANG Lei, WANG Xin, et al. Overview of self-emulsifying drug delivery system[J]. Chinese Science and Technology Bibliography-Chinese Herbal Medicine, 2019, 42(3): 563−569.
    [39]
    CHEN Y, LI G, WU X, et al. Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine:Formulation development and in vivo assessment[J]. Biological & Pharmaceutical Bulletin,2008,31(1):118−125.
    [40]
    黎鹏, 程永婷, 马峰, 等. 乳香没药精油自微乳的制备与抗炎镇痛作用评价[J]. 药物评价研究,2023,46(4):795−802. [LI Peng, CHENG Yongting, MA Feng, et al. Preparation of frankincense myrrh essential oil self-microemulsion and evaluation of anti-inflammatory and analgesic effects[J]. Drug Evaluation Research,2023,46(4):795−802.]

    LI Peng, CHENG Yongting, MA Feng, et al. Preparation of frankincense myrrh essential oil self-microemulsion and evaluation of anti-inflammatory and analgesic effects[J]. Drug Evaluation Research, 2023, 46(4): 795−802.
    [41]
    SANEJA A. Recent advances in self-emulsifying drug-delivery systems for oral delivery of cancer chemotherapeutics[M]. 2016.
    [42]
    毛昕宇. 虾青素微纳米载体的制备与评价[D]. 南京:东南大学, 2019. [MAO Xinyu. Preparation and evaluation of astaxanthin micro nano carriers[D]. Nanjing:Southeast University, 2019.]

    MAO Xinyu. Preparation and evaluation of astaxanthin micro nano carriers[D]. Nanjing: Southeast University, 2019.
    [43]
    WANG Y, CHEN L, ADU-FRIMPONG M, et al. Preparation, in vivo and in vitro evaluation, and pharmacodynamic study of DMY-loaded self-microemulsifying drug delivery system[J]. European Journal of Lipid Science and Technology,2021,123(6):2000369. doi: 10.1002/ejlt.202000369
    [44]
    DHOLAKIYA A, DUDHAT K, PATEL J, et al. An integrated QbD based approach of SMEDDS and liquisolid compacts to simultaneously improve the solubility and processability of hydrochlorothiazide[J]. Journal of Drug Delivery Science and Technology, 2020:102162.
    [45]
    VISETVICHAPORN V, KIM K H, JUNG K, et al. Formulation of self-microemulsifying drug delivery system (SMEDDS) by D-optimal mixture design to enhance the oral bioavailability of a new cathepsin K inhibitor (HL235)[J]. International Journal of Pharmaceutics,2020,573:118772. doi: 10.1016/j.ijpharm.2019.118772
    [46]
    HUANG J, WANG Q, SUN R, et al. A novel solid self-emulsifying delivery system (SEDS) for the encapsulation of linseed oil and quercetin:Preparation and evaluation[J]. Journal of Food Engineering,2018,226(JUN.):22−30.
    [47]
    张建, 叶珍珍, 崔升淼. 固体自乳化新剂型的研究进展[J]. 中南药学,2011,9(5):358−362. [ZHANG Jian, YE Zhenzhen, CUI Shengmiao. Research progress on new solid self-emulsifying formulations[J]. Zhongnan Pharmacy,2011,9(5):358−362.] doi: 10.3969/j.issn.1672-2981.2011.05.011

    ZHANG Jian, YE Zhenzhen, CUI Shengmiao. Research progress on new solid self-emulsifying formulations[J]. Zhongnan Pharmacy, 2011, 9(5): 358−362. doi: 10.3969/j.issn.1672-2981.2011.05.011
    [48]
    POUTON C W. Formulation of poorly water-soluble drugs for oral administration:Physicochemical and physiological issues and the lipid formulation classification system[J]. European Journal of Pharmaceutical Sciences,2006,29(3-4):278−287. doi: 10.1016/j.ejps.2006.04.016
    [49]
    黄娟, 岳晶晶, 冯璇, 等. 二氢杨梅素固体自微乳的制备及表征[J]. 食品科学,2022,43(16):145−152. [HUANG Juan, YUE Jingjing, FENG Xuan, et al. Preparation and characterization of dihydromyricetin solid self-microemulsion[J]. Food Science,2022,43(16):145−152.] doi: 10.7506/spkx1002-6630-20210905-053

    HUANG Juan, YUE Jingjing, FENG Xuan, et al. Preparation and characterization of dihydromyricetin solid self-microemulsion[J]. Food Science, 2022, 43(16): 145−152. doi: 10.7506/spkx1002-6630-20210905-053
    [50]
    TANG B, CHENG G, GU J C, et al. Development of solid self-emulsifying drug delivery systems:Preparation techniques and dosage forms[J]. Drug Discovery Today,2008,13(13-14):606−612. doi: 10.1016/j.drudis.2008.04.006
    [51]
    马祖兵. 大黄素自微乳—微丸释药体系的构建与评价研究[D]. 成都:成都中医药大学, 2019. [MA Zubing. Construction and evaluation of emodin release system from microemulsion to micropellet[D]. Chengdu:Chengdu University of Traditional Chinese Medicine, 2019.]

    MA Zubing. Construction and evaluation of emodin release system from microemulsion to micropellet[D]. Chengdu: Chengdu University of Traditional Chinese Medicine, 2019.
    [52]
    SELJAK K B, ILIĆ I G, GAŠPERLIN M, et al. Self-microemulsifying tablets prepared by direct compression for improved resveratrol delivery[J]. International Journal of Pharmaceutics,2018,548(1):263−275. doi: 10.1016/j.ijpharm.2018.06.065
    [53]
    王丽娜, 李校娜, 王树鹏, 等. 中药固体自微乳化给药系统的研究进展[J]. 畜牧与兽医,2019,51(5):135−138. [WANG L N, LI X N, WANG S P, et al. Research progress of solid self-microemulsification drug delivery system of traditional Chinese medicine[J]. Animal Husbandry and Veterinary Medicine,2019,51(5):135−138.]

    WANG L N, LI X N, WANG S P, et al. Research progress of solid self-microemulsification drug delivery system of traditional Chinese medicine[J]. Animal Husbandry and Veterinary Medicine, 2019, 51(5): 135−138.
    [54]
    金可欣, 吕江维, 贲昱文, 等. 固体自微乳药物递送系统的研究进展[J]. 药学研究,2019,42(2):126−129,144. [JIN Kexin, LÜ Jiangwei, BEN Yuwen, et al. Research progress of solid self-microemulsion drug delivery system[J]. Pharmaceutical Research,2019,42(2):126−129,144.]

    JIN Kexin, LÜ Jiangwei, BEN Yuwen, et al. Research progress of solid self-microemulsion drug delivery system[J]. Pharmaceutical Research, 2019, 42(2): 126−129,144.
    [55]
    梅康康, 胡容峰, 罗志红, 等. 球晶技术固体自微乳法制备水飞蓟宾缓释微丸[J]. 中国医院药学杂志,2014,34(21):1826−1831. [MEI Kangkang, HU Rongfeng, LUO Zhihong, et al. Preparation of silybin sustained-release pellets by solid self-emulsion method[J]. Chinese Journal of Hospital Pharmacy,2014,34(21):1826−1831.]

    MEI Kangkang, HU Rongfeng, LUO Zhihong, et al. Preparation of silybin sustained-release pellets by solid self-emulsion method[J]. Chinese Journal of Hospital Pharmacy, 2014, 34(21): 1826−1831.
    [56]
    LLERA-ROJAS V G, DEL REAL L A, MENDOZA-MUÑOZ N, et al. Feasibility of obtaining in situ nanocapsules through modified self-microemulsifying drug delivery systems. A new manufacturing approach for oral route administration[J]. Drug Development and Industrial Pharmacy,2017,43(6):925−931. doi: 10.1080/03639045.2017.1285308
    [57]
    GUILAN Q, BOYI N, VIKRAMJEET S, et al. Supersaturable solid self-microemulsifying drug delivery system:Precipitation inhibition and bioavailability enhancement[J]. International Journal of Nanomedicine,2017,12:8801−8811. doi: 10.2147/IJN.S149717
    [58]
    KAMBOJ S, RANA V. Quality-by-design based development of a self-microemulsifying drug delivery system to reduce the effect of food on nelfinavir mesylate[J]. International Journal of Pharmaceutics,2016(501):311−325.
    [59]
    张莉莉, 李婉菁, 彭锦学, 等. 应用离子液体溶剂体系提取天然虾青素的研究进展[J]. 食品工业科技,2020,41(8):341−346. [ZHANG Lili, LI Wanjing, PENG Jinxue, et al. Research progress of natural astaxanthin extraction by ionic liquid solvent system[J]. Science and Technology of Food Industry,2020,41(8):341−346.]

    ZHANG Lili, LI Wanjing, PENG Jinxue, et al. Research progress of natural astaxanthin extraction by ionic liquid solvent system[J]. Science and Technology of Food Industry, 2020, 41(8): 341−346.
    [60]
    张智衡. 玉米醇溶蛋白基多酚递送体系构建及其消化特性研究[D]. 无锡:江南大学, 2023. [ZHANG Zhiheng. Study on the construction of zein-based polyphenoldelivery systems and their digestion characteristics[D]. Wuxi:Jiangnan University, 2023.]

    ZHANG Zhiheng. Study on the construction of zein-based polyphenoldelivery systems and their digestion characteristics[D]. Wuxi: Jiangnan University, 2023.
    [61]
    HOLM R, PORTER C, EDWARDS G A, et al. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides[J]. European Journal of Pharmaceutical Sciences,2003,20(1):91−97. doi: 10.1016/S0928-0987(03)00174-X
    [62]
    谭亚男, 尹宗宁. 自微乳化给药系统促进卤泛群经淋巴转运的研究[J]. 食品与药品,2021(4):332−337. [TAN Yanan, YIN Zongning. Study on the promotion of translymphatic transport of halopantrin by self-microemulsification drug delivery system[J]. Food and Drug,2021(4):332−337.] doi: 10.3969/j.issn.1672-979X.2021.04.009

    TAN Yanan, YIN Zongning. Study on the promotion of translymphatic transport of halopantrin by self-microemulsification drug delivery system[J]. Food and Drug, 2021(4): 332−337. doi: 10.3969/j.issn.1672-979X.2021.04.009
    [63]
    梁鑫淼, 王超然, 郭志谋, 等. 一种酸枣仁黄酮磷脂复合物及其制备方法和应用:CN112544972A[P]. 2021. [LIANG Xinmiao, WANG Chaoran, GUO Zhimo, et al. A kind of jujube kernel flavonoid phospholipid complex and its preparation method and application:CN112544972A[P]. 2021.]

    LIANG Xinmiao, WANG Chaoran, GUO Zhimo, et al. A kind of jujube kernel flavonoid phospholipid complex and its preparation method and application: CN112544972A[P]. 2021.
    [64]
    EL-SAYED H S, CHIZZOLA R, RAMADAN A A, et al. Chemical composition and antimicrobial activity of garlic essential oils evaluated in organic solvent, emulsifying, and self-microemulsifying water based delivery systems[J]. Food Chemistry,2017,221(APR.15):196−204.
    [65]
    ALMASI L, RADI M, AMIRI S. The release rate and antimicrobial activity of calcium-alginate films containing self-microemulsifying Thymus vulgaris essential oil against Escherichia coli and Staphylococcus aureus[J]. Journal of Food Safety,2020,40(5):e12828. doi: 10.1111/jfs.12828
    [66]
    ALMASI L, RADI M, AMIRI S, et al. Fabrication and characterization of antimicrobial biopolymer films containing essential oil-loaded microemulsions or nanoemulsions[J]. Food Hydrocolloids,2021,117(1):106733.
    [67]
    胡万超, 唐建国. 大蒜提取物抗白念珠菌作用机制研究进展[J]. 中国感染与化疗杂志,2020,20(2):221−225. [HU Wanchao, TANG Jianguo. Research progress of garlic extracts against Candida albicans[J]. Chinese Journal of Infection and Chemotherapy,2020,20(2):221−225.]

    HU Wanchao, TANG Jianguo. Research progress of garlic extracts against Candida albicans[J]. Chinese Journal of Infection and Chemotherapy, 2020, 20(2): 221−225.
    [68]
    LONG Y, HUANG W, WANG Q, et al. Green synthesis of garlic oil nanoemulsion using ultrasonication technique and its mechanism of antifungal action against Penicillium italicum[J]. Ultrasonics Sonochemistry,2020,64:104970. doi: 10.1016/j.ultsonch.2020.104970
    [69]
    赵家亮, 李春, 刘宁, 等. 食品级非离子表面活性剂微乳的制备及抗菌性研究[J]. 食品工业,2011(9):92−95. [ZHAO Jialiang, LI Chun, LIU Ning, et al. Preparation and antibacterial activity of food grade non-ionic surfactant microemulsion[J]. Food Industry,2011(9):92−95.]

    ZHAO Jialiang, LI Chun, LIU Ning, et al. Preparation and antibacterial activity of food grade non-ionic surfactant microemulsion[J]. Food Industry, 2011(9): 92−95.
    [70]
    王浩. 丁香油乳化体系的制备及抗菌特性的研究[D]. 无锡:江南大学, 2014. [WANG Hao. Study on preparation and antibacterial properties of clove oil emulsification system[D]. Wuxi:Jiangnan University, 2014.]

    WANG Hao. Study on preparation and antibacterial properties of clove oil emulsification system[D]. Wuxi: Jiangnan University, 2014.
    [71]
    肖小年, 周洁, 易孜成, 等. 大蒜油自微乳的制备及其初步稳定性[J]. 南昌大学学报(理科版),2020,44(1):42−48. [XIAO Xiaonian, ZHOU Jie, YI Zicheng, et al. Preparation and preliminary stability of garlic oil self-microemulsion[J]. Journal of Nanchang University:Science Edition,2020,44(1):42−48.] doi: 10.3969/j.issn.1006-0464.2020.01.008

    XIAO Xiaonian, ZHOU Jie, YI Zicheng, et al. Preparation and preliminary stability of garlic oil self-microemulsion[J]. Journal of Nanchang University: Science Edition, 2020, 44(1): 42−48. doi: 10.3969/j.issn.1006-0464.2020.01.008
    [72]
    肖小年, 盛丹梅, 周洁, 等. 大蒜油自微乳的抑菌作用[J]. 中国食品学报,2021,21(12):73−80. [XIAO Xiaonian, SHENG Danmei, ZHOU Jie, et al. Bacteriostasis of garlic oil self-microemulsion[J]. Chinese Journal of Food Science,2021,21(12):73−80.]

    XIAO Xiaonian, SHENG Danmei, ZHOU Jie, et al. Bacteriostasis of garlic oil self-microemulsion[J]. Chinese Journal of Food Science, 2021, 21(12): 73−80.
    [73]
    李媛媛, 于良晓, 裴海生, 等. 药食同源生物活性物质降脂减重机制研究进展[J]. 食品安全质量检测学报,2022,13(22):7407−7414. [LI Yuanyuan, YU Liangxiao, PEI Haisheng, et al. Research progress on the mechanism of lipid and weight loss of homologous bioactive substances[J]. Journal of Food Safety and Quality Inspection,2022,13(22):7407−7414.] doi: 10.3969/j.issn.2095-0381.2022.22.spaqzljcjs202222032

    LI Yuanyuan, YU Liangxiao, PEI Haisheng, et al. Research progress on the mechanism of lipid and weight loss of homologous bioactive substances[J]. Journal of Food Safety and Quality Inspection, 2022, 13(22): 7407−7414. doi: 10.3969/j.issn.2095-0381.2022.22.spaqzljcjs202222032
    [74]
    杨春红, 潘琳, 唐茜, 等. 辅助降血糖功能的药食同源原料的应用概况[J]. 中药与临床,2022,13(1):103−107, 114. [YANG Chunhong, PAN Lin, TANG Qian, et al. Application of homologous materials of medicine and food to assist hypoglycemic function[J]. Chinese Medicine and Clinic,2022,13(1):103−107, 114.] doi: 10.3969/j.issn.1674-926X.2022.01.023

    YANG Chunhong, PAN Lin, TANG Qian, et al. Application of homologous materials of medicine and food to assist hypoglycemic function[J]. Chinese Medicine and Clinic, 2022, 13(1): 103−107, 114. doi: 10.3969/j.issn.1674-926X.2022.01.023
    [75]
    田翠芳, 张昭寰, 陶倩, 等. 抗生物被膜材料在食品微生物安全领域的应用研究进展[J]. 食品科学,2022,43(11):265−272. [TIAN Cuifang, ZHANG Zhaohuan, TAO Qian, et al. Research progress on application of anti-biofilm materials in food microbial safety[J]. Food Science,2022,43(11):265−272.]

    TIAN Cuifang, ZHANG Zhaohuan, TAO Qian, et al. Research progress on application of anti-biofilm materials in food microbial safety[J]. Food Science, 2022, 43(11): 265−272.
    [76]
    张家旭, 郭玉儿, 王信, 等. 金樱子活性成分, 生物功能及其在食品应用中的研究进展[J]. 食品科技,2023,48(1):98−106. [ZHANG Jiaxu, GUO Yuer, WANG Xin, et al. Research progress of active ingredients, biological functions and application in food[J]. Food Science and Technology,2023,48(1):98−106.]

    ZHANG Jiaxu, GUO Yuer, WANG Xin, et al. Research progress of active ingredients, biological functions and application in food[J]. Food Science and Technology, 2023, 48(1): 98−106.
    [77]
    MOSTAFA D M, EL-ALIM S, KASSEM A A. Nanoemulsions:A new approach for enhancing phytonutrient efficacy[M]//Nanotechnology Applications in Food. Academic Press, 2017:107−127.
    [78]
    金栋, 胡容峰, 周安, 等. 灵芝孢子油自微乳的制备及其质量评价[J]. 安徽中医药大学学报,2017,36(6):89−92. [JIN Dong, HU Rongfeng, ZHOU An, et al. Preparation and quality evaluation of Ganoderma lucidum spore oil self-microemulsion[J]. Journal of Anhui University of Traditional Chinese Medicine,2017,36(6):89−92.] doi: 10.3969/j.issn.2095-7246.2017.06.024

    JIN Dong, HU Rongfeng, ZHOU An, et al. Preparation and quality evaluation of Ganoderma lucidum spore oil self-microemulsion[J]. Journal of Anhui University of Traditional Chinese Medicine, 2017, 36(6): 89−92. doi: 10.3969/j.issn.2095-7246.2017.06.024
    [79]
    XU Y, WANG Q, FENG Y, et al. Enhanced oral bioavailability of [6]-Gingerol-SMEDDS:Preparation, in vitro and in vivo evaluation[J]. Journal of Functional Foods,2016,27:703−710. doi: 10.1016/j.jff.2016.10.007
    [80]
    CHEN Y, ZHANG H, YANG J, et al. Improved antioxidant capacity of optimization of a self-microemulsifying drug delivery system for resveratrol[J]. Molecules,2015,20(12):21167−21177. doi: 10.3390/molecules201219750
    [81]
    LYU Q, CHEN L, LIN S, et al. A designed self-microemulsion delivery system for dihydromyricetin and its dietary intervention effect on high-fat-diet fed mice[J]. Food Chemistry,2022(Oct.1):390.
    [82]
    CHOU Y C, LI S, HO C T, et al. Preparation and evaluation of self-microemulsifying delivery system containing 5-demethyltangeretin on inhibiting xenograft tumor growth in mice[J]. International Journal of Pharmaceutics,2020,579:119134. doi: 10.1016/j.ijpharm.2020.119134
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