Analysis of Four Avermectin Drugs Residual Levels in Rose Flower Cakes and Chronic Dietary Risk Assessment

HUANG Yuyuan; XU Xing; DUAN Jiyan; ZHANG Yan; ZI Jiejun

doi:10.13386/j.issn1002-0306.2023060208

Volume 45 Issue 6

Mar. 2024

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Science and Technology of Food Industry > 2024 > 45(6): 219-225. > DOI: 10.13386/j.issn1002-0306.2023060208

HUANG Yuyuan, XU Xing, DUAN Jiyan, et al. Analysis of Four Avermectin Drugs Residual Levels in Rose Flower Cakes and Chronic Dietary Risk Assessment[J]. Science and Technology of Food Industry, 2024, 45(6): 219−225. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023060208.

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Analysis of Four Avermectin Drugs Residual Levels in Rose Flower Cakes and Chronic Dietary Risk Assessment

1.
The School of Public Health, Dali University, Dali 671000, China
2.
Dali Comprehensive Inspection Centre of Quality and Technical Supervision, Dali 671000, China

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Received Date: June 24, 2023
Available Online: January 09, 2024

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Abstract

To understand whether there was a drug residue in the rose flower cake, and whether there was a risk of chronic dietary intake. In this paper, the residues of four avermectins in rose flower cake were detected, the residual levels of drug residues were analyzed, and the risk of chronic dietary intake was evaluated. The four drugs were avermectin, doramectin, acetylamineavermectin and ivermectin. A total of 43 rose flower cake samples were collected, and the optimized QuEChERS method was used to pre-treat the samples. The residue levels of the four compounds were determined by high performance liquid chromatography-tandem mass spectrometry, and their chronic dietary intake risk assessment and risk rank were performed. Results show that the four kinds of abamectin drugs line of correlation coefficient were greater than 0.99, the detection limit of the range of 0.1~0.7 µg/kg, recovery range of 94.97%~102.09%. Only avermectin was detected in the 4 target compounds, the detection rate was 79%, and residual range of 1.89~4.58 µg/kg. The food safety index analysis (IFS) of the four drugs was 1.3×10⁻³ for avermectin, 1.0×10⁻⁴ for doramectin, 1.7×10⁻⁶ for acetylavermectin, and 1.2×10⁻⁵ for ivermectin. Risk assessment on four kinds of target compounds, and to the risk of ordering, total four drugs were less than 50. This indicated that the residual level of avermectins in rose flower cakes was not high at present, and the risk was low. It was suggested that it should be included in the registration list of pesticides and the corresponding limit standards should be established.
- risk assessment of dietary intake,
- avermectin drugs,
- pesticide residues,
- rose flower cakes

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References

[1]	章琳. 电商平台下云南鲜花供应链协同发展研究[D]. 昆明:昆明理工大学, 2019. [ZHANG Lin. Research on collaborative development of Yunnan flower supply chain under e-commerce platform[D]. Kunming:Kunming University of Science and Technology, 2019.] ZHANG Lin. Research on collaborative development of Yunnan flower supply chain under e-commerce platform[D]. Kunming: Kunming University of Science and Technology, 2019.
[2]	缪建华. 东明县露地花卉的分布与病虫害防治[J]. 现代园艺,2017(19):156−157. [MIU Jianhua. Distribution of open field flowers and pest control in Dongming County[J]. Modern Horticulture,2017(19):156−157.] MIU Jianhua. Distribution of open field flowers and pest control in Dongming County[J]. Modern Horticulture, 2017（19）: 156−157.
[3]	黄雅俊, 宋会鸣, 丁佩, 等. 25%阿维·乙螨唑SC防治观赏玫瑰红蜘蛛药效评价[J]. 农药,2016,55(7):539−540,546. [HUANG Yajun, SONG Huiming, DING Pei, et al. Efficacy evaluation of abamectin etoxazole 25% SC against red spider in ornamental rose[J]. Agrochemicals,2016,55(7):539−540,546.] HUANG Yajun, SONG Huiming, DING Pei, et al. Efficacy evaluation of abamectin etoxazole 25% SC against red spider in ornamental rose[J]. Agrochemicals, 2016, 55（7）: 539−540,546.
[4]	LORENZO R G, MARIA D N H, JOSE M R M, et al. Edible flowers as a health promoter:An evidence-based review[J]. Trends in Food Science & Technology,2021,117:46−59.
[5]	MATYJASZCZYK E , MARIA S. Edible flowers. Benefits and risks pertaining to their consumption[J]. Trends in Food Science & Technology, 2019, 91:670-674.
[6]	QIN H, DENG X Q, LI B C, et al. Volatiles, polysaccharides and total polyphenols in Chinese rose tea infusions and their antioxidant activities[J]. Journal of Food Processing and Preservation,2017,42(1):13323.
[7]	蔺国仓, 任向荣, 孙美乐. 食用玫瑰主要病虫害综合防控技术[J]. 园艺与种苗,2021,41(2):23−24,29. [LIN Guocang, REN Xiangrong, SUN Meile. Intergrated pest control technology of edible rose[J]. Horticulture & Seed,2021,41(2):23−24,29.] LIN Guocang, REN Xiangrong, SUN Meile. Intergrated pest control technology of edible rose[J]. Horticulture & Seed, 2021, 41（2）: 23−24,29.
[8]	李爽. 高效液相色谱法测定菠菜中阿维菌素残留量[J]. 食品安全导刊,2023,374(9):69−71. [LI Shuang. Determination of avermectin residues in spinach powder by high performance liquid chromatography[J]. China Food Safety Magazine,2023,374(9):69−71.] LI Shuang. Determination of avermectin residues in spinach powder by high performance liquid chromatography[J]. China Food Safety Magazine, 2023, 374（9）: 69−71.
[9]	赵云龙, 火红艳, 金燕, 等. QuECHERS-HPLC测定大白菜中阿维菌素残留量[J]. 食品与发酵科技,2021,57(6):109−112,131. [ZHAO Yunlong, HUO Hongyan, JIN Yan, et al. QuECHERS-HPLC determination of abamectin residues in chinese cabbage[J]. Food and Fermentation Science & Technology,2021,57(6):109−112,131.] ZHAO Yunlong, HUO Hongyan, JIN Yan, et al. QuECHERS-HPLC determination of abamectin residues in chinese cabbage[J]. Food and Fermentation Science & Technology, 2021, 57（6）: 109−112,131.
[10]	缑仲轩, 和凤, 李紫萱, 等. 阿维菌素研究进展与产业综述[J]. 中国抗生素杂志,2022,47(11):1139−1148. [GOU Zhongxuan, HE Feng, LI Zixuan, et al. Research advances and the industry of avermectin[J]. Chinese Journal of Antibiotics,2022,47(11):1139−1148.] GOU Zhongxuan, HE Feng, LI Zixuan, et al. Research advances and the industry of avermectin[J]. Chinese Journal of Antibiotics, 2022, 47（11）: 1139−1148.
[11]	李卫平. 阿维菌素的研究进展[J]. 中国药业,2012,21(19):108−110. [LI Weiping. Research progress of avermectin[J]. China Pharmaceuticals,2012,21(19):108−110.] LI Weiping. Research progress of avermectin[J]. China Pharmaceuticals, 2012, 21（19）: 108−110.
[12]	庄无忌. 国际食品饲料中农药残留限量法规第一卷(CAC及亚洲地区卷)[M]. 北京:化学工业出版社, 2010. [ZHUANG Wuji. The global refulations on maximum residue limits (MRLs) for pesticides in foodstuffs and feedstuffs Volume I (CAC and Asia volume)[M]. Beijing:Chemical Industry Press, 2010.] ZHUANG Wuji. The global refulations on maximum residue limits （MRLs） for pesticides in foodstuffs and feedstuffs Volume I （CAC and Asia volume）[M]. Beijing: Chemical Industry Press, 2010.
[13]	庄无忌. 国际食品饲料中农药残留限量法规第三卷(欧盟卷)[M]. 北京:化学工业出版社, 2010. [ZHUANG W J. The global refulations on maximum residue limits(MRLs) for pesticides in foodstuffs and feedstuffs Volume III (EU volume)[M]. Beijing:Chemical Industry Press, 2010.] ZHUANG W J. The global refulations on maximum residue limits（MRLs） for pesticides in foodstuffs and feedstuffs Volume III （EU volume）[M]. Beijing: Chemical Industry Press, 2010.
[14]	BIAN Yanli, FENG Yizhi, ZHANG Aijuan, et al. Residue behaviors, processing factors and transfer rates of pesticides and metabolites in rose from cultivation to consumption[J]. Journal of Hazardous Materials 2023, 442:130104.
[15]	何洁, 刘文锋, 胡承成, 等. 贵州黔东南州番茄农药残留膳食摄入风险评估[J]. 食品科学,2019,40(1):202−208. [HE Jie, LIU Wenfeng, HU Chengcheng, et al. Risk assessment of pesticide residues via dietary intake of tomatoes from qiandongnan, Guizhou[J]. Food Science,2019,40(1):202−208.] HE Jie, LIU Wenfeng, HU Chengcheng, et al. Risk assessment of pesticide residues via dietary intake of tomatoes from qiandongnan, Guizhou[J]. Food Science, 2019, 40（1）: 202−208.
[16]	马新耀, 王静, 朱九生. 山西省黄瓜农药残留检测及膳食摄入风险评估[J]. 生态毒理学报,2020,15(5):333−344. [MA Xinyao, WANG Jing, ZHU Jiusheng. Detecting cucumber pesticide residues and assessing its dietary intake risk in Shanxi province[J]. Asian Journal of Ecotoxicology,2020,15(5):333−344.] MA Xinyao, WANG Jing, ZHU Jiusheng. Detecting cucumber pesticide residues and assessing its dietary intake risk in Shanxi province[J]. Asian Journal of Ecotoxicology, 2020, 15（5）: 333−344.
[17]	常薇, 李慧, 李春梅, 等. 成都市售果蔬中农药残留水平分析及慢性膳食风险评估[J]. 食品工业科技,2022,43(6):258−268. [CHANG Wei, LI Hui, LI Chunmei, et al. Residue levels and chronic dietary intake risk of pesticide residues in fruits and vegetables in Chengdu[J]. Science and Technology of Food Industry,2022,43(6):258−268.] CHANG Wei, LI Hui, LI Chunmei, et al. Residue levels and chronic dietary intake risk of pesticide residues in fruits and vegetables in Chengdu[J]. Science and Technology of Food Industry, 2022, 43（6）: 258−268.
[18]	何洁, 刘文锋, 胡承成, 等. 黔东南州黄瓜农药残留膳食摄入风险评估[J]. 浙江农业科学,2018,59(7):1246−1250. [HE Jie, LIU Wenfeng, HU Chengcheng, et al. Dietary intake risk assessment of cucumber pesticide residues in cucumbers in Qiandongnan[J]. Journal of Zhejiang Agricultural Sciences,2018,59(7):1246−1250.] HE Jie, LIU Wenfeng, HU Chengcheng, et al. Dietary intake risk assessment of cucumber pesticide residues in cucumbers in Qiandongnan[J]. Journal of Zhejiang Agricultural Sciences, 2018, 59（7）: 1246−1250.
[19]	MEBDOUA S, LAZALI M, OUNANE S M, et al. Evaluation of pesticide residues in fruits and vegetables from Algeria[J]. Food Additives and Contaminants: Part B,2017,10(2):91−98. doi: 10.1080/19393210.2016.1278047
[20]	BOLOR V K, BOADI N O, BORQUAYE L S, et al. Human risk assessment of organochlorine pesticide residues in vegetables from Kumasi, Ghana[J]. Journal of Chemistry,2018,2018:1−11.
[21]	温馨, 黎小鹏, 谭淑铧, 等. 2021年中山市种植蔬菜农药残留及膳食风险评估[J]. 浙江农业科学,2023,64(2):455−462. [WEN Xin, LI Xiaopeng, TAN Shuhua, et al. Assessment of pesticide residues and dietary intake risk of vegetables planted in Zhongshan City in 2021[J]. Journal of Zhejiang Agricultural Sciences,2023,64(2):455−462.] WEN Xin, LI Xiaopeng, TAN Shuhua, et al. Assessment of pesticide residues and dietary intake risk of vegetables planted in Zhongshan City in 2021[J]. Journal of Zhejiang Agricultural Sciences, 2023, 64（2）: 455−462.
[22]	兰珊珊, 林昕, 邹艳红, 等. 蔬菜中多效唑残留的膳食暴露与风险评估[J]. 现代食品科技,2016,32(2):336−341,245. [LAN Shanshan, LIN Xin, ZOU Yanhong, et al. Dietary exposure and risk assessment of polybulobuzole residues in vegetables[J]. Modern Food Science and Technology,2016,32(2):336−341,245.] LAN Shanshan, LIN Xin, ZOU Yanhong, et al. Dietary exposure and risk assessment of polybulobuzole residues in vegetables[J]. Modern Food Science and Technology, 2016, 32（2）: 336−341,245.
[23]	贾秦岚, 王贤, 钦巧眉, 等. 新疆杏农药残留的风险评估与排序[J]. 食品工业科技,2023,44(21):267−274. [JIA Qinlan, WANG Xian, QIN Qiaomei, et al. Risk assessment and ranking of pesticide residues in Xinjiang apricot[J]. Science and Technology of Food Industry,2023,44(21):267−274.] JIA Qinlan, WANG Xian, QIN Qiaomei, et al. Risk assessment and ranking of pesticide residues in Xinjiang apricot[J]. Science and Technology of Food Industry, 2023, 44（21）: 267−274.
[24]	张志涛, 娄雨豪, 岳诗博, 等. 稻米中丙草胺农药残留消解规律及膳食风险评估[J]. 粮食与油脂,2023,36(4):155−159. [ZHANG Zhitao, LOU Yuhao, YUE Shibo, et al. Degradation law of pesticide residues in rice and dietary risk assessment[J]. Cereals & Oils,2023,36(4):155−159.] ZHANG Zhitao, LOU Yuhao, YUE Shibo, et al. Degradation law of pesticide residues in rice and dietary risk assessment[J]. Cereals & Oils, 2023, 36（4）: 155−159.
[25]	王微, 鄢人雨, 兰吉玉, 等. 黔东南州茶叶农药残留膳食摄入风险评估[J]. 茶叶科学,2019,39(5):567−575. [WANG Wei, YAN Renyu, LAN Jiyu, et al. Dietary intake risk assessment of pesticide residues in tea in Qiandongnan prefecture[J]. Journal of Tea Science,2019,39(5):567−575.] WANG Wei, YAN Renyu, LAN Jiyu, et al. Dietary intake risk assessment of pesticide residues in tea in Qiandongnan prefecture[J]. Journal of Tea Science, 2019, 39（5）: 567−575.
[26]	殷雪琰, 王洁琼, 王国庆, 等. 茶叶中农药残留检测及膳食摄入风险评估[J]. 浙江农业科学,2022,63(10):2393−2399,2405. [YIN Xueyan, WANG Jieqiong, WANG Guoqin, et al. Determination of pesticide residues in tea and its risk assessment of dietary intake[J]. Journal of Zhejiang Agricultural Sciences,2022,63(10):2393−2399,2405.] YIN Xueyan, WANG Jieqiong, WANG Guoqin, et al. Determination of pesticide residues in tea and its risk assessment of dietary intake[J]. Journal of Zhejiang Agricultural Sciences, 2022, 63（10）: 2393−2399,2405.
[27]	高贯威, 刘明雨, 匡立学, 等. 鲜枣中21种农药气相色谱串联质谱测定及膳食风险评估[J]. 中国果树,2023,231(1):95−99. [GAO Guanwei, LIU Mingyu, KUANG Lixue, et al. Gas chromatography-tandem mass spectrometry determination and risk assessment of 21 pesticides in jujube[J]. China Fruits,2023,231(1):95−99.] GAO Guanwei, LIU Mingyu, KUANG Lixue, et al. Gas chromatography-tandem mass spectrometry determination and risk assessment of 21 pesticides in jujube[J]. China Fruits, 2023, 231（1）: 95−99.
[28]	中华人民共和国国家卫生健康委员会, 国家市场监督管理总局. GB 23200.121-2021食品安全国家标准植物源性食品中 331 种农药及其代谢物残留量的测定液相色谱-质谱联用法[S]. 北京:中国农业出版社, 2021:2−5. [National Health Commission of the People's Republic of China, State Administration for Market Regulation. GB 23200.121-2021 National standards for food safety. Determination of 331 pesticides and their metabolites residues in plant-derived foods-liquid chromatography-mass spectrometry[S]. Beijing:China Agriculture Press, 2021:2−5.] National Health Commission of the People's Republic of China, State Administration for Market Regulation. GB 23200.121-2021 National standards for food safety. Determination of 331 pesticides and their metabolites residues in plant-derived foods-liquid chromatography-mass spectrometry[S]. Beijing: China Agriculture Press, 2021: 2−5.
[29]	冒玉娟, 邢晓玲, 沈小艮, 等. UPLC-MS/MS法测定鸡肉中阿维菌素类药物残留检测方法的建立[J]. 江苏农业科学,2018,46(15):146−150. [MAO Yujuan, XING Xiaoling, SHENG Xiaogen, et al. Determination of abamectin residues in chicken muscle by ultra performance liquid chromatography-tandem mass spectrometry[J]. Jiangsu Agricultural Sciences,2018,46(15):146−150.] MAO Yujuan, XING Xiaoling, SHENG Xiaogen, et al. Determination of abamectin residues in chicken muscle by ultra performance liquid chromatography-tandem mass spectrometry[J]. Jiangsu Agricultural Sciences, 2018, 46（15）: 146−150.
[30]	XU X, ZHANG X M, DUHORANIMANA E, et al. Determination of methenamine residues in edible animal tissues by HPLC-MS/MS using a modified QuEChERS method:Validation and pilot survey in actual samples[J]. Food Control,2016,61:99−104. doi: 10.1016/j.foodcont.2015.09.030
[31]	焦晓伟. 芹菜农药残留检测及膳食摄入风险评估[J]. 食品安全导刊,2021,318(25):79−82. [JIAO Xiaowei. Detection of pesticide residues in celery and risk assessment of dietary intake[J]. China Food Safety Magazine,2021,318(25):79−82.] JIAO Xiaowei. Detection of pesticide residues in celery and risk assessment of dietary intake[J]. China Food Safety Magazine, 2021, 318（25）: 79−82.
[32]	中华人民共和国卫生部, 中华人民共和国农业部. 食品安全国家标准食品中农药最大残留限量:GB 2763-2021[S]. 北京:中国标准出版社, 2022:10−13. [Ministry of Health of the People's Republic of China, Ministry of Agriculture of the People's Republic of China. Maximum residue limits for pesticides in food:GB 2763-2021[S]. Beijing:China Standards Press, 2022:10−13.] Ministry of Health of the People's Republic of China, Ministry of Agriculture of the People's Republic of China. Maximum residue limits for pesticides in food: GB 2763-2021[S]. Beijing: China Standards Press, 2022: 10−13.
[33]	中华人民共和国卫生部, 中华人民共和国农业部. 食品安全国家标准食品中兽药最大残留限量:GB 31650—2019[S]. 北京:中国标准出版社, 2019:18−34. [Ministry of Health of the People's Republic of China, Ministry of Agriculture of the People's Republic of China. Maximum residue limits for veterinary drugs in food:GB 31650—2019[S]. Beijing:China Standards Press, 2022:10−13.] Ministry of Health of the People's Republic of China, Ministry of Agriculture of the People's Republic of China. Maximum residue limits for veterinary drugs in food: GB 31650—2019[S]. Beijing: China Standards Press, 2022: 10−13.
[34]	中华人民共和国农业部农药检定所. 中国农药信息网[DB/OL]. 2014-1-16. http://www.chinapesticide.gov.cn/service/zhcx/yxcfxx.html. [Institute for the Control of Agrochemicals. China pesticide information network[DB/OL]. 2014-1-16. http://www.chinapesticide.gov.cn/service/zhcx/yxcfxx.html.] Institute for the Control of Agrochemicals. China pesticide information network[DB/OL]. 2014-1-16. http://www.chinapesticide.gov.cn/service/zhcx/yxcfxx.html.
[35]	林莉. 中国焙烤行业发展现状及趋势洞察[J]. 食品工业科技,2023,44(13):483-489. [LIN Li. Current situation and trend analysis of China’s bakery industry[J]. Science and Technology of Food Industry,2023,44(13):483-489.] LIN Li. Current situation and trend analysis of China’s bakery industry[J]. Science and Technology of Food Industry, 2023, 44（13）: 483-489.
[36]	药物在线. 化学物质索引数据库[DB/OL]. 2017-12-06. http://www.drugfuture.com/chemdata/. [Drugfuture. Chemical substances index database[DB/OL]. 2017-12-06. http://www.drugfuture.com/chemdata/.] Drugfuture. Chemical substances index database[DB/OL]. 2017-12-06. http://www.drugfuture.com/chemdata/.
[37]	曹清明, 王蔚婕, 张琳, 等. 中国居民平衡膳食模式的践行—《中国居民膳食指南(2022)》解读[J]. 食品与机械,2022,38(6):22−29. [CAO Qingming, WANG Weijie, ZHANG Lin, et al. The practice of balanced diet model for Chinese residents:Interpretation of dietary guidelines for Chinese residents (2022)[J]. Food & Machinery,2022,38(6):22−29.] CAO Qingming, WANG Weijie, ZHANG Lin, et al. The practice of balanced diet model for Chinese residents: Interpretation of dietary guidelines for Chinese residents （2022）[J]. Food & Machinery, 2022, 38（6）: 22−29.
[38]	赵丽云, 郭齐雅, 李淑娟, 等. 加强营养调查与监测, 改善中国居民营养与健康状况[J]. 卫生研究,2019,48(4):517−522. [ZHAO Liyun, GUO Qiya, LI Shujuan, et al. Strengthen nutrition investigation and monitoring to improve the nutrition and health status of Chinese people[J]. Journal of Hygiene Research,2019,48(4):517−522.] ZHAO Liyun, GUO Qiya, LI Shujuan, et al. Strengthen nutrition investigation and monitoring to improve the nutrition and health status of Chinese people[J]. Journal of Hygiene Research, 2019, 48（4）: 517−522.

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