Optimization of Ultrasound-Assisted Alkali Alcohol Extraction and Macroporous Resin Purification of Ferulic Acid from Corn Husk

ZHANG Naidan; ZUO Zhaohang; WANG Ying; SUN Wei; PANG Weiqiao

doi:10.13386/j.issn1002-0306.2023030342

Volume 44 Issue 22

Nov. 2023

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Science and Technology of Food Industry > 2023 > 44(22): 1-11. > DOI: 10.13386/j.issn1002-0306.2023030342

ZHANG Naidan, ZUO Zhaohang, WANG Ying, et al. Optimization of Ultrasound-Assisted Alkali Alcohol Extraction and Macroporous Resin Purification of Ferulic Acid from Corn Husk[J]. Science and Technology of Food Industry, 2023, 44(22): 1−11. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023030342.

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Optimization of Ultrasound-Assisted Alkali Alcohol Extraction and Macroporous Resin Purification of Ferulic Acid from Corn Husk

ZHANG Naidan^1,,
ZUO Zhaohang¹,
WANG Ying^{1, 2, 3, 4, ,},
SUN Wei¹,
PANG Weiqiao¹

1.
College of Food, Heilongjiang Bayi Agricultural University, Daqing 163319, China
2.
National Coarse Cereals Engineering Research Center, Daqing 163319, China
3.
Engineering Research Center of Processing and Utilization of Grain By-products, Ministry of Education, Daqing 163319, China
4.
Key Laboratory of Agro-Products Processing and Quality Safety of Heilongjiang Province, Daqing 163319, China

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Received Date: March 29, 2023
Available Online: September 13, 2023

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Abstract

Abstract

To explore the extraction and purification process of ferulic acid from corn bran, ferulic acid from corn husks was extracted by ultrasound-assisted alkali alcohol method. The best extraction conditions were obtained by using the content of ferulic acid in the crude extract of corn husk as the index through single factor tests and response surface optimization test. Further purification of corn ferulic acid was used macroporous adsorption resin method, and suitable resin was selected by static adsorption method. Determined the optimal sample loading amount in the dynamic adsorption method, and obtained the optimal purification process conditions using recovery rate as an indicator through single factor experiments and response surface optimization experiment. Results showed that, the best extraction conditions of ferulic acid from corn bran were obtained as follows: Solid-liquid ratio 1:12 g/mL, mass concentration of lye was 4%, alkali-alcohol ratio was 2:1, ultrasound time 30 min, ultrasonic thermometer 59℃, ultrasonic power 229 W, and the amount of ferulic acid extracted could reached 22.31 mg/g under these conditions. The purification of ferulic acid was performed using HPD-100 macroporous adsorption resin. The optimal loading volume was 6 times the bed volume. The optimal purification process conditions are as follows: Sample loading concentration 0.3 mg/mL, loading flow rate 3 mL/min, mass concentration of ethanol 75%, elution flow rate 1 mL/min. Under these conditions, the recovery rate of ferulic acid from corn peel was up to 95.17%, and the purity of ferulic acid was 81.56%. This experiment increased the added value of corn brans, and would provide the theoretical basis and data support for the further processing of corn brans and the development of ferulic acid.
- corn bran,
- ferulic acid,
- ultrasound-assisted alkali-alcohol method,
- macroporous adsorption resin method,
- process optimization

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References (31)

References

[1]	XUE J, SHENG X, ZHANG B J, et al. The sirtuin-1 relied antioxidant and antiaging activity of 5,5'-diferulic acid glucoside esters derived from corn bran by enzymatic method[J]. Food Biochem,2020,44(12):e13519.
[2]	曹亚倩, 肖军霞, 蒋林宏, 等. 玉米纤维素在Pickering乳液制备中的应用研究[J]. 中国粮油学报,2020,35(4):54−60 doi: 10.3969/j.issn.1003-0174.2020.04.010 CAO Y Q, XIAO J X, JIANG L H, et al. Application of corn fiber in the preparation of Pickering emulsions[J]. Journal of the Chinese Cereals and Oils Association,2020,35(4):54−60. doi: 10.3969/j.issn.1003-0174.2020.04.010
[3]	刘宽博, 施晶晶, 何贝贝, 等. 玉米皮及发酵玉米皮的营养特性及研究进展[J]. 饲料工业,2023,44(3):17−22 doi: 10.13302/j.cnki.fi.2023.03.004 LIU K B, SHI J J, HE B N, et al. Research progress on nutritional characteristics of corn bran and fermented corn bran[J]. Feed Industry,2023,44(3):17−22. doi: 10.13302/j.cnki.fi.2023.03.004
[4]	WANG L, LIU H M, XIE A J, et al. Dietary fiber extraction from defatted corn hull by hot-compressed water[J]. Polish Journal of Food and Nutrition Sciences,2018,68(2):133−140. doi: 10.1515/pjfns-2017-0015
[5]	赵战利, 宁占国, 李宁, 等. 玉米皮中阿魏酸的提取工艺研究[J]. 食品工业,2014,35(3):37−40 ZHAO Z L, NING Z G, LI N, et al. Study on the extraction process of ferulic acid from maize bran[J]. The Food Industry,2014,35(3):37−40.
[6]	QIN F, HUANG X. Guanxin II (II) for the management of coronary heart disease[J]. Chin J Integr Med,2009,15(6):472−476. doi: 10.1007/s11655-009-0472-6
[7]	文为, 杨芰, 姚琰. 阿魏酸钠对冠心病病人SOD, LPO及纤溶系统的影响[J]. 中国药师,2002(9):555−556 doi: 10.3969/j.issn.1008-049X.2002.09.023 WEN W, YANG Z, YAO Y. Effect of sodium ferulate injection on superoxide dismutase, lipid peroxide, and fibrinolysis system in patients with coronary disease[J]. China Pharmacist,2002(9):555−556. doi: 10.3969/j.issn.1008-049X.2002.09.023
[8]	JIN C, CHEN D, ZHU T, et al. Poly(ferulic acid)-hybrid nanofibers for reducing thrombosis and restraining intimal hyperplasia in vascular tissue engineering[J]. Biomaterials Advances,2023,146:213278. doi: 10.1016/j.bioadv.2023.213278
[9]	SHI Y, CHEN X, QIANG S, et al. Anti-oxidation and anti-inflammatory potency evaluation of ferulic acid derivatives obtained through virtual screening[J]. International Journal of Molecular Sciences,2021,22(21):11305. doi: 10.3390/ijms222111305
[10]	HAN H, DYE L, MACKIE A. The impact of processing on the release and antioxidant capacity of ferulic acid from wheat:A systematic review[J]. Food Research International,2023,164:112371. doi: 10.1016/j.foodres.2022.112371
[11]	GUPTA A, SINGH A K, LOKA M, et al. Ferulic acid-mediated modulation of apoptotic signaling pathways in cancer[J]. Adv Protein Chem Struct Biol,2021,125:215−257.
[12]	VILLANUEVA M P, GIOIA C, SISTI L, et al. Valorization of ferulic acid from agro-industrial by-products for application in agriculture[J]. Polymers-Basel,2022,14(14):2874. doi: 10.3390/polym14142874
[13]	谢伊莎, 傅新鑫, 郑佳楠, 等. 天然保鲜剂对预制南美白对虾贮藏品质的影响[J]. 食品工业科技,2021,42(4):264−270 doi: 10.13386/j.issn1002-0306.2020050159 XIE Y S, FU X X, ZHENG J N, et al. Effects of bio-preservatives on the quality of pre-cooked pacific whiteshrimp ( Penaeus vannamei) during refrigerated storage[J]. Science and Technology of Food Industry,2021,42(4):264−270. doi: 10.13386/j.issn1002-0306.2020050159
[14]	KAWABATA K, YAMAMOTO T, HARA A, et al. Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats[J]. Cancer Lett,2000,157(1):15−21. doi: 10.1016/S0304-3835(00)00461-4
[15]	赵文红, 冯丽然, 关二旗, 等. 均匀设计法优化麦麸阿魏酸的酶法提取工艺[J]. 食品工业,2020,41(5):38−43 ZHAO W H, FENG L R, GUAN R Q, er al. Optimization of extraction process of wheat bran ferulic acid by uniform design method[J]. The Food Industry,2020,41(5):38−43.
[16]	宋微, 辛嘉英, 路雪纯, 等. 小麦中阿魏酸的分布、存在形式以及制备方法的研究进展[J]. 食品工业科技,2022,43(14):445−452 doi: 10.13386/j.issn1002-0306.2021070224 SONG W, XIN J Y, LU X C, et al. Research progress on distribution, forms and preparation methods of ferulic acid in wheat[J]. Science and Technology of Food Industry,2022,43(14):445−452. doi: 10.13386/j.issn1002-0306.2021070224
[17]	刘珂, 徐成, 郭玉梅, 等. 酚酸类化合物阿魏酸的研究进展[J]. 当代化工研究,2022,121(20):70−74 LIU K, X C, GUO Y M, et al. Research progress of phenolic acid compound ferulic acid[J]. Moderm Chemical Research,2022,121(20):70−74.
[18]	杨徐宁, 张国治. 超声辅助碱醇法提取青麦仁麸皮中阿魏酸的工艺研究[J]. 河南工业大学学报(自然科学版),2020,41(1):72−77 YANG X N, ZHANG G Z. Extraction process of ferulic acid from green wheat bran by ultrasonic-assisted alkali alcohol method[J]. Journal of Henan University of Technology (Natural Science Edition),2020,41(1):72−77.
[19]	胡迎丽, 夏璐, 雷福厚. 大孔吸附树脂在天然产物的分离纯化中的应用进展[J]. 化工技术与开发,2021,50(11):29−34 doi: 10.3969/j.issn.1671-9905.2021.11.009 HU Y L, XIA L, LEI F H. Application progress on macroporous adsorption resin in separation and purification of natural products[J]. Technology & Development of Chemical Industry,2021,50(11):29−34. doi: 10.3969/j.issn.1671-9905.2021.11.009
[20]	王蓓. 麦麸中阿魏酸提取及纯化技术的研究[D]. 西安:陕西科技大学, 2012 WANG B. Study on extra ction and purification of ferulic acid in wheat bran[D]. Xi’an:Shaanxi University of Science & Technology, 2012.
[21]	张康逸, 杨妍, 康志敏. 超声辅助碱醇提取青麦仁中阿魏酸的工艺研究[J]. 粮食加工,2020,45(2):5−10 ZHANG K Y, YANG Y, KANG Z M. Studies on technologies for extracting ferulic acid from green wheat berry by ultrasonic assisted with alkaline- alcohol hydrolysis[J]. Grain Processing,2020,45(2):5−10.
[22]	谭诗涵, 雷雅婷, 张也, 等. HPD100与D101大孔吸附树脂纯化禾本科芦笋总黄酮与总酚酸研究[J]. 中国药师,2020,23(5):839−844 doi: 10.3969/j.issn.1008-049X.2020.05.010 TAN S H, LEI Y T, ZHANG Y, et al. Study on the static and dynamic adsorption properties of total flavonoids and total phenolic acids in asparagus from gramineae by HPD100 and D101 macroporous adsorbent resins[J]. China Pharmacist,2020,23(5):839−844. doi: 10.3969/j.issn.1008-049X.2020.05.010
[23]	尹丽, 王华坤, 蒋德旗, 等. 大孔吸附树脂纯化九节总黄酮工艺的研究[J]. 饲料研究,2023,46(5):70−75 doi: 10.13557/j.cnki.issn1002-2813.2023.05.015 YIN L, WANG H K, JIANG D Q, et al. Optimization of purification process of total flavonoids from Psychotria asiatica by macroporous resin[J]. Feed Research,2023,46(5):70−75. doi: 10.13557/j.cnki.issn1002-2813.2023.05.015
[24]	马浩淼, 吴海, 王德发, 等. 面积归一法测定萜烯试剂纯度[J]. 计量学报,2018,39(5):736−740 doi: 10.3969/j.issn.1000-1158.2018.05.27 MA H R, WU H, WANG D F, et al. Purity analysis of some terpenes by peak area normalization method[J]. Acta Metrologica Sinica,2018,39(5):736−740. doi: 10.3969/j.issn.1000-1158.2018.05.27
[25]	阿来·海拉希. 新疆阿魏中阿魏酸的提取纯化、结构修饰及生物活性研究[D]. 乌鲁木齐:新疆师范大学, 2018 ALAI H L X. Study on extraction, purification, determination method, biological activities of Ferula sinkiangensis for ferulic acid[D]. Urumqi:Xinjiang Normal University, 2018.
[26]	段红梅, 王丹丹, 王顺余, 等. 响应面法优化高盐腌长白楤木嫩芽脱盐工艺[J]. 食品研究与开发,2020,41(4):88−94 doi: 10.12161/j.issn.1005-6521.2020.04.015 DUAN H M, WANG D D, WANG S Y, et al. Optimization of process for desalting high-salted Aralia continentalis Kitagwa by response surface methodology[J]. Food Research and Development,2020,41(4):88−94. doi: 10.12161/j.issn.1005-6521.2020.04.015
[27]	王迪, 王颖, 张艳莉, 等. 芸豆酵素复合发酵工艺优化及功能性分析[J]. 中国粮油学报,2021,36(7):62−68 doi: 10.3969/j.issn.1003-0174.2021.07.012 WANG D, WANG Y, ZHANG Y L, et al. Optimization and functional analysis on complex fermentation process of kidney bean ferment[J]. Journal of the Chinese Cereals and Oils Association,2021,36(7):62−68. doi: 10.3969/j.issn.1003-0174.2021.07.012
[28]	王丹丹, 刘芫汐, 左甜甜, 等. 大孔吸附树脂及其在中药领域应用研究进展[J]. 中国药事,2022,36(7):826−835 doi: 10.16153/j.1002-7777.2022.07.012 WANG D D, LIU R X, ZUO T T, et al. Research progress of macroporous adsorption resin and its application in traditional Chinese medicines[J]. Chinese Pharmaceutical Affairs,2022,36(7):826−835. doi: 10.16153/j.1002-7777.2022.07.012
[29]	孙开芬, 陈胤睿, 徐文芬, 等. 大孔吸附树脂分离纯化红禾麻总黄酮工艺的优化[J]. 中成药,2022,44(8):2619−2623 doi: 10.3969/j.issn.1001-1528.2022.08.035 SUN K F, CHEN Y R, XU W F, et al. Optimization of separation and purification of total flavonoids from red herba flax by macroporous adsorption resin[J]. Chinese Traditional Patent Medicine,2022,44(8):2619−2623. doi: 10.3969/j.issn.1001-1528.2022.08.035
[30]	何安乐, 熊瑶. 大孔吸附树脂对罗汉果甜苷V竞争吸附行为研究及纯化工艺优化[J]. 食品科技,2023,48(1):188−196 HE A L, XIONG Y. Study on competitive adsorption behavior of mogroside V by macroporous adsorption resin and purification process optimization[J]. Food Science and Technology,2023,48(1):188−196.
[31]	郝彩琴, 冷晓红, 李军, 等. 柴胡地上部分总黄酮的大孔吸附树脂分离纯化工艺及抑菌活性研究[J]. 北京化工大学学报(自然科学版),2022,49(6):64−72 HAO C Q, LENG X H, LI J, et al. Separation, purification and antibacterial activity of total flavonoids from the aboveground parts of Bupleurum chinense DC. using a macroporous adsorption resin[J]. Journal of Beijing University of Chemical Technology (Natural Science Edition),2022,49(6):64−72.

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[9]	大蒜油提取的比较研究[J]. Science and Technology of Food Industry, 1999, (05): 16-18. DOI: 10.13386/j.issn1002-0306.1999.05.004
[10]	黄刺玫叶片中黄酮物质的提取和分析[J]. Science and Technology of Food Industry, 1999, (05): 14-15. DOI: 10.13386/j.issn1002-0306.1999.05.003