Citation: | YU Dehan, LI Li, SU Shi. Research Progress on Extraction of Flavonoids Using Natural Deep Eutectic Solvents[J]. Science and Technology of Food Industry, 2023, 44(24): 367−375. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023020204. |
[1] |
许晓路, 戴国庆, 韦涵峰, 等. 双水相提取金银花叶总黄酮工艺优化及其抗氧化活性[J/OL]. 食品工业科技:1−15[2023-02-18]. doi:10.13386/j.issn1002-0306.2022100038. [XU X L, DAI G Q, WEI H F, et al. Optimization of aqueous two-phase extraction technology of total flavonoids from Lonicera japonica thunb. leaves and its antioxidant activity[J/OL]. Science and Technology of Food Industry:1−15[2023-02-18]. doi:10.13386/j.issn1002-0306.2022100038.
XU X L, DAI G Q, WEI H F, et al. Optimization of aqueous two-phase extraction technology of total flavonoids from Lonicera japonica thunb. leaves and its antioxidant activity[J/OL]. Science and Technology of Food Industry: 1−15[2023-02-18]. doi: 10.13386/j.issn1002-0306.2022100038.
|
[2] |
陆希, 林翠英, 张维琦, 等. 桑寄生族植物化学成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2023, 29(12):209-221. [LU X, LIN C Y, ZHANG W Q, et al. Research progress on chemical constituents and pharmacological activities of Trib. Lorantheae in China[J]. Chinese Journal of Experimental Traditional, 2023, 29(12):209-221.
LU X, LIN C Y, ZHANG W Q, et al. Research progress on chemical constituents and pharmacological activities of Trib. Lorantheae in China[J]. Chinese Journal of Experimental Traditional, 2023, 29(12): 209-221.
|
[3] |
范腾运, 刘娅琛, 刘喜富, 等. 黄酮类化合物对白血病的抗肿瘤作用[J]. 中国细胞生物学学报,2022,44(6):1139−1146. [FAN T Y, LIU Y C, LIU X F, et al. Anti-tumor effects of flavonoids on leukemia[J]. Chinese Journal of Cell Biology,2022,44(6):1139−1146.
|
[4] |
ABBOTT A P, CAPPER G, DAVIES D, et al. Novel solvent properties of choline chloride/urea mixtures[J]. Chemical Communications,2003,9(1):70−71.
|
[5] |
REDHA A A. Review on extraction of phenolic compounds from natural sources using green deep eutectic solvents[J]. Journal of Agricultural and Food Chemistry,2021,69(3):878−912. doi: 10.1021/acs.jafc.0c06641
|
[6] |
BENVENUTTI L, ZIELINSKI A A F, FERREIRA S R S. Which is the best food emerging solvent:IL, DES or NADES?[J]. Trends in Food Science & Technology,2019,90:133−146.
|
[7] |
GONZÁLEZ C G, MUSTAFA N R, WILSON E G, et al. Application of natural deep eutectic solvents for the "green"extraction of vanillin from vanilla pods[J]. Flavour and Fragrance Journal,2018,33(1):1−6. doi: 10.1002/ffj.3419
|
[8] |
NGUYEN T H, TRIEU T T U, NGUYEN V P. Green extraction of apigenin and luteolin from celery seed using deep eutectic solvent[J]. Journal of Pharmaceutical and Biomedical Analysis,2021,207:114406.
|
[9] |
HANG N T, TRANG V T H, PHUONG N V. Application of multivariate linear regression models for selection of deep eutectic solvent for extraction of apigenin and luteolin from Chrysanthemum indicum L.[J]. Phytochem Analysis,2022,33(3):427−440. doi: 10.1002/pca.3099
|
[10] |
WANG G, CUI Q, YIN L J, et al. Efficient extraction of flavonoids from Flos Sophorae Immaturus by tailored and sustainable deep eutectic solvent as green extraction media[J]. Journal of Pharmaceutical and Biomedical Analysis,2019,170:285−294. doi: 10.1016/j.jpba.2018.12.032
|
[11] |
MANSUR A R, SONG N E, JANG H W, et al. Optimizing the ultrasound-assisted deep eutectic solvent extraction of flavonoids in common buckwheat sprouts[J]. Food Chemistry,2019,293:438−445. doi: 10.1016/j.foodchem.2019.05.003
|
[12] |
YU J Q, ZHAO L, SUN X W, et al. Application of choline chloride deep eutectic solvents and high-speed counter-current chromatography to the extraction and purification of flavonoids from the thorns of Gleditsia sinensis Lam.[J]. Phytochemical Analysis,2021,32(4):457−465. doi: 10.1002/pca.2993
|
[13] |
IVANOVIĆ M, GRUJIĆ D, CERAR J, et al. Extraction of bioactive metabolites from Achillea Millefolium L. with choline chloride based natural deep eutectic solvents:A study of the antioxidant and antimicrobial activity[J]. Antioxidants,2022,11(4):724. doi: 10.3390/antiox11040724
|
[14] |
KALTSA O, LAKKA A, GRIGORAKIS S, et al. A green extraction process for polyphenols from elderberry ( Sambucus nigra) flowers using deep eutectic solvent and ultrasound-assisted pretreatment[J]. Molecules,2020,25(4):921. doi: 10.3390/molecules25040921
|
[15] |
CIARDI M, IANNI F, SARDELLA R, et al. Effective and selective extraction of quercetin from onion (Allium cepa L.) skin waste using water dilutions of acid-based deep eutectic solvents[J]. Materials, 2021, 14 :465.
|
[16] |
GUO H L, FENG C H, HU L J, et al. Exploration of a ternary deep eutectic solvent for the efficient extraction of plantamajoside, acteoside, quercetin and kaempferol from Plantago asiatica L.[J]. Phytochemical Analysis,2022,33(1):94−104. doi: 10.1002/pca.3071
|
[17] |
LUO S B, REN X M, SHI X Q, et al. Study on enhanced extraction and seasonal variation of secondary metabolites in Eucommia ulmoides leaves using deep eutectic solvents[J]. Journal of Pharmaceutical and Biomedical Analysis,2022,209:114514. doi: 10.1016/j.jpba.2021.114514
|
[18] |
LI J, CHEN W, NIU D B, et al. Efficient and green strategy based on pulsed electric field coupled with deep eutectic solvents for recovering flavonoids and preparing flavonoid aglycones from noni-processing wastes[J]. Journal of Cleaner Production,2022,368:133019. doi: 10.1016/j.jclepro.2022.133019
|
[19] |
RASHID R, WANI S M, MANZOOR S, et al. Green extraction of bioactive compounds from apple pomace by ultrasound assisted natural deep eutectic solvent extraction:optimisation, comparison and bioactivity[J]. Food Chemistry,2023,398:133871. doi: 10.1016/j.foodchem.2022.133871
|
[20] |
BRAHMI-CHENDOUH N, PICCOLELLA S, GRAVINA C, et al. Ready-to-use nutraceutical formulations from edible and waste organs of algerian artichokes[J]. Foods,2022,11(24):3955. doi: 10.3390/foods11243955
|
[21] |
LIU Y J, ZHANG H, YU H M, et al. Deep eutectic solvent as a green solvent for enhanced extraction of narirutin, naringin, hesperidin and neohesperidin from aurantii fructus[J]. Phytochemical Analysis,2019,30(2):156−163. doi: 10.1002/pca.2801
|
[22] |
TOPRAKCI G, TOPRAKCI I, SAHIN S. Highly clean recovery of natural antioxidants from lemon peels:Lactic acid-based automatic solvent extraction[J]. Phytochemical Analysis,2022,33(4):554−563. doi: 10.1002/pca.3109
|
[23] |
LI G, LEI J, LI S H, et al. Extraction of flavonoids from Citri reticulatae pericarpium viride using a deep eutectic solvent[J]. Royal Society of Chemistry,2022,12:26975.
|
[24] |
YU P, LI Q, FENG Y M, et al. Extraction and analysis of six effective components in G lycyrrhiza uralensis fisch by deep eutectic solvents (DES) combined with quantitative analysis of multi-components by single marker (QAMS) method[J]. Molecules,2021,26(5):1310. doi: 10.3390/molecules26051310
|
[25] |
SHIKOV A N, SHIKOVA V A, WHALEY A O, et al. The ability of acid-based natural deep eutectic solvents to co-extract elements from the roots of Glycyrrhiza glabra L. and associated health risks[J]. Molecules,2022,27(22):7690. doi: 10.3390/molecules27227690
|
[26] |
XING C, CUI W Q, ZHANG Y, et al. Ultrasound-assisted deep eutectic solvents extraction of glabridin and isoliquiritigenin from Glycyrrhiza glabra:Optimization, extraction mechanism and in vitro bioactivities[J]. Ultrasonics Sonochemistry,2022,83:105946. doi: 10.1016/j.ultsonch.2022.105946
|
[27] |
陈凯, 魏平慧, 史琳. 葛根异黄酮类成分的药理作用研究进展[J]. 药物评价研究,2022,45(12):2602−2610. [CHEN K, WEI P H, SHI L. Research progress on pharmacological effects of isoflavones from Pueraria lobata[J]. Drug Evaluation Research,2022,45(12):2602−2610.
|
[28] |
SHANG X C, DOU Y Q, ZHANG Y J, et al. Tailor-made natural deep eutectic solvents for green extraction of isoflavones from chickpea (Cicer arietinum L.) sprouts[J]. Industrial Crops and Products, 2019, 140:111724.
|
[29] |
DURU K C, SLESAREV G P, ABOUSHANAB S A, et al. An eco-friendly approach to enhance the extraction and recovery efficiency of isoflavones from kudzu roots and soy molasses wastes using ultrasound-assisted extraction with natural deep eutectic solvents (NADES)[J]. Industrial Crops and Products,2022,182:114886. doi: 10.1016/j.indcrop.2022.114886
|
[30] |
HUANG Y, YANG J L, ZHAO Y, et al. Screening, optimization, and bioavailability research of natural deep eutectic solvent extracts from Radix pueraria[J]. Molecules,2021,26(3):729. doi: 10.3390/molecules26030729
|
[31] |
方琦璐, 辛文秀, 李清林, 等. 查尔酮及其衍生物防治新型冠状病毒肺炎(COVID-2019)潜在应用的研究进展[J]. 现代药物与临床,2020,35(4):620−624. [FANG Q L, XIN W X, LI Q L, et al. Research progress on potential application of chalcone and its derivatives in prevention and treatment of coronavirus disease 2019 (COVID-2019)[J]. Drugs & Clinic,2020,35(4):620−624.
|
[32] |
TONG X, YANG J H, ZHAO Y, et al. Greener extraction process and enhanced in vivo bioavailability of bioactive components from Carthamus tinctorius L. by natural deep eutectic solvents[J]. Food Chemistry, 2021, 348(24):129090.
|
[33] |
HUANG H, ZHU Y J, FU X Z, et al. Integrated natural deep eutectic solvent and pulse-ultrasonication for efficient extraction of crocins from gardenia fruits ( Gardenia jasminoides Ellis) and its bioactivities[J]. Food Chemistry,2022,380:132216. doi: 10.1016/j.foodchem.2022.132216
|
[34] |
阮怿航, 吴亮宇, 鲁静, 等. 响应面法优化低共熔溶液提取儿茶素工艺及组分分析[J]. 食品工业,2020,41(3):121−125. [RUAN Y H, WU L Y, LU J, et al. Composition and optimization of deep eutectic solvents extraction of catechine by response surface method[J]. The Food Industry,2020,41(3):121−125.
|
[35] |
WANG R M, ZHANG W M, HE R P, et al. Customized deep eutectic solvents as green extractants for ultrasonic-assisted enhanced extraction of phenolic antioxidants from dogbane leaf-tea[J]. Foods,2021,10(11):2527. doi: 10.3390/foods10112527
|
[36] |
FU X Z, BELWAL T, HE Y H, et al. UPLC-triple-TOF/MS characterization of phenolic constituents and the influence of natural deep eutectic solvents on extraction of Carya cathayensis Sarg. peels:Composition, extraction mechanism and in vitro biological activities[J]. Food Chemistry, 2022, 370:131042.
|
[37] |
徐玉岩, 张韵寒, 钱远宇, 等. 花青素类成分药理作用的研究进展[J]. 现代药物与临床,2022,37(8):1886−1891. [XU Y Y, ZHANG Y H, QIAN Y Y, et al. Research progress on pharmacological effects of anthocyanins[J]. Drugs & Clinic,2022,37(8):1886−1891.
|
[38] |
BI Y H, CHI X W, ZHANG R, et al. Highly efficient extraction of mulberry anthocyanins in deep eutectic solvents:Insights of degradation kinetics and stability evaluation[J]. Innovative Food Science & Emerging Technologies,2020,66:102512.
|
[39] |
MACLEAN A M G, SILVA Y P A, JIAO G L, et al. Ultrasound-assisted extraction of anthocyanins from haskap berries (Lonicera caerulea L.) using a deep eutectic solvent (DES)[J]. Food Technology and Biotechnology, 2021, 59(1):56-62.
|
[40] |
LIN S X, MENG X J, TAN C, et al. Composition and antioxidant activity of anthocyanins from Aronia melanocarpa extracted using an ultrasonic-microwave-assisted natural deep eutectic solvent extraction method[J]. Ultrason Sonochem,2022,89:106102. doi: 10.1016/j.ultsonch.2022.106102
|
[41] |
ZANNOU O, PASHAZADEH H, GHELLAM M, et al. Extraction of anthocyanins from borage ( Echium amoenum) flowers using choline chloride and a glycerol-based, deep eutectic solvent:Optimization, antioxidant activity, and in vitro bioavailability[J]. Molecules,2021,27(1):134. doi: 10.3390/molecules27010134
|
[42] |
BENVENUTTI L, ZIELINSKI A A F, FERREIRA S R S. Pressurized aqueous solutions of deep eutectic solvent (DES):A green emergent extraction of anthocyanins from a brazilian berry processing by-product[J]. Food Chem X,2022,13:100236. doi: 10.1016/j.fochx.2022.100236
|
[43] |
JOVANOVIĆ M S, KRGOVIĆ N, ŽIVKOVIĆ J, et al. Ultrasound-assisted natural deep eutectic solvents extraction of bilberry anthocyanins:Optimization, bioactivities, and storage stability[J]. Plants,2022,11(20):2680. doi: 10.3390/plants11202680
|
[44] |
JOVANOVIĆ M S, KRGOVIĆ N, RADAN M, et al. Natural deep eutectic solvents combined with cyclodextrins:A novel strategy for chokeberry anthocyanins extraction[J]. Food Chemistry,2023,405:134816. doi: 10.1016/j.foodchem.2022.134816
|
[45] |
张欣. 黑果腺肋花楸原花青素的提取, 抗氧化及其抑菌活性研究[D]. 长春:吉林大学, 2021. [ZHANG X. Study on extraction, antioxidant and antibacterial activity of proanthocyanidins from Sorbus melanocarpa[D]. Changchun:Jilin University, 2021.
ZHANG X. Study on extraction, antioxidant and antibacterial activity of proanthocyanidins from Sorbus melanocarpa[D]. Changchun: Jilin University, 2021.
|
[46] |
侯黔灵, 范丽美. 低共熔溶剂提取油茶籽壳原花青素的工艺研究[J]. 中国油脂, 2023, 48(2):129-132. [HOU Q L, FAN L M . Research on extraction of procyanidins from camellia oleifera seed shell with deep eutectic solvents[J]. China Oils and Fats, 2023, 48(2):129-132.
HOU Q L, FAN L M . Research on extraction of procyanidins from camellia oleifera seed shell with deep eutectic solvents[J]. China Oils and Fats, 2023, 48(2): 129-132.
|
[47] |
林赛婷, 田君飞, 史荣祥, 等. 微波辅助低共熔溶剂高效提取油茶壳原花青素的工艺优化[J]. 应用化工, 2023, 52(2):398-403. [LIN S T, TIAN J F, SHI R X, et al. Optimization of efficiently extracting procyanidins from Camellia oleifera shells by microwave-assisted deep eutectic solvent[J]. Applied Chemical Industry, 2023, 52(2):398-403.
LIN S T, TIAN J F, SHI R X, et al. Optimization of efficiently extracting procyanidins from Camellia oleifera shells by microwave-assisted deep eutectic solvent[J]. Applied Chemical Industry, 2023, 52(2): 398-403.
|
[48] |
周佳悦, 候艳丽, 王凡予, 等. 超声辅助低共熔溶剂提取红松树皮原花青素及动力学研究[J]. 食品工业科技, 2023, 44(14):229-236. [ZHOU J Y, HOU Y L, WANG F Y, et al. Ultrasonic-assisted deep eutectic solvent extraction of proanthocyanidins from korean pine bark and its kinetics[J]. Science and Technology of Food Industry, 2023, 44(14):229-236.
ZHOU J Y, HOU Y L, WANG F Y, et al. Ultrasonic-assisted deep eutectic solvent extraction of proanthocyanidins from korean pine bark and its kinetics[J]. Science and Technology of Food Industry, 2023, 44(14): 229-236.
|
[49] |
WANG X H, WANG J P. Effective extraction with deep eutectic solvents and enrichment by macroporous adsorption resin of flavonoids from Carthamus tinctorius L.[J]. Journal of Pharmaceutical and Biomedical Analysis,2019,176:112804. doi: 10.1016/j.jpba.2019.112804
|
[50] |
刘珊, 李德慧, 孙科, 等. 新型绿色低共熔溶剂用于金钱草总黄酮的提取研究[J]. 时珍国医国药,2019,30(6):1312−1314. [LIU S, LI D H, SUN K. Study on the extraction of total flavonoids from Lysimachia christinae using a new green deep eutectic solvent[J]. Lishizhen Medicine and Materia Medica,2019,30(6):1312−1314.
|
[51] |
江石平, 朱婉萍. 超声辅助低共熔溶剂提取红豆杉叶总黄酮工艺的优化[J]. 中成药,2021,43(12):3442−3445. [JIANG S P, ZHU W P. Optimization of ultrasonic-assisted deep eutectic solvent extraction of total flavonoids from Taxus chinensis leaves[J]. Chinese Traditional Patent Medicine,2021,43(12):3442−3445.
|
[52] |
邵宁, 刁洪林, 王薛, 等. 铁皮石斛花总黄酮的绿色提取工艺优化[J]. 食品工业科技,2021,42(24):181−187. [[SHAO N, DIAO H L, WANG X, et al. Optimization of green extraction process of total flavonoids from Dendrobium officinale flower[J]. Science and Technology of Food Industry,2021,42(24):181−187.
|
[53] |
王小佳, 于有伟, 崔美林, 等. 低共熔溶剂协同超声波提取红枣中总黄酮的研究[J]. 中国调味品,2022,47(1):36−39. [WANG X J, YU Y W, CUI M L, et al. Study on extraction of total flavonoids from red jujube by deep eutectic solvent and ultrasonic wave[J]. China Condiment,2022,47(1):36−39.
|
[54] |
黎莉, 杨景淇, 于德涵, 等. 超声辅助低共熔溶剂法提取玉米芯总黄酮工艺优化研究[J]. 食品工业科技,2022,43(10):223−230. [LI L, YANG J Q, YU D H, et al. Optimization of ultrasonic-assisted deep eutectic solvent extraction of total flavonoids from corncob[J]. Science and Technology of Food Industry,2022,43(10):223−230.
|
[55] |
蒋利荣, 何海燕, 覃拥灵, 等. 超声辅助绿色低共熔溶剂提取番石榴叶总黄酮的工艺研究[J]. 饲料研究,2022,45(12):72−76. [JIANG L R, HE H Y, QIN Y L, et al. Ultrasonic-assisted extraction of total flavonoids from guava leaves by natural deep eutectic solvents[J]. Feed Research,2022,45(12):72−76.
|
[56] |
SUI M H, FENG S M, LIU G D, et al. Deep eutectic solvent on extraction of flavonoid glycosides from Dendrobium officinale and rapid identification with UPLC-triple-TOF/MS[J]. Food Chemistry,2023,401:134054. doi: 10.1016/j.foodchem.2022.134054
|
[57] |
倪雪华, 王恒鹏. 低共熔溶剂提取绿茶总黄酮及其抗氧化活性[J]. 食品与机械,2022,38(1):159−163. [NI X H, WANG H P. Research on extraction of total flavonoids from green tea with deep eutectic[J]. Food & Machinery,2022,38(1):159−163.
|
[58] |
孙平, 董萍萍, 董丹华, 等. 超声波辅助低共熔溶剂提取野菊花总黄酮的工艺研究[J]. 食品工业科技,2020,41(20):147−152. [SUN P, DONG P P, DONG D H, et al. Ultrasound-assisted deep eutectic solvent extraction of total flavonoids from Chrysanthemum indicum[J]. Science and Technology of Food Industry,2020,41(20):147−152.
|
[59] |
黄文睿, 唐超凡, 陶雨峰, 等. 绿色低共熔溶剂提取野菊花中黄酮类化合物[J]. 精细化工,2022,39(3):569−576. [HUANG W R, TANG C F, TAO Y F, et al. Extraction of flavonoids from Chry santhemum indicum L. by green deep eutectic solvents[J]. Fine Chemicals,2022,39(3):569−576.
|
[60] |
LIU X M, LIU Y, SHAN C H, et al. Effects of five extraction methods on total content, composition, and stability of flavonoids in jujube[J]. Food Chemistry:X,2022,14:100287. doi: 10.1016/j.fochx.2022.100287
|
[61] |
ZHANG Y Q, BIAN S Q, HU J, et al. Natural deep eutectic solvent-based microwave-assisted extraction of total flavonoid compounds from spent sweet potato (Ipomoea batatas L.) leaves:Optimization and antioxidant and bacteriostatic activity[J]. Molecules, 2022, 27(18):5985.
|
[62] |
GAO M Z, CUI Q, WANG L T, et al. A green and integrated strategy for enhanced phenolic compounds extraction from mulberry (Morus alba L.) leaves by deep eutectic solvent[J]. Microchemical Journal, 2020, 154:104598.
|
[63] |
CAI C Y, WANG Y N, YU W, et al. Temperature-responsive deep eutectic solvents as green and recyclable media for the efficient extraction of polysaccharides from Ganoderma lucidum[J]. Journal of Cleaner Production,2020,274:123047. doi: 10.1016/j.jclepro.2020.123047
|
[64] |
ALAM M A, MUHAMMAD G, KHAN M N, et al. Choline chloride-based deep eutectic solvents as green extractants for the isolation of phenolic compounds from biomass[J]. Journal of Cleaner Production,2021(29):127445.
|
1. |
肖雪,王金浩,邵俊花,范江平,葛长荣,肖智超. 超声辅助酶法优化鸡肉蛋白水解工艺. 食品研究与开发. 2023(02): 124-131 .
![]() | |
2. |
李自会,段晓杰,刘昆仑,布冠好,王亮,张顺棠,井金锋,任伟. 鸡骨架和鸡胸肉复合底物酶解工艺优化及产物呈味特性研究. 食品工业科技. 2023(15): 184-192 .
![]() | |
3. |
李自会,张顺棠,段晓杰,布冠好,刘昆仑,高立栋,井金峰. 酶解禽类蛋白制备呈味基料的研究进展. 中国调味品. 2022(11): 211-215 .
![]() | |
4. |
司翔宇,商焱,范君君,党亚丽. 即食香辣洋姜风味改良研究. 中国果菜. 2021(08): 34-38 .
![]() |