SUN Wen, YAN Jianan, LAI Bin, et al. Preparation and Characterization of Gummies Loaded with Melatonin and Lycium barbarum L. DOI: 10.13386/j.issn1002-0306.2023020137
Citation: SUN Wen, YAN Jianan, LAI Bin, et al. Preparation and Characterization of Gummies Loaded with Melatonin and Lycium barbarum L. DOI: 10.13386/j.issn1002-0306.2023020137

Preparation and Characterization of Gummies Loaded with Melatonin and Lycium barbarum L.

More Information
  • Received Date: February 14, 2023
  • Available Online: September 12, 2023
  • In order to expand the application of melatonin in gel food, convenient gummies loaded with melatonin and Lycium barbarum L. were developed in this study. The comprehensive effects of gelatin dose, Lycium barbarum L. powder level and drying time on the properties of melatonin gummies were investigated by color difference analysis, texture analysis, low field NMR analysis and sensory evaluation. The results showed that the gummies containing with 0.4% Lycium barbarum L. powder, 18% gelatin, 5% carrageenan, 17.5% sorbitol, 17.5% erythritol and drying for 18 h were elastic and palatable with smooth surface. The gummies had moisture content less than 20% and melatonin retention rate of 92.0%~97.7%, and high sensory evaluation with potential practical application.
  • [1]
    FATEMEH G, SAJJAD M, NILOUFAR R, et al. Effect of melatonin supplementation on sleep quality:A systematic review and meta-analysis of randomized controlled trials[J]. Journal of Neurology,2021,269(1):205−216.
    [2]
    LI T, JIANG S, HAN M Z, et al. Exogenous melatonin as a treatment for secondary sleep disorders:A systematic review and meta-analysis[J]. Frontiers in Neuroendocrinology,2019,52:22−28. doi: 10.1016/j.yfrne.2018.06.004
    [3]
    梁竹, 魏玮, 陶利. 褪黑素在治疗睡眠障碍中的研究进展[J]. 解放军药学学报,2014,30(1):82−85

    LIANG Z, WEI W, TAO L. Research progress of melatonin in the treatment of sleep disorders[J]. Pharmaceutical Journal of Chinese People's Liberation Army,2014,30(1):82−85.
    [4]
    MARTÍN G V M, DE LAS H N, LAHERA V, et al. Melatonin as an anti-aging therapy for age-related cardiovascular and neurodegenerative diseases[J]. Frontiers in Aging Neuroscience,2022,14:888292. doi: 10.3389/fnagi.2022.888292
    [5]
    MARZOUGUI H, HAMMOUDA O, BEN D I, et al. Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients[J]. International Urology and Nephrology,2020,53(3):553−562.
    [6]
    FRANCO P I R, DO CARMO N J R, MILHOMEM A C, et al. Antitumor effect of melatonin on breast cancer in experimental models:A systematic review[J]. BBA-Reviews on Cancer,2023,1878(1):188838.
    [7]
    田明, 王玉伟, 李瑞锋, 等. 辅酶Q10等5种原料的保健食品纳入备案制目录管理的情况分析及启示[J]. 食品科学,2022,43(15):320−326 doi: 10.7506/spkx1002-6630-20220207-014

    TIAN M, WANG Y W, LI R F, et al. Analysis and enlightenment of health food with five raw materials such as coenzyme Q10 included in the management of archival catalogue[J]. Food Science,2022,43(15):320−326. doi: 10.7506/spkx1002-6630-20220207-014
    [8]
    李菲菲, 张李伟, 付宗强, 等. 褪黑素类保健食品注册审评审批状况分析与建议[J]. 食品与发酵工业,2020,46(7):283−288

    LI F F, ZHANG L W, FU Z Q, et al. Analysis and suggestions of evaluation and approval for health foods containing melatonin[J]. Food and Fermentation Industries,2020,46(7):283−288.
    [9]
    ZHAO S J, YE S Y, OU C F, et al. Optimization of preparation of melatonin liposomes by supercritical carbon dioxide method[J]. Journal of Agricultural Engineering,2014,30(3):251−258.
    [10]
    LI S N, ZHAO Y P. Preparation of melatonin-loaded zein nanoparticles using supercritical CO2 antisolvent and in vitro release evaluation[J]. International Journal of Food Engineering,2017,13(11):1−11.
    [11]
    GÓMEZ-GUILLÉN M C, GIMENEZ B, LOPEZ-CABALLERO M E, et al. Functional and bioactive properties of collagen and gelatin from alternative sources:A review[J]. Food Hydrocolloids,2011,25(8):1813−1827. doi: 10.1016/j.foodhyd.2011.02.007
    [12]
    MOORADIAN A D, SMITH M, TOKUDA M. The role of artificial and natural sweeteners in reducing the consumption of table sugar:A narrative review[J]. Clinical Nutrition ESPEN,2017,18:1−8. doi: 10.1016/j.clnesp.2017.01.004
    [13]
    LEI Z L, CHEN X Q, CAO F L, et al. Phytochemicals and bioactivities of Goji ( Lycium barbarum L. and Lycium chinense Mill.) leaves and their potential applications in the food industry:A review[J]. International Journal of Food Science & Technology,2021,57(3):1451−1461.
    [14]
    王燕, 王春璇, 吴文娟, 等. 枸杞多糖抑制NLRP3炎性通路改善睡眠剥夺大鼠的行为能力研究[J]. 职业与健康,2022,38(22):3050−3053

    WANG Y, WANG C X, WU W J, et al. Study on Lycium barbarum polysaccharide inhibits NLRP3 inflammatory pathway to improve behavioral ability of sleep deprived rats[J]. Occup and Health,2022,38(22):3050−3053.
    [15]
    WANG C, ZHOU L X, MO M, et al. Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides[J]. Brain Science Advances,2021,7(4):207−219. doi: 10.26599/BSA.2021.9050019
    [16]
    PERAZA-LABRADOR A, BUITRAGO D M, COY-BARRERA E, et al. Antiproliferative and pro-apoptotic effects of a phenolic-rich extract from Lycium barbarum fruits on human papillomavirus (HPV) 16-positive head cancer cell lines[J]. Molecules,2022,27(11):3568. doi: 10.3390/molecules27113568
    [17]
    WANG X J, PENG F, LIU F G, et al. Zein-pectin composite nanoparticles as an efficient hyperoside delivery system:Fabrication, characterization, and in vitro release property[J]. LWT-Food Science and Technology,2020,133:109869. doi: 10.1016/j.lwt.2020.109869
    [18]
    许粟, 姚绍炉, 刘宇泽, 等. 响应面优化淀粉型刺梨凝胶软糖配方工艺[J]. 食品工业科技,2022,43(17):240−247

    XU S, YAO S L, LIU Y Z, et al. Optimization of preparation processing of starchy roxburgh rose gel soft sweet by response surface analysis[J]. Science and Technology of Food Industry,2022,43(17):240−247.
    [19]
    YAN J N, WANG Y Q, JIANG X Y, et al. Effect of pH and mixing ratio on interpolymer complexation of scallop ( Patinopecten yessoensis) male gonad hydrolysates and κ-carrageenan[J]. Food Chemistry,2021,336:127687. doi: 10.1016/j.foodchem.2020.127687
    [20]
    KUMAR S S, CHAUHAN A S, GIRIDHAR P. Nanoliposomal encapsulation mediated enhancement of betalain stability:Characterisation, storage stability and antioxidant activity of Basella rubra L. fruits for its applications in vegan gummy candies[J]. Food Chemistry,2020,333:127442. doi: 10.1016/j.foodchem.2020.127442
    [21]
    杨兆甜, 李方巍, 等. 食品颜色评价及在食品工业中的应用[J]. 食品工业科技,2021,42(24):417−423 doi: 10.13386/j.issn1002-0306.2020110045

    YANG Z T, LI F W, WANG Z H, et al. Food color evaluation and application in food industry[J]. Science and Technology of Food Industry,2021,42(24):417−423. doi: 10.13386/j.issn1002-0306.2020110045
    [22]
    雷用东, 邓小蓉, 罗瑞峰, 等. 3种颜色体系在食品应用中的研究进展[J]. 食品科学,2016,37(1):241−246 doi: 10.7506/spkx1002-6630-201601042

    LEI Y D, DENG X R, LUO R F, et al. Progress in the application of three types of color system in color measurement of foods[J]. Food Science,2016,37(1):241−246. doi: 10.7506/spkx1002-6630-201601042
    [23]
    CHEN L, OPARA U L. Texture measurement approaches in fresh and processed foods-A review[J]. Food Research International,2013,51(2):823−835. doi: 10.1016/j.foodres.2013.01.046
    [24]
    CHENG Z H, ZHANG B J, QIAO D L, et al. Addition of κ-carrageenan increases the strength and chewiness of gelatin-based composite gel[J]. Food Hydrocolloids,2022,128:107565. doi: 10.1016/j.foodhyd.2022.107565
    [25]
    王竹清, 张莉莉, 刘志, 等. 改善罗非鱼皮明胶凝胶特性和热稳定性的因素及条件探索[J]. 食品与发酵工业,2022,48(24):226−232

    WANG Z Q, ZHANG L L, LIU Z, et al. Factors and conditions for improving gel properties and thermal stability of tilapia skin gelatin[J]. Food and Fermentation Industries,2022,48(24):226−232.
    [26]
    SHAO J H, DENG Y M, JIA N, et al. Low-field NMR determination of water distribution in meat batters with NaCl and polyphosphate addition[J]. Food Chemistry,2016,200:308−314. doi: 10.1016/j.foodchem.2016.01.013
    [27]
    AL-HABSI N A, AL-HADHRAMI S, AL-KASBI H, et al. Molecular mobility of fish flesh measured by low-field nuclear magnetic resonance (LF-NMR) relaxation:Effects of freeze-thaw cycles[J]. Fisheries Science,2017,83(5):845−851. doi: 10.1007/s12562-017-1114-0
    [28]
    吴政, 逄晓阳, 芦晶, 等. 基于核磁共振技术分析奶酪在真空干燥中的水分迁移及货架期品质变化规律[J]. 中国乳品工业,2020,48(9):25−29

    WU Z, PANG X Y, LU J, et al. Using nuclear magnetic resonance to detect the cheese moisture transfer during vacuum drying and to assess the quality changes during the shelf life[J]. China Dairy Industry,2020,48(9):25−29.
    [29]
    郭琦, 王欣, 刘宝林. κ-卡拉胶比例对明胶凝胶体系凝胶特性、水分分布及微观结构的影响[J]. 食品与发酵工业,2019,45(9):81−88

    GUO Q, WANG X, LIU B L. Effects of κ-carrageenan ratio on gel properties, water distribution, and microstructure of a gelatin-gel system[J]. Food and Fermentation Industries,2019,45(9):81−88.
    [30]
    OZEL B, OZTOP M H. A quick look to the use of time domain nuclear magnetic resonance relaxometry and magnetic resonance imaging for food quality applications[J]. Current Opinion in Food Science,2021,41:122−129.
  • Cited by

    Periodical cited type(0)

    Other cited types(2)

Catalog

    Article Metrics

    Article views (146) PDF downloads (37) Cited by(2)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return