GONG Pushuang, HU Yu, DUAN Changsong, et al. Effects of Anoectochilus roxburghii-Fagopyrum tataricum Mixed Extracts on Improving Oxidative Damage Induced by D-Galactose in Aging Mice[J]. Science and Technology of Food Industry, 2023, 44(14): 386−395. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022100095.
Citation: GONG Pushuang, HU Yu, DUAN Changsong, et al. Effects of Anoectochilus roxburghii-Fagopyrum tataricum Mixed Extracts on Improving Oxidative Damage Induced by D-Galactose in Aging Mice[J]. Science and Technology of Food Industry, 2023, 44(14): 386−395. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022100095.

Effects of Anoectochilus roxburghii-Fagopyrum tataricum Mixed Extracts on Improving Oxidative Damage Induced by D-Galactose in Aging Mice

More Information
  • Received Date: October 11, 2022
  • Available Online: May 08, 2023
  • Objective: To study the synergistic antioxidant activity of Anoectochilus roxburghii-Fagopyrum tataricum Mixed Extracts (AFME) in vitro, and the effects of AFME on aging in mice exposed to D-galactose. Methods: The synergistic antioxidant activity of AFME in vitro was evaluated by isoradiation analysis, via determining the contents of total flavonoids and total polyphenols in AFME with different mass ratios of Anoectochilus roxburghii and Fagopyrum tataricum, and measuring the ability of which to scavenge DPPH and ABTS+ free radicals. Low, medium and high dosages of AFME (1:1) (700, 1400, 2800 mg/kg) (AFME-L group, AFME-M group, AFME-H group), and vitamine C (VC) (100 mg/kg) (VC group) were gavaged to the mice for 63 days, to evaluate the effects of AFME on aging in mice exposed to D-galactose, by measuring the body weight, organ index, liver tissue morphology, and oxidative damage in serum and liver. Results: AFME (1:1) showed the optimum synergistic antioxidant effects in vitro. Compared with the control group (C group), the body weight, brain index and thymus index of aging mice were decreased (P<0.05), and the liver index was increased (P<0.01). Also, a large number of pathological changes such as degeneration and necrosis of hepatocytes and dilatation were observed in liver tissue of aging mice. The activity of superoxide dismutase (SOD) was lowerd (P<0.05), and malondialdehyde (MDA) was up-regulated in serum (P<0.01) in mice treated with D-galactose. The activity of glutathione peroxide dismutase (GSH-Px) (P<0.01), and glutathione (GSH) (P<0.05) were down-regulated. MDA (P<0.01) and advanced glycation end products (AGEs) (P<0.05) were increased in liver of the aging mice. The abnormalities above in the aging mice were improved by different dosages of AFME (1:1). Especially, the higher body weight, the higher brain and thymus index (P<0.05), the lower liver index (P<0.01), and the improved pathological changes in the liver tissue were observed in AFME-H group. Additionally, the increased activity of SOD (P<0.01) and down-regulated MDA (P<0.01) in serum, as well as the increased activity of GSH-Px (P<0.01), the decreased AGEs (P<0.05), and up-regulated GSH (P<0.01) in liver were also observed in AFME-H group. Conclusion: AFME (1:1) showed the optimum synergistic antioxidant effects in vitro. The abnormalities of body weight, brain index, thymus index, liver index, degeneration and necrosis of hepatocytes, dilatation of hepatic sinuses, and also the oxidative stress in serum and liver in aging mice could be attenuated by treating with AFME (1:1) (2800 mg/kg, i.g., 63 d), in order to slow down the aging, through inhibition of oxidative stress.
  • [1]
    YE S Y, SHAO Q S, ZHANG A L. Anoectochilus roxburghii: A review of its phytochemistry, pharmacology, and clinical applications[J]. Journal of Ethnopharmacology,2017,209:184−202. doi: 10.1016/j.jep.2017.07.032
    [2]
    WANG Y Q, ZUO R, WANG Z W, et al. Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway[J]. Aging,2019(18):7961−7977.
    [3]
    马娟. 金线莲(Anoectochilus roxburghii)提取物保肝护肝作用及其物质基础研究[D]. 武汉: 华中科技大学, 2014

    MA J. Study on the hepatoprotective effect and material basis of Anoectochilus roxburghii extracts[D]. Wuhan: Huazhong University of Science and Technology, 2014.
    [4]
    刘英孟, 张海燕, 汪镇朝, 等. 金线莲的研究进展[J]. 中成药,2022,44(1):186−192. [LIU Y M, ZHANG H Y, WANG Z C, et al. Research progress of Anoectochilus roxburghii (Wall.) Lindl

    J]. Chinese Traditional Patent Medicine,2022,44(1):186−192.
    [5]
    曾芷筠, 陈强威, 江涛, 等. 金线莲乙醇提取物对自然衰老小鼠抗衰老作用的研究[J]. 中药材,2020,43(5):1200−1204. [ZENG Z J, CHEN Q W, JIANG T, et al. Study on the anti-aging effect of ethanol extract from Anoectochilus roxburghii in senescent mice[J]. Journal of Chinese Medicinal Materials,2020,43(5):1200−1204.

    ZENG Z J, CHEN Q W, JIANG T, et al. Study on the anti-aging effect of ethanol extract from Anoectochilus roxburghii in senescent mice[J]. Journal of Chinese Medicinal Materials, 2020, 43(5): 1200−1204.
    [6]
    WANG L P, CHEN Q W, ZHUANG S Q, et al. Effect of Anoectochilus roxburghii flavonoids extract on H2O2 induced oxidative stress in LO2 cells and D-gal induced aging mice model[J]. Journal of Ethnopharmacology,2020,254:112670. doi: 10.1016/j.jep.2020.112670
    [7]
    沈灵智, 盛宇华, 鲁清峰, 等. 苦荞功能性及食品开发研究进展[J]. 食品研究与开发,2021,42(19):192−199. [SHEN L Z, SHENG Y H, LU Q F, et al. Progress in functional research and food development of tartary buckwheat[J]. Food Research and Development,2021,42(19):192−199.

    SHEN L Z, SHENG Y H, LU Q F, et al. Progress in functional research and food development of tartary buckwheat[J]. Food Research and Development, 2021, 42(19): 192−199.
    [8]
    闫文杰, 段昊, 吕燕妮, 等. 苦荞在我国保健食品中的应用进展[J]. 食品科技,2021,46(6):55−61. [YAN W J, DUAN H, LÜ Y N, et al. Application progress of tartary buckwheat in health food in china[J]. Food Science and Technology,2021,46(6):55−61.

    YAN W J, DUAN H, LÜ Y N, et al. Application progress of tartary buckwheat in health food in china[J]. Food Science and Technology, 2021, 46(6): 55−61.
    [9]
    JING R, LI H Q, HU C L, et al. Phytochemical and pharmacological profiles of three fagopyrum buckwheats[J]. International Journal of Molecular Sciences,2016,17(4):589. doi: 10.3390/ijms17040589
    [10]
    钟灵允, 赵钢, 赵江林. 荞麦黄酮及其生物合成调控研究进展[J]. 广西植物,2021,41(6):1021−1034. [ZHONG L Y, ZHAO G, ZHAO J L. Research progress on buckwheat flavonoids and their biosyntheses and regulations[J]. Guihaia,2021,41(6):1021−1034.

    ZHONG L Y, ZHAO G, ZHAO J L. Research progress on buckwheat flavonoids and their biosyntheses and regulations[J]. Guihaia, 2021, 41(6): 1021−1034.
    [11]
    LÜ L J, XIA Y, ZOU D Z, et al. Fagopyrum tataricum (L.) Gaertn. : A review on its traditional uses, phytochemical and pharmacology[J]. Food Science and Technology Research,2017,23(1):1−7. doi: 10.3136/fstr.23.1
    [12]
    蒲升惠, 高颖, 赵志峰, 等. 苦荞中活性物质及其保健功效研究进展[J]. 食品工业科技,2019,40(8):331−336. [PU S H, GAO Y, ZHAO Z F, et al. Research progress on bioactive components and health benefits of tartary buckwheat[J]. Science and Technology of Food Industry,2019,40(8):331−336.

    PU S H, GAO Y, ZHAO Z F, et al. Research progress on bioactive components and health benefits of tartary buckwheat[J]. Science and Technology of Food Industry, 2019, 40(8): 331−336.
    [13]
    李颖, 许秀举, 邓洋. 苦荞茶对衰老小鼠肝组织SOD和MDA影响的研究[J]. 食品研究与开发,2015,36(18):42−43, 133. [LI Y, XU X J, DENG Y. Study the effect of buckwheat tea on liver tissue SOD and MDA of aging mice[J]. Food Research and Development,2015,36(18):42−43, 133. doi: 10.3969/j.issn.1005-6521.2015.18.011

    LI Y, XU X J, DENG Y. Study the effect of buckwheat tea on liver tissue SOD and MDA of aging mice[J]. Food Research and Development, 2015, 36(18): 42−43, 133. doi: 10.3969/j.issn.1005-6521.2015.18.011
    [14]
    王秀萍, 邹亮, 王战国, 等. 苦荞发酵酒抗氧化活性研究[J]. 食品工业,2015,36(5):129−133. [WANG X P, ZOU L, WANG Z G, et al. Study on anti-oxidation activity of tartary buckwheat fermented wine[J]. The Food Industry,2015,36(5):129−133.

    WANG X P, ZOU L, WANG Z G, et al. Study on anti-oxidation activity of tartary buckwheat fermented wine[J]. The Food Industry, 2015, 36(5): 129−133.
    [15]
    刘厚莲. 世界和中国人口老龄化发展态势[J]. 老龄科学研究,2021,9(12):1−16. [LIU H L. Trends of population aging in china and the world as a whole[J]. Scientific Research on Aging,2021,9(12):1−16.

    LIU H L. Trends of population aging in china and the world as a whole[J]. Scientific Research on Aging, 2021, 9(12): 1−16.
    [16]
    MARTA G F, ALBERTO D R, DAVID H, et al. The road ahead for health and lifespan interventions[J]. Ageing Research Reviews,2020,59:101037. doi: 10.1016/j.arr.2020.101037
    [17]
    杨艺辉, 任利文, 郑湘锦, 等. 抗衰老靶点及药物的研究进展[J]. 中国药学杂志,2021,56(16):1282−1290. [YANG Y H, REN L W, ZHENG X J, et al. Research progress of anti-aging related targets and anti−aging drugs[J]. Chinese Pharmaceutical Journal,2021,56(16):1282−1290.

    YANG Y H, REN L W, ZHENG X J, et al. Research progress of anti-aging related targets and anti−aging drugs[J]. Chinese Pharmaceutical Journal, 2021, 56(16): 1282−1290.
    [18]
    廖水亨. 闽台名医临证处方用药配伍特色研究[D]. 福州: 福建中医药大学, 2017

    LIAO S H. Study on clinical prescriptions and drug compatibility features of Fujian and Taiwan famous doctors of traditional chinese medicine[D]. Fozhou: Fujian University of Traditional Chinese Medicine, 2017.
    [19]
    卫向龙, 许二平. 《脾胃论》甘苦配伍法探析[J]. 时珍国医国药,2010,21(10):2424. [WEI X L, XU E P. Analysis on the compatibility of sweet and bitter in spleen and stomach[J]. Lishizhen Medicine and Materia Medica,2010,21(10):2424.

    WEI X L, XU E P. Analysis on the compatibility of sweet and bitter in spleen and stomach[J]. Lishizhen Medicine and Materia Medica, 2010, 21(10): 2424.
    [20]
    福建省质量技术监督局. DB 35/1388—2013 地理标志产品 永安金线莲[S]. 福建: 中国标准出版社, 2014: 10−11

    Fujian Provincial Bureau of Quality and Technical Supervision. DB 35/1388—2013 Geographical indication product Yong'an golden lotus[S]. Fujian: China Standards Publishing House, 2014: 10-11.
    [21]
    MENG F B, LEI Y T, LIU D Y, et al. Effect of Lactobacillus plantarum and Lactobacillus acidophilus fermentation on antioxidant activity and metabolomic profiles of loquat juice[J]. LWT,2022,171:114104. doi: 10.1016/j.lwt.2022.114104
    [22]
    吕平, 潘思轶. 陈皮与普洱茶总黄酮的协同抗氧化作用研究[J]. 食品研究与开发,2020,41(3):59−64. [LÜ P, PAN S Y. Synergistic antioxidant effects of total flavonoids from tangerine peel and pu'er tea[J]. Food Research and Development,2020,41(3):59−64.

    LÜ P, PAN S Y. Synergistic antioxidant effects of total flavonoids from tangerine peel and pu'er tea[J]. Food Research and Development, 2020, 41(3): 59−64.
    [23]
    史文娟. 罗布麻和红三叶中多糖与黄酮的抗氧化活性研究[D]. 兰州: 兰州大学, 2020

    SHI W J. The study on antioxidant activities of polysaccharide and flavonoid in Apocynum venetum L. and Trifolium pratense L.[D]. Lanzhou: Lanzhou University, 2020.
    [24]
    ALI T, BADSHAH H, KIM T H, et al. Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-κB/JNK signaling pathway in aging mouse model[J]. Journal of Pineal Research,2014(1):71−85.
    [25]
    蔡启玲, 李小平, 丁欣欣. 加工方式对苦荞中的多酚及其抗氧化活性的影响研究进展[J]. 中国粮油学报,2022,37(8):305−313. [CAI Q L, LI X P, DING X X. Research progress on effects of processing methods on polyphenols and antioxidant activities in tartary buckwheat[J]. Journal of the Chinese Cereals and Oils,2022,37(8):305−313.

    CAI Q L, LI X P, DING X X. Research progress on effects of processing methods on polyphenols and antioxidant activities in tartary buckwheat[J]. Journal of the Chinese Cereals and Oils, 2022, 37(8): 305−313.
    [26]
    吴佳溶. 不同地理种源金线莲有效成分含量测定及SRAP标记[D]. 福州: 福建农林大学, 2012

    WU J R. Determination of effective components and SRAP analasis of Anoectochilus roxburghii in different geographical provenances[D]. Fuzhou: Fujian Agriculture and Forestry University, 2012.
    [27]
    孙庆雷, 王晓, 刘建华, 等. 黄酮类化合物抗氧化反应性的构效关系[J]. 食品科学,2005(4):69−73. [SUN Q L, WANG X, LIU J H, et al. Study on structure antioxidation relationship of plant flavonoids[J]. Food Science,2005(4):69−73.

    SUN Q L, WANG X, LIU J H, et al. Study on structure antioxidation relationship of plant flavonoids[J]. Food Science, 2005(4): 69−73.
    [28]
    刘玉婷, 李井雷. 多糖体外抗氧化活性研究进展[J]. 食品研究与开发,2019,40(6):214−219. [LIU Y T, LI J L. Advances in research on antioxidant activity of polysaccharides in vitro[J]. Food Research and Development,2019,40(6):214−219.

    LIU Y T, LI J L. Advances in research on antioxidant activity of polysaccharides in vitro[J]. Food Research and Development, 2019, 40(6): 214−219.
    [29]
    潘瑶, 郑时莲, 邹兴平, 等. 葡萄、芒果、草莓乙醇提取物抗氧化活性组分分析及其抗氧化相互作用[J]. 食品科学,2017,38(4):133−140. [PAN Y, ZHENG S L, ZOU X P, et al. Analysis of antioxidant compounds in ethanol extracts of grape, mango and strawberry and their interactions[J]. Food Science,2017,38(4):133−140.

    PAN Y, ZHENG S L, ZOU X P, et al. Analysis of antioxidant compounds in ethanol extracts of grape, mango and strawberry and their interactions[J]. Food Science, 2017, 38(4): 133−140.
    [30]
    高静. 天然抗氧化剂及其协同作用[J]. 食品安全质量检测学报,2020,11(6):1859−1864. [GAO J. Natural antioxidants and synergistic effects[J]. Journal of Food Safety & Quality,2020,11(6):1859−1864.

    GAO J. Natural antioxidants and synergistic effects[J]. Journal of Food Safety & Quality, 2020, 11(6): 1859−1864.
    [31]
    龚茵茵, 杨大伟. C6-C3-C6与C6-C3型单体多酚体外协同抗氧化活性[J]. 食品与营养科学,2016(3):87−89. [GONG Y Y, YANG D W. Synergistic antioxidant properties of C6-C3-C6 polyphenol monomer with C6-C3 in vitro[J]. Hans Journal of Food and Nutrition Science,2016(3):87−89.

    GONG Y Y, YANG D W. Synergistic antioxidant properties of C6-C3-C6 polyphenol monomer with C6-C3 in vitro[J]. Hans Journal of Food and Nutrition Science, 2016(3): 87−89.
    [32]
    段方娥, 何强. 辣椒素与槲皮素、芦丁协同抗氧化作用研究[J]. 食品科技,2019,44(10):294−299. [DUAN F E, HE Q. Synergistic antioxidant effect of capsaicin with quercetin or rutin[J]. Food Science and Technology,2019,44(10):294−299.

    DUAN F E, HE Q. Synergistic antioxidant effect of capsaicin with quercetin or rutin[J]. Food Science and Technology, 2019, 44(10): 294−299.
    [33]
    刘建亚, 冯文静, 王仁萍, 等. D-半乳糖致衰老动物模型及其机制研究进展[J]. 中华老年多器官疾病杂志,2018,17(3):224−227. [LIU J Y, FENG W J, WANG R P, et al. Research progress in D-galactose induced aging animal model and its mechanisms[J]. Chinese Journal of Multiple Organ Diseases in the Elderly,2018,17(3):224−227.

    LIU J Y, FENG W J, WANG R P, et al. Research progress in D-galactose induced aging animal model and its mechanisms[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2018, 17(3): 224−227.
    [34]
    邢秋娟, 施杞, 王拥军. D-半乳糖诱导衰老动物模型的机制及其在中医药方面的应用[J]. 上海中医药大学学报,2010,24(3):93−98. [XING Q J, SHI J, WANG Y J. Mechanism of establishing aging model with D-galactose and its application in research of traditional chinese medicine[J]. Academic Journal of Shanghai University of Traditional Chinese Medicine,2010,24(3):93−98.

    XING Q J, SHI J, WANG Y J. Mechanism of establishing aging model with D-galactose and its application in research of traditional chinese medicine[J]. Academic Journal of Shanghai University of Traditional Chinese Medicine, 2010, 24(3): 93−98.
    [35]
    汪学德. 亚临界萃取芝麻脂溶性和水溶性木酚素及其生物活性研究[D]. 广州: 广东工业大学, 2016

    WANG X D. Subcritical extraction of fat-soluble and water-soluble lignans of sesame and their's bioactivity[D]. Guangzhou: Guangdong University of Technology, 2016.
    [36]
    张雨曦, 曾丹. 菊花三七胶囊及其功效成分对D-半乳糖衰老模型小鼠的抗氧化作用研究[J]. 食品安全质量检测学报,2022,13(11):3627−3635. [ZHANG Y X, ZENG D. Antioxidant effects of Chrysanthemum-Panax notoginseng capsule and its functional components on senescent model mice induced by D-galactose[J]. Journal of Food Safety & Quality,2022,13(11):3627−3635.

    ZHANG Y X, ZENG D. Antioxidant effects of Chrysanthemum-Panax notoginseng capsule and its functional components on senescent model mice induced by D-galactose[J]. Journal of Food Safety & Quality, 2022, 13(11): 3627−3635.
    [37]
    ZHAO Y L, YANG Y, LI Q, et al. Understanding the unique microenvironment in the aging liver[J]. Frontiers in Medicine,2022(9):842024.
    [38]
    崔明宇, 尹义凤, 朱凤梅, 等. 蓬子菜总黄酮对D-半乳糖致过氧化损伤大鼠SOD、MDA和GSH-Px水平的影响[J]. 中医药学报,2021,49(12):47−51. [CUI M Y, YING Y F, ZHU F G, et al. Effects of FVGL (flavonoids from Galium verum L.) on levels of SOD, MDA and GSP-Px in rats with oxidative damage induced by D-galactose[J]. Acta Chinese Medicine and Pharmacology,2021,49(12):47−51.

    CUI M Y, YING Y F, ZHU F G, et al. Effects of FVGL (flavonoids from Galium verum L) on levels of SOD, MDA and GSP-Px in rats with oxidative damage induced by D-galactose[J]. Acta Chinese Medicine and Pharmacology, 2021, 49(12): 47−51.
    [39]
    HARMAN D. Aging: A theory based on free radical and radiation chemistry[J]. Journal of Gerontology,1956,11(3):298−300. doi: 10.1093/geronj/11.3.298
  • Related Articles

    [1]KAN Xutian, CHEN Weili, LI Jiaxu, HE Wenjiang, DING Liugang, LI Pan, DU Bing, LI Wenzhi. Ameliorative Effect of D-α-Tocopherol Acetate Complexes on D-Galactose-Induced Aging in Mice[J]. Science and Technology of Food Industry, 2023, 44(22): 327-334. DOI: 10.13386/j.issn1002-0306.2022120187
    [2]LI Jia, AN Miaoqing, LÜ Chenhao, GUO Rongxiang, DU Bing, HE Qing. Anti-aging Effects and Mechanisms of Recombinant Human-derived Collagen on Aging Mouse Induced by D-Galactose[J]. Science and Technology of Food Industry, 2023, 44(10): 343-352. DOI: 10.13386/j.issn1002-0306.2022070013
    [3]BAI Dongwen, BAO Xiaowei, ZENG Lanjun, LIU Xiaolu, LI Yixin, SUN Jiali, JIN Weiquan, JIANG Junfeng. Effects of Cistanche deserticola Extract on D-Galactose-Induced Aging Model Mice[J]. Science and Technology of Food Industry, 2022, 43(20): 380-386. DOI: 10.13386/j.issn1002-0306.2022010264
    [4]DU Ling-min, FU Hong-bo, DU Jun-jie, WANG Peng-fei, MU Xiao-peng, ZHANG Jian-cheng. Protection Effect of Anthocyanins from the Chinese Dwarf Cherry ‘Nongda No 4’ on Aging Mouse by D-galactose[J]. Science and Technology of Food Industry, 2020, 41(17): 292-296,307. DOI: 10.13386/j.issn1002-0306.2020.17.049
    [5]BAO Xiao-wei, LI Jian-ying, REN Wei, WEI Chen-ye, ZENG Lan-jun, ZHANG Ya-tao. Antioxidant Effects of Hippophae rhamnoides Polysaccharide on Aging Mouse Induced by D-galactose[J]. Science and Technology of Food Industry, 2020, 41(4): 293-297,306. DOI: 10.13386/j.issn1002-0306.2020.04.050
    [6]WANG Bing-ya, LIAN Xiu-yi, YANG Chen-bo, GUO Xu-ran, SHEN Pei-hong, LIU Wen-tao, LIU Le. Antioxidant Activity of Summer Black Grape Anthocyanin and Its Protective Effect on D-galactose Induced Aging Mice[J]. Science and Technology of Food Industry, 2020, 41(3): 22-26,32. DOI: 10.13386/j.issn1002-0306.2020.03.005
    [7]LI Yu-xin, SHENG Yu, DU Pei-ge, AN Li-ping, YANG Ying-ying, GUO Chang-chun, WANG Jia-qi. Extraction of Agaricus blazei Polysaccharides and Its Immunomodulatory Effect on D-galactose-induced Aging Mice[J]. Science and Technology of Food Industry, 2019, 40(12): 295-299,308. DOI: 10.13386/j.issn1002-0306.2019.12.048
    [8]BI Kai-yuan, LI Na, CUI Shan-shan, Clint Taonaishe Chimbangu, SHANG Hong-li. Protective Effects of Red Raspberry Anthocyanins on D-galactose Induced Mice Aging[J]. Science and Technology of Food Industry, 2019, 40(6): 279-284. DOI: 10.13386/j.issn1002-0306.2019.06.047
    [9]ZHAO Xin, YI Ruo-kun, SUN Peng, SONG Jia-le. Improvement effects of Kuding tea flavonoids extracts on D-galactose induced mice aging[J]. Science and Technology of Food Industry, 2017, (16): 303-308. DOI: 10.13386/j.issn1002-0306.2017.16.057
    [10]JIN Sheng-lang, QUE Fei, WANG Ying, WEI Xiao-xiao. Anti-aging effect of total polysaccharide from Dendranthema morifolium on aging mouse induced by D-galactose[J]. Science and Technology of Food Industry, 2015, (10): 349-351. DOI: 10.13386/j.issn1002-0306.2015.10.065
  • Cited by

    Periodical cited type(4)

    1. 冯庆,徐思远,任梦,郝思怡,袁欣,陈佳蕊,杨旭,马萍. 桂花提取物的抗氧化活性及对t-BHP诱导HepG2细胞氧化损伤的保护作用. 化学与生物工程. 2025(01): 53-58 .
    2. 陈琴,王顺,周坚,贾喜午,沈汪洋,陈轩. 红曲色素的抗氧化活性及对HepG2氧化损伤的保护作用研究. 食品安全质量检测学报. 2024(08): 58-65 .
    3. 王梦媛,刘咸筠,孟祥龙,李皓,李占东,殷玉和. 20-羟基蜕皮激素对高糖诱导HepG2细胞氧化损伤的作用及机制研究. 食品工业科技. 2024(20): 369-377 . 本站查看
    4. 王硕,吴华,李金铭,沈童,武小庆. 天然提取物在影响动物氧化应激中的研究进展. 饲料研究. 2023(18): 145-149 .

    Other cited types(3)

Catalog

    Article Metrics

    Article views (143) PDF downloads (15) Cited by(7)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return