Effects of Aqueous Extracts from <i>Annulohypoxylon stygium</i> Fermented Tea on Lipid Metabolism in Hypolipidemic Mice

LU Yue; HU Yongqiang; XIA Yuhong; LIU Hongcun; QI Jin; PI Dujuan; YANG Lifang; JIANG Mingguo

doi:10.13386/j.issn1002-0306.2022070308

Volume 44 Issue 15

Jul. 2023

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Science and Technology of Food Industry > 2023 > 44(15): 378-384. > DOI: 10.13386/j.issn1002-0306.2022070308

LU Yue, HU Yongqiang, XIA Yuhong, et al. Effects of Aqueous Extracts from Annulohypoxylon stygium Fermented Tea on Lipid Metabolism in Hypolipidemic Mice[J]. Science and Technology of Food Industry, 2023, 44(15): 378−384. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022070308.

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Effects of Aqueous Extracts from Annulohypoxylon stygium Fermented Tea on Lipid Metabolism in Hypolipidemic Mice

1.
Guangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning 530008, China
2.
Guangxi Marine Microbial Resources Industrialization Engineering Technology Research Center, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530008, China

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Received Date: August 01, 2022
Available Online: June 05, 2023

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Abstract

Abstract

To study the effect of Annulohypoxylon stygium fermented tea aqueous extracts (ASTAE) on blood lipids and liver protection in mice, 80 male KM mice were established hyperlipidemic model by high-fat diet induction, and then randomly divided into eight groups: blank control group (CK), model group (HF), positive control group (UA, 200 mg/kg), green tea group (GT, 400 mg/kg), Annulohypoxylon stygium group (AS, 400 mg/kg), and high (HA, 400 mg/kg), medium (MA, 200 mg/kg) and low (LA, 100 mg/kg) dose Annulohypoxylon stygium fermented tea aqueous extracts groups. After 5 weeks, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum creatinine (Scr), blood urea nitrogen (BUN) and adiponectin (ADPN) levels were detected. Detect the organ index, and liver fat lesions and distribution were observed by HE and oil red O staining. The results showed that compared with the HF group, the HA group could extremely significantly reduce the levels of TC, TG, LDL-C, AST, ALT, BUN and Scr in hyperlipidemia mice (P<0.01). The levels of HDL-C and ADPN were significantly increased (P<0.01). It could improve the degree of fatty liver histopathology and reduce liver fat particles in the HA and MA groups. The results suggested that the ASTAE could improve dyslipidemia in hyperlipidemia mice and reduced lipid deposition in the liver of hyperlipidemic mice. The mechanism might be by increasing the level of adiponectin and regulating fat metabolism, to reduce blood lipids levels, improve the fatty liver disease and protect liver.
- Annulohypoxylon stygium,
- Annulohypoxylon stygium fermented tea,
- hypolipidemic,
- adiponectin (ADPN),
- liver protection

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