Review on the Prevention and Control of Mycotoxins in Agricultural Products Using Essential Oils and Their Nanoformulations

JIANG Dongmei; WANG Liuqing; JIANG Nan; ZHAI Wenlei; WANG Meng

doi:10.13386/j.issn1002-0306.2022050271

Volume 44 Issue 19

Oct. 2023

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Science and Technology of Food Industry > 2023 > 44(19): 449-459. > DOI: 10.13386/j.issn1002-0306.2022050271

JIANG Dongmei, WANG Liuqing, JIANG Nan, et al. Review on the Prevention and Control of Mycotoxins in Agricultural Products Using Essential Oils and Their Nanoformulations[J]. Science and Technology of Food Industry, 2023, 44(19): 449−459. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022050271.

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Review on the Prevention and Control of Mycotoxins in Agricultural Products Using Essential Oils and Their Nanoformulations

Risk Assessment Laboratory for Agro-products (Beijing), Ministry of Agriculture and Rural Affairs, Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China

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Received Date: May 22, 2022
Available Online: August 04, 2023

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Abstract

Abstract

Mycotoxins are toxic metabolites produced by fungi during their growth and they are important detrimental factors endangering the quality and safety of agricultural products. Essential oils are natural inhibitors of fungal growth and accumulation of mycotoxins, but characteristics of strong volatility, poor stability and low water solubility limit their applications. In recent years, the development and utilization of nanoformulations can solve the above drawbacks of essential oils, and improve their bioavailability. This paper summarizes that essential oil can reduce the contamination level of mycotoxins in agricultural products by inhibiting the production of mycotoxins and degrading mycotoxins, overviews the inhibitory mechanism of essential oil against the growth of fungi and production of mycotoxins, reviews the research status of the prevention and control of mycotoxins in agricultural products using essential oils and their nanoformulations, and discusses the existing problems, in order to provide useful references for the further development and utilization of essential oils for the prevention and control of mycotoxins.
- essential oil,
- nanoformulation,
- fungi,
- mycotoxin,
- agricultural products

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References

[1]	MARIN S, RAMOS A J, CANO-SANCHO G, et al. Mycotoxins: occurrence, toxicology, and exposure assessment[J]. Food and Chemical Toxicology,2013,60:218−237. doi: 10.1016/j.fct.2013.07.047
[2]	VAN EGMOND H P, JONKER M A. Worldwide regulations for mycotoxins in food and feed in 2003[M].Rome: Food and Agriculture Organization of the United Nations, 2004.
[3]	REDONDO-BLANCO S, FERNÁNDEZ J, LOPEZ-IBANEZ S, et al. Plant phytochemicals in food preservation: antifungal bioactivity: A review[J]. Journal of Food Protection,2020,83(1):163−171. doi: 10.4315/0362-028X.JFP-19-163
[4]	CHAUDHARI A K, DWIVEDY A K, SINGH V K, et al. Essential oils and their bioactive compounds as green preservatives against fungal and mycotoxin contamination of food commodities with special reference to their nanoencapsulation[J]. Environmental Science and Pollution Research,2019,26(25):25414−25431. doi: 10.1007/s11356-019-05932-2
[5]	牛小杰, 孙鲁阳. 植物精油化学成分的研究进展[J]. 生物化工,2021,7(5):160−162. [NIU Xiaojie, SUN Luyang. Research progress on chemical constituents of plant essential oil[J]. Biological Chemical Engineering,2021,7(5):160−162. NIU Xiaojie, SUN Luyang. Research progress on chemical constituents of plant essential oil[J]. Biological Chemical Engineering, 2021, 7(5): 160-162.
[6]	BASSOLÉ I H N, JULIANI H R. Essential oils in combination and their antimicrobial properties[J]. Molecules,2012,17(4):3989−4006. doi: 10.3390/molecules17043989
[7]	王利敏, 邢福国, 吕聪, 等. 复合植物精油防霉剂对玉米霉菌及真菌毒素的控制效果[J]. 核农学报,2018,32(4):732−739. [WANG Limin, XING Fuguo, LÜ Cong, et al. Study on the anti-mould and anti-mycotoxins effects of combined essential oils in maize[J]. Journal of Nuclear Agricultural Sciences,2018,32(4):732−739. WANG Limin, XING Fuguo, LÜ Cong, et al. Study on the anti-mould and anti-mycotoxins effects of combined essential oils in maize[J]. Journal of Nuclear Agricultural Sciences, 2018, 32(4): 732-739.
[8]	JAYASENA D D, JO C. Essential oils as potential antimicrobial agents in meat and meat products: A review[J]. Trends in Food Science & Technology,2013,34(2):96−108.
[9]	中华人民共和国国家卫生和计划生育委员会. GB/2760-2014 食品安全国家标准食品添加剂使用标准[S]. 北京: 中国标准出版社, 2014. National Health and Family Planning Commission of People's Republic of China. GB/2760-2014 National standard for food safety standards of using food additives[S]. Beijing: Standards Press of China, 2014.
[10]	TONGNUANCHAN P, BENJAKUL S. Essential oils: Extraction, bioactivities, and their uses for food preservation[J]. Journal of Food Science,2014,79(7):R1231−R1249. doi: 10.1111/1750-3841.12492
[11]	NAZZARO F, FRATIANNI F, COPPOLA R, et al. Essential oils and antifungal activity[J]. Pharmaceuticals,2017,10(4):86. doi: 10.3390/ph10040086
[12]	JUGLAL S, GOVINDEN R, ODHAV B. Spice oils for the control of co-occurring mycotoxin-producing fungi[J]. Journal of Food Protection,2002,65(4):683−687. doi: 10.4315/0362-028X-65.4.683
[13]	HUA H, XING F, SELVARAJ J N, et al. Inhibitory effect of essential oils on Aspergillus ochraceus growth and ochratoxin A production[J]. Plos One,2014,9(9):e108285. doi: 10.1371/journal.pone.0108285
[14]	PASSONE M A, GIRARDI N S, ETCHEVERRY M. Evaluation of the control ability of five essential oils against Aspergillus section Nigri growth and ochratoxin A accumulation in peanut meal extract agar conditioned at different water activities levels[J]. International Journal of Food Microbiology,2012,159(3):198−206. doi: 10.1016/j.ijfoodmicro.2012.08.019
[15]	鞠健. 丁香酚和柠檬醛对娄地青霉和黑曲霉的协同抑菌机理探究[D]. 无锡: 江南大学, 2021. JÜ Jian. Study on the synergistic inhibitory mechanism of eugenol and citral against Penicillium roqueforti[D]. Wuxi: Jiangnan University, 2021.
[16]	SUN Q, SHANG B, WANG L, et al. Cinnamaldehyde inhibits fungal growth and aflatoxin B₁ biosynthesis by modulating the oxidative stress response of Aspergillus flavus[J]. Applied Microbiology and Biotechnology,2016,100:1355−1364. doi: 10.1007/s00253-015-7159-z
[17]	梁丹丹. 三种植物精油抑制玉米中黄曲霉生长及产毒研究[D]. 北京: 中国农业科学院, 2015. LIANG Dandan. Inhibitory effect essential oil on Aspergillus flavus growth and aflatoxin production in stored maize[D]. Beijing: Chinese Academy of Agricultural Sciences, 2015.
[18]	XU L, TAO N, YANG W, et al. Cinnamaldehyde damaged the cell membrane of Alternaria alternata and induced the degradation of mycotoxins in vivo[J]. Industrial Crops and Products,2018,112:427−433. doi: 10.1016/j.indcrop.2017.12.038
[19]	WANG L, JIANG N, WANG D, et al. Effects of essential oil citral on the growth, mycotoxin biosynthesis and transcriptomic profile of Alternaria alternata[J]. Toxins,2019,11(10):553. doi: 10.3390/toxins11100553
[20]	MARIN S, VELLUTI A, RAMOS A J, et al. Effect of essential oils on zearalenone and deoxynivalenol production by Fusarium graminearum in non-sterilized maize grain[J]. Food Microbiology,2004,21(3):313−318. doi: 10.1016/j.fm.2003.08.002
[21]	AIKO V, MEHTA A. Inhibitory effect of clove (Syzygium aromaticum) on the growth of penicillium citrinum and citrinin production[J]. Journal of Food Safety,2013,33(4):440−444. doi: 10.1111/jfs.12074
[22]	BASILICO M Z, BASILICO J C. Inhibitory effects of some spice essential oils on Aspergillus ochraceus NRRL 3174 growth and ochratoxin a production[J]. Letters in Applied Microbiology,1999,29(4):238−241. doi: 10.1046/j.1365-2672.1999.00621.x
[23]	JERŠEK B, ULRIH N P, SKRT M, et al. Effects of selected essential oils on the growth and production of ochratoxin A by Penicillium verrucosum[J]. Archives of Industrial Hygiene and Toxicology,2014,65(2):199−208. doi: 10.2478/10004-1254-65-2014-2486
[24]	袁媛, 邢福国, 刘阳. 植物精油抑制真菌生长及毒素积累的研究[J]. 核农学报,2013,27(8):1168−1172. [YUAN Yuan, XING Fuguo, LIU Yang. Role of essential oils in the inhibition of fungal growth and mycotoxin accumulation[J]. Journal of Nuclear Agricultural Sciences,2013,27(8):1168−1172. YUAN Yuan, XING Fuguo, LIU Yang. Role of essential oils in the inhibition of fungal growth and mycotoxin accumulation[J]. Journal of Nuclear Agricultural Sciences, 2013, 27(8): 1168-1172.
[25]	KOHIYAMA C Y, RIBEIRO M M Y, MOSSINI S A G, et al. Antifungal properties and inhibitory effects upon aflatoxin production of Thymus vulgaris L. by Aspergillus flavus Link[J]. Food Chemistry,2015,173:1006−1010. doi: 10.1016/j.foodchem.2014.10.135
[26]	KUMAR A, SHUKLA R, SINGH P, et al. Assessment of Thymus vulgaris L. essential oil as a safe botanical preservative against post harvest fungal infestation of food commodities[J]. Innovative Food Science & Emerging Technologies,2008,9(4):575−580.
[27]	FERREIRA F M D, HIROOKA E Y, FERREIRA F D, et al. Effect of Zingiber officinale Roscoe essential oil in fungus control and deoxynivalenol production of Fusarium graminearum Schwabe in vitro[J]. Food Additives & Contaminants:Part A,2018,35(11):2168−2174.
[28]	YAMAMOTO-RIBEIRO M M G, GRESPAN R, KOHIYAMA C Y, et al. Effect of Zingiber officinale essential oil on Fusarium verticillioides and fumonisin production[J]. Food Chemistry,2013,141(3):3147−3152. doi: 10.1016/j.foodchem.2013.05.144
[29]	KUMAR K N, VENKATARAMANA M, ALLEN J A, et al. Role of Curcuma longa L. essential oil in controlling the growth and zearalenone production of Fusarium graminearum[J]. LWT-Food Science and Technology,2016,69:522−528. doi: 10.1016/j.lwt.2016.02.005
[30]	AVANÇO G B, FERREIRA F D, BOMFIM N S, et al. Curcuma longa L. essential oil composition, antioxidant effect, and effect on Fusarium verticillioides and fumonisin production[J]. Food Control,2017,73:806−813. doi: 10.1016/j.foodcont.2016.09.032
[31]	DA SILVA BOMFIM N, KOHIYAMA C Y, NAKASUGI L P, et al. Antifungal and antiaflatoxigenic activity of rosemary essential oil (Rosmarinus officinalis L. ) against Aspergillus flavus[J]. Food Additives & Contaminants: Part A,2020,37(1):153−161.
[32]	KUMAR A, SHUKLA R, SINGH P, et al. Chemical composition, antifungal and antiaflatoxigenic activities of Ocimum sanctum L. essential oil and its safety assessment as plant based antimicrobial[J]. Food and Chemical Toxicology,2010,48(2):539−543. doi: 10.1016/j.fct.2009.11.028
[33]	余伯良, 罗惠波, 周健, 等. 山苍子油抗霉菌及抑制黄曲霉产毒的有效成分研究[J]. 四川轻化工学院学报,2002,14(1):32−36. [YU Boliang, LUO Huibo, ZHOU Jian, et al. Study on the active ingredient of antibiotic activities of Litsea cubeba oil on moulds and the effect on aflatoxin production[J]. Journal of Sichuan Institute of Light Industry and Chemical Technology,2002,14(1):32−36. YU Boliang, LUO Huibo, ZHOU Jian, et al. Study on the active ingredient of antibiotic activities of Litsea cubeba oil on moulds and the effect on aflatoxin production[J]. Journal of Sichuan Institute of Light Industry and Chemical Technology, 2002,14(1): 32-36.
[34]	RAZZAGHI-ABYANEH M, SHAMS-GHAHFAROKHI M, REZAEE M B, et al. Chemical composition and antiaflatoxigenic activity of Carum carvi L., Thymus vulgaris and Citrus aurantifolia essential oils[J]. Food Control,2009,20(11):1018−1024. doi: 10.1016/j.foodcont.2008.12.007
[35]	PRAKASH B, SINGH P, MISHRA P K, et al. Safety assessment of Zanthoxylum alatum Roxb. essential oil, its antifungal, antiaflatoxin, antioxidant activity and efficacy as antimicrobial in preservation of Piper nigrum L. fruits[J]. International Journal of Food Microbiology,2012,153(1-2):183−191. doi: 10.1016/j.ijfoodmicro.2011.11.007
[36]	PATIL R P, NIMBALKAR M S, JADHAV U U, et al. Antiaflatoxigenic and antioxidant activity of an essential oil from Ageratum conyzoides L[J]. Journal of the Science of Food and Agriculture,2010,90(4):608−614. doi: 10.1002/jsfa.3857
[37]	SOLIMAN K M, BADEAA R I. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi[J]. Food and Chemical Toxicology,2002,40(11):1669−1675. doi: 10.1016/S0278-6915(02)00120-5
[38]	RAO V K, GIRISHAM S, REDDY S M. Inhibitory effect of essential oils on growth and ochratoxin A production by Penicillium species[J]. Research Journal of Microbiology,2015,10(5):222. doi: 10.3923/jm.2015.222.229
[39]	JIANG N, WANG L, JIANG D, et al. Transcriptomic analysis of inhibition by eugenol of ochratoxin A biosynthesis and growth of Aspergillus carbonarius[J]. Food Control,2022,135:108788. doi: 10.1016/j.foodcont.2021.108788
[40]	MORCIA C, MALNATI M, TERZI V. In vitro antifungal activity of terpinen-4-ol, eugenol, carvone, 1, 8-cineole (eucalyptol) and thymol against mycotoxigenic plant pathogens[J]. Food Additives & Contaminants:Part A,2012,29(3):415−422.
[41]	余伯良, 罗惠波. 柠檬醛抗真菌及抑制黄曲霉产毒的试验报告[J]. 食品科技,2002,27(4):47−49. [YU Boliang, LUO Huibo. Antimycosis and inhibition aflatoxin’s production of citral[J]. Food Science and Technology,2002,27(4):47−49. YU Boliang, LUO Huibo. Antimycosis and inhibition aflatoxin’s production of citral[J]. Food Science and Technology, 2002, 27(4): 47-49.
[42]	DAMBOLENA J S, LÓPEZ A G, CÁNEPA M C, et al. Inhibitory effect of cyclic terpenes (limonene, menthol, menthone and thymol) on Fusarium verticillioides MRC 826 growth and fumonisin B₁ biosynthesis[J]. Toxicon,2008,51(1):37−44. doi: 10.1016/j.toxicon.2007.07.005
[43]	YIN H B, CHEN C H, KOLLANOOR-JOHNY A, et al. Controlling Aspergillus flavus and Aspergillus parasiticus growth and aflatoxin production in poultry feed using carvacrol and trans-cinnamaldehyde[J]. Poultry Science,2015,94(9):2183−2190. doi: 10.3382/ps/pev207
[44]	TIAN J, ZENG X, ZENG H, et al. Investigations on the antifungal effect of nerol against Aspergillus flavus causing food spoilage[J]. The Scientific World Journal, 2013: 230795.
[45]	黄福辉, 项发根, 周为民. 关于山苍子有效成份在储粮中的应用[J]. 粮食贮藏,1980,8(2):19−22. [HUANG Fuhui, XIANG Fagen, ZHOU Weimin. Application of effective components of Litsea cubeba in grain storage[J]. Grain Storage,1980,8(2):19−22. HUANG Fuhui, XIANG Fagen, ZHOU Weimin. Application of effective components of Litsea cubeba in grain storage[J]. Grain Storage, 1980,8(2): 19-22.
[46]	季茂聘. 浅谈粮食中黄曲霉毒素B₁的去毒方法[J]. 粮油仓储科技通讯,2005,20(2):50. [JI Maopin. Discussion on detoxification of Aflatoxin B₁ in grain[J]. Liangyou Cangchu Keji Tongxun,2005,20(2):50. JI Maopin. Discussion on detoxification of Aflatoxin B₁ in grain[J]. Liangyou Cangchu Keji Tongxun, 2005,20(2): 50.
[47]	AROYEUN S O, ADEGOKE G O. Reduction of ochratoxin A (OTA) in spiked cocoa powder and beverage using aqueous extracts and essential oils of Aframonmum danielli[J]. African Journal of Biotechnology,2007,6(5):612−616.
[48]	袁媛. 植物精油熏蒸控制玉米中真菌毒素的研究[D]. 北京: 中国农业科学院, 2013. YUAN Yuan. Study on the ontrol of mycotoxins by essential oils[D]. Beijing: Chinese Academy of Agricultural Sciences, 2013.
[49]	EL ASBAHANI A, MILADI K, BADRI W, et al. Essential oils: from extraction to encapsulation[J]. International Journal of Pharmaceutics,2015,483(1-2):220−243. doi: 10.1016/j.ijpharm.2014.12.069
[50]	PRAKASH B, KUJUR A, YADAV A, et al. Nanoencapsulation: an efficient technology to boost the antimicrobial potential of plant essential oils in food system[J]. Food Control,2018,89:1−11. doi: 10.1016/j.foodcont.2018.01.018
[51]	QUINTANILLA-CARVAJAL M X, CAMACHO-DIAZ H, MERAZ-TORRES L S, et al. Nanoencapsulation: a new trend in food engineering processing[J]. Food Engineering Reviews,2010,2(1):39−50. doi: 10.1007/s12393-009-9012-6
[52]	DWIVEDY A K, SINGH V K, PRAKASH B, et al. Nanoencapsulated Illicium verum Hook. f. essential oil as an effective novel plant-based preservative against aflatoxin B₁ production and free radical generation[J]. Food and Chemical Toxicology,2018,111:102−113. doi: 10.1016/j.fct.2017.11.007
[53]	KALAGATUR N K, NIRMAL GHOSH O S, SUNDARARAJ N, et al. Antifungal activity of chitosan nanoparticles encapsulated with cymbopogon martinii essential oil on plant pathogenic fungi Fusarium graminearum[J]. Frontiers in Pharmacology,2018,9:610. doi: 10.3389/fphar.2018.00610
[54]	WAN J, ZHONG S, SCHWARZ P, et al. Physical properties, antifungal and mycotoxin inhibitory activities of five essential oil nanoemulsions: Impact of oil compositions and processing parameters[J]. Food Chemistry,2019,291:199−206. doi: 10.1016/j.foodchem.2019.04.032
[55]	冯文旭, 吴殿辉, 蔡国林, 等. 精油纳米乳液对禾谷镰刀菌的抑制作用[J]. 食品与发酵工业,2020,46(9):94−100. [FENG Wenxu, WU Dianhui, CAI Guolin, et al. The inhibitory effect of essential oil nanoemulsions on Fusarium graminearum[J]. Food and Fermentation Industries,2020,46(9):94−100. FENG Wenxu, WU Dianhui, CAI Guolin, et al. The inhibitory effect of essential oil nanoemulsions on Fusarium graminearum[J]. Food and Fermentation Industries, 2020, 46(9): 94-100.
[56]	ANOOJ E S, CHARUMATH Y M, SHARMA V, et al. Nanogels: an overview of properties, biomedical applications, future research trends and developments[J]. Journal of Molecular Structure,2021,1239(19):130446.
[57]	YADAV A, KUJUR A, KUMAR A, et al. Encapsulation of Bunium persicum essential oil using chitosan nanopolymer: Preparation, characterization, antifungal assessment, and thermal stability[J]. International Journal of Biological Macromolecules,2020,142:172−180. doi: 10.1016/j.ijbiomac.2019.09.089
[58]	DAS S, SINGH V K, DWIVEDY A K, et al. Fabrication, characterization and practical efficacy of Myristica fragrans essential oil nanoemulsion delivery system against postharvest biodeterioration[J]. Ecotoxicology and Environmental Safety,2020,189:110000. doi: 10.1016/j.ecoenv.2019.110000
[59]	CHAUDHARI A K, SINGH V K, DEEPIKA S D, et al. Improvement of in vitro and in situ antifungal, AFB₁ inhibitory and antioxidant activity of Origanum majorana L. essential oil through nanoemulsion and recommending as novel food preservative[J]. Food and Chemical Toxicology,2020,143:111536. doi: 10.1016/j.fct.2020.111536
[60]	SINGH V K, DAS S, DWIVEDY A K, et al. Assessment of chemically characterized nanoencapuslated Ocimum sanctum essential oil against aflatoxigenic fungi contaminating herbal raw materials and its novel mode of action as methyglyoxal inhibitor[J]. Postharvest Biology and Technology,2019,153:87−95. doi: 10.1016/j.postharvbio.2019.03.022
[61]	DAS S, SINGH V K, DWIVEDY A K, et al. Nanostructured Pimpinella anisum essential oil as novel green food preservative against fungal infestation, aflatoxin B₁ contamination and deterioration of nutritional qualities[J]. Food Chemistry,2020,344:128574.
[62]	DAS S, SINGH V K, DWIVEDY A K, et al. Encapsulation in chitosan-based nanomatrix as an efficient green technology to boost the antimicrobial, antioxidant and in situ efficacy of Coriandrum sativum essential oil[J]. International Journal of Biological Macromolecules,2019,133:294−305. doi: 10.1016/j.ijbiomac.2019.04.070
[63]	LÓPEZ-MENESES A K, PLASCENCIA-JATOMEA M, LIZARDI-MENDOZA J, et al. Schinus molle L. Essential oil-loaded chitosan nanoparticles: Preparation, characterization, antifungal and anti-aflatoxigenic properties[J]. LWT-Food Science and Technology,2018,96:597−603. doi: 10.1016/j.lwt.2018.06.013
[64]	DAS S, SINGH V K, DWIVEDY A K, et al. Eugenol loaded chitosan nanoemulsion for food protection and inhibition of aflatoxin B₁ synthesizing genes based on molecular docking[J]. Carbohydrate Polymers,2020,255:117339.
[65]	CHAUDHARI A K, SINGH A, SINGH V K, et al. Assessment of chitosan biopolymer encapsulated α-Terpineol against fungal, aflatoxin B₁ (AFB₁) and free radicals mediated deterioration of stored maize and possible mode of action[J]. Food Chemistry,2020,311:126010. doi: 10.1016/j.foodchem.2019.126010
[66]	CHAUDHARI A K, SINGH V K, DAS S, et al. Antimicrobial, aflatoxin B₁ inhibitory and lipid oxidation suppressing potential of anethole-based chitosan nanoemulsion as novel preservative for protection of stored maize[J]. Food and Bioprocess Technology,2020,13:1462−1477. doi: 10.1007/s11947-020-02479-w
[67]	WAN J, JIN Z, ZHONG S, et al. Clove oil-in-water nanoemulsion: mitigates growth of Fusarium graminearum and trichothecene mycotoxin production during the malting of Fusarium infected barley[J]. Food Chemistry,2020,312:126120. doi: 10.1016/j.foodchem.2019.126120
[68]	SINGH P, DASGUPTA N, SINGH V, et al. Inhibitory effect of clove oil nanoemulsion on fumonisin isolated from maize kernels[J]. LWT-Food Science and Technology,2020,134:110237. doi: 10.1016/j.lwt.2020.110237
[69]	WU D, LU J, ZHONG S, et al. Effect of chitosan coatings on physical stability, antifungal and mycotoxin inhibitory activities of lecithin stabilized cinnamon oil-in-water emulsions[J]. LWT-Food Science and Technology,2019,106:98−104. doi: 10.1016/j.lwt.2019.02.029
[70]	YADAV A, KUJUR A, KUMAR A, et al. Assessing the preservative efficacy of nanoencapsulated mace essential oil against food borne molds, aflatoxin B₁ contamination, and free radical generation[J]. LWT-Food Science and Technology,2019,108:429−436. doi: 10.1016/j.lwt.2019.03.075
[71]	KUJUR A, KUMAR A, YADAV A, et al. Antifungal and aflatoxin B₁ inhibitory efficacy of nanoencapsulated Pelargonium graveolens L. essential oil and its mode of action[J]. LWT-Food Science and Technology,2020,130:109619. doi: 10.1016/j.lwt.2020.109619
[72]	KUMAR A, SINGH P P, GUPTA V, et al. Assessing the antifungal and aflatoxin B₁ inhibitory efficacy of nanoencapsulated antifungal formulation based on combination of Ocimum spp. essential oils[J]. International Journal of Food Microbiology,2020,330:108766. doi: 10.1016/j.ijfoodmicro.2020.108766
[73]	KUMAR A, KUJUR A, SINGH P P, et al. Nanoencapsulated plant-based bioactive formulation against food-borne molds and aflatoxin B₁ contamination: Preparation, characterization and stability evaluation in the food system[J]. Food Chemistry,2019,287:139−150. doi: 10.1016/j.foodchem.2019.02.045

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