Composition Analysis, Anticancer and Immune Activities of Polysaccharides from <i>Poria cocos</i> Residues <i>in Vitro</i>

GUAN Yuting; WEN Simeng; FENG Xue; BAI Yunpeng; CHEN Ruirui; SHEN Xiaoyong; FENG Jianing; CHANG Shimin; CHENG Xinying

doi:10.13386/j.issn1002-0306.2022010168

Volume 43 Issue 21

Oct. 2022

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Science and Technology of Food Industry > 2022 > 43(21): 381-387. > DOI: 10.13386/j.issn1002-0306.2022010168

GUAN Yuting, WEN Simeng, FENG Xue, et al. Composition Analysis, Anticancer and Immune Activities of Polysaccharides from Poria cocos Residues in Vitro[J]. Science and Technology of Food Industry, 2022, 43(21): 381−387. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022010168.

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Composition Analysis, Anticancer and Immune Activities of Polysaccharides from Poria cocos Residues in Vitro

GUAN Yuting^{1, 2,},
WEN Simeng^{1, 2,},
FENG Xue³,
BAI Yunpeng³,
CHEN Ruirui^{1, 2},
SHEN Xiaoyong^{1, 2},
FENG Jianing^{1, 2},
CHANG Shimin^{1, 2, ,},
CHENG Xinying^3, ,

1.
College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China
2.
Handan Key Laboratory of Natural Products and Functional Foods, Handan 056038, China
3.
Chenguang Biotech Group Co., Ltd., Handan 056004, China

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Received Date: January 19, 2022
Available Online: August 22, 2022

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Abstract

Abstract

Objective: The monosaccharide composition of Poria cocos polysaccharide (PCOS) from Poria cocos residue extracted by hot water, as well as its anti-cancer, anti-inflammatory factors and immune activities were studied, providing a theoretical foundation for the development of PCOS related products. Methods: The monosaccharide composition of water-extracted PCOS was analyzed by HPLC and FTIR, and the anti-tumor and immune activities of water-extracted PCOS were studied by CCK-8 method. Results: The polysaccharide content of PCOS was 76%, mainly composed of glucose, mannose, galactose and fucose, and the molar ratio was 1:0.107:0.079:0.018, with obvious polysaccharide characteristic absorption peak. The proliferation of gastric cancer cells, breast cancer cells, and liver cancer cells was decreased, with the best inhibition impact on gastric cancer cells (IC₅₀=1096 µg/mL), and spleen lymphocyte proliferation in mice was enhanced. Conclusion: The water-extracted PCOS has good anti-cancer and immune activities in vitro.
- Poria cocos,
- polysaccharide,
- structural characterization,
- antitumor activity,
- immune activity

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References

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