Research Progress of Short-Chain Fatty Acids and Its Regulation of Intestinal Inflammation

YANG Liting; WANG Ziwei; WANG Jiaqi; ZHENG Nan

doi:10.13386/j.issn1002-0306.2021120212

Volume 43 Issue 24

Dec. 2022

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Science and Technology of Food Industry > 2022 > 43(24): 433-443. > DOI: 10.13386/j.issn1002-0306.2021120212

YANG Liting, WANG Ziwei, WANG Jiaqi, et al. Research Progress of Short-Chain Fatty Acids and Its Regulation of Intestinal Inflammation[J]. Science and Technology of Food Industry, 2022, 43(24): 433−443. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021120212.

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Research Progress of Short-Chain Fatty Acids and Its Regulation of Intestinal Inflammation

1.
State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
2.
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China

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Received Date: December 19, 2021
Available Online: October 20, 2022

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Abstract

Abstract

Gastrointestinal microorganisms in mammals are part of the bacterial ecosystem and play an important role in gastrointestinal development, function and regulation. Short-chain fatty acids (SCFAs) are metabolites produced by fermentation of beneficial bacteria in gastrointestinal microbiome, mainly including acetate, propionate and butyrate. Currently, most studies focus on the effect of microorganisms on host cell metabolism, but the regulation of short-chain fatty acids on intestinal inflammation and its mechanism is still worthy of attention. More and more studies have shown that SCFAs can provide energy for intestinal epithelial cells, protect the intestinal barrier, regulate intestinal inflammation and other functions. In the treatment of intestinal inflammation, SCFAs can be used as signal molecules to activate G protein-coupled receptors (GPCRs) on the cell surface and inhibit histone deacetylases (HDACs) through substrate transporters in the cell, thus achieving anti-inflammatory goals. In this paper, the composition and source of SCFAs, the synthesis pathway and distribution in the body, the effect on intestinal health, the molecular mechanism of regulation in intestinal inflammation and the effect of dietary fiber on the synthesis of SCFAs are reviewed. The mechanism of short-chain fatty acid regulation of intestinal inflammation is emphasized to provide theoretical basis for further research.
- short-chain fatty acid,
- intestine,
- anti-inflammatory,
- G-protein-coupled receptors,
- histone deacetylase

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References

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Periodical cited type(4)

1.	陆源添，刘迪. 杨树桑黄与紫孢侧耳共培养胞内多糖提取工艺优化及抗氧化活性分析. 食品工业科技. 2025(02): 208-217 . 本站查看
2.	郭世纪，刘政，王会. 苹果多酚的提取工艺优化. 食品工业. 2024(07): 37-43 .
3.	罗诗茵，聂菁，韩文敏，林丹丹，廖兰，曾新安. 脉冲电场回收农产品加工废料中生物活性物质的研究进展. 食品工业科技. 2024(19): 392-398 . 本站查看
4.	时文盼，郭嘉欣，蔺永刚，柴雨阳，郭玉锦，武斌，王俊龙. 弯萼金丝桃总多酚提取工艺优化及抗氧化、降糖活性研究. 食品与发酵工业. 2024(21): 206-215 .