Research Progress of Short-Chain Fatty Acids and Its Regulation of Intestinal Inflammation

YANG Liting; WANG Ziwei; WANG Jiaqi; ZHENG Nan

doi:10.13386/j.issn1002-0306.2021120212

Volume 43 Issue 24

Dec. 2022

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Science and Technology of Food Industry > 2022 > 43(24): 433-443. > DOI: 10.13386/j.issn1002-0306.2021120212

YANG Liting, WANG Ziwei, WANG Jiaqi, et al. Research Progress of Short-Chain Fatty Acids and Its Regulation of Intestinal Inflammation[J]. Science and Technology of Food Industry, 2022, 43(24): 433−443. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021120212.

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Research Progress of Short-Chain Fatty Acids and Its Regulation of Intestinal Inflammation

1.
State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
2.
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China

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Received Date: December 19, 2021
Available Online: October 20, 2022

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Abstract

Abstract

Gastrointestinal microorganisms in mammals are part of the bacterial ecosystem and play an important role in gastrointestinal development, function and regulation. Short-chain fatty acids (SCFAs) are metabolites produced by fermentation of beneficial bacteria in gastrointestinal microbiome, mainly including acetate, propionate and butyrate. Currently, most studies focus on the effect of microorganisms on host cell metabolism, but the regulation of short-chain fatty acids on intestinal inflammation and its mechanism is still worthy of attention. More and more studies have shown that SCFAs can provide energy for intestinal epithelial cells, protect the intestinal barrier, regulate intestinal inflammation and other functions. In the treatment of intestinal inflammation, SCFAs can be used as signal molecules to activate G protein-coupled receptors (GPCRs) on the cell surface and inhibit histone deacetylases (HDACs) through substrate transporters in the cell, thus achieving anti-inflammatory goals. In this paper, the composition and source of SCFAs, the synthesis pathway and distribution in the body, the effect on intestinal health, the molecular mechanism of regulation in intestinal inflammation and the effect of dietary fiber on the synthesis of SCFAs are reviewed. The mechanism of short-chain fatty acid regulation of intestinal inflammation is emphasized to provide theoretical basis for further research.
- short-chain fatty acid,
- intestine,
- anti-inflammatory,
- G-protein-coupled receptors,
- histone deacetylase

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References

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Periodical cited type(13)

1.	沙琦，孙未一，范兴丽. 肠道菌群代谢物与抑郁症发病机制关系的研究. 浙江医学教育. 2025(01): 60-64 .
2.	姜浩，赵杰，王铁云. “微生物-肠-脑轴”理论下述中医治疗郁症的研究进展. 中医临床研究. 2024(03): 27-31 .
3.	姜浩，赵杰，王铁云. “微生物-肠-脑轴”理论下述中医治疗郁症的研究进展. 中医临床研究. 2024(09): 135-138 .
4.	张红娟，王崴，高敏，安邦，范雅娟，贾敏，李强. 抑郁症患者血清短链脂肪酸水平与症状及生化指标的相关性. 山西医科大学学报. 2024(06): 777-781 .
5.	康艳宝，赵龙友. 抗抑郁药联合肠道菌群调节剂治疗抑郁症疗效分析. 中国基层医药. 2024(08): 1144-1148 .
6.	徐曼华，李平，何兰英，高丽梅. 老年抑郁症患者应用微生态制剂辅助认知行为干预的效果. 国际精神病学杂志. 2024(06): 1784-1787 .
7.	赵佳，沈馨，刘红霞，郭艳荣，高广琦，孙志宏. 益生菌缓解亚健康相关症状的研究进展. 中国食品学报. 2024(12): 432-440 .
8.	胡科，张同同，张凯，王国强. 首发抑郁症患者肠道菌群多样性与抑郁症状的相关性分析. 微生物学通报. 2023(03): 1040-1051 .
9.	任煜，张童，李宁，裴环，赵童，袁嘉丽. 基于“脾与小肠相通”理论探讨脾-肠-肠道微生态治疗抑郁症. 世界中西医结合杂志. 2023(05): 1031-1035 .
10.	吴振宁，王琦，秦雪梅，田俊生. 肠道菌群及其代谢产物在中药治疗抑郁症中的研究进展. 中草药. 2023(14): 4713-4721 .
11.	李秋颖，冯静，刘婕，杨蓉蓉，骆华正，蔡伦，韦理萍. 肠道菌群在抑郁症发病机制及中医药治疗中研究进展. 辽宁中医药大学学报. 2023(12): 96-101 .
12.	袁霞红，刘林. 肠道菌群调节抑郁症机制及中医药防治研究进展. 中华中医药学刊. 2022(09): 167-170 .
13.	徐慧慧，陈煦，赵芳，毛若曦，王文利，程智美，张雅丽. 饮食结构、营养成分对抑郁症的影响研究进展. 食品科学. 2022(23): 346-355 .