<i>In Vivo </i>Hypolipidemic Effect of the Compound Composition of Crataegus, Ume, Grape Skin, Wolfberry and Mulberry

LI Ying; WU Shasha; CAO Can; XU Jianwen; LIU Ying

doi:10.13386/j.issn1002-0306.2021110291

Volume 43 Issue 18

Sep. 2022

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Science and Technology of Food Industry > 2022 > 43(18): 365-370. > DOI: 10.13386/j.issn1002-0306.2021110291

LI Ying, WU Shasha, CAO Can, et al. In Vivo Hypolipidemic Effect of the Compound Composition of Crataegus, Ume, Grape Skin, Wolfberry and Mulberry[J]. Science and Technology of Food Industry, 2022, 43(18): 365−370. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021110291.

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In Vivo Hypolipidemic Effect of the Compound Composition of Crataegus, Ume, Grape Skin, Wolfberry and Mulberry

Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150001, China

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Received Date: November 23, 2021
Available Online: July 04, 2022

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Abstract

Abstract

To explore the in vivo hypolipidemic effect of the compound composition of crataegus, ume, grape skin, wolfberry and mulberry. There were 50 SPF-grade healthy male SD rats, 10 rats were given maintenance feed as a blank control group, and 40 rats were given model feed as a model group. After the model group was given the model feed for 2 weeks, the 40 animals in the model group were randomly divided into 4 groups according to the TC level, namely high, medium and low dose groups (1.5, 0.5, 0.25g/kg·BW) and the model control group. After grouping, the three dose groups were given the test sample orally at 10mL/kg·BW every day, and the blank control group and the model control group were given the same volume of distilled water at the same time. After continuous intragastric administration for 30 days, serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured. The liver coefficient, hepatic lipase (HL), and lipoprotein lipase (LPL) activity levels were measured, and the degree of hepatic steatosis was observed by HE staining. The results showed that compared with the model control group, the levels of serum TC, TG and LDL-C in the high-dose and middle-dose groups significantly decreased (P<0.05), and the HDL-C level significantly increased (P<0.01). The activities of HL and LPL in rats significantly increased (P<0.01), and lipid droplet vacuoles and lipid droplet bubbles were significantly reduced in high and medium dose groups. Accordingly, it is believed that the composition has the effect of regulating blood lipids, indicating that it could be developed as a new type of fat-lowering health food.
- crataegus,
- ume,
- grape skin,
- hyperlipidemias,
- dyslipidemias

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