Optimization of Ultrasound-Assisted Extraction of Cyclic Adenosine 3',5'-Monophosphate from Xinjiang Jujube by Deep Eutectic Solvent

ZHANG Xue; LIU Ya; LIU Xiumin; SHAN Chunhui

doi:10.13386/j.issn1002-0306.2021100308

Volume 43 Issue 14

Jul. 2022

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Science and Technology of Food Industry > 2022 > 43(14): 243-250. > DOI: 10.13386/j.issn1002-0306.2021100308

ZHANG Xue, LIU Ya, LIU Xiumin, et al. Optimization of Ultrasound-Assisted Extraction of Cyclic Adenosine 3',5'-Monophosphate from Xinjiang Jujube by Deep Eutectic Solvent[J]. Science and Technology of Food Industry, 2022, 43(14): 243−250. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021100308.

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Optimization of Ultrasound-Assisted Extraction of Cyclic Adenosine 3',5'-Monophosphate from Xinjiang Jujube by Deep Eutectic Solvent

ZHANG Xue^1,,
LIU Ya¹,
LIU Xiumin¹,
SHAN Chunhui^{1, 2, ,}

1.
College of Food Science, Shihezi University, Shihezi 832000, China
2.
Engineering Research Center of Xinjiang Ministry of Education for Fruit and Vegetable Storage and Processing, Shihezi 832000, China

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Received Date: October 31, 2021
Available Online: May 17, 2022

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Abstract

Abstract

Using green and highly efficient deep eutectic solvent (DES) as the extraction agent, this study extracted the functional ingredient—cyclic adenosine 3',5'-monophosphate (cAMP) from Xinjiang jujube through ultrasound-assisted technology. The relationships between the molar ratio of deep eutectic solvent, water content of deep eutectic solvent, solid-liquid ratio, ultrasonic time, ultrasonic temperature and extraction amount of cAMP were studied. Through single factor experimentas and response surface optimization experiment, the optimal conditions for cAMP extraction from Xinjiang jujube were as follows: The molar ratio of choline chloride to glycerol was 1:3, the water content of DES system was 44%, the solid-liquid ratio of jujube powder to DES was 1:35 g/mL, the ultrasonic time was 45 min, and the ultrasonic temperature was 45 ℃. At this time, compared with water extraction and alcohol extraction under the same ultrasonic conditions, the highest content of cAMP extracted by deep eutectic solvent was (284.15±0.06) μg/g. Therefore, ultrasonic-assisted deep eutectic solvent extraction of cAMP in Xinjiang jujube was a new, efficient and safe method to obtain a higher extraction amount.
- Xinjiang jujube,
- cyclic adenosine monophosphate,
- deep eutectic solvent,
- ultrasonic assisted,
- high performance liquid chromatography

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References

[1]	WOJDYLO A, FIGIEL A, LEGUA P, et al. Chemical composition, antioxidant capacity, and sensory quality of dried Jujube fruits as affected by cultivar and drying method[J]. Food Chemistry,2016,207:170−179. doi: 10.1016/j.foodchem.2016.03.099
[2]	刘丹. 南疆不同品种红枣环磷酸腺苷的差异性及浓缩产品的制备[D]. 阿拉尔: 塔里木大学, 2016. LIU D. The diversity of cAMP in Southern Xinjiang Jujube cultivars and preparation of concentrated product[D]. Alaer: Tarim University, 2016.
[3]	BERGANTIN L B. Diabetes and inflammatory diseases: An overview from the perspective of Ca2+/3'-5'-cyclic adenosine monophosphate signaling[J]. World Journal of Diabetes,2021,12(6):767. doi: 10.4239/wjd.v12.i6.767
[4]	DONG J, FU X M, WANG P F, et al. Construction of industrial baker's yeast with high level of cAMP[J]. Journal of Food Biochemistry,2019,43(7):1−7.
[5]	张义军. 红枣中环磷酸腺苷的提取及成型工艺研究[D]. 石河子: 石河子大学, 2018. ZHANG Y J. Study on the extraction process and forming process for cAMP from Ziziphus jujube mill[D]. Shihezi: Shihezi University, 2018.
[6]	ABBOTT A P, CAPPER G, DAVIES D L, et al. Novel solvent properties of choline chloride/urea mixtures[J]. Chemical Communications,2003(1):70−71. doi: 10.1039/b210714g
[7]	CUNHA S C, FERNANDES J O. Extraction techniques with deep eutectic solvents[J]. TrAC Trends in Analytical Chemistry,2018,105:225−239. doi: 10.1016/j.trac.2018.05.001
[8]	唐兰芳, 王锋, 苏小军, 等. 低共熔溶剂提取对黄精多糖性质及抗氧化活性的影响[J]. 食品与发酵工业,2021,47(11):151−157. [TANG L F, WANG F, SU X J, et al. Effects of deep eutectic solvents on the properties and antioxidant activity of polysaccharides from Polygonatum cyrtonema Hua[J]. Food and Fermentation Industries,2021,47(11):151−157. TANG L F, WANG F, SU X J, et al. Effects of deep eutectic solvents on the properties and antioxidant activity of polysaccharides from Polygonatum cyrtonema Hua[J]. Food and Fermentation Industries, 2021, 47(11): 151−157.
[9]	刘金铭, 王辉, 张欢, 等. 超声辅助低共熔溶剂萃取法在活性成分提取与食品分析预处理中应用的研究进展[J]. 食品工业科技,2021,42(7):399−407. [LIU J M, WANG H, ZHANG H, et al. Research progress on extraction of active ingredients and pretreatment of food analysis by ultrasound-assisted deep eutectic solvent method[J]. Science and Technology of Food Industry,2021,42(7):399−407. LIU J M, WANG H, ZHANG H, et al. Research progress on extraction of active ingredients and pretreatment of food analysis by ultrasound-assisted deep eutectic solvent method[J]. Science and Technology of Food Industry, 2021, 42(7): 399−407.
[10]	CHEN X Q, LI Z H, LIU L L, et al. Green extraction using deep eutectic solvents and antioxidant activities of flavonoids from two fruits of Rubia species[J]. LWT,2021,148:111−708.
[11]	GAO M Z, CUI Q, WANG L T, et al. A green and integrated strategy for enhanced phenolic compounds extraction from mulberry (Morus alba L.) leaves by deep eutectic solvent[J]. Microchemical Journal,2020,154:104598. doi: 10.1016/j.microc.2020.104598
[12]	CHEN L, YANG Y Y, ZHOU R R, et al. The extraction of phenolic acids and polysaccharides from Lilium lancifolium Thunb. using a deep eutectic solvent[J]. Analytical Methods,2021,13(10):1226−1231. doi: 10.1039/D0AY02352C
[13]	XU M, RAN L, CHEN N, et al. Polarity-dependent extraction of flavonoids from citrus peel waste using a tailor-made deep eutectic solvent[J]. Food Chemistry,2019,297:124−136.
[14]	孙悦, 刘晓冰, 苏卓文, 等. 微波辅助低共熔溶剂提取鹰嘴豆中黄酮及其抗氧化活性的研究[J]. 食品工业科技,2020,41(14):120−128. [SUN Y, LIU X B, SU Z W, et al. Extraction of flavonoids from Chickpea by microwave assisted eutectic solvent and its antioxidant activity[J]. Science and Technology of Food Industry,2020,41(14):120−128. SUN Y, LIU X B, SU Z W, et al. Extraction of flavonoids from Chickpea by microwave assisted eutectic solvent and its antioxidant activity [J]. Science and Technology of Food Industry, 2020, 41(14): 120−128.
[15]	TSJOKAJEV A, ROBERG-LARSEN H, WILSON S R, et al. Mass spectrometry-based measurements of cyclic adenosine monophosphate in cells, simplified using reversed phase liquid chromatography with a polar characterized stationary phase[J]. Journal of Chromatography B,2020,1160:122−128.
[16]	岳盈肖, 王永霞, 赵彤, 等. 超声波辅助水浴法提取大枣中环磷酸腺苷工艺优化[J]. 中国食品添加剂,2019,30(9):87−93. [YUE Y X, WANG Y X, ZHAO T, et al. Optimization of extraction process of adenosine cyclic phosphate from Chinese Jujube by ultrasound-assisted water bath[J]. China Food Additives,2019,30(9):87−93. YUE Y X, WANG Y X, ZHAO T, et al. Optimization of extraction process of adenosine cyclic phosphate from Chinese jujube by ultrasound-assisted water bath[J]. China Food Additives, 2019, 30(9): 87−93.
[17]	TANG B, ZHANG H, ROW K H. Application of deep eutectic solvents in the extraction and separation of target compounds from various samples[J]. Journal of Separation Science,2015,38(6):1053−1064. doi: 10.1002/jssc.201401347
[18]	MANSUR A R, SONG N, JANG H W, et al. Optimizing the ultrasound-assisted deep eutectic solvent extraction of flavonoids in common buckwheat sprouts[J]. Food Chemistry,2019,293:438−445. doi: 10.1016/j.foodchem.2019.05.003
[19]	孙平, 董萍萍, 董丹华, 等. 超声波辅助低共熔溶剂提取野菊花总黄酮的工艺研究[J]. 食品工业科技,2020,41(20):147−152. [SUN P, DONG P P, DONG D H, et al. Ultrasound-assisted deep eutectic solvent extraction of total flavonoids from Chrysanthemum indicum[J]. Science and Technology of Food Industry,2020,41(20):147−152. SUN P, DONG P P, DONG D H, et al. Ultrasound-assisted deep eutectic solvent extraction of total flavonoids from chrysanthemum indicum[J]. Science and Technology of Food Industry, 2020, 41(20): 147−152.
[20]	张莹莹, 毛向红, 张建英. 不同方法对酸枣果实环磷酸腺苷提取效果的比较[J]. 食品科技,2018,43(3):192−195. [ZHANG Y Y, MAO X H, ZHANG J Y. Effects of different extraction methods on cAMP from wild Jujube[J]. Food Science and Technology,2018,43(3):192−195. ZHANG Y Y, MAO X H, ZHANG J Y. Effects of different extraction methods on cAMP from wild jujube[J]. Food Science and Technology, 2018, 43(03): 192−195.
[21]	CUI Q, PENG X, YAO X H, et al. Deep eutectic solvent-based microwave-assisted extraction of genistin, genistein and apigenin from pigeon pea roots[J]. Separation and Purification Technology,2015,150:63−72. doi: 10.1016/j.seppur.2015.06.026
[22]	张锦钰. 低共熔溶剂提取淮山多糖及其结构、生物活性研究[D]. 长沙: 湖南农业大学, 2020. ZHANG J Y. Study on structure and bioactivity of polysaccharides extracted from Chinese Yam using deep eutectic solvents[D]. Changsha: Hunan Agricultural University, 2020.
[23]	黄秀红, 刘丽辰, 阮怿航, 等. 响应面优化低共熔溶剂提取乌龙茶多糖的研究[J]. 食品研究与开发,2020,41(11):96−103. [HUANG X H, LIU L C, RUAN Y H, et al. Optimization of deep eutectic solvents extraction of polysaccharides from oolong tea by response surface methodology[J]. Food Research and Development,2020,41(11):96−103. HUANG X H, LIU L C, RUAN Y H, et al. Optimization of deep eutectic solvents extraction of polysaccharides from oolong tea by response surface methodology[J]. Food Research and Development, 2020, 41(11): 96−103.
[24]	DAI Y, WITKAMP G J, VERPOORTE R, et al. Tailoring properties of natural deep eutectic solvents with water to facilitate their applications[J]. Food Chemistry,2015,187:14−19. doi: 10.1016/j.foodchem.2015.03.123
[25]	CONTAMINE R F, WILHELM A M, BERLAN J, et al. Power measurement in sonochemistry[J]. Ultrasonics Sonochemistry,1995,2(1):43−47. doi: 10.1016/1350-4177(94)00010-P
[26]	MENG Z R, ZHAO J, DUAN H X, et al. Green and efficient extraction of four bioactive flavonoids from Pollen typhae by ultrasound-assisted deep eutectic solvents extraction[J]. Journal of Pharmaceutical and Biomedical Analysis,2018,161:246−253. doi: 10.1016/j.jpba.2018.08.048
[27]	HSIEH Y H, LI Y B, PAN Z C, et al. Ultrasonication-assisted synthesis of alcohol-based deep eutectic solvents for extraction of active compounds from ginger[J]. Ultrasonics Sonochemistry,2020,63:104−115.
[28]	BUBALO M C, ĆURKO N, TOMAŠEVIĆ M, et al. Green extraction of grape skin phenolics by using deep eutectic solvents[J]. Food Chemistry,2016,200:159−166. doi: 10.1016/j.foodchem.2016.01.040
[29]	THU H N, VAN P N, MINH K N, et al. Optimization of extraction conditions of flavonoids from celery seed using response surface methodology[J]. Journal of Food Measurement and Characterization,2020,52(22):4215−4218.
[30]	孙悦, 何莲芝, 苏卓文, 等. 超声辅助低共熔溶剂提取甘草多糖的研究[J]. 食品研究与开发,2021,42(2):84−91. [SUN Y, HE L Z, SU Z W, et al. Ultrasonic-assisted eutectic solvent extraction of glycyrrhiza polysaccharide[J]. Food Research and Development,2021,42(2):84−91. SUN Y, HE L Z, SU Z W, et al. Ultrasonic-assisted eutectic solvent extraction of glycyrrhiza polysaccharide[J]. Food Research and Development, 2021, 42(2): 84−91.
[31]	董嘉琪, 张晓松, 彭晓婷, 等. 响应面法优化红芪多糖的提取工艺[J]. 动物医学进展, 2021, 42(4): 64−71. DONG J Q, ZHANG X S, PENG X T, et al. Optimization of extraction process of Radix hedysari polysaccharide by response surface methodology[J]. Progress in Veterinary Medicine, 2021, 42(4): 64−71.
[32]	李辉, 赵亮, 李建贵, 等. 高效液相色谱法测定我国北方红枣中环磷酸腺苷的含量[J]. 分析测试技术与仪器,2020,26(1):42−48. [LI H, ZHAO L, LI J G, et al. Determination of cAMP in Jujube from north of China by high performance liquid chromatography[J]. Analysis and Testing Technology and Instruments,2020,26(1):42−48. LI H, ZHAO L, LI J G, et al. Determination of cAMP in Jujube from north of China by high performance liquid chromatography[J]. Analysis and Testing Technology and Instruments , 2020, 26(1): 42−48.
[33]	袁辉, 张煌涛, 王建玲. HPLC法测定新疆地区红枣中黄酮类物质的含量[J]. 食品工业,2020,41(8):284−287. [YUAN H, ZHANG H T, WANG J L. Determination of flavonoids in Jujube from Xinjiang by HPLC[J]. Food Industry,2020,41(8):284−287. YUAN H, ZHANG H T, WANG J L. Determination of Flavonoids in Jujube from Xinjiang by HPLC[J]. Food Industry, 2020, 41(8): 284−287.
[34]	李利芬, 胡英成, 吴志刚, 等. 杨木木粉在酸性氯化胆碱/丙三醇中的快速液化研究[J]. 西北林学院学报,2019,34(6):172−177. [LI L F, HU Y C, WU Z G, et al. Rapid liquefaction of poplar wood in choline chloride/glycerol solvent[J]. Journal of Northwest Forestry University,2019,34(6):172−177. doi: 10.3969/j.issn.1001-7461.2019.06.27 LI L F, HU Y C, WU Z G, et al. Rapid liquefaction of poplar wood in choline chloride/glycerol solvent[J]. Journal of Northwest Forestry University , 2019, 34(6): 172−177. doi: 10.3969/j.issn.1001-7461.2019.06.27

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