SHEN Wen, WU Lixin, LIU Shuxing, et al. Preparation of Royal Jelly Effervescent Tablets and Determination of 10-HDA Dissolution[J]. Science and Technology of Food Industry, 2022, 43(14): 276−282. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021100180.
Citation: SHEN Wen, WU Lixin, LIU Shuxing, et al. Preparation of Royal Jelly Effervescent Tablets and Determination of 10-HDA Dissolution[J]. Science and Technology of Food Industry, 2022, 43(14): 276−282. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021100180.

Preparation of Royal Jelly Effervescent Tablets and Determination of 10-HDA Dissolution

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  • Received Date: October 18, 2021
  • Available Online: May 04, 2022
  • Objective: To solve the problem of low dissolution rate of 10-hydroxy-2-decenoic acid (10-HDA) in royal jelly effervescent tablets. Methods: The disintegration time and gas production were used as evaluation indexes. Single factor experiments and orthogonal test were used to optimize the amount of effervescent agent, the ratio of effervescent agent (citric acid:NaHCO3), and the amount of sweetener added. Then different food additives were added to the formula. The effect of different food additives on the dissolution of 10-HDA was explored. And the optimum formula was obtained. Meanwhile, X-ray diffraction (XRD) was used to characterize the crystallinity of royal jelly effervescent tablets. Results: The optimum formula were royal jelly lyophilized powder 10%, effervescent agent 45%, best effervescent ratio (citric acid:NaHCO3)=1.5:1, mannitol 10%, mogroside 1%, and magnesium stearate 0.8%, 15% calcium lactate or 0.5% polyglycerol fatty acid ester, and the rest was filled with lactose to 100%. The royal jelly effervescent tablets prepared by the formula had a good taste and rapid disintegration. In about 15 minutes, the cumulative dissolution rate of 10-HDA could reach 85% or more. Conclusion: Adding calcium lactate or polyglycerol fatty acid ester to the royal jelly effervescent tablets’ formulation could effectively improve the dissolution rate of 10-HDA. This study provided data reference for improving 10-HDA dissolution rate in royal jelly related products.
  • [1]
    GUO J Y, WANG Z X, CHEN Y X, et al. Active components and biological functions of royal jelly[J]. Journal of Functional Foods,2021,82:104514. doi: 10.1016/j.jff.2021.104514
    [2]
    KOCOT J, KIELCZYKOWSKA M, LUCHOWSKA-KOCOT D, et al. Antioxidant potential of propolis, bee pollen, and royal jelly: Possible medical application[J]. Oxidative Medicine and Cellular Longevity,2018:7074209.
    [3]
    FAN P, HAN B, HU H, et al. Proteome of thymus and spleen reveals that 10-hydroxydec-2-enoic acid could enhance immunity in mice[J]. Expert Opinion on Therapeutic Targets,2020,24(3):267−279. doi: 10.1080/14728222.2020.1733529
    [4]
    ESLAMI-KALIJI F, SARAFBIDABAD M, KIANI-ESFAHANI A, et al. 10-hydroxy-2-decenoic acid a bio-immunomodulator in tissue engineering; generates tolerogenic dendritic cells by blocking the toll-like receptor4[J]. Journal of Biomedical Materials Research. Part A,2021,109(9):1575−1587. doi: 10.1002/jbm.a.37152
    [5]
    LIN X M, LIU S B, LUO Y H, et al. 10-HDA induces ROS-mediated apoptosis in A549 human lung cancer cells by regulating the MAPK, STAT3, NF-κB, and TGF-β1 signaling pathways[J]. BioMed Research International,2020(2):1−15.
    [6]
    YANG Y C, CHOU W M, WIDOWATI D A, et al. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells[J]. BMC Complementary and Alternative Medicine,2018,18(1):202. doi: 10.1186/s12906-018-2267-9
    [7]
    YOU M M, MIAO Z N, TIAN J, et al. Trans 10-hydroxy-2-decenoic acid protects against LPS-induced neuroinflammation through FOXO1-mediated activation of autophagy[J]. European Journal of Nutrition,2020,59(7):2875−2892. doi: 10.1007/s00394-019-02128-9
    [8]
    陶文卿. 10-HDA对大肠杆菌抑制机理的研究[D]. 济南: 山东轻工业学院, 2012.

    TAO W Q. Study on inhibition mechanism of 10-HDA to E. coli[D]. Jinan: Shandong Institute of Light Industry, 2012.
    [9]
    JAMAR A, SHAMSUL A M, MOHD T S. Frictional effects, mechanical strength, and disintegration of coffee mix tablet, effervescent coffee mix tablet and with added lubricant[J]. Particulate Science and Technology,2019(3):1−6.
    [10]
    ELSAMALIGY S, BODMEIER R. Development of extended release multiple unit effervescent floating drug delivery systems for drugs with different solubilities[J]. Journal of Drug Delivery Science & Technology,2015,30:467−477.
    [11]
    IQBAL N, AGRAWAL A, KUMAR J. An effervescent generated tablet for rapid control of mosquito problem in early stages from different breeding sites[J]. Arabian Journal of Chemistry,2021,14(1):103082.
    [12]
    BANSAL S, BEG S, GARG B, et al. QbD-oriented development and characterization of effervescent floating-bioadhesive tablets of cefuroxime axetil[J]. AAPS PharmSciTech,2016,17(5):1086−1099. doi: 10.1208/s12249-015-0431-9
    [13]
    CHOIRI S, SULAIMAN T N S, ROHMAN A. Assessment of the effect of polymers combination and effervescent component on the drug release of swellable gastro-floating tablet formulation through compartmental modeling-based approach[J]. Drug Development and Industrial Pharmacy,2020,46(1):146−158. doi: 10.1080/03639045.2019.1711387
    [14]
    谭亚南. 功能性修饰糖脂纳米给药系统线粒体靶向与敏感释放的抗肿瘤研究[D]. 杭州: 浙江大学, 2019.

    TAN Y N. Mitochondrial targeting and responsive drug release mediated cancer therapy by functional modified glycolipid-like drug delivery system[D]. Hangzhou: Zhejiang University, 2019.
    [15]
    贾利娜. 基于分子模拟方法丙磺舒药物固液相平衡研究[D]. 北京: 北京化工大学, 2018.

    JIA L N. Study on solid-liquid phase equilibrium of probenecid based on molecular simulation[D]. Beijing: Beijing University of Chemical Technology, 2018.
    [16]
    ALAMA T, KUSAMORI K, MORISHITA M, et al. Mechanistic studies on the absorption-enhancing effects of gemini surfactant on the intestinal absorption of poorly absorbed hydrophilic drugs in rats[J]. Pharmaceutics,2019,11(4):170. doi: 10.3390/pharmaceutics11040170
    [17]
    HAYES D G. 可持续生产再生资源表面活性剂的国际研究进展[J]. 粮油食品科技,2020,28(5):31−40. [HAYES D G. The global research progress on sustainable production of surfactants from renewable resources[J]. Science and Technology of Cereals, Oils and Foods,2020,28(5):31−40.

    HAYES D G. The global research progress on sustainable production of surfactants from renewable resources[J]. Science and Technology of Cereals, Oils and Foods, 2020, 28(5): 31-40.
    [18]
    张金彦, 匡雯婕, 吉绍长, 等. 拉莫三嗪-邻苯二甲酰亚胺药物共晶在有机溶剂中溶解度及三元相图测定[J]. 化工学报,2019,70(11):4153−4161. [ZHANG J Y, KUANG W J, JI S C, et al. Determination of solubility and ternary phase diagram of lamotrigine-phthalimide pharmaceutical cocrystal in pure solvent[J]. CIESC Journal,2019,70(11):4153−4161.

    ZHANG J Y, KUANG W J, JI S C, et al. Determination of solubility and ternary phase diagram of lamotrigine-phthalimide pharmaceutical cocrystal in pure solvent[J]. CIESC Journal, 2019, 70(11): 4153-4161.
    [19]
    SARAF A, SHARMA S, SACHAR S. Evaluation of surfactants as solubilizing medium for levofloxacin[J]. Journal of Molecular Liquids,2020,319:114060. doi: 10.1016/j.molliq.2020.114060
    [20]
    王艺萌, 国佳鑫, 孔庆新, 等. 荔枝草泡腾片的制备工艺及质量评价[J]. 食品工业科技,2019,40(2):165−169. [WANG Y M, GUO J X, KONG Q X, et al. Preparation technology and quality evaluation of Salvia plebeia R. Br. effervescent tablets[J]. Science and Technology of Food Industry,2019,40(2):165−169.

    WANG Y M, GUO J X, KONG Q X, et al. Preparation technology and quality evaluation of Salvia plebeia R. Br. effervescent tablets[J]. Science and Technology of Food Industry, 2019, 40(2): 165-169.
    [21]
    国家药典委员会编. 中华人民共和国药典(四部)[M]. 北京: 中国医药科技出版社, 2015: 118−120.

    Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China (Volume IV)[M]. Beijing: China Pharmaceutical Science and Technology Press, 2015: 118−120.
    [22]
    王文宝, 杨俊涛, 毛讯, 等. 猴头菇水提取物泡腾片的制备工艺[J]. 食品工业,2021,42(5):139−142. [WANG W B, YANG J T, MAO X, et al. Preparation of effervescent tablets of Hericium erinaceus water extract[J]. Food Industry,2021,42(5):139−142.

    WANG W B, YANG J T, MAO X, et al. Preparation of effervescent tablets of Hericium erinaceus water extract[J]. Food Industry, 2021, 42(5): 139-142.
    [23]
    徐焰, 李柏林, 程明, 等. 10-羟基-2-癸烯酸的紫外分光光度法快速测定的研究[J]. 上海水产大学学报,2004(1):84−87. [XU Y, LI B L, CHENG M, et al. Study on the rapid determination of 10-hydroxy-2-decenoic acid by ultraviolet spectrophotometry[J]. Journal of Shanghai Fisheries University,2004(1):84−87.

    XU Y, LI B L, CHENG M, et al. Study on the rapid determination of 10-hydroxy-2-decenoic acid by ultraviolet spectrophotometry[J]. Journal of Shanghai Fisheries University, 2004(1): 84-87.
    [24]
    柴宝丽, 王双侠. 粉末直接压片法制备布洛芬分散片[J]. 哈尔滨商业大学学报(自然科学版),2020,36(2):137−141. [CHAI B L, WANG S X. Preparation of ibuprofen dispersible tablets by direct powder compression[J]. Journal of Harbin University of Commerce (Natural Science Edition),2020,36(2):137−141.

    CHAI B L, WANG S X. Preparation of ibuprofen dispersible tablets by direct powder compression[J]. Journal of Harbin University of Commerce (Natural Science Edition), 2020, 36(2): 137-141.
    [25]
    YUSRIADI Y, SULASTRI E, LEMBANG N P. Synthesis of type a zeolite from rice husk ash and its application as a builder on effervescent tablet form detergent[J]. Tenside Surfactants Detergents,2020,57(3):203−210. doi: 10.3139/113.110683
    [26]
    姚洪礼, 邢爽, 丁之恩, 等. 响应面设计法优化甘草山楂泡腾片配方的研究[J]. 宿州学院学报,2021,36(3):41−46. [YAO H L, XING S, DING Z E, et al. Optimization of the formula of licorice and hawthorn effervescent tablets using Box-Behnken surface response design[J]. Journal of Suzhou University,2021,36(3):41−46. doi: 10.3969/j.issn.1673-2006.2021.03.010

    YAO H L, XING S , DING Z E, et al. Optimization of the formula of licorice and hawthorn effervescent tablets using Box-Behnken surface response design[J]. Journal of Suzhou University, 2021, 36(3): 41-46. doi: 10.3969/j.issn.1673-2006.2021.03.010
    [27]
    BASALEH S, BISHARAT L, CESPI M, et al. Temperature: An overlooked factor in tablet disintegration[J]. European Journal of Pharmaceutical Sciences,2020:151.
    [28]
    李晓溪. 抗天花病毒创新药物特考韦瑞三元组合物及其增溶机制的研究[D]. 北京: 中国人民解放军军事医学科学院, 2016.

    LI X X. The design, evaluation and mechanism study of ternary complex of tecovirimat, a novel anti-samllpox drug[D]. Beijing: PLA Academy of Military Medical Sciences, 2016.
    [29]
    孟天宇, 刘英丹, 娄永江. 长效二氧化氯缓释剂的制备[J]. 食品工业科技,2020,41(16):26−31. [MENG T Y, LIU Y D, LOU Y J. Preparation of sustained-release agent of long-acting chlorine dioxide[J]. Science and Technology of Food Industry,2020,41(16):26−31.

    MENG T Y, LIU Y D, LOU Y J. Preparation of sustained-release agent of long-acting chlorine dioxide[J]. Science and Technology of Food Industry, 2020, 41(16): 26-31.
    [30]
    SAKATA Y, SHIRAISHI S, OTSUKA M. Characterization of dehydration and hydration behavior of calcium lactate pentahydrate and its anhydrate[J]. Colloids & Surfaces B Biointerfaces,2005,46(3):135−141.
    [31]
    张雪龄, 雷旭东, 王菲菲, 等. 水合无机盐热化学储热材料及技术研究进展[J]. 化工新型材料,2021,49(8):6−11. [ZHANG X L, LEI X D, WANG F F, et al. Research progress on hydrated salt thermochemical heat storage materials and technology[J]. New Chemical Materials,2021,49(8):6−11.

    ZHANG X L, LEI X D, WANG F F, et al. Research progress on hydrated salt thermochemical heat storage materials and technology[J]. New Chemical Materials, 2021, 49(8): 6-11.
    [32]
    LIAN H, PENG Y, SHI J Y, et al. Effect of emulsifier hydrophilic-lipophilic balance (HLB) on the release of thyme essential oil from chitosan films[J]. Food Hydrocolloids,2019,97:105213. doi: 10.1016/j.foodhyd.2019.105213
    [33]
    ANUAR N, SABRI A H, EFFENDI T J B, et al. Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability[J]. Heliyon,2020,6(7):e04570. doi: 10.1016/j.heliyon.2020.e04570
    [34]
    PENG B, XIONG C Y, HUANG Y, et al. Study on enzymatic synthesis of polyglycerol fatty acid esters and its application as an emulsion stabilizer[J]. Journal of Agricultural and Food Chemistry,2018,66(30):8104−8113. doi: 10.1021/acs.jafc.8b00222
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