Research Progress of Anti-lung Cancer Effect of Quercetin in Vitro

Quercetin is a flavonol compound containing o-diphenol hydroxyl and resorcinol hydroxyl. In order to analyze the current status of quercetin in vitro anti-lung cancer, this article uses domestic Knowledge Network, Wanfang, foreign SpringerLink and PubMed databases, entered the subject terms “quercetin”, “quercetin derivative”, “lung cancer”, and then searched for quercetin’s anti-lung cancer in recent years. Retrieving the relevant data on the research of quercetin and its derivatives in anti-lung cancer in recent years, review of its new preparations, derivatives and mechanism of action. The new anti-lung cancer preparations of quercetin include nanoparticles, nanoemulsions, nanomicelles, liposomes and other preparations. From more than 120 quercetin derivatives that have been synthesized, 11 compounds with stronger effects on lung cancer than quercetin are found. Quercetin and its derivative play an anti-lung cancer effect by inducing cell apoptosis, inhibiting enzyme activity, blocking cell cycle, and reversing tumor drug resistance. It could provide a basis for the research, development and utilization of quercetin and its derivatives in lung cancer.