Advance on Nattokinase Microbial Production and Physiological Function

YAO Mingjing; YANG Yang; FAN Jing; ZHAO Xiangying; REN Likun; BIAN Xin; XING Tonglin; ZHU Pengyu; SUN Zhihui; ZHANG Na

doi:10.13386/j.issn1002-0306.2021070016

Volume 43 Issue 14

Jul. 2022

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Science and Technology of Food Industry > 2022 > 43(14): 435-444. > DOI: 10.13386/j.issn1002-0306.2021070016

YAO Mingjing, YANG Yang, FAN Jing, et al. Advance on Nattokinase Microbial Production and Physiological Function[J]. Science and Technology of Food Industry, 2022, 43(14): 435−444. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021070016.

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Advance on Nattokinase Microbial Production and Physiological Function

1.
Key Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Science and Engineering, Harbin University of Commerce, Harbin 150076, China
2.
Shandong Provincial Key Laboratory of Food and Fermentation Engineering, Shandong Food Ferment Industry Research & Design Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250013, China

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Received Date: July 01, 2021
Available Online: May 07, 2022

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Abstract

Abstract

With the improvement of people’s living standard, the number of patients with thromboembolism is increasing gradually. Among the existing thrombotic drugs, nattokinase attracts great attention due to its advantages of long half-life, strong specificity, small side effects, and can be taken orally directly. Based on the related research results at home and abroad, the structure features of nattokinase, the fibrinolytic activity and the mechanism of action of antithrombotic activity of NK are described. Also, the hard work in strain breeding, strain transformation for higher enzyme yield or better enzyme character and medium optimization are also summarized. Moreover, the physiological function of nattokinase are expounded. Finally, the challenges and future development trends of nattokinase application are prospected in order to provide theoretical basis for further research on nattokinase.
- nattokinase,
- Bacillus subtilis (natto),
- production by microbial fermentation,
- physiological function

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References (99)

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