YANG Maohui, ZHOU Xin, QIAO Zhengwen, et al. Recent Advances in Polygonatum Polysaccharides: Extraction, Isolation, Purification and Bioactivities[J]. Science and Technology of Food Industry, 2022, 43(12): 407−416. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060142.
Citation: YANG Maohui, ZHOU Xin, QIAO Zhengwen, et al. Recent Advances in Polygonatum Polysaccharides: Extraction, Isolation, Purification and Bioactivities[J]. Science and Technology of Food Industry, 2022, 43(12): 407−416. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060142.

Recent Advances in Polygonatum Polysaccharides: Extraction, Isolation, Purification and Bioactivities

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  • Received Date: June 17, 2021
  • Available Online: April 13, 2022
  • Polygonatum is a herbaceous plant of Polygonatum in Liliaceae., which has the functions of tonifying Qi, nourishing Yin, strengthening spleen, moistening lung and benefiting kidney. Polygonatum polysaccharide is one of the main components of Polygonatum and Polygonatum is rich in polysaccharides. Polygonatum polysaccharide is a kind of natural product resource used as medicine and food, in which complex structure and rich biological activity have become one of the hot spots in the development and research of food, medicine and other fields. In this paper, the extraction, purification, structure analysis and bioactivities of Polygonatum polysaccharides are reviewed. The research direction and application prospect of Polygonatum polysaccharides are prospected in order to provide theoretical reference for further development and utilization of Polygonatum polysaccharides.
  • [1]
    中国科学院中国植物志编辑委员会. 中国植物志[M]. 北京: 科学出版社, 2006(15): 52

    Editorial board of flora of China, Chinese Academy of Sciences. Flora of China[M]. Beijing: Science Press, 2006 (15): 52.
    [2]
    国家药典委员会. 中华人民共和国药典(一部)[M]. 北京: 中国医药科技出版社, 2020: 319

    State Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China[M]. Beijing: China Medical Science and Technology Press, 2020: 319.
    [3]
    陶弘景. 名医别录(尚志钧校注)[M]. 北京: 中国中医药出版社, 2013: 19−20

    TAO H J. Distinguished records of famous doctors[M]. Beijing: China traditional Chinese Medicine Press, 2013: 19−20
    [4]
    CHENG M E, WANG D Q. Anatomical structure and physiochemical localization about rhizome of five species of Polygonatum[J]. Chin H Chin Materia Med,2013,38(13):2068−2072.
    [5]
    WANG S, CUI X, CAO H, et al. A review: the bioactivities and pharmacological applications of Polygonatum sibiricum polysaccharides[J]. Molecules,2018,23(5):1170. doi: 10.3390/molecules23051170
    [6]
    WANG Y J, LIU N, XUE X, et al. Purification, structural characterization and in vivo immunoregulatory activity of a novel polysaccharide from Polygonatum sibiricum[J]. International Journal of Biological Macromolecules,2020,160:688−694. doi: 10.1016/j.ijbiomac.2020.05.245
    [7]
    LONG T T, LIU Z J, SHANG J C, et al. Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways[J]. International Journal of Biological Macromolecules, 2018(May), 111: 813-821.
    [8]
    SHEN F M, SONG Z J, XIE P, et al. Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage[J]. Journal of Ethnopharmacology,2021,275:114164. doi: 10.1016/j.jep.2021.114164
    [9]
    LI L, KIRAN T, LIAO B Y, et al. Antioxidant and antimicrobial potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua[J]. International Journal of Biological Macromolecules,2018:317−323.
    [10]
    王毅, 穆麒麟, 田小海, 等. 正交法优化黄精多糖的提取工艺[J]. 湖北农业科学,2020,59(15):114−117. [WANG Y, MU Q L, TIAN X H, et al. Optimization of extraction technology of Polygonatum polysaccharide by orthogonal design[J]. Hubei Agricultural Sciences,2020,59(15):114−117.

    WANG Y, MU Q L, TIAN X H, et al. Optimization of extraction technology of Polygonatum polysaccharide by orthogonal design[J]. Hubei Agricultural Sciences, 2020, 59(15): 114-117.
    [11]
    张梓原, 徐伟, 王鑫, 等. 黄精多糖的提取工艺对比研究[J]. 包装工程,2020,423(9):60−67. [ZHANG Z Y, XU W, WANG X, et al. Comparative study on extraction technology of Polygonatum polysaccharide[J]. Packaging Engineering,2020,423(9):60−67.

    ZHANG Z Y, XU W, WANG X, et al. Comparative study on extraction technology of Polygonatum polysaccharide[J]. Packaging Engineering, 2020, 423(9): 60-67.
    [12]
    李月, 王昀, 左绍远. 植物多糖脱色工艺研究进展[J]. 现代化工,2018,38(10):37−39. [LI Y, WANG Y, ZUO S Y. Research progress on decolorization technology of plant polysaccharides[J]. Modern chemical industry,2018,38(10):37−39.

    LI Y, WANG Y, ZUO S Y. Research progress on decolorization technology of plant polysaccharides[J]. Modern chemical industry, 2018, 38(10): 37-39.
    [13]
    YUE H, ZENG H, DING K. A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species[J]. Chinese Journal of Natural Medicines,2020,18(1):1−27. doi: 10.1016/S1875-5364(20)30001-7
    [14]
    楚冬海. 响应面分析法优化黄精多糖提取工艺及含量测定[J]. 辽宁中医杂志,2020,513(2):162−165. [CHU D H. Optimization of extraction process and determination of Polygonatum polysaccharide by response surface methodology[J]. Liaoning Journal of Traditional Chinese Medicine,2020,513(2):162−165.

    CHU D H. Optimization of extraction process and determination of Polygonatum polysaccharide by response surface methodology[J]. Liaoning Journal of Traditional Chinese Medicine, 2020, 513(2): 162-165.
    [15]
    李智敏, 石瑶, 赵纯希, 等. 滇黄精多糖的提取工艺及其抗氧化活性研究[J]. 云南民族大学学报(自然科学版),2020,124(6):13−18. [LI Z M, SHI Y, ZHAO C X, et al. Study on extraction technology and antioxidant activity of Polygonatum kingianum polysaccharide[J]. Journal of Yunnan University for Nationalities (Natural Science Edition),2020,124(6):13−18.

    LI Z M, SHI Y, ZHAO C X, et al. Study on extraction technology and antioxidant activity of Polygonatum kingianum polysaccharide[J]. Journal of Yunnan University for Nationalities (Natural Science Edition), 2020, 124(6): 13-18.
    [16]
    赵瑞萌, 孙庭阁, 张玲. 碱法提取黄精多糖及提取工艺流程的优化[J]. 泰山医学院学报,2010(1):45−47. [ZHAO R M, SUN T G, ZHANG L. Optimization of alkali extraction of Polygonatum polysaccharide and extraction process[J]. Journal of Taishan Medical College,2010(1):45−47.

    ZHAO R M, SUN T G, ZHANG L. Optimization of alkali extraction of Polygonatum polysaccharide and extraction process[J]. Journal of Taishan Medical College, 2010(1): 45-47.
    [17]
    魏炜, 李彦伟, 刘凤霞, 等. 响应面法优化超高压提取黄精多糖工艺[J]. 精细化工,2019,36(5):875−881. [WEI W, LI Y W, LIU F X, et al. Optimization of ultra high pressure extraction of Polygonatum polysaccharide by response surface methodology[J]. Fine Chemical Industry,2019,36(5):875−881.

    WEI W, LI Y W, LIU F X, et al. Optimization of ultra high pressure extraction of Polygonatum polysaccharide by response surface methodology[J]. Fine Chemical Industry, 2019, 36(5): 875-881.
    [18]
    杨军宣, 张毅, 吕姗珊, 等. 减压内部沸腾法提取黄精多糖的工艺[J]. 中成药,2016(2):460−463. [YANG J X, ZHANG Y, LÜ S S, et al. Extraction technology of Polygonatum polysaccharide by vacuum internal boiling method[J]. Chinese Patent Medicine,2016(2):460−463.

    YANG J X, ZHANG Y, LV S S, et al. Extraction technology of Polygonatum polysaccharide by vacuum internal boiling method[J]. Chinese Patent Medicine, 2016(2): 460-463.
    [19]
    陈艳, 王杰, 李慧, 等. 黄精多糖的闪式提取及对乳酸菌发酵特性的影响[J]. 食品工业,2017(6):161−166. [CHEN Y, WANG J, LI H, et al. Flash extraction of Polygonatum polysaccharide and its effect on fermentation characteristics of lactic acid bacteria[J]. Food Industry,2017(6):161−166.

    CHEN Y, WANG J, LI H, et al. Flash extraction of Polygonatum polysaccharide and its effect on fermentation characteristics of lactic acid bacteria[J]. Food Industry, 2017(6): 161-166.
    [20]
    胡芳, 周娟娟, 陈爱娟. 黄精多糖微波辅助提取工艺研究[J]. 现代中药研究与实践,2015,29(4):52−54. [HU F, ZHOU J J, CHEN A J. Microwave assisted extraction of Polygonatum polysaccharide[J]. Research and Practice of Modern Chinese medicine,2015,29(4):52−54.

    HU F, ZHOU J J, CHEN A J. Microwave assisted extraction of Polygonatum polysaccharide[J]. Research and Practice of Modern Chinese medicine, 2015, 29(4): 52-54.
    [21]
    杜泽飞, 陶爱恩, 夏从龙, 等. 正交试验优选滇黄精中多糖超声提取工艺研究[J]. 海峡药学,2019,236(9):56−58. [DU Z F, TAO A E, XIA C L, et al. Optimization of ultrasonic extraction technology of polysaccharide from Polygonatum kingianum by orthogonal test[J]. Strait Pharmacy,2019,236(9):56−58.

    DU Z F, TAO A E, XIA C L, et al. Optimization of ultrasonic extraction technology of polysaccharide from Polygonatum kingianum by orthogonal test[J]. Strait Pharmacy, 2019, 236(9): 56-58.
    [22]
    ZHANG H, CAI X T, TIAN Q H, et al. Microwave assisted degradation of polysaccharide from Polygonatum sibiricum and antioxidant activity[J]. Journal of Food Science,2019,4(4):754−761.
    [23]
    雍潘. 多花黄精的多糖提取, 纯化, 结构解析及活性研究[D]. 成都: 西南民族大学, 2019

    YONG P. Extraction, purification, structure elucidation and bioactivity of Polygonatum multiflorum[D]. Chengdu: Southwest University for Nationalities, 2019.
    [24]
    杨德, 薛淑静, 黄蕾, 等. Box-Behnken设计优化黄精多糖酶法提取工艺[J]. 湖北农业科学,2017,56(16):3121−3124. [YANG D, XUE S J, HUANG L, et al. Optimization of enzymatic extraction process of Polygonatum polysaccharide by Box Behnken design[J]. Hubei Agricultural Sciences,2017,56(16):3121−3124.

    YANG D, XUE S J, HUANG L, et al. Optimization of enzymatic extraction process of Polygonatum polysaccharide by Box Behnken design[J]. Hubei Agricultural Sciences, 2017, 56(16): 3121-3124.
    [25]
    苑璐, 冷凯良, 周余航, 等. 复合酶解法优化黄精多糖提取工艺[J]. 食品与生物技术学报,2017(9):106−111. [YUAN L, LENG K L, ZHOU Y H, et al. Optimization of extraction process of Polygonatum polysaccharide by complex enzymatic hydrolysis[J]. Journal of Food and Biotechnology,2017(9):106−111.

    YUAN L, LENG K L, ZHOU Y H, et al. Optimization of extraction process of Polygonatum polysaccharide by complex enzymatic hydrolysis[J]. Journal of Food and Biotechnology, 2017(9): 106-111.
    [26]
    刘日斌, 张宇鹏, 马崇坚, 等. 超声波辅助酶法优化黄精多糖提取工艺的研究[J]. 食品研究与开发,2021,42(7):141−146. [LIU R B, ZHANG Y P, MA C J, et al. Optimization of extraction technology of Polygonatum polysaccharide by ultrasonic assisted enzymatic method[J]. Food Research and Development,2021,42(7):141−146.

    LIU R B, ZHANG Y P, MA C J, et al. Optimization of extraction technology of Polygonatum polysaccharide by ultrasonic assisted enzymatic method[J]. Food Research and Development, 2021, 42(7): 141-146.
    [27]
    周桃英, 陈年友, 陈中建, 等. 超声波-微波协同法提取黄精多糖工艺研究[J]. 江苏农业科学,2013,41(6):231−233. [ZHOU T Y, CHEN N Y, CHEN Z J, et al. Study on extraction technology of Polygonatum polysaccharide by ultrasonic microwave synergistic method[J]. Jiangsu Agricultural Sciences,2013,41(6):231−233. doi: 10.3969/j.issn.1002-1302.2013.06.085

    ZHOU T Y, CHEN N Y, CHEN Z J, et al. Study on extraction technology of Polygonatum polysaccharide by ultrasonic microwave synergistic method[J]. Jiangsu Agricultural Sciences, 2013, 41(6): 231-233. doi: 10.3969/j.issn.1002-1302.2013.06.085
    [28]
    刘小攀, 田启建, 田春莲. 黄精多糖酶法脱蛋白的工艺研究[J]. 西北林学院学报,2016,31(1):238−242. [LIU X P, TIAN Q J, TIAN C L. Study on enzymatic deproteinization of Polygonatum polysaccharide[J]. Journal of Northwest Forestry University,2016,31(1):238−242. doi: 10.3969/j.issn.1001-7461.2016.01.41

    LIU X P, TIAN Q J, TIAN C L. Study on enzymatic deproteinization of Polygonatum polysaccharide[J]. Journal of Northwest Forestry University, 2016, 31 (1): 238-242. doi: 10.3969/j.issn.1001-7461.2016.01.41
    [29]
    施伽, 杨浩, 杨思文, 等. 三氯乙酸法脱除黄精多糖中蛋白的工艺优化[J]. 安徽农学通报,2017,23(6):35−37. [SHI J, YANG H, YANG S W, et al. Optimization of protein removal from Polygonatum polysaccharide by trichloroacetic acid method[J]. Anhui Agronomy Bulletin,2017,23(6):35−37.

    SHI J, YANG H, YANG S W, et al. Optimization of protein removal from Polygonatum polysaccharide by trichloroacetic acid method[J]. Anhui Agronomy Bulletin, 2017, 23(6): 35-37.
    [30]
    李旭颖. 黄精多糖的提取工艺及提取液树脂法脱色的研究[J]. 化工管理,2015(26):230. [LI X Y. Study on extraction technology of Polygonatum polysaccharide and decolorization of extract by resin method[J]. Chemical Management,2015(26):230. doi: 10.3969/j.issn.1008-4800.2015.26.192

    LI X Y. Study on extraction technology of Polygonatum polysaccharide and decolorization of extract by resin method[J]. Chemical Management, 2015(26): 230. doi: 10.3969/j.issn.1008-4800.2015.26.192
    [31]
    梁引库, 吴三桥. 黄精多糖脱色和脱蛋白工艺研究[J]. 食品科技,2012(12):166−169. [LIANG Y K, WU S Q. Decolorization and deproteinization of Polygonatum polysaccharide[J]. Food Science and Technology,2012(12):166−169.

    LIANG Y K, WU S Q. Decolorization and deproteinization of Polygonatum polysaccharide[J]. Food Science and Technology, 2012(12): 166-169.
    [32]
    王艳, 董鹏, 金晨钟, 等. 黄精多糖组成及其抗氧化活性分析[J]. 基因组学与应用生物学,2019,38(5):2191−2199. [WANG Y, DONG P, JIN C Z, et al. Composition and antioxidant activity of Polygonatum sibiricum polysaccharides[J]. Genomics and Applied Biology,2019,38(5):2191−2199.

    WANG Y, DONG P, JIN C Z, et al. Composition and antioxidant activity of Polygonatum sibiricum polysaccharides[J]. Genomics and Applied Biology, 2019, 38(5): 2191-2199
    [33]
    张庭廷, 胡威, 汪好芬, 等. 九华山黄精多糖的分离纯化及化学表征[J]. 食品科学,2011(10):48−51. [ZHANG T T, HU W, WANG H F, et al. Isolation, purification and chemical characterization of polysaccharides from Polygonatum jiuhuashanense[J]. Food Science,2011(10):48−51.

    ZHANG T T, HU W, WANG H F, et al. Isolation, purification and chemical characterization of polysaccharides from Polygonatum jiuhuashanense[J]. Food Science, 2011(10): 48-51
    [34]
    LI R, TAO A, YANG R, et al. Structural characterization, hypoglycemic effects and antidiabetic mechanism of a novel polysaccharides from Polygonatum kingianum Coll. et Hemsl[J]. Biomedicine & Pharmacotherapy,2020(131):110687.
    [35]
    王坤, 岳永德, 汤锋, 等. 多花黄精多糖的分级提取及结构初步分析[J]. 天然产物研究与开发,2014,26(3):364−369. [WANG K, YUE YUE Y D, TANG F, et al. Hierarchical extraction and preliminary structure analysis of Polygonatum polysaccharide[J]. Research and Development of Natural Products,2014,26(3):364−369.

    WANG K, YUE YUE Y D, TANG F, et al. Hierarchical extraction and preliminary structure analysis of Polygonatum polysaccharide[J]. Research and Development of Natural Products, 2014, 26(3): 364-369.
    [36]
    LIU N, DONG Z, ZHU X, et al. Characterization and protective effect of Polygonatum sibiricum polysaccharide against cyclophosphamide-induced immunosuppression in Balb/c mice[J]. International Journal of Biological Macromolecules, 2018, 107: 796-802
    [37]
    CHEN Z, LIU J, KONG X, et al. Characterization and Immunological Activities of polysaccharides from Polygonatum sibiricum[J]. Biological & Pharmaceutical Bulletin,2020,43(6):959−967.
    [38]
    SHU G, XU D, ZHAO J, et al. Protective effect of Polygonatum sibiricum polysaccharide on cyclophosphamide-induced immunosuppression in chickens[J]. Research in Veterinary Science,2021:135.
    [39]
    叶绍凡. 黄精多糖对力竭运动小鼠胸腺胸腺指数, 脾脏指数, T淋巴细胞亚群, 巨噬细胞吞噬功能的影响[J]. 基因组学与应用生物学,2015,34(1):60−65. [YE S F. Effects of Polygonatum polysaccharide on thymus index, spleen index, tlymphocyte subsets and phagocytic function of macrophages in exhausted exercise mice[J]. Genomics and Applied Biology,2015,34(1):60−65.

    YE S F. Effects of Polygonatum polysaccharide on thymus index, spleen index, tlymphocyte subsets and phagocytic function of macrophages in exhausted exercise mice[J]. Genomics and Applied Biology, 2015, 34(1): 60-65.
    [40]
    华岩, 周碎平, 梁金孟. 黄精多糖对大强度运动大鼠外周血肌酸激酶, 尿素氮及部分免疫指标的影响[J]. 现代预防医学,2019,46(5):875−878. [HUA Y, ZHOU X P, LIANG J M. Effects of Polygonatum polysaccharide on creatine kinase, urea nitrogen and some immune indexes in peripheral blood of rats with high intensity exercise[J]. Modern Preventive Medicine,2019,46(5):875−878.

    HUA Y, ZHOU X P, LIANG J M. Effects of Polygonatum polysaccharide on creatine kinase, urea nitrogen and some immune indexes in peripheral blood of rats with high intensity exercise[J]. Modern Preventive Medicine, 2019, 46(5): 875-878.
    [41]
    HUANG H, CHEN F, LONG R, et al. The antioxidant activities in vivo of bitter gourd polysaccharide[J]. International Journal of Biological Macromolecules,2019:145.
    [42]
    DUAN M Y, SHANG H M, CHEN S L, et al. Physicochemical properties and activities of comfrey polysaccharides extracted by different techniques[J]. International Journal of Biological Macromolecules,2018:876−882.
    [43]
    原丽容, 叶艺璐. 黄精多糖体外抗氧化作用研究[J]. 海峡药学,2020,241(2):22−25. [YUAN L R, YE Y L. Study on antioxidant effect of Polygonatum polysaccharide in vitro[J]. Taiwan Pharmaceutical,2020,241(2):22−25. doi: 10.3969/j.issn.1006-3765.2020.02.007

    YUAN L R, YE Y L. Study on antioxidant effect of Polygonatum polysaccharide in vitro[J]. Taiwan Pharmaceutical, 2020, 241(2): 22-25. doi: 10.3969/j.issn.1006-3765.2020.02.007
    [44]
    TRISHNA D, SA R P, DA H K, et al. Antioxidant and anti-inflammatory activity of Polygonatum sibiricum rhizome extracts[J]. Asian Pacific Journal of Tropical Disease,2013,3(4):308−313. doi: 10.1016/S2222-1808(13)60074-2
    [45]
    宫江宁, 云成悦, 吴婕, 等. 黄精多糖的提取优化及抗氧化活性研究[J]. 贵州师范大学学报:自然科学版,2019,37(3):18−23. [GONG J N, YUN C Y, WU J, et al. Study on extraction optimization and antioxidant activity of Polygonatum polysaccharide[J]. Journal of Guizhou Normal University: Natural Science Edition,2019,37(3):18−23.

    GONG J N, YUN C Y, WU J, et al. Study on extraction optimization and antioxidant activity of Polygonatum polysaccharide[J]. Journal of Guizhou Normal University: Natural Science Edition, 2019, 37(3): 18-23.
    [46]
    LIU Y T, YOU Y X, LI Y W, et al. The characterization, selenylation and antidiabetic activity of mycelial polysaccharides from Catathelasma ventricosum[J]. Carbohydrate Polymers,2017,174:72−81. doi: 10.1016/j.carbpol.2017.06.050
    [47]
    LU J M, WANG Y F, YAN H L, et al. Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats[J]. Journal of Ethnopharmacology,2015,179:291−300.
    [48]
    王艺, 彭国庆, 江新泉, 等. 黄精多糖对糖尿病大鼠模型的保护机制研究[J]. 中医药导报,2017,23(2):8−16. [WANG Y, PENG G Q, JIANG X Q, et al. Protective mechanism of Polygonatum sibiricum polysaccharides on diabetic rat model[J]. Chinese Medicine Guide,2017,23(2):8−16.

    WANG Y, PENG G Q, JIANG X Q, et al. Protective mechanism of Polygonatum sibiricum polysaccharides on diabetic rat model[J]. Chinese Medicine Guide, 2017, 23(2): 8-16.
    [49]
    王秋丽, 童小慧, 李小东, 等. 多花黄精多糖对STZ诱导的Ⅰ型糖尿病小鼠影响作用研究[J]. 云南中医学院学报,2019(1):1−7. [WANG Q L, DONG X H, LI X D, et al. Effects of Polygonatum sibiricum polysaccharides on STZ induced type 1 diabetic mice[J]. Journal of Yunnan University of Traditional Chinese Medicine,2019(1):1−7.

    WANG Q L, DONG X H, LI X D, et al. Effects of Polygonatum sibiricum polysaccharides on STZ induced type 1 diabetic mice[J]. Journal of Yunnan University of Traditional Chinese Medicine, 2019(1): 1-7.
    [50]
    GU W, WANG Y, ZENG L, et al. Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet[J]. Biomedicine & Pharmacotherapy=Biomedecine & Pharmacotherapie,2020,125:109910.
    [51]
    汪光军, 李九九, 何立峰, 等. 黄精多糖预防小鼠糖脂代谢紊乱的作用研究[J]. 食品安全质量检测学报,2020,11(21):189−196. [WANG G J, LI J J, HE L F, et al. Study on the preventive effect of Polygonatum polysaccharide on glucose and lipid metabolism disorder in mice[J]. Journal of Food Safety and Quality Inspection,2020,11(21):189−196.

    WANG G J, LI J J, HE L F, et al. Study on the preventive effect of Polygonatum polysaccharide on glucose and lipid metabolism disorder in mice[J]. Journal of Food Safety and Quality Inspection, 2020, 11(21): 189-196.
    [52]
    贾璐, 石洁, 段志倩, 等. 黄精多糖对高脂饲料诱发糖尿病小鼠糖代谢功能的影响[J]. 中国医药导报,2017,14(8):24−28. [JIA L, SHI J, DUAN Z Q, et al. Effects of Polygonatum sibiricum polysaccharide on glucose metabolism in diabetic mice induced by high-fat diet[J]. China Medical Journal,2017,14(8):24−28.

    JIA L, SHI J, DUAN Z Q, et al. Effects of Polygonatum sibiricum polysaccharide on glucose metabolism in diabetic mice induced by high-fat diet[J]. China Medical Journal, 2017, 14(8): 24-28.
    [53]
    孔瑕, 刘娇娇, 李慧, 等. 黄精多糖对高脂血症小鼠脂代谢相关基因mRNA及蛋白表达的影响[J]. 中国中药杂志,2018,43(18):3740−3747. [KONG X, LIU J J, LI H, et al. Effect of Polygonatum polysaccharide on mRNA and protein expression of lipid metabolism related genes in hyperlipidemic mice[J]. Chinese Journal of Traditional Chinese Medicine,2018,43(18):3740−3747.

    KONG X, LIU J J, LI H, et al. Effect of Polygonatum polysaccharide on mRNA and protein expression of lipid metabolism related genes in hyperlipidemic mice[J]. Chinese Journal of Traditional Chinese Medicine, 2018, 43(18): 3740-3747.
    [54]
    陈婷婷, 王国贤, 付婷婷, 等. 黄精多糖对Ⅰ型糖尿病大鼠心肌炎症的保护作用[J]. 中药药理与临床,2015(4):86−90. [CHEN T T, WANG G X, FU T T, et al. Protective effect of Polygonatum polysaccharide on myocarditis in type[J]. Diabetic Rats, Chinese Medicine Pharmacology and Clinic,2015(4):86−90.

    CHEN T T, WANG G X, FU T T, et al. Protective effect of Polygonatum polysaccharide on myocarditis in type[J]. Diabetic Rats, Chinese Medicine Pharmacology and Clinic, 2015 (4): 86-90.
    [55]
    HAN C, SUN T, LIU Y, et al. Protective effect of Polygonatum sibiricum polysaccharides on gentamicin-induced acute kidney injury in rats via inhibiting p38 MAPK/ATF2 pathway[J]. International Journal of Biological Macromolecules,2020:151.
    [56]
    吕品田, 段昕波. 黄精多糖对MFC胃癌荷瘤小鼠抑瘤及免疫调节作用[J]. 中成药,2020,42(8):2169−2172. [LÜ P T, DUAN X B. Antitumor and immunomodulatory effects of Polygonatum polysaccharide on MFC gastric cancer bearing mice[J]. Chinese Patent Medicine,2020,42(8):2169−2172. doi: 10.3969/j.issn.1001-1528.2020.08.041

    LV P T, DUAN X B. Antitumor and immunomodulatory effects of Polygonatum polysaccharide on MFC gastric cancer bearing mice[J]. Chinese Patent Medicine, 2020, 42(8): 2169-2172. doi: 10.3969/j.issn.1001-1528.2020.08.041
    [57]
    XIE Y, JIANG Z, YANG R, et al. Polysaccharide-rich extract from Polygonatum sibiricum protects hematopoiesis in bone marrow suppressed by triple negative breast cancer[J]. Biomedicine & Pharmacotherapy,2021,137(6):111338.
    [58]
    李超彦, 周媛媛, 王福青. 黄精多糖联合低剂量顺铂对小鼠H22肝癌移植瘤生长的抑制及其抗氧化损伤作用[J]. 中国老年学杂志,2016,36(5):1038−1040. [LI C Y, ZHOU YY, WANG F Q. Inhibitory effect of Polygonatum polysaccharide combined with low-dose cisplatin on the growth of H22 hepatoma xenografts in mice and its antioxidant damage[J]. Chinese Journal of Gerontology,2016,36(5):1038−1040. doi: 10.3969/j.issn.1005-9202.2016.05.006

    LI C Y, ZHOU YY, WANG F Q. Inhibitory effect of Polygonatum polysaccharide combined with low-dose cisplatin on the growth of H22 hepatoma xenografts in mice and its antioxidant damage[J]. Chinese Journal of Gerontology, 2016, 36(5): 1038-1040. doi: 10.3969/j.issn.1005-9202.2016.05.006
    [59]
    YANG S F, ZHUANG T F, SI Y M, et al. Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways[J]. Mol Immunol,2015(64):144−151.
    [60]
    ZHOU W, HONG J, ZHU J, et al. Effects of Polygonatum sibiricum polysaccharides (PSP) on human esophageal squamous cell carcinoma (ESCC) via NF-κB signaling pathway[J]. International Journal of Polymer Science,2019(8):1−9.
    [61]
    LI L, THAKUR K, CAO Y Y, et al. Anticancerous potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua in human cervical cancer Hela cells[J]. International Journal of Biological Macromolecules,2020,148(1):843−850.
    [62]
    LIU X X, WAN Z J, SHI L, et al. Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua[J]. Carbohydrate Polymers,2011,83(2):737−742. doi: 10.1016/j.carbpol.2010.08.044
    [63]
    李友元, 成威, 邓洪波, 等. 黄精多糖对App转基因小鼠大脑及性腺组织端粒酶活性的影响[J]. 中国新药与临床杂志,2008,27(11):844−846. [LI Y Y, CHENG W, DENG H B, et al. Effect of Polygonatum polysaccharide on telomerase activity in brain and gonad of APP transgenic mice[J]. Chinese Journal of New Drugs and Clinical Medicine,2008,27(11):844−846. doi: 10.3969/j.issn.1007-7669.2008.11.011

    LI Y Y, CHENG W, DENG H B, et al. Effect of Polygonatum polysaccharide on telomerase activity in brain and gonad of APP transgenic mice[J]. Chinese Journal of New Drugs and Clinical Medicine, 2008, 27(11): 844-846. doi: 10.3969/j.issn.1007-7669.2008.11.011
    [64]
    张涛, 金英, 魏晓东, 等. 黄精多糖对衰老小鼠肝线粒体呼吸链酶及DNA聚合酶γ表达的影响[J]. 中国老年学杂,2009,29(16):2076−2077. [ZHANG T, JIN Y, WEI X D, et al. Effects of Polygonatum polysaccharide on the activities of respiratory chain enzyme and expression of DNA polymerase γ in liver mitochondria of aging mice[J]. Chinese Journal of Gerontology,2009,29(16):2076−2077.

    ZHANG T, JIN Y, WEI X D, et al. Effects of Polygonatum polysaccharide on the activities of respiratory chain enzyme and expression of DNA polymerase γ in liver mitochondria of aging mice[J]. Chinese Journal of Gerontology, 2009, 29(16): 2076-2077.
    [65]
    王威, 刘文博, 唐伟, 等. 黄精多糖对慢性脑缺血大鼠学习记忆及脑组织β-淀粉样蛋白表达的影响[J]. 中医药导报,2016,22(16):26−29. [WANG W, LIU W B, TANG W, et al. Effects of Polygonatum polysaccharide on learning and memory and β-amyloid protein expression of brain tissue in rats with chronic cerebral ischemia[J]. Guide of Traditional Chinese Medicine,2016,22(16):26−29.

    WANG W, LIU W B, TANG W, et al. Effects of Polygonatum polysaccharide on learning and memory and β-amyloid protein expression of brain tissue in rats with chronic cerebral ischemia[J]. Guide of Traditional Chinese Medicine, 2016, 22 (16): 26-29.
    [66]
    ZHANG H, CAO Y, CHEN L, et al. A polysaccharide from Polygonatum sibiricum attenuates amyloid-β-induced neurotoxicity in PC12 cells[J]. Carbohydrate Polymers,2015,117:879−886. doi: 10.1016/j.carbpol.2014.10.034
    [67]
    ZHU X Y, WU W, CHEN X Y, et al. Protective effects of Polygonatum sibiricum polysaccharide on acute heart failure in rats 1[J]. Acta Cirurgica Brasileira,2018,33(10):868−878. doi: 10.1590/s0102-865020180100000001
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