Research Progress on Anti-tumor Effects of Theaflavins

CHEN Xiaojing; ZHU Jinwei; ZHANG Chen; ZHOU Zhengjiang; YU Lihui; FANG Chongye

doi:10.13386/j.issn1002-0306.2021060134

Volume 43 Issue 12

Jun. 2022

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Science and Technology of Food Industry > 2022 > 43(12): 398-406. > DOI: 10.13386/j.issn1002-0306.2021060134

CHEN Xiaojing, ZHU Jinwei, ZHANG Chen, et al. Research Progress on Anti-tumor Effects of Theaflavins[J]. Science and Technology of Food Industry, 2022, 43(12): 398−406. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060134.

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Research Progress on Anti-tumor Effects of Theaflavins

Tea Academy, Yunnan Agricultural University, Yunnan Province Tea Further Processing Engineering Technology Study Center, Kunming 650201, China

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Received Date: June 16, 2021
Available Online: April 07, 2022

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Abstract

Abstract

Theaflavins (TFs) are benzopropenoids containing multiple phenolic hydroxyl groups with broad-spectrum pharmacological activities, which can control and regulate the expression of tumour-initiating enzymes or related factors or promote apoptosis, inhibit tumour cell proliferation and metastasis, thus efficiently participating in both pre-cancer prevention and post-cancer treatment. This review summarizes the available in vitro and in vivo evidence, using various tumour cell lines and animal models, to demonstrate that theophyllin inhibits tumour cell proliferation, growth and metastasis mainly by inducing cell cycle arrest and apoptosis, and identifies the targets of action of theophyllin in some tumours, with far-reaching implications for the prevention and treatment of some tumours.
- theaflavins,
- tumor cells,
- cell proliferation,
- cell apoptosis,
- cycle arrest

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References

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