Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression

YE Lufen; SONG Xujiao; MA Hao

doi:10.13386/j.issn1002-0306.2021030387

Volume 43 Issue 7

Mar. 2022

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2022 > 43(7): 424-429. > DOI: 10.13386/j.issn1002-0306.2021030387

YE Lufen, SONG Xujiao, MA Hao. Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression[J]. Science and Technology of Food Industry, 2022, 43(7): 424−429. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021030387.

Citation:

PDF (2079 KB)

Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression

1.
College of Chemistry and Biological Engineering, Yichun University, Yichun 336000, China
2.
Aesthetic Medical School, Yichun University, Yichun 336000, China

More Information

Received Date: March 30, 2021
Available Online: January 29, 2022

Graphical Abstract

Abstract

Abstract

With the rapid development of biomedicine, a series of studies have shown that there is a close relationship between depression and intestinal microorganisms. Patients with depression are usually accompanied by changes in the species, relative abundance and metabolites of intestinal microflora. Short-chain fatty acids, the metabolites of intestinal flora, are important mediators that connect the host and intestinal flora. They have biological effects and affect the physiological function of the host. In recent years, the prevention and treatment of depression based on short-chain fatty acids has been a hot topic in this field. The content of short-chain fatty acids in the intestinal tract affects the occurrence and development of depression. This article mainly reviews the possible mechanisms of SCFA on depression (regulating hypothalamus-pituitary-adrenal axis, affecting tryptophan metabolism and reducing inflammation) and the possible ways of exogenous intervention in the treatment of depression (edible probiotics, probiotics and fecal flora transplantation), in order to provide theoretical reference for the development of new depression treatment drugs.
- depression,
- metabolites of intestinal flora,
- short-chain fatty acids (SCFA),
- hypothalamic-pituitary-adrenal axis,
- tryptophan (Trp)

FullText(HTML)

References (50)

References

[1]	ZHOU B, ZHU Z, RANSOM B R, et al. Oligodendrocyte lineage cells and depression[J]. Molecular Psychiatry,2020:1−15.
[2]	SOCHOCKA M, DONSKOW-ŁYSONIEWSKA K, DINIZ B S, et al. The gut microbiome alterations and inflammation-driven pathogenesis of Alzheimer’s disease—a critical review[J]. Molecular Neurobiology,2019,56(3):1841−1851. doi: 10.1007/s12035-018-1188-4
[3]	DINAN T G, CRYAN J F. The microbiome-gut-brain axis in health and disease[J]. Gastroenterology Clinics,2017,46(1):77−89. doi: 10.1016/j.gtc.2016.09.007
[4]	KOH A, DE VADDER F, KOVATCHEVA-DATCHARY P, et al. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites[J]. Cell,2016,165(6):1332−1345. doi: 10.1016/j.cell.2016.05.041
[5]	REIGSTAD C S, SALMONSON C E, RAINEY J F, et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells[J]. The Faseb Journal,2015,29(4):1395−1403. doi: 10.1096/fj.14-259598
[6]	MARKOWIAK-KOPEĆ P, ŚLIŻEWSKA K. The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome[J]. Nutrients,2020,12(4):1107. doi: 10.3390/nu12041107
[7]	SKONIECZNA-ŻYDECKA K, GROCHANS E, MACIEJEWSKA D, et al. Faecal short chain fatty acids profile is changed in Polish depressive women[J]. Nutrients,2018,10(12):1939. doi: 10.3390/nu10121939
[8]	KELLY J R, BORRE Y, O'BRIEN C, et al. Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat[J]. Journal of Psychiatric Research,2016,82:109−118. doi: 10.1016/j.jpsychires.2016.07.019
[9]	WINTER G, HART R A, CHARLESWORTH R P G, et al. Gut microbiome and depression: What we know and what we need to know[J]. Reviews in the Neurosciences,2018,29(6):629−643. doi: 10.1515/revneuro-2017-0072
[10]	NEIS E P J G, DEJONG C H C, RENSEN S S. The role of microbial amino acid metabolism in host metabolism[J]. Nutrients,2015,7(4):2930−2946. doi: 10.3390/nu7042930
[11]	LAYDEN B T, ANGUEIRA A R, BRODSKY M, et al. Short chain fatty acids and their receptors: New metabolic targets[J]. Translational Research,2013,161(3):131−140. doi: 10.1016/j.trsl.2012.10.007
[12]	LOUIS P, FLINT H J. Formation of propionate and butyrate by the human colonic microbiota[J]. Environmental Microbiology,2017,19(1):29−41. doi: 10.1111/1462-2920.13589
[13]	FROST G, SLEETH M L, SAHURI-ARISOYLU M, et al. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism[J]. Nature Communications,2014,5(1):1−11.
[14]	KAJI I, KARAKI S, KUWAHARA A. Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release[J]. Digestion,2014,89(1):31−36. doi: 10.1159/000356211
[15]	GONZÁLEZ HERNÁNDEZ M A, CANFORA E E, JOCKEN J W E, et al. The short-chain fatty acid acetate in body weight control and insulin sensitivity[J]. Nutrients,2019,11(8):1943. doi: 10.3390/nu11081943
[16]	OKAMOTO T, MORINO K, UGI S, et al. Microbiome potentiates endurance exercise through intestinal acetate production[J]. American Journal of Physiology-Endocrinology and Metabolism,2019,316(5):E956−E966. doi: 10.1152/ajpendo.00510.2018
[17]	BHATTARAI Y, SCHMIDT B A, LINDEN D R, et al. Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology,2017,313(1):G80−G87. doi: 10.1152/ajpgi.00448.2016
[18]	HIRSCHBERG S, GISEVIUS B, DUSCHA A, et al. Implications of diet and the gut microbiome in neuroinflammatory and neurodegenerative diseases[J]. International Journal of Molecular Sciences,2019,20(12):3109. doi: 10.3390/ijms20123109
[19]	LI J, HOU L, WANG C, et al. Short term intrarectal administration of sodium propionate induces antidepressant-like effects in rats exposed to chronic unpredictable mild stress[J]. Frontiers in Psychiatry,2018,9:454. doi: 10.3389/fpsyt.2018.00454
[20]	MANRIQUE V D, GONZÁLEZ S M E. Ácidos grasos de cadena corta (ácido butírico) y patologías intestinales[J]. Nutrición Hospitalaria,2017,34:58−61.
[21]	SUN J, WANG F, HONG G, et al. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress[J]. Neuroscience Letters,2016,618:159−166. doi: 10.1016/j.neulet.2016.03.003
[22]	WU M, TIAN T, MAO Q, et al. Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice[J]. Translational Psychiatry,2020,10(1):1−10. doi: 10.1038/s41398-019-0665-5
[23]	SPENCER R L, DEAK T. A users guide to HPA axis research[J]. Physiology & Behavior,2017,178:43−65.
[24]	SUDO N. Microbiome, HPA axis and production of endocrine hormones in the gut[M]//Microbial endocrinology: The microbiota-gut-brain axis in health and disease. Springer, New York, NY, 2014: 177−194.
[25]	WOELFER M, KASTIES V, KAHLFUSS S, et al. The role of depressive subtypes within the neuroinflammation hypothesis of major depressive disorder[J]. Neuroscience,2019,403:93−110. doi: 10.1016/j.neuroscience.2018.03.034
[26]	KELLER J, GOMEZ R, WILLIAMS G, et al. HPA axis in major depression: Cortisol, clinical symptomatology and genetic variation predict cognition[J]. Molecular Psychiatry,2017,22(4):527−536. doi: 10.1038/mp.2016.120
[27]	VAN DE WOUW M, BOEHME M, LYTE J M, et al. Short-chain fatty acids: Microbial metabolites that alleviate stress-induced brain-gut axis alterations[J]. The Journal of physiology,2018,596(20):4923−4944. doi: 10.1113/JP276431
[28]	ALCAINO C, KNUTSON K R, TREICHEL A J, et al. A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release[J]. Proceedings of the National Academy of Sciences,2018,115(32):7632−7641. doi: 10.1073/pnas.1804938115
[29]	DELL'OSSO L, CARMASSI C, MUCCI F, et al. Depression, serotonin and tryptophan[J]. Current Pharmaceutical Design,2016,22(8):949−954. doi: 10.2174/1381612822666151214104826
[30]	AGUS A, PLANCHAIS J, SOKOL H. Gut microbiota regulation of tryptophan metabolism in health and disease[J]. Cell Host & Microbe,2018,23(6):716−724.
[31]	STRASSER B, GOSTNER J M, FUCHS D. Mood, food, and cognition: Role of tryptophan and serotonin[J]. Current Opinion in Clinical Nutrition & Metabolic Care,2016,19(1):55−61.
[32]	VINCENT A D, WANG X Y, PARSONS S P, et al. Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology,2018,315(5):G896−G907. doi: 10.1152/ajpgi.00237.2017
[33]	JACOB L, ROCKEL T, KOSTEV K. Depression risk in patients with rheumatoid arthritis in the United Kingdom[J]. Rheumatology and Therapy,2017,4(1):195−200. doi: 10.1007/s40744-017-0058-2
[34]	BAUER M E, TEIXEIRA A L. Inflammation in psychiatric disorders: What comes first?[J]. Annals of the New York Academy of Sciences,2019,1437(1):57−67. doi: 10.1111/nyas.13712
[35]	BEUREL E, TOUPS M, NEMEROFF C B. The bidirectional relationship of depression and inflammation: Double trouble[J]. Neuron,2020,107(2):234−256. doi: 10.1016/j.neuron.2020.06.002
[36]	WILCK N, MATUS M G, KEARNEY S M, et al. Salt-responsive gut commensal modulates TH 17 axis and disease[J]. Nature,2017,551(7682):585−589. doi: 10.1038/nature24628
[37]	FARZI A, FRÖHLICH E E, HOLZER P. Gut microbiota and the neuroendocrine system[J]. Neurotherapeutics,2018,15(1):5−22. doi: 10.1007/s13311-017-0600-5
[38]	VENEGAS D P, FUENTE M, LANDSKRON G, et al. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases[J]. Frontiers in Immunology,2019,10:277. doi: 10.3389/fimmu.2019.00277
[39]	MIYAMOTO J, HASEGAWA S, KASUBUCHI M, et al. Nutritional signaling via free fatty acid receptors[J]. International Journal of Molecular Sciences,2016,17(4):450. doi: 10.3390/ijms17040450
[40]	KIMURA I, ICHIMURA A, OHUE-KITANO R, et al. Free fatty acid receptors in health and disease[J]. Physiological Reviews,2020,100(1):171−210. doi: 10.1152/physrev.00041.2018
[41]	SILVA L G, FERGUSON B S, AVILA A S, et al. Sodium propionate and sodium butyrate effects on histone deacetylase (HDAC) activity, histone acetylation, and inflammatory gene expression in bovine mammary epithelial cells[J]. Journal of Animal Science,2018,96(12):5244−5252.
[42]	CHEN W Y, ZHANG H, GATTA E, et al. The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal[J]. Alcohol,2019,78:79−87. doi: 10.1016/j.alcohol.2019.02.005
[43]	TSAI Y L, LIN T L, CHANG C J, et al. Probiotics, prebiotics and amelioration of diseases[J]. Journal of Biomedical Science,2019,26(1):1−8. doi: 10.1186/s12929-018-0495-4
[44]	KAZEMI A, NOORBALA A A, AZAM K, et al. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial[J]. Clinical Nutrition,2019,38(2):522−528. doi: 10.1016/j.clnu.2018.04.010
[45]	LIU R T, WALSH R F L, SHEEHAN A E. Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials[J]. Neuroscience & Biobehavioral Reviews,2019,102:13−23.
[46]	NAGPAL R, WANG S, AHMADI S, et al. Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome[J]. Scientific Reports,2018,8(1):1−15.
[47]	CHEN R, XU Y, WU P, et al. Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota[J]. Pharmacological Research,2019,148:104403. doi: 10.1016/j.phrs.2019.104403
[48]	ZHENG P, ZENG B, ZHOU C, et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism[J]. Molecular Psychiatry,2016,21(6):786−796. doi: 10.1038/mp.2016.44
[49]	HUANG H L, CHEN H T, LUO Q L, et al. Relief of irritable bowel syndrome by fecal microbiota transplantation is associated with changes in diversity and composition of the gut microbiota[J]. Journal of Digestive Diseases,2019,20(8):401−408. doi: 10.1111/1751-2980.12756
[50]	ZHANG W, ZOU G, LI B, et al. Fecal microbiota transplantation (FMT) alleviates experimental colitis in mice by gut microbiota regulation[J]. Journal of Microbiology and Biotechnology,2020,30(8):1132−1141. doi: 10.4014/jmb.2002.02044

Supplements (0)

Cited By

Cited by

Periodical cited type(4)

1.	陆源添，刘迪. 杨树桑黄与紫孢侧耳共培养胞内多糖提取工艺优化及抗氧化活性分析. 食品工业科技. 2025(02): 208-217 . 本站查看
2.	郭世纪，刘政，王会. 苹果多酚的提取工艺优化. 食品工业. 2024(07): 37-43 .
3.	罗诗茵，聂菁，韩文敏，林丹丹，廖兰，曾新安. 脉冲电场回收农产品加工废料中生物活性物质的研究进展. 食品工业科技. 2024(19): 392-398 . 本站查看
4.	时文盼，郭嘉欣，蔺永刚，柴雨阳，郭玉锦，武斌，王俊龙. 弯萼金丝桃总多酚提取工艺优化及抗氧化、降糖活性研究. 食品与发酵工业. 2024(21): 206-215 .