Mechanism of Anti-depression Mechanism of Akebiae Fructus Based on Network Pharmacology

QIAN Huiqin; PENG Yuan; HUANG Xiuxiu; YU Shuyan; LIU Bingbing; WANG Ning; ZHAO Yongheng

doi:10.13386/j.issn1002-0306.2020110295

Volume 42 Issue 14

Jul. 2021

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Science and Technology of Food Industry > 2021 > 42(14): 8-15. > DOI: 10.13386/j.issn1002-0306.2020110295

QIAN Huiqin, PENG Yuan, HUANG Xiuxiu, et al. Mechanism of Anti-depression Mechanism of Akebiae Fructus Based on Network Pharmacology[J]. Science and Technology of Food Industry, 2021, 42(14): 8−15. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020110295.

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Mechanism of Anti-depression Mechanism of Akebiae Fructus Based on Network Pharmacology

1.
Sanquan College of Xinxiang Medical University, Xinxiang 453000, China
2.
Zhengzhou Yellow River Nursing Vocational College, Zhengzhou 450066, China
3.
Hubei University of Medicine, Shiyan 442000, China

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Received Date: December 01, 2020
Available Online: May 18, 2021

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Abstract

Abstract

Objective: Revealing the anti-depression mechanism of Akebiae Fructus by network pharmacology technology. Methods: The active compounds and its corresponding depression-related targets of Akebiae Fructus were mined from the TCMSP, PharmMapper, Swiss TargetPrediction, and GeneCards databases. The protein-protein interactions were gained from the String database. The compound-target and PPI networks were built by Cytoscape software. The DAVID database was exploited for enrichment analysis of GO and KEGG signaling pathways for key targets. Finally, molecular docking was carried out for verification using AutoDockTools-1.5.6 software. Results: The 6 active compounds of Akebiae Fructus were identified, including calceolarioside B, stigmasterol glucoside, and oleanolic acid, etc. 8 major depression-related targets were predicted, such as EGFR, MAPK1/8, SRC, HSP90AA1, AR, etc. 16 depression-related signaling pathways were modulated, namely the prolactin signaling pathway, ErbB signaling pathway, GnRH signaling pathway, focal adhesion, etc. The results of molecular docking showed that the kernel components had good binding activity with the key targets. Conclusion: Akebiae Fructus exerted anti-depression effect through the comprehensive combination of multiple components, multiple targets and multiple pathways.
- Akebiae Fructus,
- anti-depression,
- network pharmacology,
- pathway

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References (38)

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