SHENG Huadong, WANG Jian, ZHANG Shuifeng, PAN Xiangjie, FENG Tingting, LI Guangzu. Determination of Six Quaternary Ammonium Bacteriostatic Agents in Food Contact Paper by Dispersive Solid Phase Extraction Combined with High Performance Liquid Chromatography-tandem Mass Spectrometry[J]. Science and Technology of Food Industry, 2021, 42(6): 271-275,317. DOI: 10.13386/j.issn1002-0306.2020050167
Citation: SHENG Huadong, WANG Jian, ZHANG Shuifeng, PAN Xiangjie, FENG Tingting, LI Guangzu. Determination of Six Quaternary Ammonium Bacteriostatic Agents in Food Contact Paper by Dispersive Solid Phase Extraction Combined with High Performance Liquid Chromatography-tandem Mass Spectrometry[J]. Science and Technology of Food Industry, 2021, 42(6): 271-275,317. DOI: 10.13386/j.issn1002-0306.2020050167

Determination of Six Quaternary Ammonium Bacteriostatic Agents in Food Contact Paper by Dispersive Solid Phase Extraction Combined with High Performance Liquid Chromatography-tandem Mass Spectrometry

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  • Received Date: May 14, 2020
  • Available Online: March 15, 2021
  • A high performance liquid chromatography-tandem mass spectrometry method based on dispersive solid phase extraction was established for the simultaneous determination of six quaternary ammonium bacteriostats in food contact paper. The method integrates extraction and purification, the sample was extracted with methanol under the assistance of ultrasound. Purified by PSA and filtered through organic membrane, the sample could be analyzed by HPLC-MS/MS. Separated by Brownlee SPP C18column, 5 mmol/L ammonium acetate aqueous solution and 5 mmol/L ammonium acetate methanol solution were used as the mobile phase for gradient elution, electrospray positive ion multi-reaction monitoring mode scanning, external standard method for quantification. The results showed good linearity was achieved for the target analytes in the concentration range of 0.5~100 μg/L.The linear correlation coefficients of the calibration curves for the compounds were greater than 0.9987. The limit of detection was 0.2~0.4 μg/kg and the limit of quantification was 0.8~1.0 μg/kg. The average recoveries at the three levels of addition were 79%~113%, the precision was less than 8.9%. The method is easy to operate and has high sensitivity, which is suitable for the detection of six quaternary ammonium bacteriostats in food contact paper.
  • [1]
    张雯,陈光,张新昌.季铵盐类抗菌包装纸制备技术[J].轻工机械,2017,35(5):52-56.
    [2]
    谷燕华,程康华,倪洁,等.紫外-可见分光光度法测定木材防腐剂中有效成分含量[J].中南林业科技大学学报,2015,35(9):133-138.
    [3]
    施敬文,杨晋青,李清清.固相萃取-气相色谱/质谱法测定化妆品中多种季铵盐化合物[J].香料香精化妆品,2019(2):48-52.
    [4]
    Kanno S,Hirano S,Kato H,et al. Benzalkonium chloride and cetylpyridinium chloride induce apoptosis in human lung epithelial cells and alter surface activity of pulmonary surfactant monolayers[J].Chemico-Biological Interactions,2020,317:108962.
    [5]
    姚瑞雄.QuEChERS净化结合超高效液相色谱串联质谱法测定奶粉中的季铵盐[J].现代食品科技,2017,33(10):275-280.
    [6]
    Prieto-Blanco M C,Argente-García A,Campíns-Falcó P.A capillary liquid chromatography method for benzalkonium chloride determination as a component or contaminant in mixtures of biocides[J].Journal of Chromatography A,2016,1431:176-183.
    [7]
    Tavlarakis P,Greyling J,Snow N H.Simultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC[J].Analytical Methods,2010,2(6):722.
    [8]
    Mallik R,Raman S,Liang X L,et al. Development and validation of a rapid ultra-high performance liquid chromatography method for the assay of benzalkonium chloride using a quality-by-design approach[J]. Journal of Chromatography A,2015,1413:22-32.
    [9]
    向垒,郑美洁,王雄科,等.超声萃取-气相色谱/质谱法同时测定土壤中3种季胺盐化合物[J].分析化学,2014,42(10):1459-1464.
    [10]
    Cao H W,Kang M Q,Chen Z,et al. Determination of five quaternary ammonium compounds in foodstuffs using high performance liquid chromatography-tandem mass spectrometry[J].Anal Methods,2014,6(13):4790-4796.
    [11]
    Arrebola-Liébanas F J,Abdo M A H,Moreno J L F,et al. Determination of quaternary ammonium compounds in oranges and cucumbers using QuEChERS extraction and ultra-performance liquid chromatography/tandem mass spectrometry[J].Journal of AOAC International,2014,97(4):1021-1026.
    [12]
    Slimani K,Féret A,Pirotais Y,et al. Liquid chromatography-tandem mass spectrometry multiresidue method for the analysis of quaternary ammonium compounds in cheese and milk products:Development and validation using the total error approach[J].Journal of Chromatography A,2017,1517:86-96.
    [13]
    孙龙,邵明媛,王浩.LC/MS/MS测定婴幼儿配方乳粉中3种苯扎氯铵同系物[J].食品研究与开发,2017,38(1):165-169.
    [14]
    何东.UPLC-MS/MS法测定冰淇淋与雪糕中3种季铵盐类化合物[J].分析测试学报,2016,35(5):609-613.
    [15]
    Wang X M,Kasperski K.Quantitative determination of multiple surfactants in water using HPLC-MS/MS[J].Analytical Methods,2018,10(21):2512-2525.
    [16]
    Kang H I,Shin H S.Rapid and sensitive determination of benzalkonium chloride biocide residues in soil using liquid chromatography-tandem mass spectrometry after ultrasonically assisted extraction[J].Bulletin of the Korean Chemical Society,2016,37(8):1219-1227.
    [17]
    Fernández P,Alder A C,Suter M J F,et al. Determination of the quaternary ammonium surfactant ditallowdimethylammonium in digested sludges and marine sediments by supercritical fluid extraction and liquid chromatography with postcolumn Ion-pair formation[J].Analytical Chemistry,1996,68(5):921-929.
    [18]
    Olkowska E,Polkowska,Namie ś nik J.Analytical procedures for the determination of surfactants in environmental samples[J].Talanta,2012,88:1-13.
    [19]
    魏瑞成,李国锋,高蓉,等.固相萃取-高效液相色谱-串联质谱法同时测定牛奶中多种季铵类化合物残留[J].分析化学,2014,42(5):711-716.
    [20]
    张莉敏.超声振荡提取技术的应用[J].北方环境,2011,23(Z1):52-53

    ,55.
    [21]
    Anastassiades M,Lehotay S J,Štajnbaher D,et al. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and "dispersive solid-phase extraction" for the determination of pesticide residues in produce[J].Journal of AOAC International,2003,86(2):412-431.

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