Research on three major food allergens protein and its structures
-
摘要: 目前食物过敏已成为世界各地普遍存在的食品安全问题,但引起人体过敏的大多是食物蛋白。本文主要综述了大豆、花生、牛乳三种主要食物过敏蛋白及其结构分析的研究进展,为开发低敏性食物制品提供依据。Abstract: Food allergy had become a major safety issue concern worldwide, but human allergy mostly caused by food protein. The recent research progress on the structure of the major allergens in soybean, peanut, milk was focused in this paper. All of these information were useful on account of whey protein for producing hypoallergenic dairy products.
-
Keywords:
- food allergy /
- protein structure /
- analysis
-
[1] 石良, 王锡昌, 刘源, 等.食物过敏原免疫学检测技术研究进展[J].分析测试学报, 2010, 29 (9) :981-986. [2] 陈颖, 王玮.食物过敏原检测方法研究进展[J].检疫检验学刊, 2011, 21 (3) :4-7. [3] Davis P J, Smales C M, James D C.How can thermal processing modify the antigenicity of proteins[J].Allergy, 2001, 56 (1) :56-60.
[4] Maloney J M, Sampson H A, Sicherer S H, et al.Food allergy and the introduction of solid foods to infants[J].Annals of Allergy, Asthma&Immunology, 2000, 97 (4) :470-475.
[5] Kanny G, Monere D A, Flabbee J, et al.Population study of food allergy in France[J].J Allergy Clin Immunol, 2001, 108 (1) :133-140.
[6] 源博恩.亚基解离与重聚集对大豆蛋白结构和功能特性的影响[D].广州:华南理工大学, 2012. [7] 卢家成, 孙泽威, 李婷琳.糖基化反应改善大豆抗原蛋白功能特性的研究进展[J].大豆科学, 2012, 31 (3) :483-486. [8] Catsimpoolas N, Ekenstam C.Isolation of alpha, beta, and gamma conglycinins[J].Archives of Biochemistry and Biophysics, 1969, 129 (2) :490-497.
[9] Liu B, Teng D, Yang Y, et al.Development of a competitive ELISA for the detection of soybeanαsubunit ofβ-conglycinin[J].Process Biochemistry, 2012, 47 (2) :280-287.
[10] Picariello G, Amigo-Benavent M, Castillo M D, et al.Structural characterization of the N-glycosylation of individual soybeanβ-conglycinin subunits[J].Journal of Chromatography A, 2013, 1313 (25) :96-102.
[11] Ruibao Z, Bing Z.The structure and functional properties of soybean 7S and 11S globulin proteins[J].Journal of the Chinese Cereals and Oils Association, 1998, 13 (6) :39-42.
[12] Marone M F, Bondi M C, Yada R Y.Isolation of soybean11s globulin By isoelectrie Preci Pitation and sephacryl S-300gelfiltration chromatography a new Purification technique[J].Bioscience Biotechnology and Bioehemistry, 1994, 58 (2) :413-415.
[13] Zhao X, Chen F, Xue W, et al.FTIR spectra studies on the secondary structures of 7S and 11S globulins from soybean proteins using AOT reverse micellar extraction[J].Food Hydrocolloids, 2008 (22) :568-575.
[14] Zhang H, Li L, Tatsumi E, et al.Influence of high Pressure on conformational changes of soybean glycinin[J].Innovative Food Seience&Emerging Technologies, 2003, 4 (3) :269-275.
[15] 段春红, 姚晓琳, 朱新荣, 等.大豆7S球蛋白碱性蛋白酶酶解产物的结构表征[J].食品科学, 2009, 30 (17) :181-184. [16] 许彩虹.大豆球蛋白糖基化接枝改性及其热聚集行为研究[D].广州:华南理工大学, 2010. [17] 白卫东, 沈鹏, 钱敏, 等.花生过敏原物质及其脱敏方法研究进展[J].广东农业科学, 2012 (7) :233-236. [18] Wijk F V, Hartgrng S, Koppleman S J, et al.Mixed antibody and T cell responses to peanut and the peanut allergens Ara h1, Ara h2, Ara h3 and Ara h6 in an oral sensitization model[J].Clin Exp Allergy, 2004, 34:1422-1428.
[19] Koppelman S J, Knol E F, Vlooswijk R A A, et al.Peanut allergen Ara h3, isolation from peanuts and biochemical characterization[J].Allergy, 2003, 58:1144-1151.
[20] Palmer G W, Dibbern D A Jr, Burks A W, et al.Comparative potency of Ara h1 and Ara h2 in immunochemical and functional essays of allergenicity[J]Clin Immunol, 2005, 115 (3) :302-312.
[21] Rouge P, Culerrier R, Sabatier V, et al.Mapping and conformational analysis of Ig E-binding epitopic regions on the molecular surface of the major Ara h3 legumin allergen of peanut (Arachis hypogaea) [J].Molecular Immunology, 2009, 46 (6) :1067-1075.
[22] 徐宏, 沈亮亮, 胡章立.花生过敏原Ara h1的热变性及其与还原糖相互作用的研究[J].光谱学与光谱分析, 2013, 33 (8) :2128-2131. [23] 胡纯秋, 高金燕, 陈红兵, 等.热加工对花生过敏原Ara h2抗原性及构象的影响[J].光谱学与光谱分析, 2010, 30 (9) :2550-2554. [24] 赵冠里.酶解与多糖接枝改性花生蛋白及其构效机理研究[D].广州:华南理工大学, 2011. [25] Liu, Y, Zhao G, Zhao M, et al.Improvement of functional properties of peanut protein isolate by conjugation with dextran through Maillard reaction[J].Food Chemistry, 2012, 131:901-906.
[26] 李冰, 龙再浩.牛乳蛋白过敏及其改性研究[J].农产品加工, 2012 (6) :41-44. [27] Fany B, Herv B, Stefano A.Update on optimized purification and characterization of natural milk allergens[J].Mol Nutr Food Res, 2008, 52:166-175.
[28] Restani P, Ballabio C, Lorenzo C D, et al.Molecular aspects of milk allergens and their role in clinical events[J].Anal Bioanal Chem, 2009, 395:47-56.
[29] 蔡小虎, 李欣, 陈红兵, 等.牛乳中主要过敏原的分离纯化研究进展[J].食品科学, 2010, 31 (23) :429-433. [30] J J Kehoe, E A Foegeding.The characteristics of heatinduced aggregates formed by mixtures ofβ-lactoglobulin andβ-casein[J].Food Hydrocolloids, 2014, 39:264-271.
[31] 齐晓彦.酶水解降低牛乳清蛋白抗原性研究进展[J].食品工业, 2013, 34 (7) :166-169. [32] Nicoleta S, Gabriela R, Gabriela B, et al.p H and heatinduced structural changes of bovine apo-α-lactalbumin[J].Food Chemistry, 2012, 131 (3) :956-963.
[33] 杨同香, 陈俊亮, 吴孔阳, 等.水牛奶酪蛋白胶束结构的荧光光谱研究[J].食品科学, 2014 (5) :1-8. [34] Kim D A, Cornec M, Narsimhan G.Effect of thermal treatment on interfacial properties ofβ-lactoglobulin[J].Journal of Colloid and Interface Science, 2005, 285 (1) :100-109.
[35] Navarra G, Leone M, Militello V, et al.Influence of metal ions on thermal aggregation of bovine serum albumin:aggregation kinetics and structural changes[J].J Inorq Biochem, 2009, 103 (12) :1729-1738.
[36] Ashtonl L, Blanch E W.p H-induced conformational transitions inα-lactalbumin investigated with two-dimensional Raman correlation variance plots and moving windows[J].Journal of Molecular Structure, 2010, 974 (1/3) :132-138.
[37] 林花, 于淑娟.牛血清白蛋白-葡聚糖接枝改性及机理研究 (Ⅰ) [J].食品科学, 2010, 31 (5) :15-22. [38] 孙炜炜.乳清分离蛋白-葡聚糖接枝改性及功能性质研究[D].广州:华南理工大学, 2012. [39] 任珊, 康慧, 杨峥.低聚异麦芽糖糖基化法降低牛乳β-乳球蛋白抗原性[J].食品工业科技, 2009, 30 (7) :85-90.
计量
- 文章访问数: 238
- HTML全文浏览量: 26
- PDF下载量: 523