响应面法优化藜芦胺的提取工艺

基金项目:

国家自然科学基金项目(20662007,20961007)；

详细信息

Optimization of veratramine extraction by response surface methodology

摘要: 为了优化藜芦胺的提取工艺,采用响应面法优化提取时间、提取温度和料液比,分析并建立数学模型。结果表明,提取时间、提取温度、料液比对藜芦胺的提取量均有极显著影响(p<0.01);并确定最佳提取工艺参数为时间2h,提取温度75.0℃,料液比1∶9(g/mL)。在此优化条件下,20.0g干燥藜芦根提取得到藜芦胺的量为98.23mg,与模型预测值得比较误差为2.66%。与模型预测值吻合,说明所建立的模型符合实际操作。
- 藜芦胺; /
- 响应面法; /
- 优化;
Abstract: In order to optimize the veratramine extraction, response surface methodology was used to establish models for optimization of extraction time, extraction temperature, liquid-to-material ratio. Results showed that extraction time , extraction temperature , liquid - to - material ratio had significant affects on extraction of veratramine. Optimal conditions for achieving the high extraction of veratramine were extraction time 2.0h, extraction temperature 75.0℃, liquid-to-material ratio 1∶9 (g/mL) . Under these optimized conditions, with 20g raw materials extraction get veratramine 98.23mg, and the model prediction was worth 2.66 percent error. Extraction were conducted under the optimum condition and the result showed the model fitted well with the experimental data and the model was feasible.
- veratramine;response surface method;optimization; /
- undefined /
- undefined

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