摘要:
以黄芪、罗汉果、梨为原料,研制一种具有抗霾清肺作用的饮料。以黄芪甲苷含量和感官评价为指标,在单因素实验基础上结合正交试验法优选制备工艺。通过构建雾霾小鼠模型,以肺脏病理情况与肺组织中白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量评价抗霾清肺饮的功效。结果表明:最佳配比工艺为黄芪9%、罗汉果2%、梨50%和黄原胶0.1%,在此条件下,饮料中黄芪甲苷含量0.84 mg/mL,感官评分94.67分,产品均匀透亮,梨的果香与药香味相结合,酸甜适中,口感适宜。抗霾清肺饮对雾霾小鼠肺组织病理损伤有明显改善作用,与模型组比较,治疗组IL-6、TNF-α含量极显著降低(P<0.01),可能通过降低炎症反应而发挥作用。
Abstract:
With Astragalus membranaceus, Siraitia grosvenorii and pear as raw materials, a kind of anti-haze and lung-clearing drink was developed. Taking contents of astragaloside and sensory evaluation as the index, orthogonal design on the basis of single factor tests were adopted to optimize the preparation process.By establishing the haze mouse model, the efficacy of anti-haze Qingfei drink was evaluated by the pathological conditions of the lungs and the contents of IL-6, TNF-α in the lung tissues. The results showed that the optimize preparative parameters were 9% of Astragalus membranaceus, 2% of Siraitia grosvenorii, 50% of pear and 0.1% of xanthan gum, the contents of Astragaloside of beverage was 0.84 mg/mL and the sensory evaluation scores were 94.67 under optimum formulation conditions.The product was uniform and bright with combining pear flavor and medicine fragrance, sweet and sour, taste appropriate.The anti-haze Qingfei drink could significantly improve the pathological damage of lung tissue in haze mice. Compared with model group, the contents of IL-6 and TNF-α in the treatment group was significantly decreased (P<0.01), which would play a role by reducing the inflammatory response.
百度学术
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