Abstract: Extraction process for phenolic substance from potato(Solanum tuberosum L.)peel using response surface methodology was optimized in this study. Single factors and response surface methodology trails were applied to optimizer conditions of phenolic substance extract from potato peel. The effects of extract time,temperature and sample-to-solvent ratio on content of phenolic substance were studied. Results:The optimized conditions were as follows:sample-to-solvent ratio of 1∶15(g/mL),extract time 59 min,extract temperature 62 ℃ and the polyphenol yield was 0.620 mg/g. The results provide a theoretical basis for the further development and utilization of potato polyphenols.