Abstract: Infant formula milk powder, a crucial nourishment for newborns, holds immense significance in relation to their healthy development and overall safety. The presence of chloropropanol ester, perchlorate, and chlorate (collectively known as "trichloride") in these products has garnered significant attention due to their potential harm to infants' growth. In the past three years, through stringent formula registration review requirements and urging enterprises to adopt risk prevention and control measures, remarkable progress has been made in mitigating the risk of "trichloride" in infant formula milk powder. Drawing from recent registration and evaluation work and investigative findings, this paper comprehensively outlines the primary hazards, contamination sources, limit standards, and detection methods for "trichloride" in infant formula milk powder. It further delves into the status of "trichloride" prevention and control measures implemented by both raw material suppliers and manufacturers. By incorporating current registration and evaluation criteria, this paper puts forward opinions and suggestions on how to further minimize the contamination risk of "trichloride," providing technical guidance for infant formula milk powder risk prevention and control efforts. Additionally, it serves as a reference for production enterprises to enhance their quality management standards.