Abstract: The transition metal Ni is widely used because of its low price, fast electron transfer rate and high catalytic activity. The electrochemical performance of the sensor will be improved by combining metallic Ni with other materials through different preparation methods. This combination can be applied to glucose detection in the food industry, health care and other fields. This paper reviews the methods of constructing electrodes from metal Ni-based composites and the effects of metal Ni compounded with carbon materials, monometallics, metal oxides, and metal hydroxides on sensor performance for the construction of high-performance electrochemical sensors and the practical application of glucose detection.