Abstract: With the formation and development of Microbiology, a wealth of inspirational cases which closely related to scientific and social progress, civil and healthy lifestyle were emerged. In them, all-around ideological and political elements such as seeking the truth, serving the public, pursuing excellence, serving the country through scientific and technological innovations, social responsibility, ect. could be effectively applied in college ideological and political education (CIPE). As a subject foundation requisite, Microbiology plays an important role in forming the thought and cognition of bioengineering college students. Therefore, digging deeper into the core spiritual elements and fusing them into teaching practice of Microbiology would be an important way to strengthen CIPE for the goal of 'Building Morality and cultivating people'. According to the ideological and political objectives of the Microbiology, an abundant of ideological and political cases are collected by point to point in all chapters of Microbiology. Then, they were applied to teaching practice so that to bring amounts of helpful concepts into college students by setting up the proper study scene, inducting students to collect dispose data, encouraging students to discuss, advancing students to exhibit and communicate, teaching them think themselve, etc. Finally, the teaching effectiveness of before and after implementing CIPE in the aspects of students and teachers were compared. The results showed that after CIPE, in the aspact students, the indexes of clarity of course teaching objectives, participation rate in teachers' research, activity of network learning platform, course satisfaction were increased in a rang of 8%~50%. Similar, in the aspact teachers, the indexes of student raise-head rate, students' participation in classroom teaching, classroom activity and reaching degree of course objectives were increased in a rang of 5%~20%. All the teaching practice indicated that the effective implementation of CIPE could be an important way to realizate CIPE objectives of Microbiology.