Abstract: The effect of yak collagen peptide on reducing blood sugar was studied by diabetes mice model. A diabetic mouse model was prepared by intraperitoneal injection of alloxan (200 mg/kg) into Kunming mice. The modeled mice were randomly divided into normal group, model group, positive control group (metformin 200 mg/kg) and yak collagen peptide group (200 mg/kg), with 6 mice in each group. Relevant medicines were intragastric administration, given to each group once a day for consecutive 2 weeks, and normal group and model group were given constant volume of normal saline. The blood glucose, body weight, low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and high-density lipoprotein (HDL) content of each group were measured after 7 and 14 days of administration. At the same time, pancreatic morphology of mice were detected by HE staining. Compared with the normal group, amount of body weight change and blood sugar content of the model group were significantly different (P<0.01). The TG, TC, and LDL levels of serum were all significantly reduced (P<0.01). The pancreatic tissue was severely damaged with incomplete morphology and obvious vacuoles. Compared with the model group, treatment of 200 mg/kg yak collagen peptides could significantly improve the symptoms of diabetic mice, alleviate the increasing tendency of blood sugar and other blood indicators and pancreatic damage in diabetic mice. The results showed that yak collagen peptide could obviously down-regulate the blood glucose level of diabetic mice, relieve symptoms of diabetes.