Abstract: Objective: Taking Suaeda salsa from different areas of Caofeidian in Tangshan City as the research object to explore the relationship between soil salinity, available nutrients and quality, and evaluate the composition indexes of Suaeda salsa comprehensively. Methods: By measuring the content of water, ascorbic acid, protein, amino acid, nitrite, total flavonoids, correlation analysis, principal component analysis and cluster analysis were performed. Results: There were significant differences in the compositional indicators of Suaeda salsa in different regions. Among them, the content of nitrite had the largest difference, with a coefficient of variation greater than 50%, and the difference in content of water was the smallest, with a coefficient of variation of only 1.83%. The results of principal component analysis showed that the content of ascorbic acid, flavonoids and amino acids were the core indicators that affect the quality of Suaeda salsa. Combined with the results of hierarchical clustering, the 8 regions of Suaeda salsa in Caofeidian could be divided into 3 categories. Among them, the quality of Suaeda salsa in Nanpu District, No. 1 and No. 7 fields was better, and the quality of Suaeda salsa in No. 2 field was the worst. Combined with the analysis of the results of soil salt and available nutrients, it showed that the content of soil salt and available potassium were high, which could significantly increase the content of protein and nitrite of Suaeda salsa, but inhibited the accumulation of total flavonoids. Conclusion: It is suggest that the development of Suaeda salsa should pay more attention to content of soil salinity and available nutrient, and this research providing a reliable analysis method and reference basis for the quality evaluation of Suaeda salsa in Caofeidian district.