Antiobesity Effects of Plantain flour on Obese Rats Induced by High-fat Diet
-
摘要: 为利用天然产物对肥胖进行预防和干预，以特色香蕉新品种‘美食蕉’（Musa spp.Plantain ABB）为材料，以高脂饮食诱导的肥胖大鼠模型为实验对象，设置3个剂量组[1.25、2.5、5.0 g/（kg·BW·d）]及奥利司他阳性对照组，研究美食蕉对肥胖大鼠体重、肝脏、血生化指标、肝功能指标的影响。结果显示，美食蕉干预6周后，低、中、高3个剂量组的大鼠体重极显著低于肥胖对照组（P<0.01），分别降低13.77%、8.44%、11.82%。美食蕉低剂量组明显抑制肥胖大鼠体内脂肪的积累，脂肪系数较肥胖组下降21.11%。肝脏切片显示美食蕉能够减少肝脏脂肪蓄积和炎症。美食蕉干预显著降低血清总胆固醇和甘油三酯水平，与肥胖组相比，干预效果最好的低剂量组分别下降43.85%、66.67%。在美食蕉的干预下，低剂量组的血糖显著低于肥胖组，下降19.31%。美食蕉干预显著降低肝功能指标中的谷草转氨酶的含量。综上所述，美食蕉具有良好的减轻体重效果，并有利于缓解脂肪肝、修复肝损伤和降低血糖、血脂。Abstract: In order to prevent and intervene obesity with natural products, a new banana variety ‘plantain’ (Musa spp. Plantain ABB) was used. The banana flour produced with green unripe fruits of plantain, rich in resistant starch. Hereby, the plantain flour was made from a new selected variety, to evaluate the antiobesity effects on obese rats induced by high-fat diet. Three doses(1.25, 2.5, 5.0 G/(kg BW) d) and orlistat positive control were designed and grouped separately, and the parameters of body weight, liver and blood biochemical indexes in obese rats, were measured after 6 weeks intervention. The results showed that after 6 weeks intervention, the body weight of the rats in the three dose groups was significantly lower than that in the obese control group(P<0.01), which decreased by 13.77%, 8.44% and 11.82% respectively. Low dose of plantain could obviously inhibit the fat accumulation in obese rats, and the fat coefficient decreased by 21.11% compared with obese rats. Liver biopsies observation showed that plantain reduced fat accumulation and inflammation in the liver. The intervention significantly reduced total cholesterol and triglyceride levels, compared with the obesity group, the low dose group with the best effect of intervention decreased by 43.85% and 66.67% respectively. Under the intervention of plantain, the blood sugar in the low dose group was significantly lower than that of the obese group, with a decrease of 19.31%. The intervention of plantain significantly reduced the content of aspartate transaminase which is liver function index. To sum up, plantain had a good effect on antiobesity, and it was benefit for the alleviation of fatty liver, repairing the liver damage and reduction of blood sugar and blood fat.
-
Keywords:
- plantain /
- antiobesity /
- liver /
- weight /
- body fat /
- aspartate aminotransferase
-
[1] Leandra Abarca-Gómez,Ziad A Abdeen,Zargar Abdul Hamid,et al. Worldwide trends in body-mass index,underweight,overweight,and obesity from 1975 to 2016:A pooled analysis of 2416 population-based measurement studies in 128·9 million children,adolescents,and adults[J].The Lancet,2017,390(10113):2627-2642.
[2] Jessica Fanzo,Corinna Hawkes,Emorn Udomkesmalee,et al. Shining a light to spur action on nutrition[J].Global Nutrition Report,2018.
[3] 汪雨亭,陈挺强,王娟.香蕉低聚糖对小鼠脏器的影响研究[J].食品研究与开发,2017,38(8):1-5. [4] 陈挺强. 香蕉低聚糖的通便功能评价及其对肠道微生物的影响研究[D]. 广东:华南理工大学,2016. [5] 陈平生,黄智君,王娟.不同热处理方式对大蕉抗性淀粉理化性质的影响[J].现代食品科技,2012,28(1):9-13 ,51.
[6] 王娟,汪雨亭,杨公明.香蕉不溶性膳食纤维的理化特性与通便功能研究[J].食品工业科技,2017,38(2):337-341. [7] Wang J,Huang J H,Cheng Y F,et al. Banana resistant starch and its effects on constipation model mice[J].Journal of Medicinal Food,2014,17(8):902-907.
[8] Wang J,Tang X J,Chen P S,et al. Changes in resistant starch from two banana cultivars during postharvest storage[J].Food Chemistry,2014,156:319-325.
[9] 谭思敏,林玉婷,王娟.香蕉抗性淀粉、单宁的含量及酶解单宁的研究[J].食品研究与开发,2017,38(7):1-4. [10] Wang J,Huang H H,Chen P S.Structural and physicochemical properties of banana resistant starch from four cultivars[J].International Journal of Food Properties,2017,20(6):1338-1347.
[11] 谭思敏,王娟,陈平生,等.香蕉成熟度对抗性淀粉理化性能的影响[J].食品工业科技,2017,38(23):23-28. [12] Ble-Castillo,Jorge L,Aparicio-Trapala,Maria A Francisco-Luria,et al. Banana resistant starch flour supplementation reduces body weight and insulin resistance in obese type 2 diabetics[J]. Obesity,2018,16(Supply):152-153.
[13] 朱小花. 香蕉粉对Ⅱ型糖尿病胰岛素抵抗的改善作用及其机制研究[D]. 广州:华南农业大学,2016. [14] Rosado C P,Rosa V H C,Martins B C,et al. Resistant starch from green banana(Musa sp.)attenuates non-alcoholic fat liver accumulation and increases short-chain fatty acids production in high-fat diet-induced obesity in mice[J].International Journal of Biological Macromolecules,2020,145:1066-1072.
[15] 王娟,盛鸥,肖军秀,等. 香蕉抗性淀粉的减肥功能及作用机理研究[C]//中国食品科学技术学会(Chinese Institute of Food Science and Technology).中国食品科学技术学会第十六届年会暨第十届中美食品业高层论坛论文摘要集.中国食品科学技术学会(Chinese Institute of Food Science and Technology):中国食品科学技术学会,2019:139-140. [16] 汪雨亭. 香蕉抗性淀粉的减肥功能及其对肠道菌群的影响研究[D].广州:华南理工大学,2018. [17] 白永亮,徐勇,黄志强,等.香蕉粉毒理学安全评价及减肥功效研究[J].食品工业科技,2012,33(24):406-409. [18] 谭思敏,王娟.香蕉粉等5种产品的减肥功能研究[J].食品科技,2018,43(12):61-66. [19] Flores-Silva P C,Berrios J D J,Pan J,et al. Gluten-free spaghetti made with chickpea,unripe plantain and maize flours:Functional and chemical properties and starch digestibility[J].International Journal of Food Science & Technology,2014,49(9):1985-1991.
[20] Pillay M,Tenkouano A. Banana breeding:Progress and challenges[M]. Florida:CRC,2011.banana peel for biodiesel synthesis[J].Green Energy &Environment,2019,4(3):322-327.
[21] 谢江辉.新中国果树科学研究70年:香蕉[J].果树学报,2019,36(10):1429-1440. [22] Zuo C W,Deng G M,Li B,et al. Germplasm screening of Musa spp.for resistance to Fusarium oxysporum f.sp.cubense tropical race 4(Foc TR4)[J].European Journal of Plant Pathology,2018,151(3):723-734.
[23] 王凯. 五种来源石斛对小鼠肝脏细胞色素P450酶表达的影响及对肝损伤的保护作用[D].镇江:江苏大学,2017. [24] 陈晨,曹野,覃雅婷,等.多不饱和脂肪酸不同构成及配比对ApoE-/-小鼠动脉粥样硬化的影响[J].中国动脉硬化杂志,2019,27(12):1018-1024. [25] 侯德萍.200例高脂血症并肥胖病人肝脏脾脏声像图分析[J].贵阳医学院学报,2001,26(4):350-352. [26] 盛银行.伴肝脂肪病变肝癌患者肝部分切除术的疗效及预后影响分析[J].中国临床研究,2015,28(4):464-466. [27] 王永芹.非酒精性脂肪肝患者免疫球蛋白及补体水平的变化及临床意义[J].国际检验医学杂志,2016,37(8):1153-1154. [28] 杨红,骆抗先.慢性肝炎临床诊断与病理分级分期诊断的对比分析[J].临床肝胆病杂志,1996,12(4):213-214. [29] 李军.脂肪肝患者与健康者的血清中肝功能及血脂指标的差异研究[J].临床检验杂志(电子版),2018,7(3):444. [30] 高春芳.肥胖相关肝病的常见生物化学改变[J].中华肝脏病杂志,2004(7):433-434. [31] 赵敏. 高脂饮食对大鼠肝脏内质网应激和炎症的影响及低脂膳食干预效果研究[D].武汉:华中科技大学,2013. [32] Furukawa H,Carroll R J,Swift H H,et al. Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6[J].Diabetes,1999,48(7):1395-1401.
[33] 王玮.非酒精性脂肪肝超声诊断与血糖血脂、体质量指数的关系[J].激光生物学报,2018,27(4):349-353 ,366.
[34] 朱治省,金辉华.健康体检人群体质量指数与血压、血脂及血糖关系的研究[J].国际检验医学杂志,2014,35(7):936-937. -
期刊类型引用(2)
1. 傅金凤，涂师运，王娟，盛鸥. 美食蕉的降血糖活性及其对糖脂代谢指标、激素的影响. 食品科学. 2022(19): 165-173 . 
百度学术
2. 杨凤，刘灿灿，邓贵明，何维弟，李春雨，易干军，盛鸥. 香蕉营养品质与功能特性研究进展. 广东农业科学. 2022(10): 146-154 . 百度学术
其他类型引用(0)
计量
- 文章访问数: 384
- HTML全文浏览量: 45
- PDF下载量: 42
- 被引次数: 2
下载:
