Abstract: To explore the anti-Candida albicans activity and safety of Cinnamomum camphora essential oil and its components,the anti-Candida albicans activity of Cinnamomum camphora essential oil that compared with grapefruit,lemon and lavender was determined by disk diffusion method and dilution method. Meanwhile,the GC-MS was used to detect the volatile components of essential oil. Moreover,the significant difference analysis among the chemical components and its correlation with anti-Candida acbicans activity were conducted. Finally,the Cinnamomum camphora essential oil and its components to stimulate the skin of guinea pigs and vascular permeability were observed. The results showed that the anti-Candida albicans activity of Cinnamomum camphora essential oil was stronger than that of grapefruit,lemon and lavender essential oil and it was mainly derived from α-Terpineol,Terpinolene,α-Terpinene,Terpinen-4-ol,Sabinene,1,8-Eucalyptol. The skin of guinea pigs showed slight erythema after 5 days of continuous application of 4% Cinnamomum camphora essential oil,while 4% terpinen-4-ol showed slight erythema after 2 days of application. In addition,4% terpinene-4-ol could significantly increase the vascular permeability of mice. The results would provide a theoretical basis for the development and utilization of Cinnamomum camphora essential oil and the treatment of Candida albicans-related diseases.