Abstract: Objective:To explore the protective mechanism of ginsenoside CK on liver injury in type 2 diabetes(T2DM)rats. Methods:In this experiment,the T2DM rat model was established,the FBG of the rats was recorded,and OGTT test after 8 weeks of gavage. Detection of relevant indicators in serum,related indicators and levels of four inflammatory factors in liver tissue homogenate. Detection of liver tissue lesions by HE staining. Western Blot method was used to detect the expression of TLR/Myd88/NF-κB signaling pathway protein. Results:The group of ginsenoside CK could significantly reduced FBG levels in T2DM rats(P<0.05),restored its glucose tolerance level,increased the levels of TC,TG,LDL-C,ALT,AST,SOD,GSH,CAT significantly(P<0.05),reduced the expression levels of HDL-C,MDA,four inflammatory factors and TLR4,Myd88,p65 and p-IKB-α protein significantly(P<0.05),liver tissue morphology was restored. Conclusion:Ginsenoside CK could protect the liver injury of T2DM rats by reducing inflammation and oxidative stress,and regulate TLR/Myd88/NF-κB signaling pathway.