Effect of Low-carbohydrate Diet on Patients with Type 2 Diabetes
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摘要: 低碳水化合物饮食是目前较为关注的控制糖尿病的饮食方式,包含低碳水化合物高脂肪饮食和低碳水化合物高蛋白质饮食。低碳水化合物饮食通过糖异生和酮生成作用降低葡萄糖的可用性来控制体重和血糖。但这种饮食方式对人体有很多负面影响。本文综述了低碳水化合物饮食对2型糖尿病患者的血管、心肌、肾脏的影响,以及此饮食方式的饮食依从性的研究进展,为低碳水化合物饮食对2型糖尿病患者的影响提供参考。
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关键词:
- 低碳水化合物饮食 /
- 2型糖尿病 /
- 低碳水化合物高脂肪饮食 /
- 低碳水化合物高蛋白饮食
Abstract: Low-carbohydrate diet is currently a more focused diet for diabetes,which includes low-carbohydrate,high-fat diet and low-carbohydrate,high-protein diet. Low-carbohydrate diets control weight and blood sugar by reducing glucose availability through gluconeogenesis and ketogenesis. But this diet has a lot of negative effects on the body. This paper reviews the effects of low carbohydrate diet on blood vessels,myocardium and kidney in patients with type 2 diabetes mellitus,and the research progress of dietary compliance of this diet,so as to provide reference for the influence of low carbohydrate diet on patients with type 2 diabetes. -
[1] 李昌艳,刘娟,顾芳,等.2型糖尿病患者进展为早期糖尿病肾脏病的影响因素分析[J].中国全科医学,2020,23(26):3291-3296. [2] 罗雪婷,徐昕.糖尿病心肌病与心肌代谢研究进展[J].中国老年学杂志,2020,40(7):2891-2895. [3] 柳怡莹,万沁.糖尿病患者内脏脂肪面积与糖尿病视网膜病变的相关性研究[J].医学研究杂志,2020,49(5):72-75. [4] 丁力,贾杰.老年糖尿病周围神经病功能障碍及其全周围期康复与护理[J].老年医学与保健,2020,26(3):338-340. [5] Sylvetsky A C,Edelstein S L,Walford G,et al. A High-carbohydrate,high-fiber,low-fat diet results in weight loss among adults at high risk of type 2 diabetes[J]. Journal of Nutrition,2017,147(11):2060-2066.
[6] 樊晓莉,孙桂菊.糖尿病饮食控制方法的研究进展[J].健康教育与健康促进,2020,15(2):143-149. [7] Accurso A,Bernstein R K,Dahlqvist A,et al. Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome:Time for a critical appraisal[J]. Nutrition & Metabolism,2008,5(1):9-16.
[8] Frigolet M,BarragánV R,González M V. Low-carbohydrate diets:A matter of love or hate[J]. Annals of Nutrition & Metabolism,2011,58(4):320-334.
[9] 王敏,程敏,洪思琦.生酮饮食在儿童药物难治性癫痫中的作用[J].儿科药学杂志,2016,22(3):63-64. [10] Abbasi J.Interest in the ketogenic diet grows for weight loss and type 2 diabetes[J]. Jama,2018,319(3):215.
[11] 张月华.生酮饮食治疗儿童难治性癫痫[J].中国实用儿科杂志,2011,26(7):494-497. [12] Paoli A,Bianco A,Damiani E,et al. Ketogenic diet in neuromuscular and neurodegenerative diseases[J]. Biomed Research International,2014,2014:474296.
[13] Lauritzen K H,Hasan-Olive M M,Regnell C E,et al. A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain[J]. Neurobiology of Aging,2016,48:34-47.
[14] Demura S,YamadaT,Yamaji S,et al. The effect of L-ornithine hydrochloride ingestion on performance during incremental exhauxtive ergometer bicycle exercise and anmonia metabolism during and after exercise.[J]. European Journal of Clinical Nutrition,1988,42(10):818.
[15] Van Wyk H J,Davis R E,Davies J S. A critical review of low-carbohydrate diets in people with Type 2 diabetes[J]. Diabetic Medicine,2016,33(2):148-157.
[16] Hall D K. A review of the carbohydrate-insulin model of obesity[J]. European Journal of Clinical Nutrition,2017,71(3):323.
[17] Fred Brouns.Overweight and diabetes prevention:Is a low-carbohydrate-high-fat diet recommendable?[J]European Journal of Nutrition,2018,4(57):1301-1312.
[18] Saslow L R,Daubenmier J J,Moskowitz J T,et al. Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes[J]. Nutrition & Diabetes,2017,7(12):304.
[19] 钟冬赐,詹思延.糖尿病患者采用生酮饮食效果的Meta分析[J].糖尿病新世界,2020(2):32-36. [20] Wylierosett J,Aebersold K,Conlon B,et al. Health effects of low-carbohydrate diets:Where should new research go?[J]. Current Diabetes Reports,2013,13(2):271-278.
[21] Rock C L,Flatt S W,Pakiz B,et al. Weight loss,glycemic control,and cardiovascular disease risk factors in response to differential diet composition in a weight loss program in type 2 diabetes:A randomized controlled trial[J]. Diabetes Care,2014,37(6):1573-1580.
[22] Boden G,Sargrad K,Homko C,et al. Effect of a low-carbohydrate diet on appetite,blood glucose levels,and insulin resistance in obese patients with type 2 diabetes[J]. Annals of Internal Medicine,2005,142(6):403-11.
[23] Ludwig D.Always hungry? Conquer cravings,retrain your fat cells,and lose weight permanently[J]. Library Journal,2016,141(1):126.
[24] Shapiro H,Theilla M,Attal-Singer J.Effects of polyunsaturated fatty acid consumption in diabetic nephropathy[J]. Nat Rev Nephrol,2011,7(2):110-121.
[25] 林秀红,陈超刚,林刁珠,等.新诊断2型糖尿病患者膳食血糖负荷与血糖、血脂的关系[J].中华内分泌代谢杂志,2014,30(7):562-564. [26] Gannon M C,Nuttall J A,Damberg G,et al. Effect of protein ingestion on the glucose appearance rate in people with type 2 diabetesr,1[J]. The Journal of Clinical Endocrinology & Metabolism,2001,86(3):1040-1047.
[27] Gannon M C,Nuttall F Q,Saeed A,et al. An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes[J].Am J Clin Nutr,2003,78:734-741.
[28] Gannon M C,Nuttall F Q.Effect of a High-protein,low-carbohydrate diet on blood glucose control in people with type 2 diabetes[J].Diabetes,2004,53(9):2375-2382.
[29] Westerterp-Plantenga M S,Nieuwenhuizen A,Tomé D,et al.Dietary protein,weight loss,and weight maintenance[J]. Current Opinion in Clinical Nutrition & Metabolic Care,2014,17(1):75-79.
[30] Azadbakht L,Atabak S,Esmaillzadeh A.Soy protein intake,cardiorenal indices,and C-reactive protein in type 2 diabetes with nephropathy:Alongitudinal randomized clinical trial[J]. Diabetes Care,2008,31(4):648-654.
[31] Zhang X,Qin J,Zhao Y,et al. Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice[J]. Nutrition Research,2016,36(4):349-358.
[32] Asrih M,Altirriba J,Rohnerjeanrenaud F,et al. Ketogenic diet impairs FGF21 signaling and promotes differential inflammatory responses in the liver and white adipose tissue[J]. Plos One,2015,10(5):e0126364.
[33] Ellenbroek J H,Van D L,Töns H A,et al. Long-term ketogenic diet causes glucose intolerance and reduced β-and α-cell mass but no weight loss in mice.[J]. Am J Physiol Endocrinol Metab,2014,306(5):E552.
[34] Desiree A,Xing Q T,Chern C W,et al. Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized13C pyruvate,butyrate,and acetoacetate probes[J].Diabetes,Obesity & Metabolism,2019,21(4):949-960.
[35] Petersen K F,Dufour S,Savage D B,et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.[J]. Proceedings of the National Academy of Sciences of the United States of America,2007,104(31):12587-12594.
[36] Mansoor N,Vinknes K J,Veierød M B,et al. Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors:a meta-analysis of randomised controlled trials[J]. British Journal of Nutrition,2016,115(3):466-479.
[37] Nordmann A J,Nordmann A,Briel M,et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors:A meta-analysis of randomized controlled trials[J]. Archives of Internal Medicine,2006,166(3):285-293.
[38] Westman E C,Feinman R D,Mavropoulos J C,et al. Low-carbohydrate nutrition andmetabolism[J].American Journal of Clinical Nutrition,2007,86(2):276-84.
[39] Hu T,Mills K T,Yao L,et al. Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors:A meta-analysis of randomized controlled clinical trials[J]. American Journal of Epidemiology,2012,176(suppl 7):S44.
[40] Wood T R,Robert H,Siguresson Axel F,et al. The cardiovascular risk reduction benefits of a low-carbohydrate diet outweigh the potential increase in LDL-cholesterol[J]. British Journal of Nutrition,2016,115(6):1126-1128.
[41] Furth S L,Casey J C,Pyzik P L,et al. Risk factors for urolithiasis in children on the ketogenic diet[J].Pediatric Nephrology,2000,15(1-2):125-128.
[42] Sampath A,Kossoff E H,Furth S L,et al. Kidney stones and the ketogenic diet:Risk factors and prevention[J].Journal of Child Neurology,2007,22(4):375.
[43] Martin W F,Armstrong L E,Rodriguez N R. Dietary protein intake and renal function[J]. Nutrition & Metabolism,2005,2(1):25.
[44] Wakefield A P,House J D,Ogborn M R,et al. A diet with 35% of energy from protein leads to kidney damage in female Sprague-Dawley rats[J].Br J Nutr,2011,106(5):656-663.
[45] Hall K D,Chung S T. Low-carbohydrate diets for the treatment of obesity and type 2 diabetes[J]. Curr Opin Clin Nutr Metab Care,2018,21(4):308-312.
[46] Leidy H J,Clifton P M,Astrup A,et al. The role of protein in weight loss and maintenance[J]. American Journal of Clinical Nutrition,2015,101(6):1320S-1329S.
[47] 胡安妮,任梦晓,张笑燕,等.2型糖尿病患者低碳水化合物饮食管理依从性影响因素的质性研究[J].中国现代护理杂志,2020,26(9):1182-1187. -
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