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中国精品科技期刊2020

益生菌对微生态系统的改善作用及其应用研究进展

张彦位, 路江浩, 鄢梦洁, 赵星, 张士成, 杨玉红, 杨玲, 何方, 赵林森

张彦位, 路江浩, 鄢梦洁, 赵星, 张士成, 杨玉红, 杨玲, 何方, 赵林森. 益生菌对微生态系统的改善作用及其应用研究进展[J]. 食品工业科技, 2021, 42(4): 369-379. DOI: 10.13386/j.issn1002-0306.2020020126
引用本文: 张彦位, 路江浩, 鄢梦洁, 赵星, 张士成, 杨玉红, 杨玲, 何方, 赵林森. 益生菌对微生态系统的改善作用及其应用研究进展[J]. 食品工业科技, 2021, 42(4): 369-379. DOI: 10.13386/j.issn1002-0306.2020020126
ZHANG Yanwei, LU Jianghao, YAN Mengjie, ZHAO Xing, ZHANG Shicheng, YANG Yuhong, YANG Ling, HE Fang, ZHAO Linsen. Research on Probiotics to Improve Micro-ecosystem and Its Application[J]. Science and Technology of Food Industry, 2021, 42(4): 369-379. DOI: 10.13386/j.issn1002-0306.2020020126
Citation: ZHANG Yanwei, LU Jianghao, YAN Mengjie, ZHAO Xing, ZHANG Shicheng, YANG Yuhong, YANG Ling, HE Fang, ZHAO Linsen. Research on Probiotics to Improve Micro-ecosystem and Its Application[J]. Science and Technology of Food Industry, 2021, 42(4): 369-379. DOI: 10.13386/j.issn1002-0306.2020020126

益生菌对微生态系统的改善作用及其应用研究进展

详细信息
    作者简介:

    张彦位(1990-),女,硕士研究生,研究方向:食品微生物,E-mail:572193507@qq.com。

    通讯作者:

    赵林森(1969-),男,硕士,高级工程师,研究方向:食品相关的微生态制剂研究,E-mail:Zhaolinsen@yrsw.cn。

  • 中图分类号: TS201.3

Research on Probiotics to Improve Micro-ecosystem and Its Application

  • 摘要: 人体微生态系统与宿主相互作用、相互影响,在维护机体健康方面发挥着重要作用。当饮食、环境或其他不利因素迫使微生态系统失去平衡时,机体抗感染能力降低,相关疾病也随之而来。益生菌即"有益的微生物",以乳杆菌和双歧杆菌为主,益生菌可以对微生态系统进行正向调节,在维护肠道健康、阴道生殖健康和口腔健康方面具有积极的作用。随着消费者对益生菌认知度的不断提高,益生菌相关的产品广泛流行,益生菌作为活菌型产品的稳定性备受关注。本文综述了益生菌在调节微生态系统、维护机体健康方面的具体作用机制和效果,概括了其在应用过程中面临的问题和相应的解决方案,加深对益生菌益生功能理解的同时,为益生菌的产业应用提供新的思路。
    Abstract: Human micro-ecosystem interacts with the host,and plays an important role to maintain their health. Diet,environment,or other unfavorable factors could implicate the micro-ecosystem by which to influence the resistance of host against various infection decreases. Probiotics are defined as "good microorganisms",mainly containing microbes from Lactobacillus and Bifidobacterium. Probiotics can alter the micro-ecosystem positively and play an active role to maintain the health of gut,vaginal reproduction and oral. As a result,the products made up with probiotics are becoming widespread.The concern of consumers to probiotics is increasing.Furthermore,the stability of products,as a live bacteria preparation,has attracted much attention.This study was conduct to review the specific mechanisms and effects of probiotics to regulate micro-ecosystems and to maintain health,and to outline the problems and corresponding solutions which appearduring application. This study can deepening the understanding of probiotics function and provide new ideas for its industrial application.
  • [1] 李桥兴,赵红艳.大健康产业发展研究综述[J]. 经济研究导刊,2018(7):53-55,90.
    [2]

    Reid G.Probiotics:Definition,scope and mechanisms of action[J]. Best Practice & Research.Clinical Gastroenterology,2016,30(1):17-25.

    [3]

    Gibson G R,Hutkins R,Sanders M E,et al. Expert consensus document:The international scientific association for probiotics and prebiotics(ISAPP)consensus statement on the definition and scope of prebiotics[J]. Nature Reviews Gastroenterology & Hepatology,2017,14(8):491-502.

    [4]

    O'Toole P W,Marchesi J R,Hill C.Next-generation probiotics:The spectrum from probiotics to live biotherapeutics[J].Nature Microbiology,2017,2:17057.

    [5]

    Monteagudo-Mera A,Rastall R A,Gibson G R,et al. Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health[J]. Applied Microbiology and Biotechnology,2019,103(16):6463-6472.

    [6]

    The Integrative HMP(iHMP)Research Network Consortium.The integrative human microbiome project[J]. Nature,2019,569(7758):641-648.

    [7]

    Rodríguez J M,Murphy K,Stanton C,et al. The composition of the gut microbiota throughout life,with an emphasis on early life[J]. Microbial Ecology in Health and Disease,2015,26:26050.

    [8]

    Donaldson G P,Lee S M,Mazmanian S K.Gut biogeography of the bacterial microbiota[J]. Nature Reviews Microbiology,2016,14(1):20-32.

    [9]

    Rowland I,Gibson G,Heinken A,et al. Gut microbiota functions:metabolism of nutrients and other food components[J]. European Journal of Nutrition,2018,57(1):1-24.

    [10]

    Sanders M E,Merenstein D J,Reid G,et al. Probiotics and prebiotics in intestinal health and disease:from biology to the clinic[J]. Nature Reviews.Gastroenterology & Hepatology,2019,16(10):605-616.

    [11]

    Xian P,Xuedong Z,Xin X,et al. The oral microbiome bank of China[J]. Int J Oral Sci,2018,10(2):16.

    [12]

    Kilian M,Chapple I L C,Hannig M,et al. The oral microbiome-an update for oral healthcare professionals[J]. British Dental Journal,2016,221(10):657-666.

    [13]

    Lin T H,Lin C H,Pan T M.The implication of probiotics in the prevention of dental caries[J]. Applied Microbiology and Biotechnology,2018,102(2):577-586.

    [14]

    Wilcox C R,Stuart B,Leaver H,et al. Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat:A systematic review[J]. Clinical Microbiology and Infection,2019,25(6):673-680.

    [15]

    Krzyściak W,Kościelniak D,Papie M,et al. Effect of a Lactobacillus salivarius probiotic on a double-species Streptococcus mutans and Candida albicans caries biofilm[J]. Nutrients,2017,9(11):E1242.

    [16]

    Iwamoto T,Suzuki N,Tanabe K,et al. Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health:an open-label pilot trial[J]. Oral Surgery,Oral Medicine,Oral Pathology,Oral Radiology,and Endodontics,2010,110(2):201-208.

    [17]

    Martin-Cabezas R,Davideau J L,Tenenbaum H,et al. Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis:A systematic review and meta-analysis[J]. Journal of Clinical Periodontology,2016,43(6):520-530.

    [18]

    Barko P C,McMichael M A,Swanson K S,et al. The gastrointestinal microbiome:A review[J]. Journal of Veterinary Internal Medicine,2018,32(1):9-25.

    [19]

    Wang W L,Xu S Y,Ren Z G,et al. Application of metagenomics in the human gut microbiome[J]. World Journal of Gastroenterology,2015,21(3):803-814.

    [20]

    Wong A C N,Vanhove A S,Watnick P I.The interplay between intestinal bacteria and host metabolism in health and disease:lessons from Drosophila melanogaster[J]. Disease Models & Mechanisms,2016,9(3):271-281.

    [21]

    Li C,Nie S P,Zhu K X,et al. Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice[J]. International Journal of Food Sciences and Nutrition,2015,66(5):533-538.

    [22]

    Yeun Y,Lee J.Effect of a double-coated probiotic formulation on functional constipation in the elderly:A randomized,double blind,controlled study[J]. Archives of Pharmacal Research,2015,38(7):1345-1350.

    [23]

    Ojetti V,Ianiro G,Tortora A,et al. The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation:A randomized,double-blind,placebo-controlled trial[J]. Journal of Gastrointestinal and Liver Diseases,2014,23(4):387-391.

    [24]

    Lim Y J,Jamaluddin R,Hazizi A S,et al. Effects of synbiotics among constipated adults in serdang,Selangor,Malaysia-A randomised,double-blind,placebo-controlled trial[J]. Nutrients,2018,10(7):E824.

    [25]

    Eskesen D,Jespersen L,Michelsen B,et al. Effect of the probiotic strain Bifidobacterium animalis subsp.lactis,BB-12®,on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort:A randomised,double-blind,placebo-controlled,parallel-group trial[J]. British Journal of Nutrition,2015,114(10):1638-1646.

    [26] 陈书巧,王柯,于晓红,等. TMC3115两歧双歧杆菌对中老年人粪便性状及肠道症状的改善效果[C]. 益生菌:技术及产业化——第十三届益生菌与健康国际研讨会,2018.
    [27]

    Barker A K,Duster M,Valentine S,et al. A randomized controlled trial of probiotics for Clostridium difficile infection in adults(PICO)[J]. The Journal of Antimicrobial Chemotherapy,2017,72(11):3177-3180.

    [28]

    Suez J,Zmora N,Zilberman-Schapira G,et al. Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT[J]. Cell,2018,174(6):1406-1423.e16.

    [29] 臧凯丽,江岩,孙勇,等.益生菌剂调整肠道疾病人群菌群结构丰度水平的研究[J]. 食品科学,2018,39(13):133-143.
    [30]

    Francavilla R,Piccolo M,Francavilla A,et al. Clinical and microbiological effect of a multispecies probiotic supplementation in celiac patients with persistent IBS-type symptoms:A randomized,double-blind,placebo-controlled,multicenter trial[J]. Journal of Clinical Gastroenterology,2019,53(3):e117-e125.

    [31]

    Mezzasalma V,Manfrini E,Ferri E,et al. A randomized,double-blind,placebo-controlled trial:The efficacy of multispecies probiotic supplementation in alleviating symptoms of irritable bowel syndrome associated with constipation[J]. BioMed Research International,2016,2016:4740907.

    [32]

    Pernica J M,Steenhoff A P,Mokomane M,et al. Correction:Rapid enteric testing to permit targeted antimicrobial therapy,with and without Lactobacillus reuteri probiotics,for paediatric acute diarrhoeal disease in Botswana:A pilot,randomized,factorial,controlled trial[J]. PLoS One,2018,13(3):e0194957.

    [33]

    Sung V,D'Amico F,Cabana M D,et al. Lactobacillus reuteri to treat infant colic:a meta-analysis[J]. Pediatrics,2018,141(1):e20171811.

    [34]

    Ghaderi A,Banafshe H R,Mirhosseini N,et al. Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients[J]. BMC Psychiatry,2019,19(1):77.

    [35]

    Kijmanawat A,Panburana P,Reutrakul S,et al. Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus:A double-blind randomized controlled trial[J]. Journal of Diabetes Investigation,2019,10(1):163-170.

    [36]

    Mithieux,Gilles.Does Akkermansia muciniphila play a role in type 1 diabetes[J]. Gut(Journal of the British Society of Gastroenterology),2018,67(8):1373-1374.

    [37]

    Hänninen A,Toivonen R,Pöysti S,et al. Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice[J]. Gut,2018,67(8):1445-1453.

    [38]

    Cani P D.Microbiota and metabolites in metabolic diseases[J]. Nature Reviews.Endocrinology,2019,15(2):69-70.

    [39]

    Lee K W,Ching S M,Ramachandran V,et al. Prevalence and risk factors of gestational diabetes mellitus in Asia:A systematic review and meta-analysis[J]. BMC Pregnancy and Childbirth,2018,18(1):494.

    [40]

    Wickens K L,Barthow C A,Murphy R,et al. Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus:A randomised controlled trial[J]. The British Journal of Nutrition,2017,117(6):804-813.

    [41]

    Izzo C,Carrizzo A,Alfano A,et al. The impact of aging on cardio and cerebrovascular diseases[J]. International Journal of Molecular Sciences,2018,19(2):481.

    [42]

    Garcia-Rios A,Torres-Peña J D,Perez-Jimenez F,et al. Gut microbiota:A new marker of cardiovascular disease[J]. Current Pharmaceutical Design,2017,23(22):3233-3238.

    [43]

    Tang W H W,Bäckhed F,Landmesser U,et al. Intestinal microbiota in cardiovascular health and disease:JACC state-of-the-art review[J]. Journal of the American College of Cardiology,2019,73(16):2089-2105.

    [44]

    Ishimwe N,Daliri E B,Lee B H,et al. The perspective on cholesterol-lowering mechanisms of probiotics[J]. Molecular Nutrition & Food Research,2015,59(1):94-105.

    [45]

    Wang K,Yu X H,Li Y,et al. Bifidobacterium bifidum TMC3115 can characteristically influence glucose and lipid profile and intestinal microbiota in the middle-aged and elderly[J]. Probiotics and Antimicrobial Proteins,2019,11(4):1182-1194.

    [46] 赵林森.一种植物乳杆菌及其应用:中国,CN103642716A[P].2014-03-19.
    [47] 朱诗雅,翟齐啸,赵星,等.不同乳杆菌缓解慢性酒精性肝损伤的作用比较[J]. 食品与发酵工业,2019,45(22):20-26.
    [48]

    Grander C,Adolph T E,Wieser V,et al. Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease[J]. Gut,2018,67(5):891-901.

    [49]

    Plovier H,Everard A,Druart C,et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice[J]. Nature Medicine,2017,23(1):107-113.

    [50]

    NCD-RisC.Worldwide trends in body-mass index,underweight,overweight,and obesity from 1975 to 2016:A pooled analysis of 2416 population-based measurement studies in 128·9 million children,adolescents,and adults[J]. Lancet,2017,390(10113):2627-2642.

    [51]

    Thaiss C A.Microbiome dynamics in obesity[J]. Science,2018,362(6417):903-904.

    [52]

    Sun L J,Ma L J,Ma Y B,et al. Insights into the role of gut microbiota in obesity:Pathogenesis,mechanisms,and therapeutic perspectives[J]. Protein & Cell,2018,9(5):397-403.

    [53]

    Depommier C,van Hul M,Everard A,et al. Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice[J]. Gut Microbes,2020,11(5):1231-1245.

    [54]

    Nagata S,Chiba Y,Wang C,et al. The effects of the Lactobacillus casei strain on obesity in children:A pilot study[J]. Beneficial Microbes,2017,8(4):535-543.

    [55] 龄南.具有抑制脂肪细胞的两歧双歧杆菌TMC3115及其应用:中国,CN104630096A[P].2015-05-20.
    [56]

    Pushpa Pandiyan N B,Mangge Zou,Elizabeth Schneider. Microbiome dependent regulation of Tregs and Th17 cells in mucosa[J]. Frontiers in Immunology,2019,10.

    [57]

    Walker W A.Mechanisms of action of probiotics[J]. Clinical Infectious Diseases,2008,46(s2):S87-S91.

    [58]

    Michal P Kuczma E A S,Anna Cebula,Benoit Chassaing. Commensal epitopes drive differentiation of colonic Tregs[J]. Science advances,2020,6(16).

    [59]

    Wang L J,Tang L,Feng Y M,et al. A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+T cells in mice[J]. Gut,2020,69(11):1988-1997.

    [60]

    Fan H Y,Chen Z H,Lin R Q,et al. Bacteroides fragilis strain ZY-312 defense against Cronobacter sakazakii-induced necrotizing enterocolitis in vitro and in a neonatal rat model[J]. mSystems,2019,4(4).

    [61] .智发朝.Bacteroides fragilis:From gut commensals to live therapeutics[R].南方医科大学南方医院广东省南方消化病研究所,2019.
    [62]

    Chung L,Thiele Orberg E,Geis A L,et al. Bacteroides fragilis toxin coordinates a pro-carcinogenic inflammatory cascade via targeting of colonic epithelial cells[J]. Cell Host & Microbe,2018,23(2):203-214.e5.

    [63]

    Liu Y Y,Tran D Q,Rhoads J M.Probiotics in disease prevention and treatment[J]. The Journal of Clinical Pharmacology,2018,58:S164-S179.

    [64]

    Pu F F,Guo Y,Li M,et al. Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections:a randomized controlled open-label trial[J]. Clinical Interventions in Aging,2017,12:1223-1231.

    [65]

    Michalovich D,Rodriguez-Perez N,Smolinska S,et al. Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients[J]. Nature Communications,2019,10(1):5711.

    [66]

    Watts A M,Cox A J,Smith P K,et al. A specifically designed multispecies probiotic supplement relieves seasonal allergic rhinitis symptoms[J]. The Journal of Alternative and Complementary Medicine,2018,24(8):833-840.

    [67]

    Kepert I,Fonseca J,Müller C,et al. D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease[J]. The Journal of Allergy and Clinical Immunology,2017,139(5):1525-1535.

    [68] 沈曦,李鸣,石磊,等.乳酸杆菌的免疫调节及抗过敏作用研究[J]. 四川大学学报(医学版),2016,47(2):192-196.
    [69]

    Cheng R Y,Guo J W,Pu F F,et al. Loading ceftriaxone,vancomycin,and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood[J]. Scientific Reports,2019,9(1):3254.

    [70]

    Colosimo D A,Kohn J A,Luo P M,et al. Mapping interactions of microbial metabolites with human G-protein-coupled receptors[J]. Cell Host & Microbe,2019,26(2):273-282.e7.

    [71]

    Kennedy P J,Murphy A B,Cryan J F,et al. Microbiome in brain function and mental health[J]. Trends in Food Science & Technology,2016,57:289-301.

    [72]

    Buffington S A,di Prisco G V,Auchtung T A,et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring[J]. Cell,2016,165(7):1762-1775.

    [73]

    Shaaban S Y,El Gendy Y G,Mehanna N S,et al. The role of probiotics in children with autism spectrum disorder:A prospective,open-label study[J]. Nutritional Neuroscience,2018,21(9):676-681.

    [74]

    Pinto-Sanchez M I,Hall G B,Ghajar K,et al. Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity:A pilot study in patients with irritable bowel syndrome[J]. Gastroenterology,2017,153(2):448-459.e8.

    [75]

    Slykerman R F,Hood F,Wickens K,et al. Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety:A randomised double-blind placebo-controlled trial[J]. Ebio Medicine,2017,24:159-165.

    [76]

    Akkasheh G,Kashani-Poor Z,Tajabadi-Ebrahimi M,et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder:A randomized,double-blind,placebo-controlled trial[J]. Nutrition,2016,32(3):315-320.

    [77]

    Cheng R Y,Xu T,Zhang Y J,et al. Lactobacillus rhamnosus GG and Bifidobacterium bifidum TMC3115 can affect development of hippocampal neurons cultured in vitro in a strain-dependent manner[J]. Probiotics and Antimicrobial Proteins,2020,12(2):589-599.

    [78]

    Yang Y J,Zhong Z Q,Wang B J,et al. Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila[J]. Neuropsychopharmacology,2019,44(12):2054-2064.

    [79]

    Kim J M,Park Y J.Probiotics in the prevention and treatment of postmenopausal vaginal infections:Review article[J]. Journal of Menopausal Medicine,2017,23(3):139-145.

    [80]

    Moreno I,Codoñer F M,Vilella F,et al. Evidence that the endometrial microbiota has an effect on implantation success or failure[J]. American Journal of Obstetrics and Gynecology,2016,215(6):684-703.

    [81]

    Verdenelli M C,Coman M M,Cecchini C,et al. Evaluation of antipathogenic activity and adherence properties of human Lactobacillus strains for vaginal formulations[J]. Journal of Applied Microbiology,2014,116(5):1297-1307.

    [82]

    Zhang X H,Liao Q P,Wang F Y,et al. Association of gestational diabetes mellitus and abnormal vaginal flora with adverse pregnancy outcomes[J]. Medicine,2018,97(34):e11891.

    [83]

    Kroon S J,Ravel J,Huston W M.Cervicovaginal microbiota,women's health,and reproductive outcomes[J]. Fertility and Sterility,2018,110(3):327-336.

    [84]

    Wang S,Wang Q Y,Yang E C,et al. Antimicrobial compounds produced by vaginal Lactobacillus crispatus are able to strongly inhibit Candida albicans growth,hyphal formation and regulate virulence-related gene expressions[J]. Frontiers in Microbiology,2017,8:564.

    [85]

    Castro J,Martins A P,Rodrigues M E,et al. Lactobacillus crispatus represses vaginolysin expression by BV associated Gardnerella vaginalis and reduces cell cytotoxicity[J]. Anaerobe,2018,50:60-63.

    [86]

    Takada K,Komine-Aizawa S,Kuramochi T,et al. Lactobacillus crispatus accelerates re-epithelialization in vaginal epithelial cell line MS74[J]. American Journal of Reproductive Immunology,2018,80(3):e13027.

    [87]

    Parolin C,Frisco G,Foschi C,et al. Lactobacillus crispatus BC5 interferes with Chlamydia trachomatis infectivity through integrin modulation in cervical cells[J]. Frontiers in Microbiology,2018,9:2630.

    [88]

    Ñahui Palomino R A,Vanpouille C,Laghi L,et al. Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues[J]. Nature Communications,2019,10:5656.

    [89]

    Klatt N R,Cheu R,Birse K,et al. Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women[J]. Science,2017,356(6341):938-945.

    [90]

    Tabatabaei N,Eren A,Barreiro L,et al. Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth:a case-control study[J]. BJOG:an International Journal of Obstetrics & Gynaecology,2019,126(3):349-358.

    [91]

    Daskalakis G J,Karambelas A K.Vaginal probiotic administration in the management of preterm premature rupture of membranes[J]. Fetal Diagnosis and Therapy,2017,42(2):92-98.

    [92]

    Kaye L,Bartels C,Bartolucci A,et al. Old habits Die hard:retrospective analysis of outcomes with use of corticosteroids and antibiotics before embryo transfer[J]. Fertility and Sterility,2017,107(6):1336-1340.

    [93]

    Mujagic Z,de Vos P,Boekschoten M V,et al. The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription;a randomized double-blind placebo controlled trial[J]. Scientific Reports,2017,7:40128.

    [94]

    Gagliardi A,Totino V,Cacciotti F,et al. Rebuilding the gut microbiota ecosystem[J]. International Journal of Environmental Research and Public Health,2018,15(8):E1679.

    [95]

    Kelly J R,Allen A P,Temko A,et al. Lost in translation?The potential psychobiotic Lactobacillus rhamnosus(JB-1)fails to modulate stress or cognitive performance in healthy male subjects[J]. Brain Behavior and Immunity,2017,61:50-59.

    [96]

    Fenster K,Freeburg B,Hollard C,et al. The production and delivery of probiotics:A review of a practical approach[J]. Microorganisms,2019,7(3):83.

    [97]

    Daglia M.Polyphenols as antimicrobial agents[J]. Current Opinion in Biotechnology,2012,23(2):174-181.

    [98]

    Lai C H,Wu S R,Pang J C,et al. Designing primers and evaluation of the efficiency of propidium monoazide-Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius[J]. Journal of Food and Drug Analysis,2017,25(3):533-542.

    [99]

    Massoud R,Fadaei V,Khosravi-Darani K,et al. Improving the viability of probiotic bacteria in yoghurt by homogenization[J].Journal of Food Processing and Preservation,2015,39(6):2984-2990.

    [100]

    Terpou A,Papadaki A,Lappa I,et al. Probiotics in food systems:Significance and emerging strategies towards improved viability and delivery of enhanced beneficial value[J]. Nutrients,2019,11(7):1591.

    [101]

    Zhou S B,Gravekamp C,Bermudes D,et al. Tumour-targeting bacteria engineered to fight cancer[J]. Nature Reviews.Cancer,2018,18(12):727-743.

    [102]

    Isabella V M,Ha B N,Castillo M J,et al. Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria[J]. Nature Biotechnology,2018,36(9):857-864.

    [103]

    Ainsworth C.Therapeutic microbes to tackle disease[J]. Nature,2020,577(7792):S20-S22.

    [104]

    Ebrahimi B,Mohammadi R,Rouhi M,et al. Survival of probiotic bacteria in carboxymethyl cellulose-based edible film and assessment of quality parameters[J]. LWT,2018,87:54-60.

    [105]

    Singh P,Medronho B,Alves L,et al. Development of carboxymethyl cellulose-chitosan hybrid micro-and macroparticles for encapsulation of probiotic bacteria[J]. Carbohydrate Polymers,2017,175:87-95.

    [106]

    de Araújo Etchepare M,Raddatz G C,de Moraes Flores é M,et al. Effect of resistant starch and chitosan on survival of Lactobacillus acidophilus microencapsulated with sodium alginate[J]. LWT-Food Science and Technology,2016,65:511-517.

    [107]

    Praepanitchai O A,Noomhorm A,Anal A K.Survival and behavior of encapsulated probiotics(Lactobacillus plantarum)in calcium-alginate-soy protein isolate-based hydrogel beads in different processing conditions(pH and temperature)and in pasteurized mango juice[J]. BioMed Research International,2019,2019:9768152.

    [108]

    Behboudi-Jobbehdar S,Soukoulis C,Yonekura L,et al. Optimization of spray-drying process conditions for the production of maximally viable microencapsulated L.acidophilus NCIMB 701748[J]. Drying Technology,2013,31(11):1274-1283.

    [109]

    Singh P,Medronho B,Santos T D,et al. On the viability,cytotoxicity and stability of probiotic bacteria entrapped in cellulose-based particles[J]. Food Hydrocolloids,2018,82:457-465.

    [110]

    Yao M F,Li B,Ye H W,et al. Enhanced viability of probiotics(Pediococcus pentosaceus Li05)by encapsulation in microgels doped with inorganic nanoparticles[J]. Food Hydrocolloids,2018,83:246-252.

    [111]

    Coghetto C C,Flores S H,Brinques G B,et al. Viability and alternative uses of a dried powder,microencapsulated Lactobacillus plantarum without the use of cold chain or dairy products[J]. LWT-Food Science and Technology,2016,71:54-59.

    [112]

    Zaeim D,Sarabi-Jamab M,Ghorani B,et al. Electrospray assisted fabrication of hydrogel microcapsules by single-and double-stage procedures for encapsulation of probiotics[J]. Food and Bioproducts Processing,2017,102:250-259.

    [113]

    Gomez-Mascaraque L G,Morfin R C,Pérez-Masiá R,et al. Optimization of electrospraying conditions for the microencapsulation of probiotics and evaluation of their resistance during storage and in-vitro digestion[J]. LWT-Food Science and Technology,2016,69:438-446.

    [114]

    Moayyedi M,Eskandari M H,Rad A H E,et al. Effect of drying methods(electrospraying,freeze drying and spray drying)on survival and viability of microencapsulated Lactobacillus rhamnosus ATCC 7469[J]. Journal of Functional Foods,2018,40:391-399.

    [115]

    Vaziri A S,Alemzadeh I,Vossoughi M,et al. Co-microencapsulation of Lactobacillus plantarum and DHA fatty acid in alginate-pectin-gelatin biocomposites[J]. Carbohydrate Polymers,2018,199:266-275.

    [116]

    Rodrigues F J,Omura M H,Cedran M F,et al. Effect of natural polymers on the survival of Lactobacillus casei encapsulated in alginate microspheres[J]. Journal of Microencapsulation,2017,34(5):431-439.

    [117]

    Reid G,Abrahamsson T,Bailey M,et al. How do probiotics and prebiotics function at distant sites?[J]. Beneficial Microbes,2017,8(4):521-533.

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  • 收稿日期:  2020-02-15
  • 网络出版日期:  2021-03-01
  • 刊出日期:  2021-02-14

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