摘要:
目的:研究南非叶总黄酮对高血脂模型小鼠脂质代谢的影响。方法:以昆明种小鼠为实验动物,随机分成6组:空白对照组、高脂模型组、辛伐他汀阳性对照组(25 mg/kg)和南非叶总黄酮低、中、高组(10、50、100 mg/kg)。空白对照组喂以基础饲料,5组试验组喂以高脂饲料,小鼠灌胃南非叶总黄酮,4周后称重并解剖,测定血清中总甘油三酯(Triglyceride,TG)、总胆固醇(Total cholesterol,TC)、高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)和低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)的含量,计算动脉粥样硬化指数和肝指数。结果:与模型组比较,南非叶总黄酮能显著降低高血脂小鼠血清中TG、TC、LDL-C的含量,提高HDL-C含量,并有效降低动脉粥样硬化指数和肝指数。其中100 mg/kg南非叶总黄酮试验组效果最好,与模型组相比,TG、TC值和LDL-C值分别降低了28.29%、17.55%和63.32%,HDL-C值提高了44.20%。结论:南非叶总黄酮具有显著的降血脂作用。
关键词:
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南非叶
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总黄酮
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小鼠
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降血脂作用
Abstract:
Objective:To study the effect of total flavonoids from Bitter Leaf in hyperlipidemia model mice. Method:Kunming mice were randomly divided into 6 groups:Control group,high fat model group,simvastatin positive control group and bitter leaf total flavonoids in low,medium and high groups(10,50,100 mg/kg). The mice of control group were fed with normal diet and the mice of other groups were fed with high fat diets. After 4 weeks,the mice were decapitated after measuring the body weight,and the contents of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)in serum were determined. Result:Compared with the model group,the content of TG,TC and LDL-C in the serum of the mice could be reduced with the treatment of the total flavonoids of bitter leaf,and the content of HDL-C was improved. Compared with high fat model group,the TG,TC and LDL-C in the mice serum of the bitter leaf total flavonoids group(100 mg/kg)were decreased by 28.29%,17.55% and 63.32%,respectively and HDL-C was increased by 44.20%. Conclusion:The total flavonoids of the bitter leaf have a significant hypolipidemic activity.
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