Abstract: To establish a method for the determination of sixteen rare elements(La,Ce,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y and Sc)in Lycium barbarum L.,microwave digestion was used for pretreatment and ICP-MS for determination. Rh was used as internal standard to correct the quantitative results. The results showed that the linear correlation was more than 0.9999,the detection limit was between 0.009~0.821 μg/kg,and the limit of quantitation was between 0.030~2.736 μg/kg. The recovery(n=6)was ranged from 86.0% to 108.6% and the relative standard deviation ranged 1.25%~9.14%. The national standard substance carrot(GSBW10047)was selected to verify the reliability of the method. The measured values of the rare elements were basically within the allowable range of the standard values. The method was simple,rapid,sensitive,wide linear range.