体外模拟亚硝化体系中优选阻断NDMA生成的香辛料精油复合抑制剂

Inhibiting NDMA-generated Spice Essential Oil Compound Inhibitors in Simulated Nitrosation System in Vitro

摘要: 为了有效抑制N-二甲基亚硝胺(N-nitrosodimethylamine,NDMA)的形成,在体外模拟亚硝化反应体系中,先通过单因素实验研究市售常见的9种香辛料精油对NDMA的抑制作用,再利用二次回归正交组合试验设计,筛选最佳精油复合抑制剂配比。结果表明,9种香辛料精油对NDMA的形成均有抑制作用,二次回归正交组合设计得到的最优复合配比是胡椒2.078 mL/L、姜汁3.118 mL/L、花椒3.692 mL/L、八角2.833 mL/L和丁香0.218 mL/L,该条件下NDMA的抑制率为64.412%±0.25%。

Abstract: In order to effectively inhibit the formation of N-nitrosodimethylamine(NDMA),single factor experiments were used to study nine kinds of common spice essential oil in a simulated nitrosation reaction system. Andquadratic regression orthogonal combination design were used to screen the optimal ratio. Results showed that all nine spice essential oils inhibited the formation of NDMA. The optimal ratio of quadratic regression orthogonal combination design were pepper 2.078 mL/L,ginger 3.118 mL/L,Chinese prickly ash 3.692 mL/L,star anise 2.833 mL/L and clove 0.218 mL/L,and the inhibition rate of NDMA was 64.412%±0.25%.