Optimization of Extraction and Optimization of Total Flavonoids from Tussilago Farfara L.and Anti-hyperlipidemic and Anti-oxidative Effects
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摘要: 探讨利用醇提超声波辅助法提取的款冬总黄酮对高血脂模型小鼠降血脂及抗氧化作用。试验结果表明:在提取时间30 min,乙醇体积分数80%,料液比41:1(mL:g),超声温度58℃条件下,款冬总黄酮得率最大,为7.18%;经SP-825大孔吸附树脂纯化后,款冬总黄酮纯度为63.2%;款冬总黄酮可以有效调节高血脂模型小鼠血清中TC、TG、LDL-C、HDL-C浓度,且降脂作用与剂量呈依赖关系;也能降低其肝组织中MDA的含量,提高GSH、T-SOD的含量,说明款冬总黄酮可以降低高血脂模型小鼠的血脂水平,具有一定的降脂抗氧化作用。Abstract: Total flavonoids were extracted by alcohol extraction and ultrasonic assisted method from Tussilago farfara L. to investigate the the anti-hyperlipidemic and anti-oxidative effects in hyperlipidemia mice.The results showed that the yield of total flavonoids from Tussilago farfara L. was about 7.18% under the conditions of extraction time 30 min, ethanol volume fraction 80%, liquid ratio 41:1 (mL:g) and ultrasonic temperature 58℃, the best extraction process of total flavonoids from Tussilago farfara L. was stable and feasible. Purified by SP-825 macroporous resin, the purity of total flavonoids of Colletotrichum was 63.2%.Tussilago farfara L.total flavonoids can effectively regulate the concentration of TC, TG, LDL-C, HDL-C, and lipid-lowering effect in dose dependence; can also reduce the content of MDA in liver tissue, increased the contents of GSH and T-SOD, shows that Tussilago farfara L. toal flavonoids can reduce blood lipid level in hyperlipidemia mice, and has a certain antioxidant effect.
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Keywords:
- Tussilago farfara L. /
- total flavonoids /
- extraction /
- lipid /
- antioxidant
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