Abstract: A technique for the rapid determination of bisphenol-A ( BPA) in infant formula milk powder was developed by ultrasound-assisted solvent bar microextraction coupled with high performance liquid chromatography.The system of ultrasound-assisted solvent bar microextraction was designed. The optimized microextraction conditions were as follows: the length of solvent bar was 30 mm, 1-octanol was used as the extraction solvent, the stirring rate was 600 r/min, the ultrasonic time was 10 min and the extraction time was 15 min, the pH of sample solutions was 6, 0.12 mol/L of NaOH was used as the acceptor phase, the concentration of NaCl was 60 g/L. Under the optimal microextraction conditions, the average enrichment factor was102, the linear range was 0.1 ~ 100 μg/L ( r = 0.9989) , the limits of detection was 0.35 μg/L ( S/N = 3) , and the relative standard deviations ( RSD) was lower than 4.32% ( n = 6) . The proposed method was applied to the determination of BPA in infant formula milk powder samples.The spiked recoveries were in the range of 89.7% ¹02.8%.It was showed that the proposed method was environmentally for the rapid determination of BPA in infant formula milk powder.