靶向代谢组学技术在营养性疾病研究中的应用

龚凌霄; 迟海林; 王静; 张慧娟; 刘英丽

doi:10.13386/j.issn1002-0306.2017.18.061

靶向代谢组学技术在营养性疾病研究中的应用

北京食品营养与人类健康高精尖创新中心食品添加剂与配料北京高校工程研究中心北京工商大学

基金项目:

国家自然科学基金(31501480,31571940)；北京市留学人才科技活动项目优秀类项目；

详细信息

作者简介:
龚凌霄 (1981-) , 女, 博士, 讲师, 研究方向:功能性食品研究与开发, E-mail:gonglingxiao@btbu.edu.cn。;

王静 (1976-) , 女, 博士, 教授, 研究方向:功能性食品配料, E-mail:wangjing@th.btbu.edu.cn。;

中图分类号: R591
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出版历程
- 收稿日期: 2017-03-15

Application of targeted metabolomics technology in nutritional diseases

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Technology & Business University (BTBU)

摘要

摘要: 营养性疾病发生是营养素失衡的体现,是体内一类或几类物质代谢异常的结果,尤其是与饮食中脂肪、糖类、蛋白质等密切相关的脂质代谢、糖代谢、氨基酸代谢等。因此,以营养性疾病的代谢物着手,运用靶向代谢组学技术找到丰度改变有统计学意义的内源性代谢物从而探明其代谢异常的机制,是寻找具有针对性的治疗手段的有效方法。本文就肥胖、糖尿病、心血管疾病等营养性疾病的代谢特征以及靶向代谢组学技术在营养性疾病动物模型和营养干预等研究中的应用进展进行综述,以期为寻找预防营养性疾病的发生的有效途径提供新思路和理论依据。
- 靶向代谢组学 /
- 营养性疾病 /
- 脂肪代谢 /
- 糖代谢 /
- 氨基酸代谢
Abstract: Nutritional diseases are caused by the imbalance of nutrients, which led to a class or several types of metabolic abnormalities, particularly to the abnormality of lipid metabolism, glucose metabolism and amino acid metabolism. Thus, the timely measurement of metabolic profiles could help to prevent nutritional diseases. Targeted metabonomics is a powerful approach that simultaneously measures the low-molecular-weight endogenous metabolites, which could characterize the metabolic status of a biological system. This paper had reviewed the progress of targeted metabolomics techniques and their application in exploration of metabolic characteristics of obesity, diabetes mellitus, cardiovascular disease and other nutritional diseases.It was aimed to provide new ideas and theoretical basis for finding effective ways to prevent nutritional diseases.
- targeted metabolomics technology /
- nutritional diseases /
- lipid metabolism /
- glucose metabolism /
- amino acid metabolism

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