花生过敏原检测、降敏加工及脱敏治疗研究进展

田阳; 饶欢; 薛文通

doi:10.13386/j.issn1002-0306.2017.18.058

花生过敏原检测、降敏加工及脱敏治疗研究进展

田阳^1,2,
饶欢^1,2,
薛文通^1,2

1. 中国农业大学食品科学与营养工程学院北京食品营养与人类健康高精尖创新中心
2. 中国农业大学食品科学与营养工程学院

基金项目:

国家自然科学基金(31471614)；国家现代农业产业技术体系(CARS-09-G15)；

详细信息

作者简介:
田阳 (1992-) , 女, 博士研究生, 研究方向:蛋白质工程, E-mail:Tiany@cau.edu.cn。;

薛文通 (1962-) , 男, 博士, 教授, 研究方向:蛋白质工程, E-mail:xwt@cau.edu.cn。;

中图分类号: R593.1;TS201.6
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- 文章访问数: 205
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出版历程
- 收稿日期: 2017-02-22

Advances in research on the detection of peanut allergens, desensitized process and therapy

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University
College of Food Science and Nutritional Engineering, China Agriculture University

摘要

摘要: 花生过敏在世界范围内的发病率较高,目前尚无有效治疗方法。本文对花生过敏原检测、降敏加工方法进行综述,同时对尚处于研究阶段的花生过敏治疗方法进行整理,为低致敏花生制品的开发及脱敏方法的有效建立提供参考。
- 花生致敏原 /
- 检测 /
- 加工 /
- 脱敏治疗
Abstract: The morbidity of peanut allergy around the world is relatively high, and for now there is no effective treatment.In this paper, the allergen detection and desensitization processing methods were reviewed.Desensitization and treatment methods were also reviewed in this paper, which would provide reference for the development of low-sensitized peanut products and desensitization methods.
- peanut allergens /
- detection /
- processing /
- desensitization therapy

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参考文献(60)

[1]	Sicherer S H, Sampson H A.Food allergy:epidemiology, pathogenesis, diagnosis, and treatment[J].Journal of Allergy and Clinical Immunology, 2014, 133 (2) :291-307.
[2]	周催.利用动物模型研究食物潜在致敏性及其致敏机理[D].北京:中国农业大学, 2014.
[3]	孙娜.细胞模型用于食物蛋白致敏性评价及过敏机制研究[D].北京:中国农业大学, 2015.
[4]	饶欢, 田阳, 陶莎, 等.加工方式对花生致敏性的影响及其致敏性评价研究进展[J].食品科学, 2015, 36 (23) :283-287.
[5]	Fleischer D M, Sicherer S, Greenhawt M, et al.Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants[J].World Allergy Organization Journal, 2015, 8 (1) :27.
[6]	李颖超.加工处理对花生致敏原的影响及其机理[D].无锡:江南大学, 2016.
[7]	Zeleny R, Schimmel H.Towards comparability of ELISA results for peanut proteins in food:A feasibility study[J].Food Chemistry, 2010, 123 (4) :1343-1351.
[8]	Pedrosa M, Boyano-Martínez T, García-Ara C, et al.Utility of specific Ig E to Ara h 6 in peanut allergy diagnosis[J].Annals of Allergy, Asthma&Immunology, 2015, 115 (2) :108-112.
[9]	Klemans R J B, Os-Medendorp H, Blankestijn M, et al.Diagnostic accuracy of specific Ig E to components in diagnosing peanut allergy:a systematic review[J].Clinical&Experimental Allergy, 2015, 45 (4) :720-730.
[10]	Ebisawa M, Movérare R, Sato S, et al.The predictive relationship between peanut-and Ara h 2-specific serum Ig E concentrations and peanut allergy[J].Journal of Allergy and Clinical Immunology.In Practice, 2015, 3 (1) :131.
[11]	韩远龙, 吴志华, 闫飞, 等.花生过敏原检测方法研究进展[J].食品科学, 2012, 33 (13) :305-308.
[12]	Zeleny R, Schimmel H.Towards comparability of ELISA results for peanut proteins in food:A feasibility study[J].Food Chemistry, 2010, 123 (4) :1343-1351.
[13]	贾敏, 张亦凡, 张银志, 等.牛奶过敏原检测方法研究进展[J].食品工业科技, 2015, 36 (12) :385-389.
[14]	马月瑭, 邓列华.花生过敏症[J].实用皮肤病学杂志, 2014 (1) :34-37.
[15]	Eller E, Bindslev-Jensen C.Clinical value of componentresolved diagnostics in peanut-allergic patients[J].Allergy, 2013, 68 (2) :190-194.
[16]	Bock S A, Sampson H A, Atkins F M, et al.Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure:a manual[J].Journal of Allergy and Clinical Immunology, 1988, 82 (6) :986-997.
[17]	李颖超, 钱和, 孙秀兰, 等.典型热加工对花生致敏蛋白及其免疫反应性的影响[J].食品工业科技, 2015 (5) :95-98.
[18]	Rao H, Tian Y, Tao S, et al.Key factors affecting the immunoreactivity of roasted and boiled peanuts:Temperature and water[J].LWT-Food Science and Technology, 2016 (72) :492-500.
[19]	Beyer K, Morrowa E, Li X M, et al.Effects of cooking methods on peanut allergenicity[J].Journal of Allergy and Clinical Immunology, 2001, 107 (6) :1077-1081.
[20]	Guillon B, Bernard H, Drumare M F, et al.Heat processing of peanut seed enhances the sensitization potential of the major peanut allergen Ara h 6[J].Molecular Nutrition&Food Research, 2016, 60 (12) :2722-2735.
[21]	Cai Q, Zhang W, Zhu Q, et al.Influence of heat treatment on the structure and core Ig E-binding epitopes of r Ara h 2.02[J].Food Chemistry, 2016 (202) :404-408.
[22]	Tate M D, Job E R, Deng Y M, et al.Playing hide and seek:how glycosylation of the influenza virus hemagglutinin can modulate the immune response to infection[J].Viruses, 2014, 6 (3) :1294-1316.
[23]	Vissers Y M, Blanc F, Skov P S, et al.Effect of heating and glycation on the allergenicity of 2S albumins (Ara h 2/6) from peanut[J].PLo S One, 2011, 6 (8) :e23998.
[24]	Vissers Y M, Iwan M, Adel-Patient K, et al.Effect of roasting on the allergenicity of major peanut allergens Ara h 1 and Ara h 2/6:the necessity of degranulation assays[J].Clinical&Experimental Allergy, 2011, 41 (11) :1631-1642.
[25]	Liu Y, Zhao G, Zhao M, et al.Improvement of functional properties of peanut protein isolate by conjugation with dextran through Maillard reaction[J].Food Chemistry, 2012 (131) :901-906.
[26]	Blanc F, Vissers Y M, Adel-Patient K, et al.Boiling peanut Ara h 1 results in the formation of aggregates with reduced allergenicity[J].Molecular Nutrition&Food Research, 2011, 55 (12) :1887-1894.
[27]	Radosavljevic J, Nordlund E, Mihajlovic L, et al.Sensitizing potential of enzymatically cross-linked peanut proteins in a mouse model of peanut allergy[J].Molecular Nutrition&Food Research, 2014, 58 (3) :635-646.
[28]	Mihajlovic L, Radosavljevic J, Nordlund E, et al.Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase[J].Food&Function, 2016, 7 (5) :2357-2366.
[29]	Li H, Yu J, Ahmedna M, et al.Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment[J].Food Chemistry, 2013, 141 (2) :762-768.
[30]	周阳.微生物发酵对花生蛋白中致敏因子的影响研究[D].郑州:河南工业大学, 2014.
[31]	Zhao X, Yang W, Chung S Y, et al.Reduction of Ig E immunoreactivity of whole peanut (Arachis hypogaea L.) after pulsed light illumination[J].Food and Bioprocess Technology, 2014, 7 (9) :2637-2645.
[32]	许舒婷, 高美须, 支玉香, 等.电子束辐照对花生过敏原免疫原性及生化性质影响的研究[J].核农学报, 2012, 26 (7) :1006-1011.
[33]	Yang W W, Mwakatage N R, Goodrich-Schneider R, et al.Mitigation of major peanut allergens by pulsed ultraviolet light[J].Food and Bioprocess Technology, 2012, 5 (7) :2728-2738.
[34]	Cabanillas B, Maleki S J, Rodríguez J, et al.Heat and pressure treatments effects on peanut allergenicity[J].Food Chemistry, 2012, 132 (1) :360-366.
[35]	Bublin M, Breiteneder H.Developing therapies for peanut allergy[J].International Archives of Allergy and Immunology, 2014, 165 (3) :179-194.
[36]	White B L, Shi X, Burk C M, et al.Strategies to mitigate peanut allergy:production, processing, utilization, andimmunotherapy considerations[J].Annual Review of Food Science and Technology, 2014 (5) :155-176.
[37]	Chung S Y, Reed S.Reducing food allergy:is there promise for food applications[J].Current Pharmaceutical Design, 2014, 20 (6) :924-930.
[38]	邹丽, 李欣, 高金燕, 等.I型超敏反应中肥大细胞脱颗粒活性物质及其信号通路研究进展[J].食品安全质量检测学报, 2015 (11) :4532-4537.
[39]	温立婷.阻断树突状细胞TSLP受体对TH2免疫反应的影响[D].西安:第四军医大学, 2014.
[40]	Duke Medicine News and Communications.Allergy Treatment Helps Kids Tolerate Some Peanuts[OL].http://corporate.dukemedicine.org/news_andpublications/news_office/news/allergy-treatment-helps-kids-tolerate-some-peanuts/view, 2011-02-09/2014-01-10.
[41]	Schofield A T.A case of egg poisoning[J].The Lancet, 1908, 171 (4410) :716.
[42]	Tang M L K, Ponsonby A L, Orsini F, et al.Administration of a probiotic with peanut oral immunotherapy:a randomized trial[J].Journal of Allergy and Clinical Immunology, 2015, 135 (3) :737-744.
[43]	Canani R B, Nocerino R, Terrin G, et al.Effect of Lactobacillus GG on tolerance acquisition in infants with cow’s milk allergy:A randomized trial[J].Journal of Allergy and Clinical Immunology, 2012, 129 (2) :580.
[44]	Canani R B, Nocerino R, Terrin G, et al.Formula selection for management of children with cow’s milk allergy influences the rate of acquisition of tolerance:a prospective multicenter study[J].The Journal of Pediatrics, 2013, 163 (3) :771-777.
[45]	Hol J, van Leer EHG, Schuurman BEEE, et al.The acquisition of tolerance toward cow’s milk through probiotic supplementation:a randomized, controlled trial[J].Journal of Allergy and Clinical Immunology, 2008, 121 (6) :1448-1454.
[46]	Nadeau K C, Schneider L C, Hoyte L, et al.Rapid oral desensitization in combination with omalizumab therapy in patients with cow’s milk allergy[J].The Journal of Allergy and Clinical Immunology, 2011, 127 (6) :1622.
[47]	Schneider L C, Rachid R, Le Bovidge J, et al.A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients[J].Journal of Allergy and Clinical Immunology, 2013, 132 (6) :1368-1374.
[48]	Bégin P, Dominguez T, Wilson S P, et al.Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab[J].Allergy, Asthma&Clinical Immunology, 2014, 10 (1) :7.
[49]	Wood R A, Kim J S, Lindblad R, et al.A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow’s milk allergy[J].Journal of Allergy and Clinical Immunology, 2016, 137 (4) :1103-1110.
[50]	杨成彬, 闫浩, 刘晓宇, 等.花生过敏小鼠腹腔肥大细胞SOC活性与ROS相关性研究[J].江西师范大学学报 (自然版) , 2012 (1) :29-34.
[51]	Marth K, Focke-Tejkl M, Lupinek C, et al.Allergen peptides, recombinant allergens and hypoallergens for allergenspecific immunotherapy[J].Current Treatment Options in Allergy, 2014, 1 (1) :91-106.
[52]	Zhu Z, Yu J, Niu Y, et al.Enhanced Prophylactic and Therapeutic Effects of Polylysine-Modified Ara h 2 DNA Vaccine in a Mouse Model of Peanut Allergy[J].International Archives of Allergy and Immunology, 2016, 171 (3-4) :241-250.
[53]	Wood R A, Sicherer S H, Burks A W, et al.A phase 1 study of heat/phenol-killed, E.coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy[J].Allergy, 2013, 68 (6) :803-808.
[54]	Prickett S R, Voskamp A L, Dacumos-Hill A, et al.Ara h 2peptides containing dominant CD4+T-cell epitopes:candidates for a peanut allergy therapeutic[J].Journal of Allergy and Clinical Immunology, 2011, 127 (3) :608-615.
[55]	Sampson H A.Peanut oral immunotherapy:is it ready for clinical practice?[J].The Journal of Allergy and Clinical Immunology:In Practice, 2013, 1 (1) :15-21.
[56]	Starkl P, Felix F, Krishnamurthy D, et al.An unfolded variant of the major peanut allergen Ara h 2 with decreased anaphylactic potential[J].Clinical&Experimental Allergy, 2012, 42 (12) :1801-1812.
[57]	Schulz V J, Smit J J, Willemsen K J, et al.Activation of the Aryl Hydrocarbon Receptor Suppresses Sensitization in a Mouse Peanut Allergy Model[J].Toxicological Sciences An Official Journal of the Society of Toxicology, 2011, 123 (2) :491-500.
[58]	Nelson H S.Subcutaneous immunotherapy versus sublingual immunotherapy:which is more effective?[J].The Journal of Allergy and Clinical Immunology:In Practice, 2014, 2 (2) :144-149.
[59]	Dupont C, Agbotounou W K, Thébault C, et al.Deciphering the dose-response effect of Peanut Epicutaneous Immuno Therapy (EPIT) in peanut allergic subjects[J].Allergy:European Journal of Allergy and Clinical Immunology, 2015 (70) :117.
[60]	Ye P, Kulis M D, Guo R, et al.Sublingual Immunotherapy (SLIT) Regulates the Expression of Transcription Factors and Interleukins in Peanut Allergic Children[J].Journal of Allergy and Clinical Immunology, 2016, 137 (2) :AB194.