Abstract: Objective: To compare the antioxidant activity of the ordinary rice peptides, selenomethionine and selenium-riched peptides.Methods: The mice ( 12 months of age) were administrated by the gavage of ordinary rice peptides ( 400 mg/kg·bw, Ⅰgroup) , selenium-riched peptides ( 400 mg/kg·bw, Ⅱ group) , selenomethionine ( 2.5 μg/kg·bw, Ⅲ group) , selenium-riched peptides ( 200 mg/kg·bw) + selenomethionine ( 1.225 μg/kg·bw, Ⅳ group) and resveratrol ( 10 mg/kg·bw, PC group) for 30 d respectively in different groups. The selenium content of Ⅱ group, Ⅲ group and Ⅳ group was same. Results: It showed that compared with the model group, YC group、Ⅱ group、Ⅲ group、Ⅳ group、PC group showed highly significant improvement on SOD in the serum ( p < 0.01) ; YC group、Igroup、Ⅳ group showed significant improvement on GSH in the serum ( p < 0.05) , Ⅱgroup and PC group showed highly significant improvement on GSH ( p < 0.01) ; YC group、Ⅱ group、PC group showed significant improvement on CAT in the serum ( p < 0.05) ; Ⅲ group、Ⅳ group showed significant improvement on GSH-Px in liver homogenateand ( p < 0.05) , II group showed highly significant improvement on GSH-Px ( p < 0.01) ; Ⅱ group、Ⅳ group、PC group showed significant improvement on T-AOC in liver homogenateand ( p < 0.05) ; YC group、Ⅱ group showed significant decrease on MDA in liver homogenateand ( p < 0.05) , PC group showed highly significant decrease on MDA ( p < 0.01) ; YC group、PC group showed significant improvement on GSH in liver homogenateand ( p < 0.05) , II group showed highly significant improvement on GSH ( p < 0.01) , and thymus and spleen index showed different degrees of improvement.The effect of selenium-riched peptides was almost the best, which the antioxidant activities of selenium-riched peptides were significantly higher than that of the ordinary rice peptides and most indexes of selenium-riched peptides were also significantly better than the same selenium content of selenomethionine. Conclusion: It suggested that selenium and peptides in selenium-riched rice peptides had a certain synergy effect on improving antioxidant activities.