叶黄素酯/α-环糊精包合研究

蔡浩锋; 薛可; 卜慧敏; 陈洋; 李文玎; 任勇

doi:10.13386/j.issn1002-0306.2017.15.020

叶黄素酯/α-环糊精包合研究

南京师范大学生命科学学院,江苏省医药超分子材料及应用重点实验室

详细信息

作者简介:
蔡浩锋 (1991-) , 男, 硕士研究生, 研究方向:药物超分子技术, E-mail:f949711833@163.com。;

任勇 (1959-) , 男, 博士, 副教授, 研究方向:药物化学与超分子药学研究, E-mail:renyongphd@126.com。;

中图分类号: TS218
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出版历程
- 收稿日期: 2016-12-28

Evaluation of α-cyclodextrin inclusion compound of lutein esters

College of Life Sciences, Nanjing Normal University, Jiangsu Key Laboratory For Supramolecular Medicinal Materials & Applications

摘要

摘要: 目的:研究叶黄素酯与α-环糊精的包合性能。方法:紫外法测定包合行为并计算表观包合常数;研磨法制备包合物;溶解度为指标确定包合比;DTA、DR-FTIR、UV-vis DRS验证包合物;与β-环糊精和混合环糊精的包合作用比较,测定其溶解度、稳定性。结果:叶黄素酯与α-环糊精表观包合常数Ka为127 L/mol;包合比1∶5时溶解度最佳;α-环糊精使叶黄素酯稳定性增强,溶解度提高为叶黄素酯原料的6倍以上。结论:α-环糊精应用于叶黄素酯性能优于β-环糊精和混合环糊精。
- 叶黄素酯 /
- 环糊精 /
- 包合物 /
- 溶解度 /
- 稳定性
Abstract: Object: To study properties of α-cyclodextrin inclusion compound of lutein esters. Methods: Inclusion process was evaluated by UV spectroscopy and then binding constants was calculated, inclusion compound was prepared by trituration method, lutein solubility was used as the index to determine the appropriate inclusion ratio, inclusion compound was confirmed by differential thermal analysis, infrared diffuse reflection spectrum and UV-vis diffuse reflection spectrum, the solubility and the stability of α-cyclodextrin, β-cyclodextrin and mixed cyclodextrins inclusion compounds of lutein esters were compared.Results: inclusion constants of lutein esters/α-cyclodextrin was 127 L/mol, optimum inclusion mass ratio of lutein esters andα-cyclodextrin was 1 ∶ 5, the solubility of α-cyclodextrin inclusion compound was improved by more 6 times that of lutein esters, the stability of inclusion compound was enhanced.Conclusions: α-cyclodextrin is superior to β-cyclodextrin and mixed cyclodextrins in preparation of lutein esters inclusion complex.
- lutein esters /
- cyclodextrins /
- inclusion compound /
- solubility /
- stability

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